CARDIOVASCULAR SCIENCES COLLABORATIVE PROGRAM

Faculty of Medicine, University of Toronto

ANNUAL REPORT

2008 – 2009 FitzGerald Bldg., 150 College Street, Room 88, Toronto ON M5S 3E2 Tel: 416/978-0746 Fax: 416/946-5713 E-mail: cv.program@utoronto.ca Web site: www.cscp.utoronto.ca

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CONTENTS DIRECTOR’S MESSAGE……………………………………………………………………………….2 MISSION STATEMENT………………………………………………………………………………….3 COLLABORATING DEPARTMENTS…..……………………………………………………………..4 COMMITTEES…………………………………………………………………………………………….4 - Executive - Program COURSES OFFERED…………………………………………………………………………………...5 PROGRAM SPONSORED ACTIVITIES……………………………………………………………….6 - Annual Student Research Day - Student Forum Night

- Cardiovascular Summer Initiative - CSI AWARDS……...…………………………………………………………………………………………12 - Medtronic Travel Award - Bigelow Book Prize - Lorne Phenix Graduate Award

- Ontario Student Opportunity Trust Funds (OSOTF) Award - Ontario Graduate Scholarships in Science and Technology (OGSST)

ADVERTISING MATERIAL…………...……………………………………………………………….16 ACKNOWLEDGEMENTS……...………………………………………………………………………16 STUDENTS………………………………………………………………………………………………17 - Currently Enrolled - Convocated/Follow-Up - Awards and Honors - Publications - CSCP Student Association Circulation Rounds FACULTY……………………...………………………………………………………………………...26

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DIRECTOR’S MESSAGE It always amazes me how fast time goes and it is annual report time again! So, as has been the case for each report before, the following is the Cardiovascular Sciences Collaborative Program (CSCP) activities and accomplishments of our students and faculty for the 2008-2009 academic year. This past year the CSCP saw another jump in enrolment (see graph below), to a greater extent then was seen in the previous year. We now have a total of 71 (50 MSc and 21 PhD) enrolled students. These numbers are even more impressive when you take into account we graduated 18 students, the majority of which were Masters level and still increased our total enrollment numbers. This continues to reflect the support of our faculty who

encourage their students to participate and also speaks to our ongoing recruitment strategies which continue to promote the program to all departments as well as newly admitted students. The level of student satisfaction with the Program continues to be high as expressed during their annual meeting with the CSCP Student Affairs Committee Chair and the exit surveys we conduct. It is very satisfying to witness this latest surge of growth of the CSCP re-emphasizing its value to the students and confirming the CSCP as a successful educational initiative of the Faculty of Medicine.

In addition, growth was also noted in the enrollment of students in our JCV3000 series of graduate courses which continue to offer fully established web-based learning. This consists of live and archived seminars which are fully integrated into our JCV3000 level courses, providing state-of-the-art learning technology for our trainees through. This is but another example of how the education initiatives of the CSCP focus on translational delivery of current information using state-of-the-art format. Details on our other events such as the Annual Student Research Day, summer CSI initiative and Circulation Rounds can be found in the following pages of this report.

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The following objectives for 2009-2010 are to continue with the momentum established and to further focus our efforts in areas that have not moved ahead as anticipated:

• Work to bring to completion the agreement for the joint initiative with the University of Waterloo

• Further develop innovative curriculum to more appropriately serve the diverse nature of this now multi-Faculty graduate training initiative

• Seek creative funding strategies to provide permanent infrastructure support • Maintain active student recruitment • Further develop CME programs in cardiovascular sciences • Maintain high standards of our full web-based courses

The CSCP website (www.cscp.utoronto.ca) provides a complete and historic view of the CSCP which we invite those interested to peruse at their leisure. I would like to once again recognize the outstanding efforts of Victoria Simpson, our Business Officer, as well as the Executive Committee for their hard work and contributions that have made the Cardiovascular Sciences Collaborative Program the success it continues to be. And finally, I would like to take this opportunity to thank all our faculty and students for another successful year and to those individuals who have continued to provide both moral and tangible support for this Program. Dr. Carin Wittnich, O.Ont. Director, CSCP Professor of Surgery & Physiology Northrop Frye Scholar

MISSION STATEMENT “The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate Studies, exists to give formal, organized expression to cardiovascular studies and research at the graduate level. It builds on the strengths of all participating academic units, and other agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative, interdisciplinary training and research.” The above mission is achieved by advertising and promoting the importance of, and opportunities in, cardiovascular studies, by making known the results of such studies, by recruitment of excellent students, and by coordinating the graduate collaborative program in cooperation with the academic units in which they are registered. Students in this collaborative program must fulfill the requirements of their home units as well as the Program. Upon graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s academic transcript and the Program will present the student with a certificate and gift.

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COLLABORATING FACULTIES

Dentistry Medicine Nursing Pharmacy Physical Education and Health

COLLABORATING GRADUATE UNITS Dentistry Exercise Sciences

Health Policy, Management & Evaluation Laboratory Medicine and Pathobiology

Medical Biophysics Institute of Biomaterials and Biomedical Engineering Institute of Medical Science Nursing Science Pharmaceutical Sciences

Pharmacology and Toxicology Physiology Public Health Sciences Rehabilitation Science

SUPPORTING CLINICAL DEPARTMENTS Anesthesia

Medicine Surgery

COMMITTEES

The Executive Committee consists of 4 members of the Program Committee representing as wide a range of disciplines as possible and includes the Director. They also act as Chairs of the various subcommittees as noted beside their name. The Executive Committee provides student counseling, screens applicants, provides advice and acts as a Steering Committee.

Executive

Dr. C. Wittnich (Fundraising) Dr. M. Rand (Scholarships & Awards) Dr. V. Rao (Membership/Curriculum) Dr. S. Thomas (Student Affairs)

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Program The Program Committee consists of a representative from each collaborating department as well as two student representatives. It administers the Program, selects the Director, and generally meets twice per year. C. Wittnich (Chair) D. Brooks (Rehabilitation Science) S. Wu (Pharmaceutical Sciences) D. Mazer (Anesthesia) J. Parker (Pharmacology) S. Heximer (Physiology) D. Steinman (Institute of Biomaterials and Biomedical Engineering) M. Rand (Laboratory Medicine and Pathobiology) V. Rao (Institute of Medical Science) H. Tenenbaum (Dentistry) S. Thomas (Exercise Sciences) J. Tu (Health Policy, Management and Evaluation) S. Clarke (Nursing) G. Wright (Medical Biophysics) President, CSCP Student Association Vice-President, CSCP Student Association

COURSES OFFERED EXS5508H Cardiovascular Disease and Exercise JCV1060H Developmental Cardiovascular Physiology JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart Signal

Transduction JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart Function JCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular JEB1365H Ultrasound: Theory and Applications in Biology and Medicine JTC1331H Biomaterials Science LMP1015H Vascular Pathobiology LMP1504H Cell and Molecular Biology of Cardiovascular Diseases PSL1462H Molecular Aspects of Cardiac Function * Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our collaborating departments. Suggested Courses (Considered valuable but does not fulfill Program requirements) CHL5201 Introducing Biostatistics for Students in Biological Sciences LMP1404S Cellular and Molecular Mechanisms of Disease PSL1052H Fundamentals on Ion Channel Function

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PROGRAM SPONSORED ACTIVITIES ANNUAL STUDENT RESEARCH DAY The Cardiovascular Sciences Collaborative Program (CSCP) held its 10th Annual Student Research Day on February 18th, 2009. This was a fun-filled, interesting, and educational day where all CSCP trainees attend and were able to meet with students in other Departments/Faculties. Following opening remarks by Dr. Carin Wittnich, the day was planned to allow for a mix of student presentations, an awards ceremony, and guest speakers. Student Presentations Selected trainees presented their research in a series of 10-minute presentations followed by a brief question period. Presentations covered a broad range of cardiovascular research topics. Session I: Chair – Emma O’Donnell Kumar Perampaladas (MSc – Department of Pharmacology) “Effects of Rosiglitazone on nitrate-induced endothelial dysfunction” Jenna Adleman (MSc – Institute of Medical Science) “Vascular reactivity reserve and resting tonus in retinal arterioles of healthy subjects” Sonya Hui (MSc – Department of Physiology) “Targeting calcium-sensitive mechanisms of cell cycle progression for development of novel anti-proliferative vascular therapies” Sam Tirgari (MSc – Department of Physiology) “Characterizing the role of RGS5 in arterial vasculature” Carly Spragg (MSc – Department of Exercise Sciences) “Post-exercise hypotension and blood pressure’s circadian rhythm in pre-hypertensive older adults” Shawn Lacombe (MSc – Department of Exercise Sciences) “Interval exercise and post-exercise hypotension” Megan Thompson (MSc – Institute of Medical Science) “Epigenetic influences on placental function in maternal diabetes” Laura Voicu (MSc – Department of Physiology) “Deceased urine osmolality: An early sign of hypoxic renal injury in rats”

Session I Speakers (L-R): Kumar Perampaladas, Jenna Adleman, Sonya Hui, Sam Tirgari, Carly Spragg, Shawn Lacombe, Megan Thompson, and Laura Voicu

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Session 2: Chair – Geoffrey de Couto Melanie Henriques (MSc – Department of Physiology) “Human neutrophil peptides: A novel agonist of platelet activation and aggregation” Luke Tan (MSc – Department of Physiology) “Sex differences in newborn heart responses to hyperoxia” Laura Banks (MSc – Department of Exercise Sciences) “Left and right ventricular function following prolonged exercise” Talha Farid (MSc – Institute of Medical Science) “ATP sensitive potassium channels and ventricular fibrillation” Mike Sellan (MSc – Department of Physiology) “Iron-overload causes sinus bradycardia due to a reduction in firing rate of pacemaker cells in sinoatria node” Mark Moon (MSc – Department of Physiology) “The role of Mindin post myocardial infarction”

Session II Speakers (from left to right): Melanie Henriques, Luke Tan, Laura Banks, Talha Farid, Mike Sellan, and Mark Moon Guest Speaker

The afternoon component of the Research Day was highlighted by our Guest Speaker, Dr. Michelle Bendeck, Professor in the Department of Laboratory Medicine & Pathobiology at the University of Toronto. She delighted the students with an informal presentation in which she shared the highs and lows of her career path in academia and her life experiences in general. An enthusiastic question and answer period followed in which Dr. Bendeck provided insight into possible career paths for students in both academia and industry as well as the feasibility of balancing research with family life.

Awards The 2008-2009 Lorne Phenix Graduate Award was presented to Luke Tan, MSc, Department of Physiology, Supervisor: Dr. C. Wittnich. This award focuses attention on the issue of heart disease - which is still the #1 killer of both men and women in Canada. Women who have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of research to address this particular problem.

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The 2009 Bigelow Book Prize was presented to Jane MacIver, PhD, Institute of Medical Science, Supervisor: Dr. V. Rao. This award was established in 1995 to recognize and honour a pioneer clinician and scientist in the field of cardiovascular sciences; Dr. Wilfred Bigelow. Awardees should exemplify the personal traits of Dr. Bigelow, including drive, curiosity and scientific integrity.

We were honoured to have the Phenix and Bigelow families present to hand out the awards. During lunch the students and award winners enjoyed mingling and chatting with the donor families. Certificates and gifts were also presented to those students who successfully completed the Cardiovascular Sciences Collaborative Program over the past year.

Elissa Tepperman, MSc/IMS, Supervisor: Dr. V. Rao Rohit Sheshgiri, MSc/IMS, Supervisor: Dr. V. Rao Jessica Prodger, MSc/IMS, Supervisor: Dr. V. Rao Katharine Currie, MSc/EXS, Supervisor: Dr. J. Goodman Kieran Quinn, MSc/PSL, Supervisor: Dr. H. Zhang Marc Busato, MSc/EXS, Supervisor: Dr. J. Goodman Tenille Ragoonanan, MSc/PSL, Supervisor: Dr. G. Hare Galina Kichigina, MSc/IMS, Supervisor: Dr. G. Gross Mila Kisilevsky, MSc/IMS, Supervisor: Dr. C. Hudson

L-R: Kathryn Phenix (Mrs. Phenix’s daughter), Mrs. Geraldine Phenix, Luke Tan, and Dr. Margaret Rand, Chair, Awards Subcommittee)

L-R: Dr. Carin Wittnich, Pixie Currie (Dr. Bigelow’s daughter), Jane MacIver, Dr. Margaret Rand (Chair, Awards Subcommittee)

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Lara Gotha, MSc/IMS, Supervisor: Dr. B. Strauss Anton Mihic, MSc/PSL, Supervisor: Dr. R. Tsushima

After the awards ceremony, a special presentation was made to all the students and guests. The Cardiovascular Sciences Collaborative Program Student Research Day celebrated it’s 10th anniversary. Special cakes were presented and an official cake cutting ceremony was held; with the assistance of Pixie Bigelow and Geraldine Phenix.

The Student Research Day was created out of the original CSCP Scientific Day workshop. The workshop was a day long event that brought together surgeons, cardiologists, nurses, and perfusionists, as well as clinical and research trainees. Over time the workshop became the purview of the newly established Heart & Stroke/Richard Lewar Centre. This allowed the CSCP to return to its roots and create the Annual Student Research Day to allow students to showcase their research work and provide a medium for them to learn to present in the format seen at larger international meetings but in a friendly peer environment. This hugely successful day is now the highlight of the CSCP annual activities. We look forward to the next 10 years of successful Student Days.

The Student Research Day was a success and would not have been possible without the combined efforts of several individuals. The Planning Co-Chairs (Victoria Simpson and Laura Voicu) would like to thank Mostafa El Beheiry and Albert Tsui for helping out with various tasks throughout the day, Dr. Bendeck for a delightful presentation, and Session Chairs, Emma O’Donnell and Geoff de Couto. In addition, the committee gratefully acknowledges the invaluable financial support of the Heart and Stroke Foundation of Ontario.

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STUDENT FORUM The December 9, 2008 Holiday Forum/dinner was another great Cardiovascular Sciences Collaborative Program organized success. This event is an excellent opportunity for new students of the CSCP to meet one another and for senior students to catch up with old friends, and develop relationships with the up and comers. The venue at the Chestnut Residences set the atmosphere for a very interactive evening for collaboration amongst cardiovascular graduate students from multiple disciplines across the University of Toronto campus. Beginning with a short welcome and introduction to the dinner by Geoffrey de Couto, president of the CSCPSA, the evening started out with both a relaxed and interactive setting. Lively discussions took place soon afterward. Various topics were covered ranging from questions relating to transferring from a Master’s degree to a Doctoral degree, the benefits of healthy living – including heart-healthy foods, the possibility of collaborative efforts amongst students, and the enjoyment of having collaborative programs such as the CSCP to bring students together. Overall, the exchange of ideas was very well received. Everyone provided excellent feedback on the evening. Catering staff were extremely hospitable and provided for a very pleasant evening. Dinner commenced with a delightful soup and salad, followed with turkey, stuffing, potatoes, and vegetables and finished with a chocolate mousse. All in attendance thoroughly enjoy the festive dinner and the chance to meet other students. The CSCP would like to give special thanks to our external funding support, without which this event could never have been possible, the continued dedication and support from Dr. Carin Wittnich and Ms. Victoria Simpson, the organization committee of the CSCPSA, and the members of the CSCP for making this night such a valuable and rewarding experience. We look forward to more of these special occasions in the future.

CARDIOVASCULAR SUMMER INITIATIVE (CSI) 2009 The 2009 Cardiovascular Sciences Collaborative Program Cardiovascular Summer Initiative “CSI” was organized by a Committee from the Student Association. The CSI was targeted at undergraduate students involved in cardiovascular summer research. It also aimed to give

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students a more inclusive feel for the field and to provide a broader frame of reference than just lab experience alone. An orientation session outlined the upcoming CSI schedule. Altogether, 11 students signed up great student representation from research hospitals around the Toronto area (TGH, SMH, Sick Kids, PMH). The CSI began with a Mini-Symposium showcasing the diversity of research within the CSCP. Five graduate students of the CSCP gave presentations: Melissa Noronha, Anton Mihic, Mostafa El Beheiry, Andrew Ramadeen and Meghan Sauve. The summer students really enjoyed the talks and demonstrated interest by posing meaningful questions about research methods and graduate studies in general. Three field trips, two lab tours, and a CSI student presentation day were planned. The outings were structured to incorporate a diverse spectrum of material relevant to cardiovascular research. The first event comprised lab tours of the Retinal Blood Flow Lab at the Toronto Western Hospital (TWH), and the Valvular Mechanobiology Lab at the University of Toronto. Both stops were hosted by CSCP graduate students.

Our first stop was the Retinal Blood Flow Lab with Jenna Adelman at the TWH. She provided a very comprehensive overview of not only the clinical complications that arise from altered retinal blood flow but also reviewed in great detail the multiple examinations that may be employed. The students were very excited with the opportunity to observe and participate in the various respiratory tests, retinal scans and 3D rendering of captured images and had several questions upon completion.

Next, we went to see Cindy Yip in the Valvular Mechanobiology Lab in the Rosebrugh Bldg. at the University of Toronto. Cindy also provided an excellent powerpoint presentation that

Andrew Ramadeen – ‘The effect of fish oils on vulnerability in atrial arrythmias’

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reviewed and provided simplified descriptions of valvular calcification resulting in altered cardiac function. Additionally, she employed hands-on demonstrations using a porcine hearts and micro high-throughput technology to analyze blood flow. Cindy’s enthusiastic approach encouraged participation and excitement. Overall, both lab tours were an extreme success and we would like to thank and acknowledge the great efforts put forth by both Jenna and Cindy.

The second event to take place was a tour of the Surgical Skills Centre at the Mount Sinai Hospital. Students were kindly greeted by the staff and were informed, in a didactic lecture, about the complexities of surgical training and the state-of-the-art resources found at the Mount Sinai teaching hospital. Students were next taken on a tour of the facility, given the opportunity to watch some medical students dissect various tissues, and provided with the chance to ask questions. Overall, this day was well received by all. The final field trip was a tour of the Imaging Centre at

St. Michael’s Hospital (SMH). We were fortunate to have the opportunity to have two physicians, Dr. Kirpilani and Dr. Prabhudesai, provide lectures and tours of their facilities. The organization and willingness of the SMH staff to was excellent. They were extremely generous in providing everyone with a hot lunch during our visit. Subsequent tours of the MRI and CT facilities were extremely informative. Although both imaging departments were busy, both physicians went out of their way to give an informative session with Q&As and we greatly appreciate the time they and the staff took out of their busy schedules to educate the CSI undergraduate students. The CSI’s final session consisted of the undergraduate students presenting the lab work they had done over the summer. It was a very well put together event by the CSI students. All of those participating went to great lengths to incorporate and translate their work to their colleagues. Lively discussion by both the organizing committee and students reinforced a positive and encouraging atmosphere. Each presentation was well received and several students commented on having a really enjoyable time. Students were presented with a certificate for their attendance, presentation, and successful completion of the program. In conclusion, the overall impression of the CSI was that it was very good; providing an enjoyable learning environment and an opportunity to interact with several students outside of their lab. Each session was informative and well received. The organizing committee would like to thank all of the participants for their hard work and enthusiasm in making the Cardiovascular Summer Initiative a great success.

AWARDS MEDTRONIC TRAVEL AWARD Two competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were:

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Fall 2008: No applications received. Spring 2009: Jemy Joseph, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao) Canadian Society of Transplantation (CST) Annual Meeting, Alberta, 2009 “Everolimus but not Myeophenolate Mofetil Therapy is Associated with Soluble Human Leukocyte Antigen-G Expression in Heart Transplant Patients” Jenna Adleman, MSc, Institute of Medical Science (Supervisor: Dr. C. Hudson) Association for Research in Vision and Ophthalmology, Florida, 2009 “Vascular Reactivity Reserve and Resting Tonus in Retinal Arterioles of Healthy Subjects” Olena Puzyeyeva, MSc, Institute of Medical Science (Supervisor: Dr. C. Hudson) Association for Research in Vision and Ophthalmology, Florida, 2009 “High Resolution, Non-Invasive Spectral Domain OCT Imaging of Retinal and Optic Nerve Disease: A Case Series Illustrating Potential and Limitations” Anton Mihi, MSc, Department of Physiology (Supervisor: Dr. R. Tsushima) Biophysical Society 53rd Annual Meeting, Massachusetts, 2009 “Binding of Syntaxin 1A to the C-terminus of hERG Channels Affects Channel Trafficking and Inactivation” Laura Voicu, MSc, Department of Physiology (Supervisor: Dr. D. Mazer) Canadian Anesthesiologists’ Society Annual Meeting, British Columbia,, 2009 “Decreased Urine Osmolality: An Early Sign of Hypoxic Rat Renal Injury” BIGELOW BOOK PRIZE This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow - curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care. The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin” and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates are identified and the final decision is made by the Program Committee. 1995 – John S. Ikonomidis 2003 – Paul W.M. Fedak 1996 – Shona M. Torrance 2004 – Nathalie Lapointe 1997 – Vivek Rao 2005 – Karim Bandali 1998 – Bryce Cowan 2006 – Danny Ramzy 1999 – Gideon Cohen 2007 – Patricia Rose 2000 – Michael Borger 2008 – Mitesh Badiwala 2001 – Saeid Babaei 2009 – Jane MacIver 2002 – Wm. Jack Wallan

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Jane is a Doctoral candidate in the Institute of Medical Science under the Supervision of Dr. Vivek Rao. Her doctoral research is on understanding the process of decision-making for patients considering heart transplantation or ventricular assist device implantation. The work has evolved out of her clinical experience listening to and working with patients implanted with a ventricular assist device. Describing how patients make decisions is an important piece in the larger understanding of patient preferences for treatment in advanced heart failure. Upon completion of her PhD, Jane hopes to work as a clinician-scientist in the Heart Failure/Heart Transplant program at Toronto General Hospital. LORNE PHENIX GRADUATE AWARD This award was made possible by a generous donation in the memory of Mr. Lorne Phenix by Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart disease – which is still the #1 killer of both men and women in Canada. In addition, women who have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of research to address this particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis of research and academic excellence. The award consists of a cash prize and certificate and is presented to the recipient at the Annual Student Research Day. Appropriate candidates are identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart. This award is presented at the Annual Student Research Day. 2001 – Wm. Jack Wallen 2005 – Nesime Askin 2002 – Wm. Jack Wallen 2006 – Danny Quaglietta 2003 – Shathiyah Kulandavelu 2007 – Emma O’Donnell 2004 – Rachel Mitchell 2008 – Luke Tan

L-R: Kathryn Phenix (Mrs. Phenix’s daughter), Mrs. Geraldine Phenix, Luke Tan, and Dr. Margaret Rand, Chair, Awards Subcommittee)

L-R: Dr. Carin Wittnich, Pixie Currie (Dr. Bigelow’s daughter), Jane MacIver, (PhD/IMS), Dr. Margaret Rand (Chair, Awards Subcommittee)

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Luke Tan is an MSc candidate in the Department of Physiology at the University of Toronto under the supervision of Dr. Carin Wittnich. Luke’s thesis investigates whether gender plays a role in antioxidant defense systems when protecting against oxidative damage in the newborn heart during high-oxygen conditions (hyperoxia). Clinical studies in children show females have a higher risk of death than males post cardiac surgery. These studies serves as evidence suggesting female sex is a risk factor for children undergoing cardiac surgery. Luke’s research is focused on uncovering why female sex is a risk factor that leads to the pronounced female death rate. One major reason for cardiac surgery in children is the presence of congenital heart defects (CHD). As of 2008, the American Heart Association reports that CHDs are suffered by 8 in every 1000 newborns. Depending on the treatment course of CHD, newborns may be subjected to a high-oxygen (hyperoxic) condition (eg. cardiopulmonary bypass and extracorporeal membrane oxygenation). Hyperoxia generates reactive oxygen species (ROS), which are cytotoxic (damages/kills cells). However, the body has natural defenses against the oxidative stress created by ROS called antioxidants, which neutralize free radicals. Antioxidant activity is present in newborn myocardium, however whether there are gender-related differences is currently unknown and is the focus of Luke’s study. Luke’s work addresses the potential female-male differences in antioxidant defense systems and oxidative damage experienced during hyperoxia. By utilizing a well-established piglet model, Luke’s work will ultimately provide key insights on sex-related differences regarding how newborn hearts handle oxidative stress, and ultimately why females have worse outcomes post cardiac surgery. ONTARIO STUDENT OPPORTUNITY TRUST FUNDS (OSOTF) AWARD The OSOTF award refers to a class of awards that have resulted from the Ontario government’s “matching” program. Under the program every dollar of donation received for student assistance has been matched by the government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program participates in this program. There are two major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria that must be adhered to, including excellence in science and academic performance. One competition is held per academic year. The applications are handled centrally through the Office of the Associate Dean, Inter-Faculty and Graduate Affairs. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee chaired by Dr. Margaret Rand. Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine). No applications were received for the 2008-2009 competition. ONTARIO GRADUATE SCHOOL SCIENCE & TECHNOLOGY (OGSST) The OGSST program is designed to encourage excellence in graduate studies in science and technology. The program is supported through funds provided by the Ministry of Training, Colleges and Universities and by funds raised by the University of Toronto and the Heart & Stroke Foundation of Ontario. To be awarded to graduate students at the University of Toronto who are pursuing cardiovascular/stroke research. Students must have maintained an overall A- average over the last two years of study at the post-secondary level and exhibit research ability/potential, good communication skills and interpersonal/leadership abilities. The following students were ranked and offered an award: Name Degree Dept. Supervisor Michael Sellan MSc PSL P. Backx Mary, Stergion-Kita PhD REH S. Rappolt

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Forough Mohammadzadeh PhD IMS T. Parker Harinee Surendra MSc LMP G. Wilson Erin Mueller PhD LMP M. Husain Meghan Sauve PhD IMS D. Drucker Tom Lu MSc PSL Z. Feng Nadia Sachewsky PhD IMS C. Marshead Alisha Jamal MSc LMP P. Marsden Agata Bartczak PhD IMS G. Levy Andrew Ramadeen PhD PCL P. Dorian

ADVERTISING MATERIAL The CSCP maintains and updates its web site (www.cscp.utoronto.ca). Faculty information is updated whenever we are notified of relevant changes. Collaborating departments are encouraged to provide hypertext links to the CSCP on their web site.

ACKNOWLEDGEMENTS The Cardiovascular Sciences Collaborative Program would like to thank the following sponsors for their generous support: Medtronic Canada and the Heart & Stroke Foundation of Ontario.

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STUDENTS Name Supervisor Degree Department I. Eser Adiguzel M. Bendeck PhD LMP Jenna Adleman C. Hudson MSc IMS Nesime Askin C. Wittnich PhD PSL Mitesh Badiwala V. Rao PhD IMS Laura Banks J. Goodman MSc EXS Payam Bahman-Bijari D. Steinman PhD BME Carlo Cifelli S. Heximer PhD PSL Geoff de Couto P. Liu MSc PSL Kaveesh Dissanayake S. Heximer MSc PSL Mostafa El Beheiry G. Hare MSc PSL Talha Farid K. Nanthakumar MSc IMS Arash Ghashghai V. Rao MSc IMS June (Hui Jun) Guo A. Giacca MSc PSL Christy Hamilton M. Locke MSc EXS Sonya Hui M. Husain MSc PSL Jemy Joseph V. Rao MSc IMS Jalil Kalantari H. Ni MSc PSL Jeffrey Kroetsch S-S. Bolz PhD PSL Shathiyah Kulandavelu L. Adamson PhD PSL Shawn Lacombe S. Thomas MSc EXS Leanna Lee J. Goodman MSc EXS Paul Lee T. Yau MSc IMS Michael Lekas D. Stewart PhD IMS (inactive status) Sam Liu S. Thomas MSc EXS Jane MacIver V. Rao PhD IMS Matthew Machina J. Fisher MSc PSL Amir Manbachi D. Steinman MSc BME Vaska Micevski D. Stewart PhD IMS (inactive status) Anton Mihic R. Tsushima PhD IMS Mark Moon P. Liu MSc PSL Melissa Noronha A. Gramolini MSc PSL Emma O’Donnell J. Goodman PhD EXS Maral Ouzounian P. Liu PhD IMS Kumar Perampaladas J. Parker MSc PCL Olena Puzyeyeva C. Hudson MSc IMS Andrew Ramadeen P. Dorian PhD PCL Patricia Rose C. Hudson PhD IMS Anna Rosen P. Backx MSc PSL Meghan Sauve D. Drucker MSc IMS Sanjana Sen A. Hinek MSc LMP Junyan Shi A. Hinek MSc IMS Carly Spragg S. Thomas MSc EXS Renee Suen D. Stewart PhD IMS (inactive status) Luke Tan C. Wittnich MSc PSL Megan Thompson S. Mital MSc IMS Sam Tirgari S. Heximer MSc PSL Albert Tsui G. Hare MSc PSL

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Michael Ward D. Stewart PhD IMS Cindy Yip C. Simmons PhD BME Siming (Phil) Xue R-K. Li MSc IMS CONVOCATED STUDENTS/FOLLOW-UP

Gian-Marco Busato, MSc, Department of Exercise Sciences (Supervisor: Dr. J. Goodman): “The Left Ventricular Response to Prolonged Strenuous Exercise at High and Low Intensity in Healthy Middle-Aged Recreational Athletes” (Medicine – Western University) Katharine Currie, MSc, Department of Exercise Sciences (Supervisor: Dr. J. Goodman): “The Effects of Short-Term Endurance Exercise Training on Vascular Function in Young Males” (Perusing PhD Training) Lara Gotha, MSc, Institute of Medical Science (Supervisor: Dr. B. Strauss): “Vascular Smooth Muscle Cell Activity and Response to Arterial Injury in Heparan Sulfate-Deficient Perlecan Mice: Identifying a Role for Perlecan in Smooth Muscle Cell Regulation” (Medical School – University of Toronto) Nazanin Hakimzadeh, MASc, Institute of Biomaterials and Biomedical Engineering (Supervisor: Dr. D. Courtman): “Matrix Supplemented Stem Cell Microencapsulation” (Industry – Medical Research)

Melanie Henriques, MSc, Department of Physiology (Supervisor: Dr. H. Zhang): “Human Neutrophil Peptides: A Novel Agonist of Platelet Activation and Aggregation” (Medical School)

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Galina Kichigina, MSc, Institute of Medical Science (Supervisor: Dr. G. Gross): “Heart-Rate Dependent Modulation of Cardiac Myocyte Ca2+-Handling Protein Expression” (To be determined) Mila Kisilevsky, MSc, Institute of Medical Science (Supervisor: Dr. C. Hudson): “Retinal Arteriolar and Middle Cerebral Artery Responses to Combined Hypercarbic – Hyperoxic Stimuli” (Optometrist) Anton Mihic, MSc, Department of Physiology (Supervisor: Dr. R. Tsushima): “Interaction of hERG Channels and Syntaxin 1A” (Academic Cardiovascular Researcher) Mark Ormiston, PhD, Institute of Biomaterials and Biomedical Engineering (Supervisor: Dr. D. Courtman): “The Role of Innate Immunity in the Pathogenesis and Treatment of Experimental Pulmonary Hypertension” (Researcher, Biotech Industry)

Jessica L. Prodger, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao): “Early Endothelial Progenitor Cells and Cardiac Transplant Vasculopathy” (Global Health Research) Kieran Quinn, MSc, Department of Physiology (Supervisor: Dr. H. Zhang): “Human Neutrophil Peptides Induce Endothelial-Monocyte Interactions and Accelerate Foam Cell Formation” (Medical School)

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Tenille E. Ragoonanan, MSc, Department of Physiology (Supervisor: Dr. G. Hare): “Characterizing the Effect of β1 Adrenergic Blockade on the Physiological Responses to Hemodilution in Rats: Evidence for Organ-Specific Tissue Hypoxia” (Dentistry) Michael Sellan, MSc, Department of Physiology (Supervisor: Dr. P. Backx): “The Electrophysiological Effects of Iron Overload on the Heart” (Medical School – UofT)

Rohit Sheshgiri, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao): “The Role of Human Leukocyte Antigen-G in Heart Transplantation” (Medical School)

Stjepan Soric, MSc, Department of Physiology (Supervisor: Dr. C. Wittnich): “Effects of Sex Hormones on Anaerobic Metabolism and the Development of Acidosis During Ischemia: A Focus on the Liver and the Heart” (Medical School – University of Toronto) Luka Srejic, MSc, Department of Physiology (Supervisor: Dr. Wm. Hutchison): “An In Vivo Neurophysiological Model of Cortical Ischemia in the Rat” (PhD, Department of Cell & Systems Biology)

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Elissa Tepperman, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao): “The Vascular Effects of Immunosuppression: Tacrolimus Preserves Vasomotor Function and Maintains Vascular Homeostasis” (Medicine, University of Ottawa)

Laura Voicu, MSc, Department of Physiology (Supervisors: Drs. D. Mazer & G. Hare): “Hypoxia-Induced Decrease in Renal Medullary Osmolality: Prevention with DDAVP” (Medical School – University of Toronto)

Note: Should discrepancy arise between total number of students enrolled and the number convocated, it can be accounted for students that are incomplete or terminate graduate studies. AWARDS AND HONORS

NAME HONORS AND AWARDS Jenna Adleman - Open Fellowship, Medical Sciences (Ophthalmology), University of

Toronto, 2008-2009 - Vision Science Research Program, Medical Sciences (Ophthalmology), University of Toronto, 2008-2009

Nesime Askin - Gonul Anginer Award, 2008 Mitesh Badiwala - Canadian Cardiac Transplant Network Research Award, 2008, 2009

- Chisholm Memorial Fellowship, Faculty of Medicine, University of Toronto, 2008 - CCS Basic Science Student Presentation Award Finalist, Canadian Cardiovascular Scoeity, 2008 - Doctoral Research Award, CIHR, 2009 - Dr. Wilfred Bigelow Prize, Terrence Donnelly Day, St. Michael’s Hospital, 2009 - National Student Research Poster Competition Gold Award, CIHR, 2009

Laura Banks - Bertha Rosenstadt Internal Ontario Graduate Scholarship, Department of Exercise Science, University of Toronto, 2008-2009 - Ontario Graduate Scholarship, Government of Ontario, 2008-2009

Carlo Cifelli - Annual Cardiovascular Scientific Day Poster Competition, HSRLCE, University of Toronto, 3rd Place, 2009

Geoffrey de Couto - Open Fellowship Award, University of Toronto, 2008 - Stem Cell Network Travel Award, Harvard University, 2009

Kaveesh Dissanayake - New College Council Travel Grant, Yale University, 2008 - Fellowship Award, Department of Physiology, University of Toronto, 2008

Mostafa El Beheiry - Fellowship Award, Department of Physiology, University of Toronto, 2008 June Guo - Ontario Graduate Scholarship, OGS, 2008-2009

- Fellowship Award, Department of Physiology, University of Toronto, 2008-2009

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- Banting and Best Diabetes Centre Graduate Scholarship, University of Toronto, 2008-2009

Sonya Hui - Studentship, HSRLCE, University of Toronto, 2008 Jemy Joseph - Medtronic Travel Award, CSCP, University of Toronto, 2009

- Post-Graduate Scholarship, NSERC, 2008-2010 - Ontario Medal for Young Volunteers, Nomination, 2009

Shathiyah Kulandavelu - Oral Presentation, 1st Place, 8th Annaul Neonatal & Maternal-Fetal Research Day, University of Toronto, 2009 - Society of Gynecological Investigation President’s Presenter Award – Wyeth Award, 2008-2009

Shawn Lacombe - Dr. Terry Kavanagh Fellowship, University of Toronto, 2008 Leanna Lee - Bronze Medalist, World Sprint Triathlon Championships, 2008 Sam Liu - Mavis E. Berridge Scholarship, 2008

- Dr. Terry Kavanagh Fellowship, 2008 Jane MacIver

- Graduate Fellowship, CIHR, Strategic Training Program in Regenerative Medicine, 2007-2009 - Bigelow Book Prize, CSCP, University of Toronto, 2009 - Toronto Star Nightingal Award, 2009

Anton Mihic - Frederick Banting and Charles Best Canada Graduate Scholarships Doctoral Award, CIHR, 2009-2012 - Medtronic Travel Student Award, CSCP, University of Toronto 2009 - Student Research Achievement Awards & Poster Competition Finalist, Biophysical Society 53rd Annual Meeting, Boston, MA, 2009

Mark Moon - Fellowship, Department of Physiology, University of Toronto, 2007-2009 - Vice-Present, CSCP Student Association, 2007-2009

Melissa Noronha - Research Student Poster Competition Award, St. Michael’s Hospital, 2008

Maral Ouzounian - Wilfred G. Bigelow Prize, Terrence Donnelly Day, St. Michael’s Hospital, 2008 - Department of Surgery Research Day, 2nd Prize, Dalhousie University, 2009 - McDiarmid Award, Division of Cardiology, University Health Network, 2009

Andrew Ramadeen - Student Presentation Award, Canadian Cardiovascular Society, 2008 - Travel Grant, American Heart Association, 2008 - Ontario Graduate Scholarship in Science and Technology – Heart and Stroke Foundation, CSCP, University of Toronto, 2008

Anna Rosen - Ontario Graduate Scholarship in Science and Technology Award, University of Toronto, 2008-2009

Meghan Sauvé - Banting and Best Diabetes Centre Annual Trainee Award, University of Toronto, 2008-2009 - Government of Ontario/Heart & Stroke Foundation of Ontario Award, University of Toronto, 2008-2009 - Banting and Best diabetes Centre – Novo Nordisk Studentship, University Of Toronto, 2007-2009 - Samuel Lunenfeld Research Institute Fellowship, Mount Sinai Hospital, 2007-2009

Luke Tan - Lorne Phenix Graduate Award, CSCP, University of Toronto, 2008-2009 - Alexander Graham Bell Canada Graduate Scholarship, NSERC, 2008

Sam Tirgari - Ontario Graduate Scholarship in Science and Technology – Heart and Stroke Foundation, CSCP, University of Toronto, 2008

Albert Tsui - Doctoral Research Award, CIHR, 2008-2011 - Open Fellowship, Department of Physiology, University of Toronto, 2008

Michael Ward - Best Poster Winner, Canadian Society for Clinical Investigations/Clinician Investigator Trainee Assoc. of Canada, Young Investigators Forum, 2008

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- Judah Folkman Award, Cardiovascular Research Technologies 2009, Washington, D.C. - Robert & Francine Ruggles Family Graduate Fellowship, 2009

Cindy Yip - Society for Physical Regulation in Biology and Medicine Travel Award, 2008 - A.D. Sobel – American Society of Investigative Pathology Education Fund Scholar, 2008 - Fellowship, IBBME, University of Toronto, 2008-2009 - Ontario Graduate Scholarship, University of Toronto, 2008-2009 - Young Investigator Award, Canadian Cardiovascular Congress, 2009 - Gordon Research Conference Travel Award, 2009

PUBLICATIONS Badiwala MV, Rao V: Left ventricular device as destination therapy: Are we there yet? Cuu Opin Cardiol, 2009;24:184-189. Chan KK, Breen DM, Dhaliwall JK, Ward MR, Al Koudsi N, Lam L, DeSouza M, Ghanim H, Dandona P, Stewart D, Bendeck MP, Giacca A: Insulin increases re-endothelialization and inhibits cell migration and neointimal growth after arterial injury. Arterioscler Thromb Vasc Biol, 2009 Apr 9. [Epub ahead of print] Chen JH, Yip CYY, Sone ED, Simmons CA: Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Path, 2009;174(3):1109-19. Cherepanova OA, Pidkovka NA, Yoshida T, Gan Qu, Adiguzel E, Bendeck MP, Berliner J, Leitinger N, Owens GK: Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration. Circ Res, 2009;104:00.00. Gu S, Cifelli C, Wang S, Heximer SP: RGS proteins: Identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function. (invited review) Clinical Sci, 2009;116(5):391-99. Hare GM, Tsui AK, McLaren AT, Ragoonanan TE, Yu J, Mazer CD: Anemia and cerebral outcomes: Many questions, fewer answers. Anesth Anagelsia, 2008;107(4):1356-70. Review. Laurent G, Leong-Poi H, Mangat I, Korley V, Pinter A, Hu X, So PP, Ramadeen A, Dorian P: Influence of ventriculo-atrial timing on hemodynamics and symptoms during supra-ventricular tachycardia. J Cardiovasc Electrophysiol, 2008;20:176-181. Laurent G, Leong-Poi H, Tarulli E, Moe G, Hu X, So PP, Ramadeen A, Doumanovskaia L, Konig A, Hennan J, Dorian P: Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circulation: Arrhythmia and Electrophysiology; 2009. DOI: 10.1161/CIRCEP.108.790212. Li GH, Shi Y, Chen Y, Sun M, Sader S, Maekawa Y, et al…de Couto G, et al: Gelsolin regulates cardiac remodeling after myocardial infarction through DNAse I-mediated apoptosis. Circ Res, 2009;104(7):896-904.

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MacIver J, Rao V, Delgado DH, Desai N, Ivanov J, Abbey S, Ross HJ: Choices: A study of preferences for end-of-life treatments in patients with advanced heart failure. J Heart Lung Transplant, 2008;27(9):1002-7. Ouzounian M, Lee DS, Liu PP: Diastolic heart failure: Mechanisms and controversies. Nat Clin Pract Cardivasc Med, 2008;5(7):375-86. Ouzounian M, Tu JV, Austin PC, Chong A, Liu PP, Lee DS: Statin therapy and clinical outcomes in heart failure. J Card Fail, 2009;15(3):241-8. Ouzounian M, Tu JV, Austin PC, Lee DS: Mortality risk assessment and prognostication. IN: Supportive Care in Heart Failure. (Eds: Goodlin S, Beattie J), Oxford University Press, Oxford, United Kingdom, 2008. Ramzy D, Tumiati LC, Tepperman E, Sheshgiri R, Jackman J, Badiwala MV, Rao V: Dual immunosuppression enhances vasomotor injury: Interactive effect between endothelin-1 and nitric oxide bioavailability. J Thorac Cardiovasc Surg, 2008;135:938-44. Sheshgiri R, Rao V, Tumiati LC, Xiao R, Prodger JL, Badiwala ML, Librach C, Delgado DH: Progesterone induces human leukocyte antigen-G expression in vascular endothelial and smooth muscle cells. Circulation, 2008;30;118(14 Suppl):S58-64. Ward MR, Lavoie J, Stewart DJ: B2 or not B2? Kinin receptors and EPC dysfunction, Circ Res, 2008;103:1202-03. Editorial. Ward MR, Stewart DJ: Progenitor cell therapy for myocardial regeneration following acute myocardial infarction: So far so good? Can J Cardiol, 2008;24(Suppl C):5C-10C. Review. Ward MR, Stewart DJ: Erythropoietin and mesenchymal stronal cells in angiogenesis and myocardial regeneration: One plus one equals three? Cardiovasc Res, 2008;79(3):357-9. Editorial. Yip CYY, Chen JH, Zhao R, Simmons CA: Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol, 2009;29(6):936-42. CSCP STUDENT ASSOCIATION CIRCULATION ROUNDS The CSCP Student Association organizes and runs this event which highlights the diverse nature of research carried out by our faculty. These academic rounds rotate through the various research sites at the University of Toronto and each event is hosted by a faculty member where their research focus is the topic of the day. The goal of this event is to provide graduate students, post-doctoral fellows, research associates, undergraduates and project/summer students with the chance to develop an appreciation of the vast range of excellent research being conducted in our widespread community. The first Circulation Rounds for the 2008-2009 academic year was given by Dr. Paul Dorian. Dr. Dorian’s current appointments include being interim Department Director of the Division of Cardiology, as well as Staff Cardiac Electrophysiologist at St. Michael's Hospital. He is also a Professor of Medicine in the Division of Cardiology and in the Division of Clinical Pharmacology at the University of Toronto. Dr. Dorian gave a unique talk entitled “Electricity and the Heart:

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Arrhythmia Research at St. Michael’s Hospital” that highlighted areas of his own research but was also a philosophical discussion of scientific investigation. The second seminar was given by Dr. Lori West, a visiting professor from the University of Alberta, who kindly volunteered to give a talk entitled “A Change of Heart: Clinical and Basic Research in Infant Heart Transplantation”. Dr. West is Professor of Paediatrics, Surgery and Immunology and the Director of Heart Transplantation Research at the University of Alberta, a Senior Scholar for the Alberta Foundation for Medical Research (AHFMR) and a Tier 1 Canada Research Chair in Cardiac Transplantation. She is also an Adjunct Scientist at The Hospital for Sick Children Research Institute in Toronto. Dr. West is a world leader in paediatric cardiac transplantation and transplant immunobiology, including crucial translation of basic concepts and findings from murine models to clinical application in paediatric heart transplantation. The third seminar was given by Dr. Douglas Bradley where he talked about “Pathological Interactions between Sleep Apnea and Heart Failure: Role of Fluid Dynamics”. Dr. Bradley is Professor of Medicine and Director of the Centre for Sleep Medicine and Circadian Biology at the University of Toronto, the Cardiopulmonary Sleep Disorders and Research Centre at the Toronto General Hospital/University Health Network, and the Sleep Research Laboratory at the Toronto Rehabilitation Institute. Dr. Bradley’s clinical and research work focuses on the relationship between sleep apnea and cardiovascular diseases, with a particular focus on the pathophysiology and treatment of sleep apnea in patients with heart failure. In a landmark study published in the N Eng J Med, Dr. Bradley and colleagues found that heart function can be significantly improved in patients with congestive heart failure and obstructive sleep apnea by treating the sleep disorder with CPAP. The final seminar for the 2008-09 academic year was given by Dr. Anthony Gramolini. Dr. Gramolini is currently a scientist with the McLaughlin Centre for Molecular Therapeutics and an Assistant Professor recruited by the Department of Physiology and the Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research. Dr. Gramolini has brought expertise from a number of different fields of biology, including electrophysiology, molecular biology and protein biochemistry and his topic for the evening was “Investigating Cardiovascular Health and Disease Through Proteomic Approaches”. The CSCPSA does a great job organizing these events and all seminars are well attended. For more detailed information regarding the above presentations, please go to the CSCP web site at www.cscp.utoronto.ca and click on Events.

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FACULTY Faculty are divided into 3 categories (Full, Associate, Affiliate). Details on faculty research interests, and contact information are available on the CSCP web site. Departmental affiliations listed below are those within the CSCP. For annual information on faculty peer-reviewed funding and publications, please refer to their home department’s annual reports. Name Departmental Affiliation(s) Location Full Lee Adamson BME/IMS/PSL Mount Sinai Hospital Khosrow Adeli LMP Hospital for Sick Children Peter Backx Medicine/PSL UofT – FitzGerald Bldg. Jaques Belik IMS/PSL Hospital for Sick Children Michelle Bendeck LMP/Medicine UofT – MSB Sandra Black IMS Sunnybrook Health Centre Douglas Bradley IMS/Medicine Toronto General Hospital Dina Brooks REH UofT – Rehabilitation

Science Sean Clarke NUR UofT – Faculty of Nursing John Coles IMS/Surgery Hospital for Sick Children Philip Connelly LMP/Medicine St. Michael’s Hospital David Courtman BME/Surgery St. Michael’s Hospital Paul Dorian IMS/Medicine/PCL St. Michael’s Hospital Daniel Drucker IMS/LMP Mount Sinai Hospital C. Ross Ethier BME UofT – Mechanical

Engineering John Flanagan IMS Toronto Western Hospital John S. Floras IMS/Medicine Mount Sinai Hospital Stephen Fremes IMS/Surgery Sunnybrook Health Centre Adria Giacca PSL UofT - MSB Jack M. Goodman EXS UofT - Physical Ed & Health Len S. Goodman EXS Def & Civil Inst Environ Med Avrum I. Gotlieb LMP Toronto General Hospital David Hampson Pharmaceutical Science UofT – Pharmacy Aleksander Hinek IMS/LMP Hospital for Sick Children Margaret Hough IMS Sunnybrook Health Centre Chris Hudson IMS Toronto Western Hospital Mansoor Husain IMS/LMP/Medicine Toronto General Hospital K. Wayne Johnston BME/IMS/Surgery Toronto General Hospital Peter G. Kalman IMS/Surgery Community Fred Keeley LMP Hospital for Sick Children Michelle Letarte MBP Hospital for Sick Children Gary F. Lewis IMS/Medicine Toronto General Hospital Ren-Ke Li IMS/LMP/Surgery Toronto General Hospital Peter Liu IMS/Medicine Toronto General Hospital Marius Locke EXS/CHL UofT – Physical Ed & Health Philip Marsden IMS/LMP/MBP/Medicine UofT – MSB Peter McLaughlin IMS/Medicine Toronto General Hospital Alan Moody BME/IMS Sunnybrook Health Centre David Naylor IMS/Medicine/CHL/Surgery UofT – MSB Heyu Ni LMP St. Michael’s Hospital

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Peter O’Brien PHM UofT - Pharmacy John Parker IMS/Medicine Mount Sinai Hospital Tom Parker IMS/Medicine Toronto General Hospital Margaret Rand IMS/LMP Hospital for Sick Children Vivek Rao IMS/Surgery Toronto General Hospital Michael Sefton BME UofT – Wallberg Bldg. Craig Simmons BME UofT – Mechanical

Engineering Arthur S. Slutsky IMS/Medicine/Surgery Mount Sinai Hospital David Steinman BME UofT – Wallberg Bldg. Donna E. Stewart Anesthesia/IMS/Surgery/Medicine Toronto General Hospital Duncan Stewart IMS/LMP/Medicine St. Michael’s Hospital Bradley Strauss LMP/Medicine St. Michael’s Hospital Howard Tenenbaum Dentistry UofT - Dentistry Scott G. Thomas EXS/PSL UofT – Physical Ed & Health Jack Tu HPME Sunnybrook Health Centre Robert Wald IMS/Medicine Mount Sinai Hospital Richard D. Weisel IMS/Surgery Toronto General Hospital Peter Wells PHM UofT - Pharmacy Gregory Wilson IMS/LMP/PSL/Surgery Toronto General Hospital Carin Wittnich IMS/PSL/Surgery UofT - MSB Graham Wright MBP Sunnybrook Health Centre Shirley Wu PHM UofT - Pharmacy Burton Yang LMP Sunnybrook Health Centre Terry Yau IMS/Surgery Toronto General Hospital Erik L. Yeo IMS/Medicine Toronto General Hospital Yeni Yücel LMP St. Michael’s Hospital Haibo Zhang IMS/PSL St. Michael’s Hospital Associate Joel Fisher Anesthesia Toronto General Hospital Gil Gross IMS Hospital for Sick Children Gregory Hare PSL St. Michael’s Hospital Scott Heximer PSL UofT - MSB William Hutchison PSL Toronto Western Hospital Jane Irvine CHL Toronto General Hospital Howard Leong-Poi IMS St. Michael’s Hospital Valery Leytin LMP St. Michael’s Hospital Tom Lindsay IMS/Surgery Toronto General Hospital David Mazer Anesthesia/IMS St. Michael’s Hospital Seema Mital IMS Hospital for Sick Children Kumar Nanthakumar IMS Toronto General Hospital Steffen-Sebastian Bolz PSL UofT – MSB Anthony Gramolini PSL UofT – Best Institute Affiliate Jagdish Butany LMP/Medicine Toronto General Hospital Gideon Cohen Surgery Sunnybrook Health Centre Patricia Murphy Anesthesia Toronto General Hospital Faculty publications for the 2008-2009 academic year can be found through their departmental websites.