ANTIHYPERTENSIVE AGENTS

ANTIHYPERTENSIVE AGENTSMichael L. VillavertMD 17th BatchHypertensionFactorsAgeRaceGeneticsEducationEnvironmentStress (psychological)LIFESTYLE

Damage in:

KidneyHeartBrainRenal failureCoronary diseaseCardiac failureStrokeEtiologyPrimary / Essential HypertensionSecondary HypertensionRenal artery constrictionCOAPheochromocytomaCushings diseasePrimary aldosteronismBP Regulation

BP = CO X PVRBP Regulation

BaroreflexesANS

According to the principal regulatory site or mechanism on which they actDiureticsDepleting the body of sodium and reducing blood volume

Sympathoplegic agentsReducing peripheral vascular resistanceInhibits cardiac functionIncreasing venous pooling in capacitance vesselsAccording to the principal regulatory site or mechanism on which they actDirect vasodilatorsRelaxing vascular smooth muscle; thus dilating resistance vesselsAgents that block production or action of angiotensinReduce peripheral vascular resistance and (potentially) blood volume