ans mcqs
TRANSCRIPT
At GTTH, in medical OPD, Just as a trial, final year MBBS students injected a drug to 3rd year MBBS student USMAN. Drug injected was in a clinical dose. Route of administration was S/C. After 30 minutes there was dilation of pupil and a rise in systolic blood pressure of USMAN. The drug could be
a) Morphineb) Adrenalinec) Atropined) Acting by blocking gangliae) Stimulating beta receptors throughout the
body
• At SURGIMED Hospital, a Physician was discussing autonomic pharmacology with house officers. He asked “when given to man a drug causes bradycardia, increased GI motility and pupilary constriction. Which one of the following drug produces these combined effects:
a) morphineb) Histaminec) anti-histamined) nor-epinephrinee) neostigmine
• In emergency ward of Meo hospital medical officers were treating a comatose patient. They were differentiating effects of adrenaline and nor-adrenaline. One said which was true, “subcutaneous injection of noradrenaline in man” cuases:
a) Decrease in systolic BPb) Decrease in diastolic BPc) Tachycardiad) Lowers peripheral resistance e) Predominantly alpha-actions
• Beta-action of adrenaline include:a) Decreased glycogenolysis in skeletal
musclesb) Constriction of arterioles in skinc) Decrease in force of cardiac contractiond) Increase in rate of cardiac contractione) Constriction of bronchioles
3rd year MBBS students were discussing about ephedrine. There are 5 statements about the drug. Which one is correct:
a) It is contraindicated by oral routeb) Is especially indicated in patients already
taking monoamine oxidase inhibitorsc) Causes depression of the CNSd) Stimulates predominantly alpha-receptorse) It is a mixed acting amine, ie; acts directly on
receptors and by causing release of transmitter from sympathetic nerves
A 35 years old patient Muhammad Nawaz was admitted in emergency at GTTH at 11 am. He had have breathlessness. A Junior doctor was on duty, who nebulized him with SALBUTAMOL. This drug:
a) Is selective beta1 agonist
b) Has its actions competitively antagonised by chlorpheneramine
c) Produces constriction of blood vessels in skeletol muscles
d) Is used in asthmae) Produces accommodation for near vision
A young medical graduate of LM&DC was observing treatment of his 22 years brother-in-law at Jinnah Hospital, Lahore. When injected a drug to that young man, drug has no effect on resting pulse rate, does not produce a dry mouth, and depresses tachycardia, that normally follows the Valsave manoeuvre. What do you think that the drug:
a) Would be expected to block the tachycardia induced by inhalation of amyl nitrate
b) Could be atropinec) Could be bethanecol d) Could be ipratropiume) Is surely H2 receptor antagonist
The transmitter substance at:a) Parasympathetic postganglionic nerve endings
is usually nor-epinephrineb) Parasympathetic ganglia is epinephrinec) Sympathetic ganglia is nicotined) Parasympathetic preganglionic nerve endings
is muscarinee) Parasympathetic postganglionic nerve endings
is adrenaline
A 12 years old child was admitted in casualty of sheikh zaid hospital , Lahore. History revealed that he has taken 2 bottles of a drug which was used by his mother for nasal decongestion. It is basically alpha adrenoceptor agonist drug. What will you observe in this patient:
a) tachycardiab) mydriasisc) bronchodilationd) vasodilatione) none of the above
23 years nurse at GTTH was observing management of patient in shock. Doctor used drug ‘adrenaline’ in that patient. Nurse was considering about the drug. Regarding ADRENALINE:
a) It is a catalytic agentb) It is useful drug to relieve constipationc) It is indicated in glaucomad) It is commonly used by oral routee) It is commonly used in hypertensive patients
Practolol has been withdrawn from general clinical use because it:
a) Is a non-selective beta-blocker
b) Is dangerous to give it to asthmatics
c) Cause hyperurecemia
d) Induces thyrotoxicosis
e) Causes ocular damage
Salivary secretion is under autononmic control. Sympathetic activity produces a small amount of thick mucus secretion rich in enzyme content, whilst parasympathetic activity produces a copious watery secretion. Ganglion blockade blocks all secretion,and an unpleasant dry mouth results.Which drug of the following has ganglion blocking activity:
• A)adrenaline• B)nor-adrenaline• C)hexamethonium• D)haloperidol• E)carbachol
LM&DC graduate of 2005 Dr. Amin is GP at Shadman town , Lahore. He prescribed tablet alpha methyl dopa, in patient who was suffering from………………..
a) hyperlipidemiab) Diabetes mellitusc) hypertensiond) goute) Peptic ulcer
Which of the statement is correct:
a) Adrenaline is a rational choice in the treatment of sinus bradycardia
b) Noradrenaline is useful in all types of cardiac arrhythmiasc) Guanethidine prevents release of noradrenaline from
sympathetic neuronsd) Pempidine is a useful antihistaminee) Salbutamol produces more tachycardia than isoprenaline
Sympathetic ganglia can be
a) Blocked by alpha methyl dopab) Stimulated by acetylcholinec) Stimulated by nicotined) Blocked by pempidinee) Stimulated by bradykinin
• 25 years old male patient was admitted in General Hospital Lahore at 4 pm, due to hypersensitivity reaction to some drug ingestion 4 hours before. At emergency he was treated by a drug which causes dilattion of vessels in muscle, constriction of cutaneous vessels, and positive inotropic and chronotropic effects on the heart. The drug given may be:
A) isoproterenolB) acetylcholineC) adrenalineD) metaproterenolE) noradrenaline
A 9 years old baby was brought at medicine OPD of the hospital. Mother told physician that child has bed-wetting problem. Which drug may be prescribed for this problem:
a) phenylephrineb) adrenalinec) ephedrined) antihistaminee) tricyclic antidepressant
In Opthalmology OPD doctors are used to administered following drug for routine examination of EYE. That drug should be mydriatic but not cycloplegic. Which one of the following drugs has that property:
a) tropicamideb) pilocarpinec) phenylephrined) homatropinee) isoproterenol
SEXUAL DYSFUNCTION IS COMMON SIDE EFFECT of:
a) Lorazepamb) Antihistaminesc) Beta blockersd) Ephedrinee) Sildenafil
Write short note on:
1) Indications of beta blockers2) SEs of non-selective beta blockers3) Dobutamine4) Contra-indications of epinephrine5) Clinical uses of Phenoxybenzamine
14 years old Ms. Fahmida was brought at casualty of GTTH, complain with epistaxis. It was due to fragile vessels of the nose. Doctor on duty kept adrenaline swab at her nose. Which of the following effects of adrenaline would be blocked by phentolamine but not by metoprolol:
a) Contraction of radial smooth muscle in the iris
b) Cardiac stimulation
c) Increase of cAMP in fat
d) Relaxation of bronchial smooth muscle
e) Relaxation of uterus
Phenoxybenzamine is not used in:
a) Pheochromocytoma b) Raynaud’s phenomenon c) Essential hypertensiond) Carcinoid e) Mastocytosis
28 years male patient, already diagnosed case of pheochromocytoma was admitted in Surgical ward of Meo Hospital. At day-0, surgeon started IV injection of Phentolamine Mesylate for this patient. Phentolamine was used in this patient, because:
a) It has antipsychotic effects
b) It increases BP by increasing peripheral resistance
c) It decreases BP by blocking α-receptors, both α1 and α2
d) It has anxiolytic effect
e) It decreases adrenaline presynaptically
28 years Haqnawaz was hypertensive since last 5 years. He came to GP at Mustafabad, Dharampura for his treatment. GP prescribed tablet Minipress (prazosin) 5 mg OD for him, for three days.Regarding PRAZOSIN:
a) It is highly α-1 selective blocker agentb) It dilates arterioles more than veinsc) It causes postural hypotensiond) Dizziness and fainting occurs as “1st DOSE EFFECT”e) All are true about prazosin
An accident occured at north canal road, near DYAL HOUSE. Driver of that car was severely injured and shifted to GTTH. There was remarkable blood & fluid loss in the patient. PATIENT IS INFRONT OF YOU. What will you do?
a) Start fresh blood and dextrose saline, immediately b) You will start adrenaline s/c immediatelyc) You will observe all vital functions then you will decide
what to do?d) Immediately inject corticosteroids (SOLUCORTEF)e) Do not think, just administer atropine IV
47 years old patient has benign hypertrophy of prostate. He visited surgical OPD of AADIL HOSPITAL, bediyan road, Lahore. Before surgical treatment of the case, Doctor may prescribe some drugs for this patient. Which drugs should be prescribed:
a) α-1 adrenergic blocker like prazosin
b) Propranolol
c) Atenolol
d) Combined propranolol + atenolol
e) None of the above
35 years old patient was operated for inguinal hernia. Surgeon decided to operate him under GA. After recovery from anesthesia, on routine investigations at ICU, tachycardia and extrasystoles were observed by doctor. For this patient at this stage, which drugs are helpful:
a) Bethanichol may improve extrasystoles
b) Ipratropium may be helpful to control tachycardia
c) Beta blockers suppress extrasystoles and tachycardia
d) Esmolol is special beta blocker used in this case
e) No any drug available to control tachycardia & extrasystoles