antihypertensive therapy holds promise for isolated systolic hypertension in the elderly

2 AIit.ihyper,tensive therapy holds promise for isolated systolic hypertension in- the iHderly . . .. The prevalence of isolated systolic hypertension ranges from ' 6% in 60-year-olds to 180/0 inpatients aged>' 80 years . . Several studies have .shown the efficacy of antihypertensive therapy in elderly patients with isolated systolic hypertension bufthe effect on the risk- of cardiovascular events and adverse metabolic effects was unclear. Results of a 5-yearfollow-up of the Systolic Hypertension in the Elderly Programme [see Therapy section, this issue. p 10] confirm the efficacy and safety of chlorthalidone therapy in patients aged); 60 years with isolated systolic hypertension. The risk of stroke in these patients was found to be significantly reduced by antih ypertensive therapy regardless of medication prior to the trial. Interestingly, treatment was found to be effective in patients over 80 years of age. an age group previously thought not to benefit from antihypertensive therapy. The incidence of cardiovascular events was signit1cantly reduced in patients receiving antihypertensives compared with placebo but no significant reduction in overall mortality occurred. While these results do not yet warrant recommending chlorthalidone as first-line therapy in isolated systolic hypertension, the low cost of such therapy. its apparent efficacy and a low rate of adverse effects make it an appealing choice. Winker MA. Murphy MB. Isolated systolic hypertension in the elderly. Journal of the American Medical Association 265: 3301-3302. 26 Jun M% 6 Jul1991 INPHARMA® ISSN fiI56-1703/91/0706-()OOl/()SiJJ.o% ID Adis International Ltd

Upload: dangkien

Post on 16-Mar-2017

215 views

Category:

Documents

0 download

Report

Download

Embed Size (px):

TRANSCRIPT

Page 1: Antihypertensive therapy holds promise for isolated systolic hypertension in the elderly

AIit.ihyper,tensive therapy holds promise for isolated systolic hypertension in-the iHderly . . ..

The prevalence of isolated systolic hypertension ranges from ' 6% in 60-year-olds to 180/0 inpatients aged>' 80 years . . Several studies have .shown the efficacy of antihypertensive therapy in elderly patients with isolated systolic hypertension bufthe effect on the risk-of cardiovascular events and adverse metabolic effects was unclear. Results of a 5-yearfollow-up of the Systolic Hypertension in the Elderly Programme [see Therapy section, this issue. p 10] confirm the efficacy and safety of chlorthalidone therapy in patients aged); 60 years with isolated systolic hypertension. The risk of stroke in these patients was found to be significantly reduced by antihypertensive therapy regardless of medication prior to the trial. Interestingly, treatment was found to be effective in patients over 80 years of age. an age group previously thought not to benefit from antihypertensive therapy. The incidence of cardiovascular events was signit1cantly reduced in patients receiving antihypertensives compared with placebo but no significant reduction in overall mortality occurred.

While these results do not yet warrant recommending chlorthalidone as first-line therapy in isolated systolic hypertension, the low cost of such therapy. its apparent efficacy and a low rate of adverse effects make it an appealing choice. Winker MA. Murphy MB. Isolated systolic hypertension in the elderly. Journal of the American Medical Association 265: 3301-3302. 26 Jun I~I M%

6 Jul1991 INPHARMA® ISSN fiI56-1703/91/0706-()OOl/()SiJJ.o% ID Adis International Ltd

Antihypertensive Agents Dr S. O. Olayemi. HYPERTENSION Chronically persistent elevated blood pressure>/=140 mm Hg systolic blood pressure and or diastolic

Hypertension in PregnancyPregnancy (2013) Hypertension in Pregnancy Hypertension is Defined as . . . Systolic blood pressure ≥ 140 mmHg or Diastolic blood pressure ≥ 90 mmHg Based

Hypertension as a disease Hypertension affecting approximately 15% of the USA population (60 million). Hypertension defined as either a sustained systolic

Antihypertensive drug therapy for mild to moderate ...files.sld.cu/hta/files/2013/05/revisiones-antihypertensive-drug... · Mild to moderate hypertension during pregnancy is common

CHAPTER Antihypertensive Drugs - · PDF file2 Deﬁne hypertension and compare primary and secondary hypertension and their related manifestations. 3 ... Pharmacology Overview

Management of Hypertension of Hypertension ... Classification ... pressure should not be taken when inmates are acutely ill or taking antihypertensive drugs,Published in: The American

2014 HYPERTENSION GUIDELINES - Wild Apricot twomey.p… · antihypertensive therapy to a lower BP goal on progression of kidney disease In population with hypertension and proteinuria:

Antihypertensive emergencies & Hypertension in pregnancyndi.fda.moph.go.th/uploads/evidance_file/20170503182228.pdf · 1 Antihypertensive emergencies & Hypertension in pregnancy No

Are the New “Lenient” Hypertension Guidelines Best for ... 2015...Many robust, very old individuals have hypertension. Antihypertensive treatment in those individuals is beneficial

Antihypertensive Drugs - psau.edu.sa · Antihypertensive drugs, Hypertension - Introduction Causes of Hypertension: The are two basic types of hypertension: I. Primary (essential)

CLINICAL PRACTICE GUIDELINE THE MANANGEMENT OF ...€¦ · Moderate Hypertension: Diastolic blood pressure 100–109mmHg, systolic blood pressure 150–159mmHg. Severe Hypertension: