uncovering the basis of a severe degree of acidemia in a patient with diabetic ketoacidosis by m....

Post on 31-Dec-2015

212 Views

Category:

Documents

0 Downloads

Preview:

Click to see full reader

TRANSCRIPT

Uncovering the basis of a severe degree of acidemia in a patient with diabetic ketoacidosis

by M. Gowrishankar, A.P.C.P. Carlotti, C. St George-Hyslop, D. Bohn, K.S. Kamel, M.R. Davids, and M.L. Halperin

QJMVolume 100(11):721-735

October 30, 2007

© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Overview of the biochemistry and physiology of ketoacidosis.

M. Gowrishankar et al. QJM 2007;100:721-735

© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Uncoupling of oxidative phosphorylation and hepatic ketogenesis.

M. Gowrishankar et al. QJM 2007;100:721-735

© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Balance for H+ and β-HB− when ketoacids are accumulating.

M. Gowrishankar et al. QJM 2007;100:721-735

© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Indirect loss of NaHCO3.

M. Gowrishankar et al. QJM 2007;100:721-735

© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Buffering of H+ in the brain in a patient with a contracted ‘effective’ arterial blood volume.

M. Gowrishankar et al. QJM 2007;100:721-735

© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Time course for the rise in the PHCO3 in this patient.

M. Gowrishankar et al. QJM 2007;100:721-735

© The Author 2007. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

top related