angioedema: pathophysiology and presentation clinical...angioedema: pathophysiology and presentation...
TRANSCRIPT
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Angioedema: Pathophysiology
and Presentation
Timothy J. Craig, DO
Distinguished Educator
Chief, Allergy, Asthma, and Immunology
Program Director
Director of Clinical Allergy and Respiratory Research
Pennsylvania State University College of Medicine
Hershey, Pennsylvania
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Conflicts of Interest
Company Speaker Research Consultant
Dyax XX XX XX
CSL Behring
XX XX XX
Viropharma XX XX
Pharming XX
Shire XX
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Objectives
1. Know the mechanisms behind HAE
2. Understand how HAE presents
3. Improve outcomes of patients with
HAE by early diagnosis and treatment
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Case of a 26 yo female with recurrent
swelling
• Bell is a 26 yo female
• She presents to the ED with severe swelling of the
face.
• She states she thinks she is having difficulty
swallowing and breathing.
• Her symptoms started late last night and have have
progressed over the past few hours
• What other questions about her present illness do
you want to ask Bell?
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• Bell has similar symptoms about every other week.
• She has never had hives.
• She also frequently has abdominal pain, but no one has been able to find out why.
• Her swelling and abdominal pain usually last about 3 days.
• She denies having lightheadedness.
• What questions about her PMH, family and social history do you want to ask?
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• Medications- thyroid replacement, codeine for pain,
antihistamines for swelling and frequent use of
prednisone for angioedema
• PMH- positive for thyroid deficiency
• PSH- chole, appy, and a exploratory abd surgery
• FH- DM-II, HTN, CVA, CAD
• No drug allergies, bee allergies or food allergies
• What would you expect on physical exam?
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What is your working diagnosis?
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Differential Diagnosis• Anaphylaxis
• Idiopathic angioedema
• Acquired angioedema
• Hereditary Angioedema type 1 of 2
• Hereditary Angioedema type 3
• Drug allergy
• Food allergy
• Narcotic induced angioedema
• What laboratory tests would you get now?
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Laboratory tests:
• CBC- WBC was 18,000
• UA and CMP were normal
• Lateral neck X-ray was positive for upper
airway swelling
• C4- 6 (normal 14)
• Tryptase was normal
• 2 weeks earlier a CT of the abd- see next page.
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During Abd. pain
What is the diagnosis?
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Diagnosis is Hereditary Angioedema (HAE)
What is the treatment?
• 1
• 2
• 3
• 4
• 5
• 6
• 7
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Diagnosis is HAE
What is the treatment?
• 1- C-1-esterase inhibitor if available
• 2- ecallantide
• 3- FFP- but be careful
• 4- intubation precautions
• 5- volume support
• 6- pain control
• 7- confirm with repeat C-1 quant, C-4, C-1-esterase inhibitor level and functional assay.
• 8- on discharge start prophylaxis with androgens or C-1-esterase inhibitor OR arrange acute therapy with C1-INH, icatibant or ecallantide
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The edema associated with HAE is due to?
• 1. histamine
• 2. bradykinin
• 3. Factor 12
• 4. Plasmin
• 5. Complement
• Answer- 2
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Differential of Angioedema
Kinin-
mediated
Mast-cell mediated
H1/H2 antagonists
Corticosteroids
Epinephrine
Confirmation
of cause
• Hereditary w/
Normal C1-INH
• Acquired
• ACE
Hereditary: C1-INH
deficiency
Airway, analgesia, FFP,
C1-INH, ecallantide, icatibant
Determine etiology
IdiopathicAllergic
Urticaria Present Urticaria Absent
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C1INH gene +/+ +/+ -/- -/- -/-
B2BKR gene +/+ +/+ +/+ +/+ -/-
Evans blue No Yes Yes Yes Yes
C1INH therapy No No No Yes No
C1INH Null Mice and Vascular Permeability
Adapted from Han ED, et al. J Clin Invest. 2002;109:1057-1063.
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In Vivo Generation of Kinins in HAE
From Nussberger J, et al. J Allergy Clin Immunol. 1999;104:1321-1322; with permission.
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Actin stress fibersVE-cadherin
Nonstimulated
Stimulated
Increased vascular permeability
From Tiruppathi C, et al. Vascul Pharmacol. 2003;39:173-185; with permission.
How Does BK Cause Angioedema?
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What are the genetics?
Crowder JR, Crowder TR. Five generations of angioneurotic edema. Arch Inter Med 1917; 20:840-52
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Autosomal Dominant Defect
Crowder JR, Crowder TR. Five generations of angioneurotic edema. Arch Inter Med 1917; 20:840-52
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What Is C1-Inhibitor?
Human plasma protein …that mediates inflammation
Key regulator of threebiochemical pathways
1. Complement 2. Contact 3. Fibrinolytic4. Coagulation
C1-Inhibitor deficiencycan cause:
– debilitating pain
– disfiguring swelling
– asphyxiation & death
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ActiveCleaved: Inactive
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Bissler JJ, et al. Proc Assoc Am Physicians. 1997;109:164-173.
Davis AE 3rd. Annu Rev Immunol. 1988;6:595-628.
Verpy E, et al. Am J Hum Genet. 1996;59:308-319.
Zuraw BL, Herschbach J. J Allergy Clin Immunol. 2000;105:541-546.
HAE Is Caused By C1 Inhibitor Mutations
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C1-INH involved in 3 systems → C1-INH depletion
Kallikrein
HMW-K
Factor XII
Prekallikrein
Contact SystemContact System
C4C2
C1
Complement Complement SystemSystem
Increased vascular permeability →→→→ANGIOEDEMA
C1-
INH
C1-
INH
C1-INHC1-INHC
1-IN
HC
1-IN
H
C1-
INH
C1-
INH
Bradykinin
FibrinolyticFibrinolyticSystemSystem
Factor XIIa
Plasmin
Plasminogen
C1rs
C1-INH
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What is an attack like?
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Common triggers of HAE attacks
Trauma Menstruation
Infection
Stress
Medications
AngioedemaAngioedema attack
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Erythema Marginatum
Rash on arm of patient during HAE attack.
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Prodromal Symptoms That Patients Reported
Before Their Last HAE Attack
Prematta M, et al. Allergy and Asthma Proceedings. 2009
Percentage of Patients
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The Percentage of Time That Patients Report Being Able to Predict an
Acute HAE Attack Based on Prodromal Symptoms
Prematta M, et al. Allergy and Asthma Proceedings. 2009
8.6%
26.1%
8.7%
50%
6.5%
Unable to predict
25% of attacks
50% of attacks
75% of attacks
100% of attacks
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The Time Between the Onset of Patients’ Prodromal
Symptoms and Their Last HAE Attack
Prematta M, et al. Allergy and Asthma Proceedings. 2009; in press.
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Query Percent of patients
Had Prodromal Symptoms prior to the last attack 85%
Have prodromal symptoms before 75% or greater of acute attacks
50%
Have prodromal symptoms before 25% or greater of acute attack
86%
Prematta et al. Allergy and Asthma Proceedings. 2009
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Case of a 26 yo female with recurrent
swelling
• Bell is a 26 yo female
• She presents to the ED with severe swelling of the
face.
• She states she thinks she is having difficulty
swallowing and breathing.
• Her symptoms started late last night and have have
progressed over the past few hours
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• Bell has similar symptoms about every other week.
• She has never had hives.
• She also frequently has abdominal pain, but no one has been able to find out why.
• Her swelling and abdominal pain usually lasts about 3 days.
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• Medications- codeine for pain, refractory to
antihistamines and prednisone
• PSH- chole, appy, and a exploratory abd surgery
• FH- negative for HAE
• No drug allergies, bee allergies or food allergies
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Laboratory tests:
• CBC- WBC was 18,000
• UA and CMP were normal
• Lateral neck X-ray was positive for upper
airway swelling
• C4- 6 (normal 14)
• Tryptase was normal
• 2 weeks earlier a CT of the abd- see next page.
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During Abd. pain
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Differential Diagnosis
• Anaphylaxis
• Idiopathic angioedema
• Acquired angioedema
• Hereditary Angioedema type 1 of 2
• Hereditary Angioedema type 3
• Drug allergy
• Food allergy
• Narcotic induced angioedema
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HAE
What is the treatment?
• 1- C-1-esterase inhibitor
• 2- ecallantide
• 3. icatibant
• 3- FFP- but be careful
• 4- intubation precautions
• 5- volume support
• 6- pain control
• 7- re-confirm with repeat C-1 quant, C-4, C-1-esterase inhibitor level and functional assay.
• 8- on discharge start prophylaxis with androgens or C-1-esterase inhibitor OR arrange acute therapy with C1-INH, icatibant or ecallantide
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In Summary
• Angioedema without hives think of HAE
• C4 is the best screening test for HAE
• To distinguish HAE from AAE use a C1
• Treat allergic and most idiopathic angioedema
with adrenaline, antihistamines and steroids
• For HAE unique therapy is indicated and Dr
Konrad Bork will be discussing treatment
options.
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HAE Awareness & Management
e-survey
Please stop by the “LAITAI” booth to complete the survey
and receive a free CD on HAE CME activities
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