trifunctional aminoamide cellulose derivative and its characterization

Trifunctional Aminoamide Cellulose Derivative and its

Characterization

Outline• Objectives• Problem statement and motivation of

the study• Presuppositions from Literature• Methodology

Objectives• To illustrate how to use a couple of

techniques to confirm the structural of a newly synthesized material and its intermediate.

• To illustrate how to use a couple of techniques to characterize a final product and so provide some information for applications.

Problem statement and motivation of the study

• What are dendrimers?• “A dendrimer is a

molecule with a form like the branches of a tree.”[1]

• Dendrimers can be used in pharmaceutics, genetics, catalyst chemistry and superconductor currently or potentially. [2][1] Wikipedia[2] Sand, Anders. Dendrimers and Their Technical Applicability

Cellulose-based dendrimers

Zhang, Changde et al. Biomacromolecules (2006), 7(1), 139-145.

Presuppositions from Literature• Narrow molecular weight

distribution• The most exciting physical

property of dendrimers is the variation of their intrinsic viscosities with molecular weight. [6] It is found that, when the generation increases beyond a certain point, the intrinsic viscosity begins to decline, contrary to the behavior of linear polymers (Fig.4).

[6] http://www.dendritech.com/pamam.html

Methodology • Using 1H to confirm the structural of intermediate

product:• Using FT-IR to confirm and characterize the

structural of CMCBA and CMCBADMPDA:• Using NMR to confirm and characterize the

structural of CMCBA and CMCBADMPDA: • Using TGA to Characterize the Degree of

Substitution of CMCBA and CMCBADMPDA: • Using Intrinsic Viscosity to characterize the

conformation of CMCBADMPDA:• Using GPC-LS to characterize the MW and MWD of

CMCBADMPDA:

Using 1H to confirm the structural of intermediate product:

Using FT-IR to confirm and characterize the structural

Using NMR to confirm and characterize the structural of CMCBA

and CMCBADMPDA:

Using TGA to Characterize the Degree of Substitution

Using Intrinsic Viscosity to characterize the conformation

• CMC 5.62 dL/g, • CMCDMPDA 3.57 dL/g • CMCBADMPDA 0.39 dL/g

Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:

Conclusions• The author got the “right ” product.• The product is of very low viscosity,

which is suitable for drug delivery.