antibiotics have saved millions of lives antibiotics are losing their effect
DESCRIPTION
The Rise of Antibacterial Resistance and the Decline in Innovation The proportion (%) of MRSA among positive blood cultures of Staphylococcus aureus in The proportion (%) of MRSA among positive blood cultures of Staphylococcus aureus in England &Wales Antibacterial new molecular entities approved for use in the United States From Kaplan, Laing et al., Priority medicines for Europe and the world, 2004TRANSCRIPT
Antibiotics have saved millions of
lives
Antibiotics are losing their effect
Global mortality in infectious diseases (WHO estimates for 2002, from World Health Report
2004)
0
1
2
3
4
5
Acuterespiratoryinfections
HIV/AIDS Diarrhoealdiseases
Tuberculosis Malaria
Milli
ons
of d
eath
s
The Rise of Antibacterial Resistance and the Decline in Innovation
The proportion (%) of MRSA among The proportion (%) of MRSA among positive blood cultures of Staphylococcus positive blood cultures of Staphylococcus aureus in aureus in England &Wales1989-2002
0
5
10
15
20
1983-1987 1988-1992 1993-1997 1998-2002
No.
of F
DA
appr
oved
ant
ibac
teria
l NM
Es
Antibacterial new molecular entities approved for use in the United States 1983-2002
From Kaplan, Laing et al., Priority medicines for Europe and the world, 2004
Increased knowledge on an increasing problem
number of hits in Pub-MED for (antibiotic or antimicrobial) + resistance by 5 year’s periods
02,0004,0006,0008,000
10,00012,00014,00016,00018,000
1965-70
1971-75
1976-80
1981-85
1986-90
1991-95
1996-2000
2001-05
ReviewsOriginal publ.
Seminar on the Global Threat of Antibiotic Resistance
Exploring Roads towards Concerted Action
Uppsala 5-7 May, 2004
www.reactgroup.orgwww.reactgroup.org
Since May 2004….• The clusters
– Communicating the message– Ensuring appropriate use– Ensuring supply of new antibiotics
• Some outcomes– Website (www.reactgroup.org)– WHA resolution– Priority medicines– Innovation study– Network broadened
Current and future generations of people around the globe
should have access to effective
treatment of bacterial infections.
Will we respond to antibiotic Will we respond to antibiotic resistance in time?resistance in time?
A seminar on the growing threat of antibiotic resistance September 14-17, 2005, Uppsala
STRAMA IHCAR
The way forward?
1 + 1 >2
Will we React in time?