LOOKBOOK

BEFORE AND AFTER BUILDER:

MENRichard D. lost 66 pounds in 14 months and 1 week using Plexus Slim®, performing moderate exercise (2-4 days/week), and maintaining a daily diet consisting of 2000 to 2500 calories. Richard is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used one pack of Slim twice a day lost an average of 5.45 pounds in 8 weeks, while the placebo group lost an average of 3.12 pounds. There was a trend to weight decrease with Slim group (p=0.059).

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Jordan W. lost 41 pounds in 13 months and 1 week using Plexus TriPlex™, light exercise (0-1 days/week), and a 2000 to 2500 average calorie diet. Jordan is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Clark {Hank} T. lost 75 pounds in 10 months and 1 week using Plexus TriPlex™, performing moderate exercise (2-4 days/week), and maintaining a daily diet consisting of 1500 to 2000 calories. Clark {Hank} is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Jim J. lost 30 pounds in 7 months using Plexus TriPlex™, moderate exercise (2-4 days/week), and a 1200 to 1500 average calorie diet. Jim is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Cale G. lost 34 pounds in 3 months and 2 weeks using Plexus TriPlex™, performing light exercise (0-1 days/week), and maintaining a daily diet consisting of 2000 to 2500 calories. Cale is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Chris P. lost 50 pounds in 12 months using Plexus TriPlex™, heavy exercise (4 days/week), and a 2500 to 3000 calories average calorie diet. Chris is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Eric P. lost 27 pounds in 9 weeks and 5 days using Plexus TriPlex™, performing moderate exercise (2-4 days/week), and maintaining a daily diet consisting of 1500 to 2000 calories.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Jason M. lost 50 pounds in 7 months using Plexus TriPlex™, performing moderate exercise (2-4 days/week), and maintaining a daily diet consisting of 2000 to 2500 calories. Jason is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

John G. lost 61 pounds in 6 months and 4 weeks using Plexus TriPlex™, performing heavy exercise (4 days/week), and maintaining a daily diet consisting of 1200 to 1500 calories. John is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Keith S. lost 20 pounds in 9 months and 4 weeks using Plexus TriPlex™, performing moderate exercise (2-4 days/week), and maintaining a daily diet consisting of 2000 calories. Keith is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Michael G. lost 25 pounds in 3 months using Plexus TriPlex™, performing light exercise (0-1 days/week), and main-taining a daily diet consisting of 1500 to 2000 calories. Michael is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

WOMENAmber B. lost 52 pounds in 8 months and 2 weeks using Plexus TriPlex™, perfroming moderate exercise (2-4 days/week), and maintaing a daily diet consisting of 1000 to 1200 calories. Amber is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Alaina C. lost 13 pounds in 4 months and 3 weeks using Plexus TriPlex™, moderate exercise (2-4 days/week), and a 1200 to 1500 average calorie diet. Alaina is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Mary N. lost 60 pounds in 11 months and 1 week using Plexus TriPlex™, light exercise (0-1 days/week), and a 1500 to 2000 average calorie diet. Mary is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Amy R. lost 14 pounds in 6 weeks and 3 days using Plexus TriPlex™, performing light exercise (0-1 days/week), and maintaining a daily diet consisting of 1500 to 2000 calories. Amy is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Brenda S. lost 51 pounds in 14 months and 1 week using Plexus TriPlex™, moderate exercise (2-4 days/week), and a 1500 to 2000 average calorie diet. Brenda is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Misty W. lost 80 pounds in 10 months using Plexus TriPlex™, heavy exercise (4 days/week), and a 2000 to 2500 average calorie diet. Misty is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Gina S. lost 32 pounds in 5 months using Plexus TriPlex™, moderate exercise (2-4 days/week), and a 1500 to 2000 average calorie diet. Gina is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Theresa B. lost 32 pounds in 5 months using Plexus TriPlex™, moderate exercise (2-4 days/week), and a 1500 to 2000 average calorie diet. Theresa is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Shelby S. lost 35 pounds in 8 months and 1 week using Plexus TriPlex™, performing moderate exercise (2-4 days/week), and maintaining a daily diet consisting of 1500 to 2000 calories. Shelby is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Sherry K. lost 42 pounds in 5 months using Plexus TriPlex™, moderate exercise (2-4 days/week), and a 1500 to 2000 average calorie diet. Sherry is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Ashton S. lost 75 pounds in 13 months and 3 weeks using Plexus TriPlex™, light exercise (0-1 days/week), and a 1000 to 1200 average calorie diet. Ashton is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Marissa A. lost 24 pounds in 6 months using Plexus TriPlex™, moderate exercise (2-4 day/week), and a 1200 to 1500 average calorie diet. Marissa is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Elena S. lost 25 pounds in 6 months and 2 weeks using Plexus TriPlex™, heavy exercise (4 days/week), and a 1200 to 1500 average calorie diet. Elena is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Stacy A. lost 25 pounds in 3 months using Plexus TriPlex™, performing heavy exercise (4 days/week), and maintain-ing a daily diet consisting of 1200 to 1500 calories. Stacy is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Heather R. lost 46 pounds in 6 months using Plexus TriPlex™, moderate exercise (2-4 days/week), and a 1500 to 2000 average calorie diet. Heather is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Meghan F. lost 43 pounds in 12 months using Plexus TriPlex™, performing moderate exercise (2-4 days/week), and maintaining a daily diet consisting of 1500 to 2000 calories. Meghan is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Ketrah H. lost 62 pounds in 18 months and 1 week using Plexus TriPlex™, moderate exercise (2-4 days/week), and a 1000 to 1200 average calorie diet. Ketrah is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Julie A. lost 30 pounds in 10 months using Plexus TriPlex™, light exercise (0-1 days/week), and a 1500 to 2000 average calorie diet. Julie is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Rachel S. lost 15 pounds in 7 months and 1 week using Plexus TriPlex™, performing heavy exercise (4 days/week), and maintaining a daily diet consisting of 1500 to 2000 calories. Rachel is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Kristen W. lost 71 pounds in 8 months using Plexus TriPlex™, performing light exercise (0-1 days/week), and main-taining a daily diet consisting of 1500 to 2000 calories. Kristen is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Kerrie S. lost 54 pounds in 9 months using Plexus TriPlex™, performing light exercise (0-1 days/week), and main-taing a daily diet consisting of 1200 to 1500 calories. Kerrie is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Kathy H. lost 50 pounds in 12 months and 1 week using Plexus TriPlex™, performing moderate exercise (2-4 days/week), and maintaining a daily diet consisting of 500 to 1500 calories. Kathy is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

Lauren G. lost 27 pounds in 3 months using Plexus TriPlex™, light exercise (0-1 days/week), and a 1500 to 2000 average calorie diet. Lauren is a Plexus Ambassador.

Participants in an independent, randomized, double-blind, placebo-controlled, human clinical study who used Slim twice a day and BioCleanse and ProBio 5 lost an average of 7.21 pounds in 8 weeks, while the placebo group only lost an average of 0.19 pounds.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PLEXUS SLIM® AND TRIPLEX CLINICAL STUDY ABSTRACT

BACKGROUND

The frequency of people being overweight has risen dramatically in recent years. Numerous natural weight management products are marketed claiming to help with weight loss. However few weight management products undergo scientific research demonstrating their safety and efficacy.

CONCLUSIONS

COPYRIGHT 2016 ©PLEXUS WORLDWIDE LLC. ALL RIGHTS RESERVED.

Both Plexus Slim and Tri-Plex administrations are safe and effective adjunct to an eight-week diet weight loss program by inducing weight loss. In particular, both Slim and Triplex demonstrated significantly greater reductions in body weight in subjects who have heavier initial body weight (BMI≥35).

OBJECTIVES

The present study investigated the safety and efficacy of dietary supplements on weight loss in men and women with a BMI ≥27 kg/m2 over 8 weeks.

STUDY DESIGN AND METHODS

In a multi-center, double-blind, placebo-controlled, randomized trial, 196 subjects were randomly assigned to either Plexus Slim supplement (one pack, twice a day) or Plexus Triplex™ supplements (one pack of Slim, twice a day; one capsule of BioCleanse, twice a day; and one capsule of ProBio5), or the corresponding placebo controls. During the study, subjects were guided to adhere to a Mediterranean Diet.

RESULTS

Of the 175 subjects who completed the study, subjects in the Triplex treatment group had lost a mean of 7.21lb (SEM = 0.70) body weight, while the placebo group lost a mean of 0.19 lb (SEM = 0.59) body weight (p<0.001). Mean change in body weight from baseline to endpoint lost 5.45 lb (SEM = 0.94) and 3.12 lb (SEM = 0.76) for the Slim treatment and placebo groups, respectively; there was a trend to weight decrease with the Slim group (p=0.059). The Triplex group had a much greater weight loss than the Slim group (p<0.001), suggesting a substantially greater effect for Triplex. When using a body-mass index (BMI) cutoff of ≥35, there were statistically significant differences in both mean body weight (-6.59 vs. -2.67 lb, p = 0.025) and BMI (-1.25 vs. -0.52, p = 0.033) changes in the Slim group, compared with placebo. Significantly greater reductions in both body weight (-8.84 vs. -0.42 lb, (p < 0.001) and BMI (-2.32 vs. 1.13, p = 0.002) were also found in the Triplex group, compared with placebo. There was a significant difference in the proportion of subjects achieving at least 5% of weight loss between the treatment and placebo groups (p = 0.01). There were 11.1% and 25.6% of individuals in the Slim and Triplex groups, respectively, who lost at least 5% of their initial body weight, while no individuals were found to have lost this much weight in the both placebo groups. No clinically significant adverse effects were observed.