translating exposure science for decision-makers and the ......an opportunity for collaboration epa...
TRANSCRIPT
1 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
Translating Exposure Science for Decision-makers and the Informed Public:
An Opportunity for Collaboration
EPAExposureScienceCommunityofPrac6ceConferenceCallJanuary12,2010
EliseMiller,M.Ed.Director
Collabora6veonHealthandtheEnvironment1646DowRoad,Freeland,WA98249Ph:360‐331‐7904;Fax:360‐331‐7908
Email:[email protected]:www.healthandenvironnment.org
2
Interacting factors that influence health and development
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
Heredity Gene‐environmentinterac6ons Exposurestotoxicchemicals Pharmaceu6cals Infec6ousdisease Socioeconomicstatus Nutri6on Stress
3
Environmental exposures
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
Timingofexposure Bioaccumula6onandpersistance Mechanismsofdisrup6on Variablesensi6vity Evidenceofexposures(bodyburden) Mixtures
4 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
Child Health Exposures Prenatal
transplacental developmentalwindows
Postnatal poundperpoundchildreneat,drinkandbreathfarmorethanadults
prolongedgastricemptying
increasedmetabolicrate increased6meindoors&onfloors(hand‐to‐mouthac-ons)
breastmilk(s-llbesttobreas4eed,butbreastmilknowcontainsmanycontaminants)
5
Environmental agents
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
LeadMercuryPCBsPBDEsBPAPhthalates
ArsenicSolventsPAHsPes6cidesManganeseDioxins
Environmentalagentsthatareknownorsuspected
tointerferewithhealthydevelopment:
6
Lead
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
Whatwasconsidereda“safe”thresholdforexposuretoleadcon6nuestodrop
Thereisnosafelevelofleadexposureforchildren
60
40
3025
2015
10
20
10
20
30
40
50
60
Bloo
d Le
ad (u
g/dl
)
CDC1960
CDC1973
CDC1975
CDC1985
WHO1986
EPA1986
CDC1990
CDCWhen?
Agency and Year
Acceptable Childhood Blood Lead Levels Globalmarkets
Environmentaljus6ce
7
Endocrine disrupting chemicals
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
DosedoesNOTmakethepoison–LaboratoryexperimentsshowthatexposuretoEDCscanhaveimpactsatlevelsfarlowerthanhadbeenconsideredpossibleintradi6onaltoxicology.
8 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
Endocrine Society’s Statement
ReleasedJune2009
“…Theevidenceforadversereproduc-veoutcomes(infer-lity,cancers,malforma-ons)fromexposuretoendocrinedisrup-ngchemicalsisstrong,andthereismoun-ngevidenceforeffectsonotherendocrinesystems,includingthyroid,neuroendocrine,obesityandmetabolism,andinsulinandglucosehomeostasis….”
9
Collaborative on Health and the Environment (CHE)
Diseasedatabase Consensusstatements,whitepapersandfactsheets
10Workinggroups
Na6onalcallswithexpertsonspecifictopics Conferencesandworkshops
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
10
CHE Fertility and Reproductive Health Working Group
VallombrosaConsensusstatement
“ShapingourLegacy”summit “Girl,Disrupted”report “Naviga6ngtheScience”
conference
Resourcedatabase Workinggroupcalls New:Sciencetrainingsfor
advocates
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
11 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
CHE Learning and Developmental Disabilities Initiative (LDDI)
Educa6ngstateandna6onallearninganddevelopmentaldisabili6es(LDD)groups.
Transla6ngemergingscienceintoinforma6onandfactsheetstobeusedatworkshopsandonwebsitesforlayaudiences.
Holdingmee6ngsna6onallyandregionallytobuildcollabora6vepartnershipsbetweenLDDgroups,researchers,healthprofessionalsandenvironmentalhealthadvocates.
Cul6va6ngopportuni6esforinterestedgroupstoeducatepolicymakersonspecificbillsthatwouldeliminateneurotoxicants.
12 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
LDDI: Specific Steps Forward
LDA,AAIDD,ASA,NADDini6a6ves “Prac6cePreven6on”columns LDDIScien6ficConsensusStatement LDDIPolicyStatement
Bi‐weeklye‐bulle6ns Na6onalcalls New:LDDIBiomonitoringProject
13
LDDI Biomonitoring Project
Firstbiomonitoringstudyonahealth‐affectedgroup
11par6cipants Testedover60substancesinbloodandurine
Mediarelease Congressionalbriefing
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
14
CHE Cancer Working Group
Scien6ficconsensusstatement Presenta6onsforPresident’sCancerPanel Factsheets
• IndustrialManufacturing• AgriculturalExposures
• Indoor/OutdoorAirPollu6onandWaterContamina6on
• NuclearFallout,Electromagne6cFields,andRadia6onExposure
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
15 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
Science-based Policy
Somecurrentrelevantpoliciesunderconsidera6on:
‐TSCAreform
‐EndocrineDisrup6ngChemicalsAct
‐SafeCosme6cs(phthalates)
‐BPA
‐PBDEs
16
Some stakeholder concerns Con6nuetoimproveCDCNHANES‐manychemicalsnotyettested,e.g.,thosewithshorterhalf‐lives
Addressexposurestomixturesandimpactonvulnerablepopula6ons
Includenonlinearandlowdose‐responseassessments
Makeconsciousdesignformula6ondecisionsearlyinriskassessmentprocess
Ensureexposureinforma6onisuser‐friendly
Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
17 Collaborative on Health and the Environment Learning and Developmental Disabilities Initiative
For more information
JoinCHE‐www.healthandenvironment.org
Contactme: EliseMiller,MEd,Director Collabora6veonHealth andtheEnvironment(CHE) Ph:360‐331‐7904 [email protected]