translating exposure science for decision-makers and the ......an opportunity for collaboration epa...

1 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

Translating Exposure Science for Decision-makers and the Informed Public:

An Opportunity for Collaboration

EPAExposureScienceCommunityofPrac6ceConferenceCallJanuary12,2010

EliseMiller,M.Ed.Director

Collabora6veonHealthandtheEnvironment1646DowRoad,Freeland,WA98249Ph:360‐331‐7904;Fax:360‐331‐7908

Email:elise@healthandenvironment.orgWebsite:www.healthandenvironnment.org

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Interacting factors that influence health and development

Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

  Heredity  Gene‐environmentinterac6ons  Exposurestotoxicchemicals  Pharmaceu6cals  Infec6ousdisease  Socioeconomicstatus  Nutri6on  Stress

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Environmental exposures

Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

  Timingofexposure  Bioaccumula6onandpersistance  Mechanismsofdisrup6on  Variablesensi6vity  Evidenceofexposures(bodyburden)  Mixtures

4 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

Child Health Exposures   Prenatal

  transplacental  developmentalwindows

  Postnatal  poundperpoundchildreneat,drinkandbreathfarmorethanadults

  prolongedgastricemptying

  increasedmetabolicrate  increased6meindoors&onfloors(hand‐to‐mouthac-ons)

  breastmilk(s-llbesttobreas4eed,butbreastmilknowcontainsmanycontaminants)

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Environmental agents

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LeadMercuryPCBsPBDEsBPAPhthalates

ArsenicSolventsPAHsPes6cidesManganeseDioxins

Environmentalagentsthatareknownorsuspected

tointerferewithhealthydevelopment:

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Lead

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  Whatwasconsidereda“safe”thresholdforexposuretoleadcon6nuestodrop

  Thereisnosafelevelofleadexposureforchildren

60

40

3025

2015

10

20

10

20

30

40

50

60

Bloo

d Le

ad (u

g/dl

)

CDC1960

CDC1973

CDC1975

CDC1985

WHO1986

EPA1986

CDC1990

CDCWhen?

Agency and Year

Acceptable Childhood Blood Lead Levels  Globalmarkets

  Environmentaljus6ce

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Endocrine disrupting chemicals

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DosedoesNOTmakethepoison–LaboratoryexperimentsshowthatexposuretoEDCscanhaveimpactsatlevelsfarlowerthanhadbeenconsideredpossibleintradi6onaltoxicology.

8 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

Endocrine Society’s Statement

ReleasedJune2009

“…Theevidenceforadversereproduc-veoutcomes(infer-lity,cancers,malforma-ons)fromexposuretoendocrinedisrup-ngchemicalsisstrong,andthereismoun-ngevidenceforeffectsonotherendocrinesystems,includingthyroid,neuroendocrine,obesityandmetabolism,andinsulinandglucosehomeostasis….”

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Collaborative on Health and the Environment (CHE)

 Diseasedatabase Consensusstatements,whitepapersandfactsheets

 10Workinggroups

 Na6onalcallswithexpertsonspecifictopics Conferencesandworkshops

Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

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CHE Fertility and Reproductive Health Working Group

  VallombrosaConsensusstatement

  “ShapingourLegacy”summit  “Girl,Disrupted”report  “Naviga6ngtheScience”

conference

  Resourcedatabase  Workinggroupcalls  New:Sciencetrainingsfor

advocates

Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

11 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

CHE Learning and Developmental Disabilities Initiative (LDDI)

  Educa6ngstateandna6onallearninganddevelopmentaldisabili6es(LDD)groups.

  Transla6ngemergingscienceintoinforma6onandfactsheetstobeusedatworkshopsandonwebsitesforlayaudiences.

  Holdingmee6ngsna6onallyandregionallytobuildcollabora6vepartnershipsbetweenLDDgroups,researchers,healthprofessionalsandenvironmentalhealthadvocates.

  Cul6va6ngopportuni6esforinterestedgroupstoeducatepolicymakersonspecificbillsthatwouldeliminateneurotoxicants.

12 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

LDDI: Specific Steps Forward

  LDA,AAIDD,ASA,NADDini6a6ves  “Prac6cePreven6on”columns  LDDIScien6ficConsensusStatement  LDDIPolicyStatement

  Bi‐weeklye‐bulle6ns Na6onalcalls New:LDDIBiomonitoringProject

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LDDI Biomonitoring Project

  Firstbiomonitoringstudyonahealth‐affectedgroup

  11par6cipants  Testedover60substancesinbloodandurine

 Mediarelease  Congressionalbriefing

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CHE Cancer Working Group

 Scien6ficconsensusstatement Presenta6onsforPresident’sCancerPanel Factsheets

•  IndustrialManufacturing•  AgriculturalExposures

•  Indoor/OutdoorAirPollu6onandWaterContamina6on

•  NuclearFallout,Electromagne6cFields,andRadia6onExposure

Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

15 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

Science-based Policy

 Somecurrentrelevantpoliciesunderconsidera6on:

‐TSCAreform

‐EndocrineDisrup6ngChemicalsAct

‐SafeCosme6cs(phthalates)

‐BPA

‐PBDEs

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Some stakeholder concerns   Con6nuetoimproveCDCNHANES‐manychemicalsnotyettested,e.g.,thosewithshorterhalf‐lives

 Addressexposurestomixturesandimpactonvulnerablepopula6ons

  Includenonlinearandlowdose‐responseassessments

 Makeconsciousdesignformula6ondecisionsearlyinriskassessmentprocess

  Ensureexposureinforma6onisuser‐friendly

Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

17 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative

For more information

 JoinCHE‐www.healthandenvironment.org

 Contactme: EliseMiller,MEd,Director Collabora6veonHealth andtheEnvironment(CHE) Ph:360‐331‐7904 elise@healthandenvironment.org