MOLECULAR PHARMACOLOGY, 12, 1106-1114

Copyright © 1976 by Academic Press, Inc.All rights or reproduction in any form reserved.

AUTHOR INDEX FOR VOLUME 12

A

Abou-Donia, Mohamed B. See McPhai! and Rosen,

590

Abrahams, Sanders L. , Northup, John K. and Man-sour, Tag E. Adenosine Cyclic 3’ ,5’-Mono-phosphate in the Liver Fluke, Fascioki he-

patica. I. Activation of Adenylate Cyclase by

5-Hydroxytryptamine, 49

Abrahams, Sanders L. See Gentleman and Man-

sour, 59

Akera, Tai, Ku, David, Tobin, Thomas and Brody,Theodore M. The Complexes of0uabain with

Sodium- and Potassium-Activated Adenosine

Triphosphatase Formed with Various Li-

gands: Relationship to the Complex Formed

in the Beating Heart, 101

Albuquerque, E. X., Brookes, N., Onur, R. and

Warnick, J. E. Kinetics of Interaction of Ba-

trachotoxin and Tetrodotoxin on Rat Dia-

phragm Muscle, 82

Alderfer, James L. See Arya, Carter and Ts’o, 234

Alderfer, James L. See Ts’o, Levy, Marsha!!,

O’Ma!ley, Horoszewicz and Carter, 299

Alderfer, James L. See Carter, O’Malley, Beeson,

Cunnington, Kelvin, Vere-Hodge and Ts’o,

440

Allan, Paula W. See Bennett, Hill, Thomas and

Carpenter, 242

Ari#{235}ns, E. J. See Lien and Rodrigues de Miranda,

598

Arin#{231},Emel. See Philpot, 483

Arya, S. K., Carter, William A., Alderfer, James L.and Ts’o, Paul 0. P. Inhibition ofSynthesis ofMurine Leukemia Virus in Cultured Cells by

Polyribonucleotides and Their 2’-O-Alkyl De-

rivatives, 234

Arya, S. K., Helser, T. L., Carter, W. A. and Ts’o,P. 0. P. Polyxanthylic and Polyguanylic Acid

Inhibition of Murine Leukemia Virus Activi-

ties, 844

B

Baguley, Bruce C. See Cain and Wilson, 1027

Barker, L. A. See Collier and Mittag, 340

Bartels-Bernal, Eva, Rosenberry, Terrone L. and

Chang, Hai Won. A Membrane ActivationCycle Induced by Sulfhydryl Reagents after

Affinity Labeling of the Acetyicholine Recep-

tor of Electroplax, 813

Beeson, Malcolm. See Carter, O’Malley, Cunning-

1106

ton, Kelvin, Vere-Hodge, Alderfer and Ts’o,

440

Belcher, Daniel H. See Kamataki and Neal, 921

Bennett, James P., Jr. and Snyder, Solomon H.Serotonin and Lysergic Acid Diethylamide

Binding in Rat Brain Membranes: Relation-

ship to Postsynaptic Serotonin Receptors, 373

Bennett, L. Lee, Jr., Allan, Paula, W., Hill, DonaldL. , Thomas, H. Jeanette and Carpenter, JeanW. Metabolic Studies with an a-Nucleoside,9-a-D-Arabinofuranosyl-8-azaadenine, 242

Bettis, Carol J. See Wirth and Nelson, 759

Bina-Stein, Minou and Tritton, Thomas R. Aurin-

tricarboxylic Acid is a Nonspecific Enzyme

Inhibitor, 191

Birkett, D. J. See Sud!ow and Wade, 1052

Bittner, Mary A. and Ruddon, Raymond W. Induc-

tion and Decay of Aryl Hydrocarbon Hydrox-

ylase Activity in Mouse 3T3 Cells, 966

Bl#{225}ha, Karel. See Cort, Fri#{235},Carlsson, Gillessen,

Bystricky, �kopkova, Gut, Studer and

Mulder, 313

Blisard, Karen S. See Diamond, 688

Bloom, F. E. See Nathanson, 390

Boadle-Biber, Margaret C. See Morgenroth and

Roth, 41

Boggs, J. M., Yoong, T. and Hsia, J. C. Site and

Mechanism of Anesthetic Action. I. Effect of

Anesthetics and Pressure on Fluidity of Spin-

Labeled Lipid Vesicles, 127

Boggs, J. M., Roth, S. H., Yoong, T., Wong, E. and

Hsia, J. C. Site and Mechanism of AnestheticAction. II. Pressure Effect on the Nerve Con-

duction-Blocking Activity ofa Spin Label An-

esthetic, 136

Bourne, Henry R. See Melmon, Weinstein, Poon,

Shearer and Castagnoli, 701

Bourne, Henry R. Seelnsel, Maguire, Gilman, Cof-

fino and Melmon, 1062

Boyd, Helen and Martin, T. J. Changes in Catechol-

amine- and Glucagon-Responsive Adenylate

Cyclase Activity in Preneoplastic Rat Liver,195

Brody, Theodore M. See Akera, Ku and Tobin, 101

Brookes, N. See Albuquerque, Onur and Warnick,

82

Brostrom, Charles 0. See Browning and Groppi, 32Browning, Edward T., Brostrom, Charles 0. and

Groppi, Vincent E., Jr. Altered AdenosineCyclic 3’,5’-Monophosphate Synthesis and

Degradation by C-6 Astrocytoma Cells Fol-

AUTHOR INDEX

lowing Prolonged Exposure to Norepineph-

rine, 32

800

1107

Burghardt, Charles R. See Sheppard and Teitel, 854

Burt, David R., Creese, Ian and Snyder, SolomonH. Binding Interactions of Lysergic Acid Di-ethylamide and Related Agents with Dopa-

mine Receptors in the Brain, 631

Burt, David R., Creese, Ian and Snyder, SolomonH. Properties of [3H]Haloperidol and[3H]Dopamine Binding Associated with Do-pamine Receptors in Calf Brain Membranes,

Butcher, Fred R., Rudich, Lynn, Emler, Carol andNemerovski, Mark. Adrenergic Regulation ofCyclic Nucleotide Levels, Amylase Release,

and Potassium Efflux in Rat Parotid Gland,

862

Butler, K. W. See Neal, Polnasek and Smith, 144

Bylund, David B. and Snyder, Solomon H. Beta

Adrenergic Receptor Binding in Membrane

Preparations from Mammalian Brain, 568

Bystricky, SlavomIr. See Cort, Fri#{235},Carlsson, Gil-

lessen, �kopkova, Gut, Studer, Mulder and

Bldha, 313

C

Cain, Bruce F., Wilson, William Robert and Bagu-ley, Bruce C. Structure-Activity Relation-

ships for Thiolytic Cleavage Rates of Antitu-

mor Drugs in the 4’-(9-Acridinylamino)-

methanesulfonanilide Series, 1027

Cann, John R. See Hinman, 769

Carlsson, Lars. See Cort, Fri#{235},Gillessen, Bystrick?,

�kopkova, Gut, Studer, Mulder and Bldha,

313Caron, Marc G. See Mukherjee, Mullikin and Lef-

kowitz, 16

Carpenter, David 0., Greene, Lloyd A., Sham, Wil-ham and Vogel, Zvi. Effects of Eserine andNeostigmine on the Interaction of a-Bungaro-

toxin and Aplysia Acetylcholine Receptors,

999

Carpenter, Jean W. See Bennett, Allan, Hill and

Thomas, 242

Carter, William A. See Arya, Alderfer and Ts’o, 234

Carter, William A., O’Malley, Judith, Beeson, Mal-colm, Cunnington, Peter, Kelvin, Alan,Vere-Hodge, Anthony, Alderfer, James L.

and Ts’o, Paul 0. P. An Integrated and Com-parative Study of the Antiviral Effects andOther Biological Properties of the Polyino-

sinic � Polycytidylic Acid Duplex and Its Mis-

matched Analogues. III. Chronic Effects andImmunological Features, 440

Carter, W. A. See Arya, Helser and Ts’o, 844

Castagnoli, Neal, Jr. See Melmon, Weinstein,

Bourne, Poon and Shearer, 701

Chang, Hai Won. See Bartels-Bernal and Rosen-

berry, 813

Changeux, J.-P. See Kato, 92

Chan-Stier, Christine. See Minkel and Petering,

1036

Chen, Wen-Sherng. See Maglothin and Wilson, 658

Chignell, Cohn F. See Wee, Sinha and Taylor, 667

Chignell, Cohn F. See Wee, Feldmann and Tanis,

832

Chignell, Cohn F. See Weiland, Georgia, Wee and

Taylor, 1091

Chou, David. See Weinstein, Johnson, Kang and

Green, 738

Chuang, De-Maw and Costa, Erminio. Trans-syn-aptic Regulation of Ribonucleic Acid Biosyn-

thesis in Rat Adrenal Medulla, 514

Chytil, Frank. See Moses, Spelsberg and Korinek,

731

Coffino, Philip. See Insel, Maguire, Gilman,

Bourne, and Me!mon, 1062

Collier, B., Barker, L. A. and Mittag, T. W. TheRelease of Acetylated Choline Analogues by aSympathetic Ganglion, 340

Colquhoun, D. and Rang, H. P. Effects of Inhibitorson the Binding of lodinated a-Bungarotoxin

to Acetylcholine Receptors in Rat Muscle, 519

Cort, Joseph H., Frk, Ivo, Carlsson, Lars,Gillessen, Dieter, Bystricky, SlavomIr,�kopkova, Jana, Gut, Vladimir, Studer, Rolf0., Mulder, Jan L. and Bl#{225}ha,Karel. Biologi-

cal and Chiroptical Sequelae of Graded Alkyl

Substitutions in the Vasopressin Ring, 313

Costa, E. See Kurosawa and Guidotti, 420

Costa, Elizabeth. See Costa, Manen, Sipes and Rus-

sell, 871

Costa, Erminio. See Chuang, 514

Costa, Max, Costa, Elizabeth R., Manen, Carol-Ann, Sipes, I. Glenn and Russell, Diane Had-

dock. Adenosine Cyclic 3’,S’-Monophosphate-Dependent Protein Kinase and Ornithine De-carboxylase Involvement in the Induction of

Cytochrome P-450 and Hepatic Hypertrophy,

871

Coutinho, Claude B. See Lucek, 612

Creese, Ian. See Burt and Snyder, 631

Creese, Ian. See Burt and Snyder, 800

Creveling, C. R. See Rotman and Daly, 887

Cunnington, Peter. See Carter, O’Malley, Beeson,

Kelvin, Vere-Hodge, Alderfer and Ts’o, 440

Cuthbert, A. W. Importance of Guanidinium Groups

for Blocking Sodium Channels in Epithelia,

945

Czernik, Andrew J. See Petrack, 203

I)

Daly, J. W. See Rotman and Creveling, 887

Daly, J. W. See Schwabe, Miyake and Ohga, 900

Dc Clercq, E., Edy, V. G., Torrence, P. F., Waters,

1108 AUTHOR INDEX

Gentleman, Susan, Abrahams, Sanders L. and

Mansour, Tag E. Adenosine Cyclic 3’ ,5’-

J. A. and Witkop, B. Antiviral Activity of

Poly(7-deazainosinic acid)-Derived Com-

plexes in Vitro and in Vivo, 1045

DeLuca, Hector F. See Stern, Mavreas, Trummel

and Schnoes, 879

Dewey, William L. See Johnson and Harris, 345

Diamond, Jack and Blisard, Karen S. Effects of

Stimulant and Relaxant Drugs on Tension

and Cyclic Nucleotide Levels in Canine Fern-

oral Artery, 688

DiAugustine, Richard P. Formation in Vitro and in

Vivo of the Isonicotinic Acid Hydrazide Ana-

logue of Nicotinamide Adenine Dinucleotide

by Lung Nicotinamide Adenine Dinucleotide

Glycohydrolase, 291

Duceman, Barry W. See Smith, Liu, Leonard and

Vesel!, 820

Duerr, A. C. See Trifaro and Pinto, 536

Dunant, Yves. See Zubler-Faivre, 1007

Dybing, E., Nelson, S. D., Mitchell, J. R., Sasame,

H. A. and Gillette, J. R. Oxidation of a-Meth-

yldopa and Other Catechols by Cytochrome P-

450-Generated Superoxide Anion: Possible

Mechanism of Methyldopa Hepatitis, 911

E

Ebstein, Richard P. SeePark, Kashimoto and Gold-

stein, 73

Edy, V. G. See De C!ercq, Torrence, Waters and

Witkop, 1045

Eikelboom, T. D. See Rodrigues de Miranda and

van Os, 454

E mler, Carol. See Butcher, Rudich and Nemerouski,

862

F

Fain, John N. See Yamamura and Rodbel!, 693

Feldmann, Richard J. See Wee, Tanis and Chignel!,

832

Felton, James S., Nebert, Daniel W. and Thorgeirs-

son, Snorri S. Genetic Differences in 2-Ace-tylaminofluorene Mutagenicity in vitro Asso-

ciated with Mouse Hepatic Aryl Hydrocarbon

Hydroxylase Activity Induced by Polycyclic

Aromatic Compounds, 225

Fertel, Richard and Weiss, Benjamin. Properties

and Drug Responsiveness of Cyclic Nucleo-

tide Phosphodiesterases of Rat Lung, 678

Forn, Javier. SeeKrueger, Walters, Roth and Green-

gard, 639

Freedman, Daniel X. See Love!!, 620

Frit, Ivo. See Cort, Car!sson, Gi!lessen, Bystrickj,

�kopkova, Gut, Studer, Mulder and Bldha,

313

G

Monophosphate in the Liver Fluke, Fasciola

hepatica. II. Activation of Protein Kinase by

5-Hydroxytryptamine, 59

Georgia, Brian. See Weiland, Wee, Chignell and

Taylor, 1091

Gillessen, Dieter. See Cort, Fri#{235}, Carlsson, Bys-

tricks, �kopkova, Gut, Studer, Mulder and

B!#{225}ha, 313

Gillette, J. R. See Dybing, Nelson, Mitchell and

Sasame, 911

Gilman, Alfred G. See Maguire and Van Arsdale,

335

Gilman, Alfred G. See Insel, Maguire, Bourne, Cof-

fino and Melmon, 1062

Goldman, I. David. See White, 711

Goldstein, Menek. See Park, Kashimoto, and Eb-

stein, 73

Green, Jack Peter. See Weinstein, Chou, Johnson

and Kang, 738

Greene, Lloyd, A. See Carpenter, Sham and Vogel,

999

Greengard, Paul. See Krueger, Forn, Walters and

Roth, 639

Grindey, Gerald B. See Lowe, 177

Groppi, Vincent E., Jr. See Browning and Bros-

trom, 32

Guidotti, A. See Kurosawa and Costa, 420

Gupta, Surendra K., Moran, John F. and Triggle,

David J. Mechanism of Action of Benzilylcho-

line Mustard at the Muscarinic Receptor,

1019Gut, Vladimir. See Cort, Fri#{235},Carlsson, Gillessen,

Bystrick�, �kopkova, Studer, Mulder and

Bl#{225}ha,313

H

Hahn, Fred E. See Krey and Olenick, 185

Harden, T. Kendall, Wolfe, Barry B. and Molinoff,

Perry B. Binding of lodinated Beta Adrener-gic Antagonists to Proteins Derived from Rat

Heart, 1

Harris, Jane E. Beta Adrenergic Receptor-Mediated

Adenosine Cyclic 3’ ,5’-Monophosphate Accu-

mulation in the Rat Corpus Striatum, 546

Harris, Louis S. See Johnson and Dewey, 345

Harris, Ward E. and Stahl, William L. Effects of

Cations and Propranolol on a Fluorescent

Phospholipid Incorporated into Brain Synap-

tosome Membranes, 115

Heliman, Bo, Idahi, Lars-Ake, Lernmark, Ake,

T#{228}ljedal, Inge-Bert and Thomas, Emrys W.

The Pancreatic f3-Cell Recognition of Insulin

Secretagogues. XII. Insulin Release in Re-

sponse to Halogenated Hexosarnines, 208

Helser, T. L. See Arya, Carter and Ts’o, 844

Hilbers, C. W. See Rodrigues de Miranda, 279

Hill, Donald L. See Bennett, Allan, Thomas and

Carpenter, 242

Hinman, Norman D. and Cann, John R. Reversible

AUTHOR INDEX 1109

Binding of Chlorpromazine to Brain Tubulin,

769

Holohan, P. D., Pessah, N. I., Warkentin, D. and

Ross, C. R. The Purification of an Organic

Cation-Specific Binding Protein from Dog

Kidney, 494Horoszewicz, Julius S. See Ts’o, Alderfer, Marsha!!,

O’Ma!!ey and Carter, 299

Horwitz, Susan B. See Liao and Kupchan, 167

Hsia, J. C. See Boggs and Yoong, 127

Hsia, J. C. SeeBoggs, Roth, Yoong and Wong, 136

Hucho, F. See Layer and Kiefer, 958

Idahl, Lars-Ake. See Hel!man, Lernmark, Td!jedal

and Thomas, 208

Insel, Paul A., Maguire, Michael E., Gilman,

Alfred G., Bourne, Henry R., Coffino, Philip

and Melmon, Kenneth L. Beta Adrenergic

Receptors and Adenylate Cyclase: Products of

Separate Genes, 1062Iversen, L. L., Rogawski, M. A. and Miller, R. J.

Comparison of the Effects of Neuroleptic

Drugs on Pre- and Postsynaptic Dopami-

nergic Mechanisms in the Rat Striatum, 251

Iwasaki, Kuzuhide. See Sugiura and Kato, 322

J

Johnson, Carl L. See Weinstein, Chou, Kang and

Green, 738

Johnson, Kenneth M., Dewey, William L. and Har-

ris, Louis S. Some Structural Requirements

for Inhibition of High-Affinity Synaptosomal

Serotonin Uptake by Cannabinoids, 345

K

Kamataki, Tetsuya, Belcher, Daniel H. and Neal,

Robert, A. Studies of the Metabolism of Di-

ethyl p-Nitrophenyl Phosphorothionate (Par-

athion) and Benzphetamine Using an Appar-

ently Homogeneous Preparation of Rat Liver

Cytochrome P-450: Effect of Cytochrome P-

450 Antibody Preparation, 921

Kamataki, Tetsuya and Neal, Robert A. Metabolism

of Diethyl p-Nitrophenyl Phosphorothionate

(Parathion) by a Reconstituted Mixed-Func-

tion Oxidase Enzyme System: Studies of the

Covalent Binding of the Sulfur Atom, 933

Kang, Sungzong. See Weinstein, Chou, Johnson and

Green, 738

Kashimoto, Takeshi. See Park, Ebstein and Gold-

stein, 73

Kato, G. and Changeux, i-P. Studies on the effect of

Histrionicotoxin on the Monocellular Electro-

plax from Electrophorus e!ectricus and on the

Binding of [3H]Acetylcholine to Membrane

Fragments from Torpedo marmorata, 92

Kato, Ryuichi. See Sugiura and Iwasaki, 322

Kawalek, Joseph. See Thomas, Lu, Ryan, West and

Levin, 746

Kelvin, Alan. See Carter, O’Ma!!ey, Beeson, Cun-

nington, Vere-Hodge, Alderfer and Ts’o, 440

Kiefer, H. R. See Layer and Hucho, 958

Kirk, Kenneth L. See Klein, Weller, Oka, Parfitt

and Owens, 720

Klein, David C., Kirk, Kenneth L., Weller, Joan L.,

Oka, Takami, Parfitt, Andrew and Owens,

Ida S. 2-Fluoro-L-histidine, an Inhibitor of

Enzyme Induction, 720

Kon, Hideo. See Rispin and Nebert, 476

Korinek, Josef. See Moses, Spe!sberg and Chytil,

731

Krey, Anne K., Olenick, John G. and Hahn, Fred E.

Interactions of the Antibiotic Distamycin A

with Homopolymeric Single-Stranded Poly-

deoxyribonucleotides and with 1X 174 Deoxy-

ribonucleic Acid, 185

Krueger, Bruce K., Forn, Javier, Walters, Judith

R., Roth, Robert H. and Greengard, Paul.

Stimulation by Dopamine ofAdenosine Cyclic

3’ ,5’-Monophosphate Formation in Rat Cau-

date Nucleus: Effect of Lesions of the Nigro-

neostriatal Pathway, 639

Ku, David. See Akera, Tobin and Brody, 101

Kuhar, Michael i. See Murrin, 1082

Kupchan, S. Morris. See Liao and Horwitz, 167

Kurosawa, A., Guidotti, A. and Costa, E. Induction

ofTyrosine 3-Monooxygenase Elicited by Car-

bamylcholine in Intact and Denervated Adre-

nal Medulla: Role of Protein Kinase Activa-

tion and Translocation, 420

L

Layer, P., Kiefer, H. R. and Hucho, F. Selective

Labeling of Anionic Binding Sites of the Ace-

tylcholinesterase from Torpedo californica

with a Photoaffinity Label, 958

Lefkowitz, Robert J. See Mukherjee, Caron and

Mullikin, 16

Lefkowitz, Robert J. See Mickey, Tate and Mulli-

kin, 409

Lefkowitz, Robert J. See Limbird, 559

Leonard, Thomas B. See Smith , Liu , Duceman and

Vese!l, 820

Lernmark, Ake. See Hellman, Idahl, Tdljeda! and

Thomas, 208

Levin, Robert M. and Weiss, Benjamin. Mechanism

by Which Psychotropic Drugs Inhibit Adeno-

sine Cyclic 3’,S’-Monophosphate Phosphodi-

esterase of Brain, 581

Levin, Wayne. See Thomas, Lu, Ryan, West and

Kawalek, 746

Levy, Judith. See Ts’o, A!derfer, Marshal!,

O’Ma!!ey, Horoszewicz and Carter, 299

Liao, Lon-Lon, Kupchan, S. Morris and Horwitz,

Susan B. Mode of Action of the Antitumor

1110 AUTHOR INDEX

Murrin, L. Charles and Roth, Robert H. Dopami-

Compound Bruceantin, an Inhibitor of Pro-

tein Synthesis, 167

Lien, E. J., Rodrigues de Miranda, J. F. and Ari#{235}ns,

E. J. Quantitative Structure-Activity Corre-

lation of Optical Isomers: a Molecular Basis

for Pfeiffer’s Rule, 598

Limbird, Lee E. and Lefkowitz, Robert J. Adenyl-

ate Cyclase-Coupled Beta Adrenergic Recep-

tors: Effect of Membrane Lipid-Perturbing

Agents on Receptor Binding and Enzyme

Stimulation by Catecholamines, 559

Liu, Dai Kee. See Smith, Leonard, Duceman and

Vesel!, 820

Lohmann, W. See Sapper, 605

Lovell, Richard A. and Freedman, Daniel X. Stere-

ospecific Receptor Sites for d-Lysergic Acid

Diethylamide in Rat Brain: Effects of Neuro-

transmitters, Amine Antagonists, and Other

Psychotropic Drugs, 620

Lowe, Jeffrey K. and Grindey, Gerald B. Inhibition

of Growth Rate and Deoxynucleoside Triphos-

phate Concentrations in Cultured Leukemia

L1210 Cells, 177

Lu, Anthony Y. H. See Thomas, Ryan, West, Kawa-

lek and Levin, 746

Lucek, Rudolph W. and Coutinho, Claude B. The

Role of Substituents in the HydrophobicBinding of the 1,4-Benzodiazepines by Hu-

man Plasma Proteins, 612

M

Maglothin, James A., Chen, Wen-Sherng and Wil-

son, Irwin B. Free Energy Relationships in

the Inhibition of Acetylcholinesterase by Di-

ethyl Phosphates, 658

Maguire, Michael E., Van Arsdale, Pamela M. and

Gilman, Alfred G. An Agonist-Specific Effect

of Guanine Nucleotides on Binding to theBeta Adrenergic Receptor, 335

Maguire, Michael E. See Inse!, Gilman, Bourne,

Coffino and Melmon , 1062

Makman, Maynard H. See Morris, 362

Manen, Carol-Ann. See Costa, Costa, Sipes and

Russell, 871

Mansour, Tag E. See Abrahams and Northup, 49

Mansour, Tag E. See Gentleman and Abrahams, 59

Marshall, Garland R. See Turk and Needleman, 217

Marshall, Lewis W. See Ts’o, Alderfer, Levy,

O’Malley, Horoszewicz and Carter, 299

Martin, T.J. SeeBoyd, 195

Matthews, E. K. and Nordmann, J. J. The Synaptic

Vesicle: Calcium Ion Binding to the VesicleMembrane and Its Modification by Drug Ac-

tion, 778

Mavreas, Thalia. See Stern, Trumme!, Schnoes and

DeLuca, 879

McCaffrey, Timothy B. See Thurman and Mc-

Kenna, 156

McKenna, William R. See Thurman and McCaffrey,

156

McPhail, Andrew T., Abou-Donia, Mohamed B. and

Rosen, Gerald M. X-ray Crystal Structure

and Conformation of a Spin-labeled Acetyl-

choline, DL-4-[N,N-Dimethyl-N-(ethan-2’-Ol-

acetate)amino] - 2,2,6,6 - tetramethylpiperi-dine-1-oxyliodide, 590

Melmon, Kenneth L. , Weinstein, Yacob, Bourne,

Henry R., Poon, Tak, Shearer, Gene and

Castagnoli, Neal, Jr. The Pharmacological

Effects of Conjugates of Pharmacologically

Active Amines to Complex or Simple Car-

riers: a New Class of Drug, 701

Melmon, Kenneth L. See Insel, Maguire, Gilman,

Bourne, and Coffino, 1062

Mickey, John V., Tate, Robert, Mullikin, Debra

and Lefkowitz, Robert J. Regulation of Aden-

ylate Cyclase-Coupled Beta Adrenergic Re-

ceptor Binding Sites by Beta Adrenergic Cat-

echolamines in Vitro, 409

Miller, R. J. See Iversen and Rogawski, 251

Minkel, Daniel T., Chan-Stier, Christine and Peter-

ing, David H. Reactions of 3-Ethoxy-2-oxobu-

tyraldehyde Bis(N4-dimethylthiosemicarba-

zonato)-Zinc(II) with Tumor Cells and Mito-chondria, 1036

Mitchell, J. R. See Dybing, Nelson, Sasame and

Gillette, 911

Mittag, T. W. See Collier and Barker, 340

Miyake, M. See Schwabe, Ohga and Daly, 900

Molinoff, Perry B. See Harden and Wolfe, 1

Moran, John F. See Gupta and Triggle, 1019

Morgenroth, Victor H., Boadle-Biber, Margaret C.

and Roth, Robert H. Dopaminergic Neurons:

Activation of Tyrosine Hydroxylase by a Cal-

cium Chelator, 41

Morgenroth, Victor H., III. See Murrin and Roth,

1070

Morris, Stephen A. and Makman, Maynard H. Cell

Density and Receptor-Adenylate Cyclase Re-

lationships in the C-6 Astrocytorna Cell, 362

Moses, Harold L. , Spelsberg, Thomas C., Korinek,

Josef and Chytil, Frank. Porphyria-Inducing

Drugs: Comparative Effects on Nuclear Ribo-nucleic Acid Polymerases in Rat Liver, 731

Mukherjee, Chhabirani, Caron, Marc G., Mullikin,

Debra, and Leflowitz, Robert J. Structure-

Activity Relationships of Adenylate Cyclase-

Coupled Beta Adrenergic Receptors: Determi-nation by Direct Binding Studies, 16

Mulder, Jan L. See Cort, Fri#{235},Carlsson, Gillessen,

Bystricky, �kopkova, Gut and Bldha, 313Mullikin, Debra. See Mukherjee, Caron and Le/kow-

itz, 16

Mullikin, Debra. See Mickey, Tate and Lefkowitz,

409

AUTHOR INDEX 1111

nergic Neurons: Effects of Electrical Stimula-

tion on Dopamine Biosynthesis, 463

Murrin, L. Charles and Kuhar, Michael J. Activa-tion of High-Affinity Choline Uptake in Vitro

by Depolarizing Agents, 1082Murrin, L. Charles, Morgenroth, Victor H., III and

Roth, Robert H. Dopaminergic Neurons: Ef-fects of Electrical Stimulation on Tyrosine

Hydroxylase, 1070

N

Nathanson, i. A. and Bloom, F. E. Heavy Metalsand Adenosine Cyclic 3’,5’-MonophosphateMetabolism: Possible Relevance to Heavy

Metal Toxicity, 390Neal, M. J., Butler, K. W., Polnasek, C. F. and

Smith, Ian C. P. The Influence of Anesthetics

and Cholesterol on the Degree of MolecularOrganization and Mobility of Ox Brain White

Matter. Lipids in Multibilayer Membranes: a

Spin Probe Study Using Spectral Simulation

by the Stochastic Method, 144Neal, Robert A. See Kamataki and Belcher, 921

Neal, Robert A. See Kamataki, 933

Nebert, Daniel W. See Felton and Thorgeirsson, 225

Nebert, Daniel W. See Rispin and Kon, 476

Needleman, Philip. See Turk and Marshall, 217

Neff, N. H. See Yang, H.-Y. T. , 69

Neff, N. H. See Yang, 433

Nelson, S. D. See Dybing, Mitchell, Sasame and

Gillette, 911

Nelson, Wendel L. See Wirth and Bettis, 759

Nemerovski, Mark. See Butcher, Rudich and Emler,

862

Nordmann, i. J. See Matthews, 778

Northup, John K. SeeAbrahams and Mansour, 49

Novak, R. F. and Swift, T. J. Nuclear MagneticResonance Studies of Barbiturate-Phospho-lipid Interactions, 263

0

Ohga, Y. See Schwabe, Miyake and Daly, 900

Oka, Takami. See Klein, Kirk, Weller, Parfitt and

Owens, 720

Olenick, John G. See Krey and Hahn, 185

O’Malley, Judith. See Ts’o, Alderfer, Levy, Horo-

szewicz and Carter, 299O’Malley, Judith. See Carter, Beeson, Cunnington,

Kelvin, Vere-Hodge, Alderfer and Ts’o, 440

Ontjes, David A. See Ways and Zimmerman, 789

Onur, R. SeeAlbuquerque, Brooks, and Warnick, 82

Otten, U. and Thoenen, H. Selective Induction ofTyrosine Hydroxylase and Dopamine /3-Hy-

droxylase in Sympathetic Ganglia in OrganCulture: Role of Glucocorticoids as Modula-

tors, 353

Owens, Ida S. See Klein, Kirk, Weller, Oka and

Parfitt, 720

P

Parfitt, Andrew. See Klein, Kirk, Weller, Oka and

Owens, 720

Park, Dong H., Kashimoto, Takeshi, Ebstein,Richard P. and Goldstein, Menek. Purifica-

tion and Immunochemical Characterization

of Dopamine /3-Hydroxylase from Human

Pheochromocytoma, 73

Pasternak, Gavril W., Simantov, Rabi and Snyder,Solomon H. Characterization of an Endoge-

nous Morphine-like Factor (Enkephalin) in

Mammalian Brain, 504Pessah, N. I. SeeHolohan, Warkentin andRoss, 494

Petering, David H. See Minkel and Chan-Stier, 1036Petrack, Barbara and Czernik, Andrew J. Inhibi-

tion of Isoproterenol Activation of Adenylate

Cyclase by Metoprolol, Oxprenolol, and the

para Isomer of Oxprenolol, 203

Philpot, R. M. and Arin#{231}, Emel. Separation and

Purification of Two Forms of Hepatic Cyto-

chrome P-450 from Untreated Rabbits, 483

Pinto, J. E. B. See Trifaro and Duerr, 536

Polnasek, C. F. See Neal, Butler and Smith, 144

Poon, Tak. See Melmon, Weinstein, Bourne,

Shearer and Castagnoli, 701

R

Rang, H. P. See Colquhoun, 519

Rispin, Amy S., Kon, Hideo and Nebert, Daniel W.Electron Spin Resonance Study of ‘7O-En-

riched Oxybenzo[a]pyrene Radical, 476

Rodbell, Martin. See Yamamura and Fain, 693Rodriques de Miranda, J. F. and Hilbers, C. W. A

Nuclear Magnetic Resonance Study of the Ki-

netics of the Binding of the Renal Contrast

Medium Acetrizoate to Albumin, 279

Rodrigues de Miranda, J. F., Eikelboom, T. D. and

van Os, G. A. J. The Extent of HydrophobicBinding Area Studied by Fatty Acid Binding

to Albumin, 454

Rodrigues de Miranda, J. F. See Lien and Ari#{235}ns,

598

Rogawski, M. A. See Iversen and Miller, 251

Rosen, Gerald M. See McPhail and Abou-Donia, 590Rosenberry, Terrone L. See Bartels-Bernal and

Chang, 813

Ross, C. R. SeeHolohan, Pessah and Warkentin, 494Roth, Robert H. See Morgenroth and Boadle-Biber,

41

Roth, Robert H. See Murrin, 463Roth, Robert H. See Krueger, Forn, Walters and

Greengard, 639

Roth, Robert H. See Murrin and Morgenroth , 1070

Roth, S. H. See Boggs, Yoong, Wong and Hsia, 136Rotman, A., Daly, J. W. and Creveling, C. R. Oxy-

gen-Dependent Reaction of 6-Hydroxydopa-mine, 5,6-Dihydroxytryptamine, and Related

Compounds with Proteins in Vitro: a Model

1 112 AUTHOR INDEX

for Cytotoxicity, 887

Ruddon, Raymond W. See Bittner, 966

Rudich, Lynn. See Butcher, Emler and Nemerovski,

862

Russell, Diane Haddock. See Costa, Costa, Manen

and Sipes, 871

Ryan, Dene. See Thomas, Lu, West, Kawalek and

Levin , 746

S

Same, Susan E. and Strobel, Henry W. Drug Me-tabolism in Liver Tumors. Resolution of Com-

ponents and Reconstitution of Activity, 649

Sapper, H. and Lohmann, W. Self-association and

Binding Sites of Some Psychotomimetic

Tryptamine Derivatives and Related Corn-

pounds: Nuclear Magnetic Resonance Investi-

gations, 605

Sasame, H. A. See Dybing, Nelson, Mitchell and

Gillette, 911

Schnoes, Heinrich K. SeeStern, Mavreas, Trummel

and DeLuca, 879

Schwabe, U., Miyake, M., Ohga, Y. and Daly, J. W.

4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyr-

rolidone (ZK 62711): a Potent Inhibitor of

Adenosine Cyclic 3’ ,5’-Monophosphate Phos-

phodiesterases in Homogenates and Tissue

Slices from Rat Brain, 900

Sham, William. See Carpenter, Greene and Vogel,

999

Shearer, Gene. See Melmon, Weinstein, Bourne,

Poon and Castagnoli, 701

Sheppard, Herbert, Burghardt, Charles R. and Tei-

tel, Sidney. The Dopamine-Sensitive Adenyl-

ate Cyclase ofthe Rat Caudate Nucleus. II. A

Comparison with the Isoproterenol-Sensitive

(Beta ) Adenylate Cyclase of the Rat Erythro-

cyte for Inhibition or Stimulation by Tetrahy-

droisoquinolines, 854

Simantov, Rabi. See Pasternak and Snyder, 504

Simantov, Rabi, Snowman, Adele M. and Snyder,Solomon H. Temperature and Ionic Influ-

ences on Opiate Receptor Binding, 977

Simantov, Rabi and Snyder, Solomon H. Morphine-

Like Peptides, Leucine Enkephalin and Me-

thionine Enkephalin: Interactions with the

Opiate Receptor, 987

Sinha, Birandra K. See Wee, Taylor and Chignell,

667

Sipes, I. Glenn. See Costa, Costa, Manen and Rus-

sell, 871

�kopkova, Jana. See Cort, Fri#{235},Car!sson, Gillessen,

Bystricky, Gut, Studer, Mulder and Bl#{225}ha,

313

Smith, Ian C. P. See Neal, Butler and Polnasek , 144

Smith, Steven J., Liu, l)ai Kee, Leonard, Thomas

B., Duceman, Barry W. and Vesell, Elliot S.

Phenobarbital-Induced Increases in Methyla-

tion in Ribosomal Precursor Ribonucleic

Acid, 820

Snowman, Adele M. See Simantov and Snyder, 977

Snyder, Solomon H. See Bennett, 373

Snyder, Solomon H. See Pasternak and Simantov,

504

Snyder, Solomon H. See Bylund, 568

Snyder, Solomon H. See Burt and Creese, 800

Snyder, Solomon H. See Simantov and Snowman,

977

Snyder, Solomon H. See Burt and Creese, 631

Snyder, Solomon H. See Simantov, 987

Spelsberg, Thomas C. See Moses, Korinek and Chy-

til, 731

Stahl, William L. See Harris, 115

Stern, Paula H., Mavreas, Thalia, Trummel, Clar-

ence L. , Schnoes, Heinrich K. and DeLuca,

Hector F. Bone-Resorbing Activity of Ana-

logues of 25-Hydroxycholecalciferol and 1,25-

Dihydroxycholecalciferol: Effects of Side

Chain Modification and Stereoisomerization

on Responses of Fetal Rat Bones in Vitro, 879

Strobel, Henry W. See Same, 649

Studer, Rolf 0. See Cort, Fri#{235},Carlsson, Gillessen,

Bystrick�, �kopkova, Gut, Mulder and Bl#{225}ha,

313

Sudlow, G., Birkett, 1). J. and Wade, D. N. Further

Characterization of Specific Drug Binding

Sites on Human Serum Albumin, 1052

Sugiura, Masahiko, Iwasaki, Kuzuhide and Kato,Ryuichi Reduction of Tertiary Amine N-Ox-

ides by Liver Microsomal Cytochrome P-450,

322

Swift, T. J. See Novak, 263

T

T#{225}ljedal, Inge-Bert. See Hellman, ldahl, Lernmark

and Thomas, 208

Tanis, Robert J. See Wee, Feldmann and Chignell,

832

Tate, Robert. See Mickey, Mullikin and Le/kowitz,

409

Taylor, Palmer W. See Sinha, Wee and Chignell,

667

Taylor, Palmer. See Weiland, Georgia, Wee and

Chigne!!, 1091

Teitel, Sidney. See Sheppard and Burghardt, 854

Thoenen, H. See Otten, 353

Thomas, Emrys W. See He!lman, Idahl, Lernmark

and Tdljedal, 208

Thomas, H. Jeanette. See Bennett, Allan, Hill and

Carpenter, 242

Thomas, Paul E., Lu, Anthony Y. H., Ryan, Dene,

West, Susan B., Kawalek, Joseph and Levin,

Wayne. Immunochemical Evidence for Six

Forms of Rat Liver Cytochrome P450 Ob-

tamed Using Antibodies against Purified Rat

Liver Cytochromes P450 and P448, 746

AUTHOR INDEX 1113

Thorgeirsson, Snorri S. See Felton and Nebert, 225

Thurman, Ronald G., McKenna, William R. and

McCaffrey, Timothy B. Pathways Responsi-

ble for the Adaptive Increase in Ethanol Uti-

lization Following Chronic Treatment with

Ethanol: Inhibitor Studies with the Hemoglo-

bin-Free Perfused Rat Liver, 156

Tobin, Thomas. See Akera, Ku and Brody, 101

Torrence, P. F. See De C!ercq, Edy, Waters and

Witkop, 1045

Trifar#{243}, J. M., Duerr, A. C. and Pinto, J. E. B.

Membranes of the Adrenal Medulla: a Corn-

parison between the Membranes of the Golgi

Apparatus and Chromaffin Granules, 536

Triggle, David J. See Gupta and Moran, 1019

Tritton, Thomas R. See Bina-Stein, 191

Trummel, Clarence L. See Stern, Mavreas, Schnoes

and DeLuca, 879

Ts’o, Paul 0. P. See Arya, Carter and Alderfer, 234

Ts’o, Paul 0. P., Alderfer, James L., Levy, Judith,

Marshall, Lewis W., O’Malley, Judith, Horo-

szewicz, Julius S. and Carter, William A. An

Integrated and Comparative Study ofthe An-

tiviral Effects and Other Biological Proper-

ties of the Polyinosinic Acid-Polycytidylic

Acid and Its Mismatched Analogues, 299

Ts’o, Paul 0. P. See Carter, O’Mal!ey, Beeson, Con-

nington, Kelvin, Vere-Hodge and Ts’o, 440

Ts’o, P. 0. P. See Arya, Helser and Carter, 844

Turk, John, Needleman, Philip and Marshall, Gar-

land R. Analogues of Angiotensin II with Re-

stricted Conformational Freedom Including a

New Antagonist, 217

V

Van Arsdale, Pamela M. See Maguire and Gilman,

335van Os, G. A. J. See Rodrigues de Miranda and

Eikelboom , 454

Vere-Hodge, Anthony. See Carter, O’Malley, Bee-

son, Cunnington, Kelvin, Alderfer and Ts’o,

440

Vesell, Elliot S. See Smith, Liu, Leonard and Duce-

man, 820

Vogel, Zvi. See Carpenter, Greene and Sham , 999

W

Wade, D. N. See Sudlow and Birkett, 1052

Walters, Judith R. See Krueger, Forn, Roth and

Greengard, 639

Warkentin, D. See Holohan , Pessah and Ross, 494

Warnick, J. E. See Albuquerque, Brooks and Onur,

82

Waters, J. A. See De Clercq, Edy, Torrence and

Witkop, 1045

Ways, D. Kirk, Zimmerman, Carol F. and Ontjes,

David A. Inhibition of Adrenocorticotropin

Effects on Adrenal Cell Membranes by Syn-

thetic Adrenocorticotropin Analogues: Corre-

lation of Binding and Adenylate Cyclase Acti-

vation, 789

Wee, Victorio T., Sinha, Birandra K., Taylor, Pal-

mer W. and Chignell, Cohn F. Interaction of

Spin-Labeled Bisquarternary Ammonium Li-

gands with Acetylcholinesterase, 667

Wee, Victorio T., Feldmann, Richard J., Tanis,

Robert J. and Chignell, Cohn F. A Compara-

tive Study of Mammalian Erythrocyte Car-

bonic Anhydrases Employing Spin-Labeled

Analogues of Inhibitory Sulfonamides, 832

Wee, Victorio T. See Weiland, Georgia, Chignel!

and Taylor, 1091

Weiland, Gregory, Georgia, Brian, Wee, Victorio

T., Chignell, Cohn F. and Taylor, Palmer.

Ligand Interactions with Cholinergic Recep-

tor-Enriched Membranes from Torpedo: In-

fluence of Agonist Exposure on Receptor

Properties, 1091

Weinstein, Harel, Chou, David, Johnson, Carl L.,

Kang, Sungzong and Green, Jack Peter. Tau-

tomerism and the Receptor Action of Hista-

mine: a Mechanistic Model, 738

�Veinstein, Yacob. See Melmon, Bourne, Poon,

Shearer and Castagnoli, 701

%Veiss, Benjamin, See Levin, 581

Weiss, Benjamin. See Fertel, 678

Weller, Joan L. See Klein, Kirk, Oka, Parfitt and

Owens, 720

West, Susan B. See Thomas, Lu, Ryan, Kawalek

and Levin , 746

White, J. Courtland and Goldman, I. l)avid. Mecha-

nism of Action of Methotrexate. IV. Free In-

tracellular Methotrexate Required to Sup-

press Dihydrofolate Reduction to Tetrahydro-

folate by Ehrlich Ascites Tumor Cells in Vi-

tro, 711

Wilson, Irwin, B. See Maglothin and Chen, 658

Wilson, William Robert. See Cain and Bagu!ey,

1027

Wirth, Peteri., Bettis, Carol J. and Nelson, %Vendel

L. Microsomal Metabolism ofFurosemide Ev-

idence for the Nature of the Reactive Inter-

mediate Involved in Covalent Binding, 759

Witkop, B. See De Clercq, Edy, Torrence and Wa-

ters, 1045

Wolfe, Barry B. See Harden and Molinoff, 1

Wong, E. See Boggs, Roth, Yoong and Hsia, 136

Y

Yamamura, Hirohei, Rodbell, Martin and Fain,

John N. Hydroxybenzylpindolol and Hydrox-

ybenzylpropranolol: Partial Beta Adrenergic

Agonists of Adenylate Cyclase in the Rat Adi-

pocyte, 693

Yang, H.-Y. T. and Neff, N. H. N-Acetyltransferase

of Brain: Some Properties of the Enzyme and

the Identification of f3-Carboline Inhibitor

1114 AUTHOR INDEX

(Signed) Ellsworth B. Cook, Executive Secretary

Compounds, 69

Yang, H.-Y. T. and Neff, N. H. Hydroxyindole 0-

Methyltransferase: An Immunochemical

Study of the Neuronal Regulation of the Pi-

neal Enzyme, 433

Yoda, Atsunobu. Binding of Digoxigenin to Sodium-

and Potassium-Dependent Adenosine Tn-

phosphatase, 399

Yoong, T. See Boggs and Hsia, 127

Yoong, T. See Boggs, Roth, Wong and Hsia, 136

Z

Zimmerman, Carol F. See Ways and Ontjes, 789

Zubler-Faivre, Liliane and Dunant, Yves. Sodium-and Potassium-Dependent Adenosine Tn-

phosphatase of Electric Organ: Interaction

with Ouabain in Situ, in a Membrane Frac-

tion, and in the Solubilized Form, 1007

Statement ofownership, management and circulation required by the Act of October 23, 1962, Section 4369, Title 39, UnitedStates Code; of

MOLECULAR PHARMACOLOGY

Published bimonthly by Academic Press, Inc., 111 Fifth Avenue, New York, N. Y. 10003. Number of issues published an-nually: 6. Editor: G. I. Drummond, Dept. of Chemistry, The Univ. of Calgary, Alberta, T2N, 1N4, Canada.Owned by American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, Md. 20014.Known bondholders, mortgagees, and other security holders owning or holding 1 percent or more of total amount of bonds,mortgages or other securities: None.Paragraphs 2 and 3 include, in cases where the stockholder or security holder appears upon the books of the company astrustee or in any other fiduciary relation, the name of the person or corporation for whom such trustee is acting, also thestatements in the two paragraphs show the affiant’s full knowledge and belief as to the circumstances and conditions underwhich stockholders and security holders who do not appear upon the books of the company as trustees, hold stock andsecurities in a capacity other than that of a bona fide owner. Names and addresses of individuals who are stockholders of acorporation which itself is a stockholder or holder ofbonds, mortgages or other securities ofthe publishing corporation havebeen included in paragraphs 2 and 3 when the interests of such individuals are equivalent to 1 percent or more of the totalamount of the stock or securities of the publishing corporation.Total no. copies printed: average no. copies each issue during preceding 12 months: 2102; single issue nearest to filing date:1906. Paid circulation (a) to term subscribers by mail, carrier delivery or by other means: average no. copies each issue dur-ing preceding 12 months: 1494; single issue nearest to filing date: 1439. (b) Sales through agents, news dealers, or other-wise: average no. copies each issue during preceding 12 months: 0; single issue nearest to filing date: 0. Free distribution bymail, carrier delivery, or by other means: average no. copies each issue during preceding 12 months: 92; single issue nearestto filing date: 92. Total no. ofcopies distributed: average no. copies each issue during preceding 12 months: 1586; single issuenearest to filing date: 1531.

A�tasot� m4e , �rhonw §nhy4r�t� ,

A��tri�o�le, bovtn� �r�im �Ib�irnin �79

� �4�tivt4U�n to muta�in , 225Ae�ty1ehohns�Ler�s@ 65$, 667

binding si�e�, 1J911

binding sp�i�I1�(y ofbisqu�tern�ry Iig�n4s, 667

phoLo�ffinIt� Isb�l�nM ��Llbstr�le$, 840

A�etyIehoIiim r��epuir,qIplrn�Ining�*n�u�in bin4in�, UUU

bon�iIyl�holjne m�tsr4 b(ndin� 1019

binding � 999

�h�mse�l modifie�tion, $13from Torpedo rniirnortsti, 92

A�ty�mono�LhyI�ho1mne, �ynthti��erv�I gsnghon, 340

A�tylpyrru�hulin�, �ynLh�s� in �t ��p�rior �rvt�

e�I g�n�lion, 340�

bri4in,89inthwtion, 720

4 ‘-(9’A�r141nyl�mlno � �(ur� �etivity rel�tion�hip, 1027

M�ntrlti nueIeot(th� r�nsIoei�e, �iLh�nol meI�boli�min liver, 158

A4t3nQ�ine, 1400

Ad�nosine Kin�se , �,�nr�bi � ��ibstr�tt�, 242

Ad�no�in�� 3’ 5�monophoMph�te,�ff�I!L on tyrosl,m hydro�yh�bt�, 1070

Ath�no�itm 3’,S�monopho�ph�te,�nd dop�mi�w, 839

nUd IipoIy�, 898bindsn� to t’i� Ii�ng �yeIie �nwIeoti4e phospho4ius�

(�r�e, 878

III i�nine femor�l �rt�ry 8MMin Itiuktwy(�is, 701

In p�rot�t1 �1i�n4, 882

In nfl eorpt4s �trm�Rirn, 546m��bofl�m, 390

Atisnosirse 8’ S’�mcmophosphi�te phosphodie�teri�se

§�l1v1flor in bovine bri*)n, 581

hsi��vy met�I inhibition, 390

1nh�bslors, 900

Ad�innsin@ (rlpho�ph�t�t� N�*’ -� K”,

binding of 4igoM�nIn, 399

eLhi*not rn�U*boIi�rn in Iiv�r, 158oI4O�in compl�Me� in rst br�*in �nd 4o�t h�rt, 101

oui�b�*In in1�r�rtion, 1007

Adtinylsl@ eye1s�e

Bt� idrstwrgi� re�plor 1, 18, 4014, 559, 1062

III �trot�,v(onH* eell� 382

to i�ttid�te ntwtt�u�, 839inhibition b,v h�’iivy me& 890

in 1�ukoeyLe� 7111

ILl preneopI�*�tc i’�t hver 195

in r�fl �*4ipoe,v1e; 693in rat eorpi� �tr1�ILIm; 546

�sJn�lt1v1(y to dop�*mine, $f14

Adrenoeortieotrophic hormone,�wtivetion of etIenyle�e ey�Ie�e in ret e�1rennI

membrene, 789

tregmenLe es inhibstor� 789AffinIty ree�ent� for eeetykholine receptor $13

Albumin fetty eeitl hintling 454

M�ohnI dehydrogenece , ethenol meteboliem inliver 158

Mlylisopropyleeetemide 731

A/p/rn�Arebino�yle4enine 242

� 242Mp!w, heui�enomer� of nocleoLideb seperelion, 242

A/pbo�Bun�eroLo�in, bin4in� �o welyk’holine re��eptor 519 999

A/pho�Me�hyl4ope o�ideLion, 911

Mprenolol 18

hy4roMyphenyl dtirivetivee 1

Amiloride lnhihiLor of eodium Lren�porL 945

2�Amino�8,7�4ihy4r*y� 1 2,34�ietrehy4roneph�he�lens, 251

Aminophylline, $71

Amitryptyline, 581

Amphetemine, 581

fluke molility 414

Amphotericin B, 551)

Amyloherbilone, 77$

Amyle$e, end pertflid glend $62Anesthetiv eetion, 127 138, 144

Ane�Lhetic$, orc1erin� efleci t�n lipid vti���le�, 144

Angicsten$in II, 313

enelogue$ enti �on)�rmetitin 217

Mflibodiee Cyt&whrome P�4511, 746

Antimyein A� uthenol metehulism to hver, 15(1

Apomorphine 251

Arcwlor�l254, en�yme snc4uet(on $71

Ar�l hyiiroeerbon hydro�yle�e sndLwtlon 720 988

As�orhie �wid, 911

Mreeylo�i4e ethenol ,imieboliern lo ltvor, 156

A(rup�ne, $82

Aorintrwerbo�ylic ecid n#inepocs0� trniyme )nhibs-

(or in preneopleeic ret l$ver, 1111

Betreeho(ti�in, ret diephre�jm mo�ele $2

MOLECULAR PHARMACOLOGY, 12, 1115-1119

Copynght � 19711 b� #4�ssedeni�e Pres� ItwMI right� of repro4or(ion in sn� form reserved

A

SUBJECT INDEX

in �t �perior

Ills

LI

1116 SUBJECT INDEX

Benperidol, 581

Benzamil, inhibitor of sodium transport, 945

Benzanthracene, aryl hydrocarbon hydroxylase in-

duction, 966

Benzilylcholine mustard , acetylcholine receptor,

1019

Benzolalpyrene hydroxylase, 225

Benzo[a Ipyrene , liver microsome metabolism , 476

1,4-benzodiazepine, binding to plasma proteins, 612

Benzphetamine, Cytochrome P-450, 921

hydroxylation, 649

Benztropine, 251

Benzyl alcohol, 728

Beta-Adrenergic agonists, to frog erythrocyte, 16

Beta-Adrenergic antagonists,

to dog liver and heart, 203

to frog erythrocyte, 16

to rat heart, 1

Beta-Adrenergic receptor,

and adenylate cyclase, 559, 1062

and guanine nucleotides, 335

in rat and monkey brain, 568

in rat corpus striatum, 546

Beta-Carboline derivatives, brain and pineal N-ace-

tyltransferase, 69

Beta-Cell recognition, of halogenated hexosamines,

208

Bis(thiosemicarbazonato -zinc complexes , interac-

tion with mitochondria, 1036

Bovine serum albumin, acetrizoate binding, 279

N-Bromoacetylglycosylamines, insulin release, 208

8-Bromoguanosine-3’ ,5’-monophosphate,

parotid gland, 862

Bruceantin, inhibition of protein synthesis, 167

Butyrophenone haloperidol, adenylate cyclase, 251

C

Calcium, adsorption to synaptic vesicles, 778

Carbachol, 688

Carbamylcholine,

depolarization of electroplax, 92

induction of tyrosine hydroxylase and dopamine

/3-hydroxylase, 353

induction of tyrosine 3-monooxygenase, 420

Carbonic anhydrase I and II, active site topography,

832

Catecholamine , adenylate cyclase , 195

Catecholamine receptor, adenylate cyclase complex,

362

Catecholamine tolerance, /3-adrenergic receptor, 409

Catechol synthesis, 251

Chlordiazepoxide, 581

Chlorisondamine, 353

Chlorpromazine, 546, 581

binding to brain tubulin, 769

Chlorprothixene, 581

Choline uptake, by rat brain hippocampol synapto-

somes, 1082

Chromaffin granules, enzyme markers, 536

Circular dichroism, vasopressin analogues, 313

Conformation, spin labeled acetylcholine analogue,

590

Cyclic nucleotide phosphodiesterase,

epinephrine induction in astrocytoma cells, 32

in liver fluke, 49, 59

in rat lung, 678

Cyclic nucleotides,

in astrocytoma cells, 32

in canine femoral artery, 688

Cytochrome P-448, 759

reactivity with anticytochrome P-450, 746

Cytochrome P-450, 225, 649, 759, 871

antibody, 921

antibodies, 746

as N-oxide reductase, 322

catecholamine oxidation, 911

different forms in rat liver, 746

in rat liver, 921

purification of two forms, 483

Cytochrome P-450 monooxygenase, 759

Cytosine arabinoside, 966

D

1-Deamino-[8-D-argininej-vasopressin, 313

Delta-Aminolevulinic acid synthetase, 731

Deoxynucleosides, inhibitors of L1210 cell growth,

177

Deoxynucleotide triphosphate and growth inhibi-

tion of L1210 cells, 177

Deoxyribonucleic acid polymerase, inhibited by pu-

rine ribonucleotides, 844

Desipramine, 581

Dexamethasone, induction of dopamine /3-hydroxyl-

ase and tyrosine hydroxylase, 353

Dibutyryl adenosine 3’ ,5’-monophosphate, 871

3,5-Dicarbethoxy-1,4-dihydrocollidine, 731

Diethylphospho - acetylcholinesterase, activation,

658

Digoxigenin, binding to adenosine triphosphatase

(Nat + KF), 399

Dihydroalprenolol, f3-adrenergic receptor, 409, 559,

568

Dihydrofolate, effect of methotrexate on metabolism

of, 711

Dihydromorphine, 977

1 ,25-Dihydroxycholecalciferol, bone resorbing activ-

ity, 879

Dihydroxyphenyl acetic acid, see Dopa

5,6-Dihydroxytryptamine, protein binding, 887

DL-4-[N,N-Dimethyl-N-(ethan-2’-olacetate)aminol-

2,2,6,6-tetramethylpiperidine-1-oxyl iodide,

590

Dissociation constant, iodohydroxybenzylpindolol to

rat heart protein, 1

Dissociation constants, of frog erythrocyte /3-adre-

nergic receptor, 16

Distamycin, interaction with single stranded deoxy-

ribonucleic acids, 185

Dopa, 911

SUBJECT INDEX 1117

Medazepam, 581

Dopa decarboxylase, 353, 463

Dopamine, inhibitor of tyrosine hydroxylase, 1070

Dopamine, 251, 546, 911

binding to calf brain membranes, 800

stimulation of adenylate cyclase, 639

synthesis in dopaminergic neurons, 463

Dopamine beta-hydroxylase,

immunochemical characterization, 73

induction in sympathetic ganglia, 353

E

Electrical stimulation of dopaminergic neurons,

control of dopamine synthesis, 1070Electron spin resonance,

active site of carbonic anhydrase, 832

nerve conductance, 136

of lipid vesicles, 127, 144

of oxybenzo[ajpyrene radical, 476

of spin labeled bisquaternary ammonium ligands

and their interaction with acetylcholinester-

ase, 667

Enkephalin,

in mammalian brain, 504

leucine, methionine analogues, 987

Epinene, 251

Epinephrine, 546, 789, 911

stimulatidn of adenylate cyclase, 362, 789

Epoxide hydrase, 759

1 ,2-Epoxy-3,3,3-trichloropropane, 759

Eserine, and acetylcholine receptor, 999

Ethanol metabolism, 156

Ethylenediamine, 911

Ethylene glycol bis(/3-aminoethyl ether-N,N’-tet-

raacetic acid,

and tyrosine hydroxylase from dopaminergic neu-

rons, 41

inhibitor of phosphodiesterase, 581

F

Filipin, 559

Fluorescence, of drug binding to albumin, 1052Fluorescent phospholipid, brain synaptosome mem-

brane, 115

Fluoride, adenylate cyclase stimulation, 789

2-Fluoro-L-histidine, inhibitor of enzyme induction,

720

Folic acid metabolism, 711

Furosemide, binding to microsomal proteins, 759

G

Gamma-Aminobutyric acid, uptake by synapto-

somes, 1082

Genes, for adenylate cyclase and f3-adrenergic re-

ceptor, 1062

Glucagon, and adenylate cyclase, 195Glucocorticoid, induction of tyrosine hydroxylase

and dopamine /3-hydroxylase, 353Glutathione, 911

Golgi apparatus, enzyme markers, 536

Guanidinium group, blockage of sodium transport,

945

Guanine nucleotides, /3-adrenergic agonist effector,

335

Guanosine 3’ ,5’-monophosphate, 678, 688

in rat parotid gland, 862

H

Haloperidol, 251

binding to calf brain membrane, 800

Histamine, 900

conjugated to albumin, 701

tautomeric forms, 738

Histone kinase, activation in adrenal medulla, 514

Histrionicotoxin, monocellular electroplax and ace-

tylcholine receptor, 92

Human serum albumin, drug binding, 1052

Hydrophobic binding, fatty acids to albumin, 454

N-Hydroxy-2-acetylaminofluorene, mutagenicity,

225

Hydroxybenzylpindolol,

rat adipocyte adenylate cyclase, 693

rat heart adenylate cyclase, 693

Hydroxybenzylpropranolol, rat adipocyte adenylate

cyclase, 693

25-Hydroxycholecalciferol, bond resorbing activity,

879

6-Hydroxydopamine, protein binding, 887

Hydroxyindole O-methyltransferase, neuronal reg-

ulation of pineal enzyme, 433

Insulin secretagogues, 208

Interferon induction, 299, 1045

lodinated beta -adrenergic antagonists , 1

N-Iodoacetyl-2-amino-2-deoxy-D-glucose, insulin re-

lease, 208

Iodohydroxybenzylpindolol, 1 , 335, 1062

Ions, effect on opiate receptor binding, 977

Isoniazid, 291

Isoprenaline, 251

Isoproterenol, 1062

adenylate cyclase activity, 409, 900

adenylate cyclase stimulation, 1, 203

and guanosine 3’ ,5’-monophosphate, 862

L

Lidocaine, on rat diaphragm muscle, 82

D-Lysergic acid diethylamide, 581

and fluke motility, 49, 59

binding to dopamine receptors, 631

binding to rat brain membrane, 373, 800

nuclear magnetic resonance, 605

receptor in rat brain, 620

self association, 605

M

1118 SUBJECT INDEX

Papaverine, 688

Parathion, cytochrome P-450 binding, 921, 933

Membranes, golgi apparatus and chromaffin gran-

ules, 536

Metaprolol, adenylate cyclase inhibitor, 203

Methiothepin, 620

Methotrexate, dihydrofolate reductase, 711

3-Methylcholanthrene, 731, 759, 945

3’-Methyl-4-diaminoazobenzene, effect on rat liver,

195

4-Methylpyrazole, and alcohol dehydrogenase, 156

Microelectrophoresis, of synaptic vesicles, 778

Mitochondrial respiration, inhibition, 1036

Mixed disulfide, in acetylcholine receptor, 813Molecular orbital calculation, histamine, 738

Morphine, 581

Muscarinic receptor, 1019

Muscle contraction, and cyclic nucleotide levels, 688

N

NADPH-Cytochrome P-450 reductase, purification,

649, 921

Naloxone, 977Neostigmine, acetylcholine receptor, 999

Nerve conduction, pressure effect, 136

Neuroleptics, 251

Nicotinamide adenine dinucleotide glycohydrolase,

291

Nitroglycerin, 688

Norepinephrine, 251, 900, 911

conjugated to albumin, 701

level of guanosine 3’ ,5’-monophosphate, 862

Nuclear magnetic resonance,

acetrizoate and albumin, 279barbiturates and phospholipid, 263

D-lysergic acid diethylamide, 605

0

Octopamine, uptake by synaptosomes, 1082Opiate receptor, and enkephalin distribution, 504

Opiate receptor binding,of enkephalin analogues, 977

temperature and ion effect, 977Organic cation, specific binding protein, purifica-

tion from dog kidney, 494

Ornithine decarboxylase, induction, 720, 871

Ouabain,effect of digoxigenin binding to adenosine triphos-

phatase (Na� + K�), 399

ethanol metabolism in liver, 156

interaction with adenosine triphosphatase (Na� +

Ki, 1007Oxidation, of catecholamines bound to proteins, 887

N-Oxide reductase, associated with cytochrome P-

450, 322

Oxprenolol, adenylate cyclase inhibitor, 203

P

Pentobarbital, 263, 581

Pentylenepetrazol, 581

Pfeiffer’s rule, molecular basis, 598

Phenobarbital, 263, 731, 759, 820

and RNA methylation, 820

Phentolamine, 546, 862

Phenylephrine, 251, 688

and guanosine 3’ ,5’-monophosphate, 862

Phosphodiesterase activator, in lung, 678

Phosphodiesterase inhibitor, 900

Phospholipase A, C, and D, effect on f3-adrenergic

receptor, 559

Phospholipid, interaction with barbiturates, 263

Photoaffinity labelling, acetylcholinesterase, 958

Pimozide, 251, 581

Piprodol, 581

Plasma proteins, binding specificity, 612

Poly(7-deazainosinic acid), antiviral activity, 1045

Polyguanylic acid, murine leukemia virus inhibitor,

844

Polyinosinic acid, polycytidylic acid duplex, biologi-

cal properties, 299, 440

Polyribonucleotides, as inhibitors of munine leuke-

mia virus, 234

Polynibosomes breakdown, by Bruceantin, 167

Polyxanthylic acid, murine leukemia virus inhibi-

tor, 844

Potassium,

depolarizing synaptosomes, 1082

and parotid gland, 862

Procaine, on rat diaphragm muscle, 82

Promethazine, 581

Propranolol, 546, 862

effect on brain synaptosome membranes, 115

Prostaglandin E � , and /3-adrenergic receptor, 409

Protein kinase,

activation by adenosine 3,5’-monophosphate when

adrenal medulla is stimulated by canbamyl-

choline, 420

dissociation of catalytic subunits by adenosine

3’,S’-monophosphate, 420

in liver fluke, 59

in rat liver, 871

Protein sulfhydryls, and oxidation of bound cate-

cholamines, 887

Protein synthesis, and Bruceantin, 167

Protoveratrine, 251Protriptyline, 581

R

Ribosomes, reticulocyte and Bruceantin, 167

RNA biosynthesis, regulation in rat adrenal me-

dulla, 514

RNA methylation, 820

RNA Methyltransferase, induction by phenobarbi-tal, 820

RNA polymerase,distamycin on template activity, 185

SUBJECT INDEX 1119

nuclear, 731

nucleolar, 820

RNA polymerase I, activation, 871RNA polymerase II, in adrenal medulla, 514Rotenone, ethanol metabolism in liver, 156

S

Serotonin,

binding to D-lysergic acid diethylamide receptor,

620

binding to rat brain membranes, 373

uptake by synaptosomes, 1082

Sodium channel, effect of batrachotoxin and tetrodo-

toxin, 82Sodium channels, in epithelium, 945

Spin-labeled lipid vesicles, effect of anesthetics and

pressure, 127Spiroperidol, 251Structure activity relationship,

4’(9-acnidinylamino)methanesulfonanilide, 1027

and f3-adrenergic receptor, 16and dopamine and /3-adrenergic sensitive adenyl-

ate cyclase, 854

and dopamine sensitive adenylate cyclase, 251angiotensin II, 217

1,4-benzodiazepines, 612

bruceantin, 167

phenoxypropionic acid, 598

polynibonucleotides on antiviral activity, 1045

serotonin on fluke motility, 49

�9-tetrahydrocannabinol, 345

vasopressin, 313

vitamin D3 metabolites, 879

Sulfanilamide, and carbonic anhydrase, 832

Superoxide anion, catechol oxidation, 911

Superoxide dismutase, 911

Synaptic vesicles, from guinea pig cerebral cortex,778

Synaptosome, sodium dependent choline uptake,

1082

T

Temperature, effect on opiate receptor binding ac-

tivity, 977

Tetrahydrobiopterin, 1070

Tetrahydrocannabinol, effect on seratonin uptake

by synaptosomes, 345

Tetrahydrofurosemide, 759

Tetrahydroisoquinolines, effectors of adenylate cy-

clase, 854

2,2,6,6-Tetramethylpiperidine-1-oxyl, nerve con-

ductance, 136

Tetrodotoxin, on rat diaphragm muscle, 82

Thioridazine, 581

a-Toxin, interaction with cholinergic receptor, 1091

Triamterene, 945

Trifluoperazine, 546, 581, 778

a-Tubocurarine, binding to acetylcholine receptor,

999

Tubulin, binding of chlorpromazine, 769

Tyrosine aminotransferase,induction, 720

Tyrosine hydroxylase, 514

and electrical stimulation of dopaminergic neu-

rons, 1070

in dopaminergic neurons, 251, 463

induction by carbamylcholine in adrenal medulla,

420

induction in sympathetic ganglia, 353

neuronal enzyme activated by calcium chelator,

41

Tyrosine 3-monooxygenase, see Tyrosine Hydroxy!-

ase

Veratnidine, 900, 1082

V

X

Xanthine oxidase, 911

X-Ray crystal structure, of acetyicholine analogue,

590