1. Pathophysiology of Diarrhea

2. Case Presentation

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 1

3. “Diarrhea is the too rapid evacuation of too fluid sto...

4. The Amazing Intestines

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 2

5. Diarrhea and Malabsorption: Slide 5

6. Diarrhea

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 3

7. Is it Diarrhea?

8. Pathophysiology of Diarrhea

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 4

9. Case Presentation

10. Osmotic Diarrhea

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 5

11. Diarrhea and Malabsorption: Slide 11

12. Lactose Intolerance

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 6

13. Fecal Osmotic Gap

14. Case Presentation

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 7

15. Pathophysiology of Diarrhea

16. Case Presentation

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 8

17. Malabsorption

18. Diarrhea and Malabsorption: Slide 18

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 9

19. Fat Malabsorption

20. Bile Salt Inactivation

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 10

21. Conditions Predisposing to Bacterial Overgrowth

22. Diarrhea and Malabsorption: Slide 22

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 11

23. Pathophysiology of Malabsorption in Bacterial Overgrowth

24. Diagnosis of Small Intestinal Bacterial Overgrowth Syndrome...

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 12

25. Treatment of Small Intestinal Bacterial Overgrowth Syndrome...

26. Increased Bile Salt Losses

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 13

27. Case Presentation

28. Defective Nutrient Hydrolysis

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 14

29. Tests for Pancreatic Insufficiency

30. Diarrhea and Malabsorption: Slide 30

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 15

31. Malabsorption: Mucosal Loss

32. Malabsorption: Mucosal Disease

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 16

33. Mucosal Disease: Crohn’s Disease

34. Celiac Sprue

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 17

35. Celiac Sprue: Pathogenesis

36. Celiac Sprue: Pathogenesis

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 18

37. Pathogenesis of Celiac Disease

38. Celiac Sprue: Pathology

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 19

39. Celiac Sprue: Clinical Presentation

40. Celiac Sprue: Associated Diseases

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 20

41. Celiac Sprue: Diagnosis

42. Celiac Disease: Treatment

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 21

43. Drugs Causing Malabsorption

44. D-Xylose Test: General Test for Malabsorption

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 22

45. Pathophysiology of Diarrhea

46. Case Presentation

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 23

47. Secretory Diarrhea

48. Fecal Osmotic Gap

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 24

49. Secretory Diarrhea

50. Abnormal Mediators

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 25

51. Abnormal Mediators

52. Diarrhea and Malabsorption: Slide 52

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 26

53. Case Presentation

54. Pathophysiology of Diarrhea

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 27

55. Altered Intestinal Motility

56. Irritable Bowel Syndrome

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 28

57. IBS: Symptoms

58. IBS: Epidemiology

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 29

59. Extent and Impact of IBS

60. IBS: Pathophysiology

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 30

61. Diarrhea and Malabsorption: Slide 61

62. Diarrhea and Malabsorption: Slide 62

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 31

63. Role of the Enteric Nervous System

64. Evolution of Hypotheses in IBS

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 32

65. Selected Mediators of Motility and Visceral Hypersensitivity...

66. Serotonin and Enterochromaffin (EC) Cells in Altered GI Moti...

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 33

67. Rome Criteria

68. IBS Diagnosis

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 34

69. Therapeutic Options for Patients with IBS

70. Case Presentation

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 35

71. Case Presentation

72. Explanations for Diarrhea

Tufts OpenCourseWare © 2007 Tufts University

Diarrhea and Malabsorption

OCW: Gastrointestinal Pathophysiology (L. Bailen) Page - 36