An unsuspected, underdiagnosed

Endocrine

Immune mechanism causing disease in animals and humans.

PART I

I have studied and treated as many as 50,000

endocrine-immune cases in dogs, cats and horses.

What I have found is underdiagnosed or perhaps

unrecognized, or an unsuspected mechanism that

creates disease.

These cases vary from simple allergies to autoimmunity

and cancer.

It appears that a similar syndrome is found in humans called CVID (Common Variable

Immunodeficiency).

CVID appears to vary from allergies to autoimmunity

and cancer.

EI patients that I have treated all have

(a). Deficient or bound cortisol(b). Elevated total estrogen(c). Deficient or bound T3T4(d). Immunodeficient or

immunoderegulation of B & T cells

Is there a first domino that falls allowing for EI Syndrome or possible CVID Syndrome?

In animals, the 1st domino to fall is Cortisol.

What causes this Zona Fasciculata failure?

(a). Genetic damage(b). Acquired damage

This EI Syndrome can be diagnosed with blood tests in

puppies, kittens & foals as early as 4 to 6 weeks of age!

The parents of the offspring can be tested and identified as the

culprits before Breeding, enabling the prevention of

EI Syndrome in the offspring.

Acquired damage to the Zona Fasciculata may occur due

to toxicological sensitivity of this layer.

(+/- environmental toxins, vaccines, anesthesia, ingested

pharmaceuticals).

In animals, it is rare to see complete adrenal cortex

damage! Usually it is the cortisol level that is affected either

temporarily or permanently.

Quote Harvey on the toxicological sensitivity of the adrenals and particularly

the cortex as an unappreciated factor. According to British toxicology expert

Philip Harvey, in The Adrenals in Toxicity: Target Organ and Modulator of Toxicity, the adrenal gland is the most vulnerable organ in the endocrine system for toxins,

and within the adrenal gland “the majority of effects” have been observed

in the cortex. Such disturbances can “fundamentally affect the whole body

physiology and biochemistry”.

In personal communication, Harvey has told me that surveys of toxicity within the endocrine system indeed reveal that the

adrenal cortex is a very common target and factors predisposing this are at its large blood supply per unit mass, Lipophilicity and

it is also rich in cytochrome P450 enzymes.

Hans Selye’s work on stress, recognized in General Adaptation

Syndrome that chronic stress would cause adrenal exhaustion

and lead to an EI Syndrome. I also published these findings in animals in 1978. In this published

paper, I theorized that in the production from dopa to

norepinephrine, cortisol appeared to be used as a catalyst.

Selye prescribed cortisol to help people, which was successful for a while, but then moved into an

over adaptation phase which often recreated the original syndrome with the chronic

stress it caused.

In Dogs with chronic stress, thyroid supplementation with

cortisol for the EI Syndrome will be necessary for improvement.

Without thyroid supplementation, the syndrome would improve temporarily but

eventually return, due to cortisol replacement going from a

physiological dose level into a pharmacological dose level, leading to over adaptation.

What is occurring with a defective zona fasciculata?

What then does excess estrogen do?

(a). Acts like histamine – Therefore causing

inflammation(b).Binds T3T4(c). Binds cortisol (bound cortisol

disallows transferance from T4 – T3

(d).Deregulates B + T Cells

REMEMBER, THE ENDOCRINE SYSTEM REGULATES THE

IMMUNE SYSTEM IN ANIMALS. USUALLY THESE SYSTEMS DO

NOT ACT INDEPENDENTLY.

If you find similarities between an EI Syndrome on CVID

common variable syndrome, then your measuring stick is

identifying factual B cell antibody levels and correcting

them and the disease with proper hormone therapy.

Remember, each patient will and should be different.

I had to create my own clinical norms for IgG, IgM & IgA.

You will need to do this also.

The IgA level will determine if malabsorption is present and

whether oral hormone replacement will effectively

normalize the immune system.

T cell regulation usually accompanies B cell regulation.

Some of you here are familiar with the concept of low-dosage,

long term cortisone.Others may be appalled by any thought of long-term cortisone.

Among us here is William Jefferies, M.D., who has pioneered for decades the practice of

long-term, low-dosage cortisone replacement that is both safe and hugely effective for allergies, chronic fatigue, and rheumatoid

conditions. Other physicians have started to realize as well that cortisone, at low dosage, can be a major long term therapy modality.

At pharmacologic dosages, it is indeed immunosuppressive. However, at physiologic

low-dosage level, in the presence of a cortisol deficiency, which I believe is

extremely common among people because of a combination of genetic, toxicity, and

prolonged stress, this great healing medicine.

Dr’s Barnes and Hertoghe Identified the importance of thyroid therapy in humans.

With my EI syndrome in animals, in particular dogs, I have found

that proper thyroid supplementation will guarantee

keeping cortisol supplementation at a

physiological regulatory level and correct this EI Syndrome.

The next hour will discuss clinical testing and

supplementation of the EI Syndrome.

An unsuspected, underdiagnosed

Endocrine

Immune mechanism causing disease in animals and humans.

PART II

Phase 1 protocol – Blood

MALE:Blood CortisolTSHT3T4Total EstrogenTestosterone (total & free)IgA, IgM, IgG

FEMALE:Blood CortisolTSHT3T4Total EstrogenProgesteroneTestosterone (total & free)FerritinIgA, IgM, IgG

Phase 1 protocol – Urine

MALE:24 hour urine

collection1. Active Cortisol2. Free T33. Free T4

FEMALE:24 hour urine

collection1. Active Cortisol2. Free T33. Free T4

Phase 1 protocol – Basal Metabolic Temperature

MALE:Upon waking, place

thermometer in axilla for 10 minutes before getting up.

Normal temperature should be 97.8 – 98.2 degrees.

FEMALE:Upon waking, place

thermometer in axilla for 10 minutes before getting up.

Normal temperature should be 97.8 – 98.2 degrees.

Only accurate in a menstruating woman from 2nd to 4th day.

In my experience with dogs,I have found that a physiological

dose level of cortisol may become a pharmacological dose

level if used without thyroid supplementation.

If this fact is true, then what happens to any hormone

supplementation? In canines and humans, that must be a concern about a pharmacological build

up of a particular hormone causing various hormone cycles

resulting in damage to our patients.

If with CVID – common variable immunodeficiency syndrome,

how do you determine a normal immune measuring stick with

the different laboratory normals that are now available?

I analyzed reference ranges from 15 major human medical labs.

Many laboratories used the same lab kits for the immunoglobulin, yet there are wide discrepancies in what these laboratories regard

as normal.

These are the variable ranges for normal ranges according to

each to each laboratory:

IgG results from various human laboratories

IgM results from various human laboratories

IgA results from various

human laboratories

Based upon these results, you definitely need an international standardized reference range on an international basis that

you create!

By removing the high & low and possibly removing 10% of the lower and higher levels, your

immune measuring stick may be closer to being accurate.

IgG 700 - 1500mg/dl

IgM 50 - 200mg/dl

IgA 70 - 350mg/dl

Obviously, as you normalize your patients, these values will

be modified based on your clinical results.

This is merely an attempt to show you that depending on the

variability of the lab test results your patient may be normal or highly abnormal, which would

lead to improper therapy based upon inaccurate laboratory

results.

My EI Syndrome and possibly your CVID Syndrome relates from simple allergies to all

autoimmune disorders and all cancers in animals.

Finally, remember, in all animals with cancer, there is deficient or

bound cortisol, elevated total estrogen, deficient transfer defect or bound T3T4 and deregulated B & T cells.

Fortunately, you and I practice for our patient first, and our

profession second.