biological molecules ch. 3, 6.4 + 6.5 3-1: why is carbon so important in biological molecules? 3-2:...
TRANSCRIPT
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BIOLOGICAL MOLECULESCh. 3, 6.4 + 6.5
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3-1: Why is Carbon So Important in Biological Molecules?
3-2: How are Organic Molecules Synthesized?
3-3: What are Carbohydrates?
3-4: What are Lipids?
3-5: What are Proteins?
3.6: What are Nucleotides and Nucleic Acids?
6.4: How Do Enzymes Promote Biochemical Reactions
6.5: How are enzymes regulated?
Ch. 3 Biological Molecules
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Chemical Compounds
- _____________ backbone bonded to ____ atoms (CH4)
- can be very _____________- more organic cmpds than
inorganic- common in all living
_______________
- ______ carbon (H2O / NaCl) or hydrogen atoms (CO2)
- less complex - less diverse
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3.1: Why is Carbon So Important ..?
unique bonding properties of carbon are key to the complexity of organic molecules
1. ________ 4 valence electrons
(room for 8)
can form up to __ bonds with other atoms
or itselfcapable of making ______________, and
____________ bondshydrogen
carbon
nitrogen
oxygen
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2. can assume complex _______ (______________ chains,_______, _____________, and _______________)
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3. can attach to ____________________ groups which will determine characteristics and reactivity of molecule
functional groups – ____________& more likely
to _______________ with others
carboxyl
amine
phosphate
sulfhydryl
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______________________ are large polymers
Ex._____________________ _____________________
_____________________ _____________________
3.2: How Are Organic Molecules Synthesized?
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1. Biomolecules are ________________through
____________________or condensation reactions JOINS monomers together
H & OH are _________________ to form ____________molecule
https://www.youtube.com/watch?v=QltPTqEhSaQ – explains monomers & polymers as well - good
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2. Biomolecules are _________________________through
b) _____________________ breaks apart polymers into monomers
1 H2O molecule is ________________________the monomers
https://www.youtube.com/watch?v=QltPTqEhSaQ – 4:15 starts hydrolysis
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3.3: What Are Carbohydrates?
http://www.tv411.org/science/tv411-whats-cooking/carbohydrates-science-lesson - online activity for Intro to Carbs (chemistry & digestion)
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A. Carbohydrate Basics ________________atoms in the ratio of ______ most small carbs are water _______ (________________
= water loving) due to OH functional group (i.e sugar cube in H20)
provide and store ______for cells (i.e cellular respiration) structural _________ (plants, insects, bacterial cell walls)
water
hydroxylgroup
hydrogenbond
Sugar dissolving in water
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1. __________________: C6H12O6 (CH2O)n n = 3-7C
1 simple sugar (1:2:1 ratio of C,H,O) most end in “_______” and named by # of Carbons
Examples
a) _____________/hexose (6-C)-most common in organisms
b) _________ - fruit sugar (corn syrup, honey)
c) _____________- milk sugar found in lactose
d) __________/pentose (5-C) or ______________
(RNA) and (DNA)
B. Specific types of Carbohydrates
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Numbered carbons
C
CC
C
C
C
1'
2'3'
4'
5'
6'
O
energy stored in ______ bondsharvested in cellular respirationenergy stored in ______ bondsharvested in cellular respiration
These will become important!These will become important!
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_______ –molecules w/ same number of atoms but different arrangement (________________________ formula with a _________________________formula)
__________________
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Examples:
1) __________ (table sugar) = glucose+fructose 2) ___________(malt sugar)= glucose+glucose 3)__________(milk sugar) = galactose+glucose
2. _______________________: ___________________ 2 monosaccharides joined via dehydration synthesis general formula is used for _________________storage
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dehydration synthesis
Formation of a Disaccharide
Glucose(__________)
Sucrose + _________(_________________)
Fructose(___________)
H2O +
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3. Polysaccharides chains of monosaccharides (_______________________) costs little to build; easily reversible = release energy
Examples:1) ______________: plant energy-storage2) ________________: animal energy-storage3) _______________: most imp. structural polysaccharide
(cell walls of plants)4) ___________: armour of crabs, spiders, fungi
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Polysaccharide diversity
• Molecular structure determines function
isomers of glucose structure determines function…
in starch in cellulose
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Starch vs. Cellulose
starch_____ todigest
starch_____ todigest
cellulose______ todigest
cellulose______ todigest
only bacteria can digestonly bacteria can digest
enzyme
enzyme
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Cellulose = undigestible roughage • most abundant _________ cmpd on Earth
• herbivores have evolved a mechanism to digest cellulose
• most carnivores have not and that’s why they eat meat to get their energy & nutrients
But it tastes
like hay!
Who can live
on this stuff?!
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Cows digest cellulose well; no need to eat other sugars
Gorillas can’t digest cellulose well; must add another sugar source, like fruit to diet
helpful _____________ live in an herbivores digestive systems & help digest cellulose-rich (grass) meals
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Polymer + H2O _____________________________
_______________________ Disaccharides or Monosaccharides
Disaccharide + H2O ___________________________
_________________ Glucose+Glucose+Glucose+Glucose
hydrolysis
Breakdown of Disachharides & PolysaccharidesVia _________________
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Ch. 3.4
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A. Lipid Basics __________________of H to C atoms contain large chains of non-polar _______________
(hydrophobic/H2O insoluble)
_____________________energy storage (btwn C-H bonds) _________________________component; building blocks
https://www.youtube.com/watch?v=ulIjtl4FPDQ – Lipid structure and function (12 min)
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1. ________________________ (oils and fats): * only contain ______________________ * made up of 3 monomers called __________(long chains of C&H
with a carboxyl group – __________ on 1 end) attached to a ____________(3C backbone)
* uses primarily as ________________________ molecules * contain ____ as many _______/gram than Carbs &
Proteins
B. Specific types of Lipids
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Formation of Fats via Dehydration Synthesis
Triglyceride
https://www.youtube.com/watch?v=eESpP5okA1I (@ 4 min energy and formation of)
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all single bondsbtwn C-atoms- animal fats
(solids; red meat; whole milk
at least 1 double bondbtwn C-atoms
- plant oils (liquids; fish nuts)
1 double bondmore than 1 double bond
https://www.youtube.com/watch?v=E3JkXdjQJJg - differences explained between all 3
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Fats (__________)(butter/lard)
-produced by animals-______________ FA
-lots of H
Oils (___________)corn/canola oil
-found in seeds of plants-____________ FA
-less H
Good Fats vs. Bad Fats?
Hydrogenation & Trans Fats?commercial process where some double bonds in unsaturated FA are broken and hydrogens are added to the carbons -__________ liquid oils to solid fats (trans fat)
http://healthland.time.com/2013/11/07/7-foods-that-wont-be-the-same-if-trans-fats-are-banned/ - explains trans fats and shows examples of fods that contain them
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2. _____________ * chemically similar to fats (1 _____________) but have a long ____________________ * humans & most animals lack appropriate enzymes to break them down * highly _____________ (solid @ room temp.) * ___________________ component & ______________________function
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3. _________________________ * chemically similar to oils (1 ______________________) but have a ____________________________ * crucial _________________ component of cell membranes
Glycerol
Phosphate
Fatty acids
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3. ____________________ don’t resemble fats; have ________________ _________________ – most common steroid precursor to Vit D, testosteronel, estrogen __________________component in animal cell
membranes 2% of human brain (insulate/nerve cells) too much of the wrong form = bad news
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3.5: What Are Proteins?
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A. Protein Basicsconsist of _________________chains of amino acids bonded by __________ bonds via dehydration synthesisact as ___________ to promote rxns___________component (keratin)forms hair, nails, scales & feathers (silk protiens) webs cocoons
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__________ (albumin in eggs & casein in milk) hemoglobin protein _______________ oxygen ____________ (actin & myosin are contractile proteins in muscle) some are hormones (insulin & GH) some are antibodies that fight infection few are toxins (snake venom)
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Amino Acids: _________________ of Proteins
can makedisulfide bonds
1. ________________group 2. ___________(side chain)3. Single ______4. ________________group5. Central ______________
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Amino Acids join via Dehydration Synthesis to make peptides or proteins.
OH + H
a.a + a.a ___________ + H20
a.a. + a.a + a.a. + a.a. + etc ________________+
_______________
H2O H2O H2O
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Levels of Protein Organization interactions btwn the R groups of A.A. cause twists, folds, and
interconnections that give proteins _____________structure
_____________Structure
________________ Structure
_______________ Structure
_______________ Structure
https://www.youtube.com/watch?v=qBRFIMcxZNM – organization and function
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1. Primary Structure – ________________ of amino acids
depends on 1) ______, 2) ______________ and 3) _____________of amino acids
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2. Seconday Structure – simple repeating units
a) _______________or b) ________________ maintained by _____________ btwn polar portion of A.A.
Silk Keratin (hair) Hemoglobin subunits (blood)
H-bonds
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3. Tertiary Structure - 2o structure ______________forming H-bonds w/ H2O & disulfide bridges w/ cysteine A.A.
include _______________ and ____________________ disruption of 2o and 3o bonds = denatured proteins (loss
of function)
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4. Quaternary Structure – when ________________proteins are linked together
i.e. ___________ - 4 protein chains of 150 amino acids some enzymes
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Protein Function Related to Structure
http://on.aol.com/video/learn-about-protein-denaturation-83227098 - review protein organization and protein denaturation
sickle-cell anemia –__________in hemoglobin
egg frying – _______________in albumin
perms – denaturation of ________ in hair
__________ and viruses killed by denaturing their proteins
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3.6: What Are Nucleotides and Nucleic Acids?
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A. Nucleotide basics 1 ______________________ consists of 1) a ____________________(either deoxyribose or ribose) 2) a _____________________ group 3) _____ of 5 different nitrogen –containing _____________
adenine guanine cytosine thymine uracil
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B. Specific Types of Nucleotides and Nucleic Acids
_____(adenosine tri-phosphate), FAD & NAD+
• all ___________________molecules
chains of nucleotides form polymers or nucleic acids
1) __________ – deoxyribonucleic acid• deoxyribose sugar & A, T, G, C
2) ___________– ribonucleic acid• Ribose sugar & A, U, G, C
intracellular messenger molecules
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ATP as an Energy Carrier
ATP – adenosine triphosphate ____________nucleotide ___ phosphate groups
____________________in bonds btwn phosphate groups
energy released when last __________________________
available energy is then used to drive other rxns (i.e. linking amino acids)
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1. ADP + Energy + Phosphate ATP
(stores energy) ______________________________
2. ATP ADP + Phosphate + Energy
(releases energy) _______________________
How is ATP made and broken down?
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Making and Breaking Down Macromolecules
Polymer or Monomer Macromolecule (Building
Blocks)______________________________________
Carbohydrates_____________________________________
fatty acids + glycerol______________________________________
Proteins or Polypeptides ______________________________________
nucleotides_______________________________________
<-------- Dehydration SynthesisHydrolysis -------------http://www.youtube.com/watch?v=H8WJ2KENlK0 – Crash Course Bio Molecules Review(14min)
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How Do Enzymes Promote Biochemical Reactions (Ch. 6.4)
____________ energy determines the speed at which a chemical reaction occurs https://www.youtube.com/watch?v=VbIaK6PLrRM – explains activation energy
* some rxns occur too slowly b/c they have a ______ activation energyenzymes (proteins) are biological _____________which help speed up the rate of reactions (by ___________ activation energy) without themselves being used up or permanently alteredhttps://www.youtube.com/watch?v=1e9EvrThk1Y – how a catalytic converter works
https://www.youtube.com/watch?v=hNl5WYSM5DE Elephant Toothpaste.
not advantageous tospeed up dozens of rxnsat once; so it is a ____________ process
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______________ of enzyme ____________its ____________ (just
like proteins); that structure allows them to catalyze specific reactions
_________________________
shape and charges of the ________________(a.a.) determines what molecules can enter (amylase can digest starch but not cellulose)
https://www.youtube.com/watch?v=lfuOQZJ_MIM (firefly)
each catalyzes only a few types of reactions (most only catalyze _)https://www.youtube.com/watch?v=tI69AVRW0DU (cartoon enzymes in human digestion)
https://www.youtube.com/watch?v=r1ryDVgx0zw (how enzymes work)
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________________________
_______________
Reactant(1 _______________)
Products(2
________________)
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Cells regulate metabolic pathways by controlling the _____ produced. a) ________ of enzymes
b) ___________ of enzymes c) ______ levels of enzymes
as substrate/enzyme levels increase, the rxn rate increases until active sites of all enzymesare being continuously occupied by a new substrate
Genes that code for enzymes can turn ________________(i.e. marathon runners after high-carb pre-competition meals)
Some enzymes only synthesized at ________________________in organisms life (65% of ppl produce less lactase as they age)
inactive forms of enzymes only become ________________when needed (i.e. protein digesting enzymes pepsin & trypsin)
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Competitive or Noncompetitive Inhibition Enzyme Control
Enzymes need to be ______________________at times to prevent 1) substrates from being used up 2) producing too much product
__________________inhibition: a substance, other than the enzyme’s normal substrate, ______________________of enzyme & competes with the actual substrate for active site)
- structural similarities
Ex. 1: _______________________(blocks active site of acetylcholinesterase; excess acetylcholine overstimulates muscles causing paralysis) https://www.youtube.com/watch?v=-gIqZ8IxctE (poisoned
grasshopper)
Ex. 2: antibiotic ___________ inhibits synthesis of bacteria cell walls Ex. 3: __________ & ibuprofen (advil) inhibits synthesis of molecules that contribute to swelling, pain, fever.
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_____________________ inhibition: molecule binds to a site on enzyme different from active site; distorts active site; enzyme less able to catalyze rxn
Ex 1: Potassium ______________ (blocks an enzyme that uses oxygen to produce ATP – deadly) https://www.youtube.com/watch?v=PILzvT3spCQ (short comparison)
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___________ regulation: noncompetitive inhibition where enzymes switch easily between 2 different shapes that either activate or inhibit the enzyme (i.e. ADP)
https://www.youtube.com/watch?v=d5fDEUhjo-M – allostericRegulation https://www.youtube.com/watch?v=DHZtOKyMPRY – feedback inhibition
________________inhibition: form of allosteric regulation; causes metabolicpathways to stop producing its end product when its concentration reachesreaches an optimal level (thermostat)
As levels of isoleucine rise,isoleucine binds to the regulatorysite on enzyme 1, inhibiting it
intermediates
enzyme 1 enzyme 2 enzyme 3 enzyme 4 enzyme 5
enzyme 1
isoleucine
isoleucine(end product)
threonine(initial
reactant)
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Factors that Affect Enzymes enzymes have a narrow range of conditions (_________________)
in which they function optimally (H-bonds btwn polar a.a.)
human cellular enzymes work best around pH 7.4; human digestive enzymes work best around pH 2
enzymes become ______________in unfavorable conditions and lose3-D structure required to functionproperly
For pepsin, maximumactivity occurs at
about pH 2
For most cellularenzymes, maximum
activity occursat about pH 7.4
For trypsin, maximumactivity occurs at
about pH 8 fast
Effect of pH on enzyme activity
For most human enzymes maximum activity occursat about 98.6F (37C)
rate of
reaction
fast
slow
Effect of temperature on enzyme activity
temperature60 (C)0 4020140 (F)32 68 104
slow
rate of
reaction
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Enzymes in our Digestive System food travels through many organs of the digestive system & broken down into usable ___________________________
1. mouth: 1 minute mechanical digestion via teeth chemical digestion via enzyme ______________________
2. esophagus: 2-3 seconds tube that leads to the stomach via peristalsis
3. stomach: 2-4 hoursmechanical digestion via muscle churningchemical digestion via enzyme ________________________
4. small intestine: 3-5 hours bile (liver/gall bladder) & ______________ chemically breaks down fat enzymes _____________________________________break down carbs nutrients are absorbed
5. large intestine: 10 hrs – days absorbs H2O and eliminates wastes
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amylase
pepsin
LipaseMaltaseSucraseLactase
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Study Ch. 3, 6.4 & 6.5 Key Vocab Terms
Read summary of key concepts Ch. 3 and 6.4 and 6.5
Be able to answer the Learning Outcomes in Ch. 3 LO 1-7 and Ch. 6.4 and 6.5 LO 5-7.
Be able to answer all the Check Your Learning questions and check answers for all sections
Complete Thinking through the Concepts and Applying the Concepts for all sections.
Go to the Study Area on MasteringBiology for practice, animations, quizzes, activities, etc.