bio-bandage which injects medicine to organ directly using extension of the hydrogel 서강대학교...
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Bio-bandage which injects medicine to organ directlyusing extension of the Hydrogel
서강대학교 화공생명공학과 연성물질공학연구실 .김정민 김영대 양태경 임승모
서강대학교 화공생명공학과 - 화공생명공학심화설계 , 2014
Background
Manufacture process
Bandage for organ
Invivo bandage!
+ injection drugs to organ directly
+ dissolve itself in body Bilayer structure
Objective
Previous study
Experiment & Result
Step1. Prepare Hydrogel Step2. 1st Layered glass
Step5. Chain-polymerization of 2nd hydrogel
Curvature of bilayerHydrogel properties
technogel,, plastic solution company
Hydrogel Timoshenko equation
Extension / Micro size processing Physical property / Micro size
Step3. Photopolymeriztion of 1st Hyrogel
Step4. Stack 2nd layered glass
Drug is injected by adequate circumstance
l l
t1
t2
E1
E2
=
m= /
Network structure polymer
Properties of hydrogel are similar with the cellEasy processing
Drug release by specific Temperature, ionic/magnetic force, PH or wavelength
Application
Pilot test product
1st gel chain
2nd gel chain
Step6. Remove glasses & residue
Degassing Hydrogel
Degassing HydrogelResidue should be removed
Control degree of crosslinking
Control bilayer thickness
Low Modulus hydrogel (Extension occur)
High Modulus hydrogel(Forming hard structure)
Remove gas in molecules by vacuum pressure
Remove Oxygen
Bio-bandage Control of injected materials Where can we use Bio-bandage?
Control of injection timeAdvantage
Change types of medicine
Extension of hydrogel by liquids
Possible to inject drug of your choice
Possible to control the quantity of in-jected medicine
Control of duration of medicine efficiencyControling the quantity of crosslink can change duration of drug emission
Duration of medicine
- Damaged organ- Place of sutures- Bleeding wound
Attach Bio-bandage to damaged or wounded organ
After attached, medicine continuously is injected by extension of hydrogel
Hard structure that prohibit gel deformation or damaged
1st hydrogel
Similar properties with cell
2nd hydrogel
Inject medicine to organ by extension of hydrogel
Low extension that prohibit gel expansion to wrong area
Control of size or shape
Swelling
Swelling by ModulusControl of gel size easilyControl of shape by Timo-shenko equation
HydrogelUsually used bio-material
Easy control of releasing
Easy control of size
No technology for drug deliv-ery to organs
Drug delivery
Purpose Hydrogel bandage
Similar properties with organ
OctoDex, Octoplus companyCure surgical site
We can control releasing time and types of drug
Hydrogel has good bio-compability
We can find hydrogel is appropriate for drug delivery
So We attempt to develop bio-bandage for internal organs
(a) Schematic degradation process (b) photographs of hydrogels in dry state and during degradation process
We can make biodegradable hydrogel with natural polymers such as collagen, DNA Also, with degradable cross linking agent , we can synthesize biodegradable hydrogel
This hydrogel is liquid in room temperature. So it is more convenient to use and more applicable material to medi-cal field
We can make bio-adhesive hydrogel synthesizing pluronic-thiol ( Plu-SH)and catechol-functionalized hyaluronic acid.It is designed to mimic the properties of mussel
No needs to additional operation for removing bandage
Bio-adhesive
Transportation of drug
Swelling
Dried hydrogels have drugs - tight network structure
A
A
B
B
Experiment of sample’s diffusion Experiment of diffusion rate
0min 15min
30min
Being able to control sample diffusion rate us-ing cross link ratio
Bio-degradable
Expected occupation of demands
Swelled hydrogels release drugs- loose network structure
PolymerizationPhotopolymerization
Chainpolymerization
1. Drug can be transported directly without additional
injecting medication.2. We can control the site where drug is injected .
4. The method of uses is simple.
the hydrogel bandage can be applied for biotechnology such as surgical operation, plastic surgery, bio-sensor, drug delivery, etc.
Diffusion rate of sampleDifference of cross link ratio
Cross linker Monomer Water(dye) Initiator7 50 140.8 2.029 50 138.8 2.0211 50 136.8 2.0212 50 135.8 2.0213 50 134.8 2.0215 50 132.8 2.02
Crosslinker ratio
Diffused dyeDiffusion
Measure average intensity on rec-tangle of UV dye by ZEN software
Detection of UV dyeMeasure intensity of UV dye
Intensity is positively time dependent
3. We can control the effective duration of medicine