self nanoprecipitating preconcentrate of primaquine phosphate
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8/16/2019 Self Nanoprecipitating Preconcentrate of Primaquine Phosphate
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Self nanoprecipitating
preconcentrate of Primaquine
Phosphate
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Method
GMSPP
AOT
GMS- 20 mg
PP- 10 mg
AOT- 10 mg
DMA- 1 ml
DD- 2 ml
EE- 35 % , PS – more than 1µ
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Batch GMS DMA AOT PP EE (%)
A 20 2 10 10 31
B 20 2 20 10 30
C 20 2 10 10 AOT IN DMA 37.9
D 1 1 1 1 51!5
E 10 1 10 10 WITH 0.2 mlTWEEN 80
10.4
" 1 1 # 1 $#!3
G 5 1 10 10 29
PA!T"#$% S"&% AS MO!% T'A( 1 )
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Batch GMS DMA AOT PP EE (%)
D-1 10 1 10 10 40
"-# 1 1 # 1 5#
Batch GMS DMA AOT PP EE (%)
D-1 10 1 10 10 35
"-# 1 1 # 1 $1
PA!T"#$% S"&% AS MO!% T'A( 1 )
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*+ ,ar+ing GMSPP ratio
Batch GMS DMA AOT PP EE ( %)
A # 2 20 10 AOT & DMA 31
B 1 1 20 10 AOT & DMA 3
C 5 1 20 10 AOT & DMA 3#
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. Primaquine phosphate - 10 mg
. AOT - 20 mg
.$utrol / - 10 mg. GMS - 10 mg
. DMA - 03 ml
. P%G 400 - 03 ml
. DD - 4 ml
%% - 0
PS 5 1 nm
PD" 5 06
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Batch GMS DMA AOT PP EE (%)
A 10 1 20 10 AOT, PP in a. !"a#$ $
B 10 1 20 10 AOT, PP in DMA '
C 10 1 20 10 Wi%" 10 m& l'%()l * +8 ina. !"a#$
'#!$
D 10 1 25 10 PP in a. P"a#$ AOT
in DMA
$3!3
PA!T"#$% S"&% AS MO!% T'A( 1 )
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Batch DMA AOT PP GMS EE (%) PS PDA 1 20 10 10 51 '## !
Bi%" l'%()l * +8
1 20 10 10 5$ '33 !1*$
Batch DMA AOT PP GMS EE (%) PS PD
A – 1 1 20 10 10 ' +# !$
B – #
i%" l'%()l * +8
1 20 10 10 '$!$ # !$
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Ba%" DMA / DDW AOT PP M EE P PDI
A 0.95 / 0.05 20 10 10 '+!* # µ
Bi%" l'%()l * +8
0.95 / 0.05 20 10 10 3$!3 # µ
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Different sol,ents
. Pharmasol,e
. Transcutol
. Soluphor P
. Solutol 'S 13
Batch So.ent /0e AOT PP GMS EE (%) PS PD
A DMA 1 m 20 10 10 43 552 0.05
B Pharma0o.e 1 m 20 10 10 27 472 0.015
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B6 a(6in& AOT/PP (a%i)
Batch DMA AOT PP GMS EE (%) PS PD
A 1 15 1 10 32 800 0.7
B 1 # 1 10 47.3 530 0.1
C 1 #5 1 10 5+ 472 0.2
D 1 3 1 10 55 4+8 0.01
B6 in($a#in& (' )n$n%(a%i)n
Batch DMA AOT PP GMS EE (%) PS PD
E 1 # 15 1 33 # µ
" 1 # # 1 - -
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B6 in($a#in& M )n$n%(a%i)n
Batch DMA AOT PP GMS EE (%) PS PD
G 1 # 1 15 #!3 # µ
2 1 # 1 # 5!3 1 µ
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Batch DMA AOT PP GMS EE (%)
C – 1 1 25 10 10 5$!$
C – # 1 25 10 10 5'
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Ba%" DMA DDW AOT PP M EE P PDI
A 1 1 m 25 10 10 20 400 1.1
B !5 1 m 25 10 10 5$ 31 !3
Ba%" DMA DDW AOT PP M EE P PDI
B – 1 !5 1 m 25 10 10 5+ 3+ !1
B – # !5 1 m 25 10 10 5 '5 !#
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T) im!()$ EE,
Ai%i)n ): #mall am)'n% ): a%$( %) DMA ; n)% #%a
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Batch DMA DD AOT PP GMS EE (%)
A !5 !5 m 25 10 10 17.8
A ; 1 !5 !5 m 25 10 10 20.3
Batch DMA DD AOT PP GMS EE (%)
B !5 1 m 25 10 10 +'!
B - 1 !5 1 m 25 10 10 +3
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