self nanoprecipitating preconcentrate of primaquine phosphate

8/16/2019 Self Nanoprecipitating Preconcentrate of Primaquine Phosphate

1/17

Self nanoprecipitating

preconcentrate of Primaquine

Phosphate


2/17

Method

GMSPP

AOT

GMS- 20 mg

PP- 10 mg

AOT- 10 mg

DMA- 1 ml

DD- 2 ml

EE- 35 % , PS – more than 1µ


3/17

Batch GMS DMA AOT PP EE (%)

A 20 2 10 10 31

B 20 2 20 10 30

C 20 2 10 10 AOT IN DMA 37.9

D 1 1 1 1 51!5

E 10 1 10 10 WITH 0.2 mlTWEEN 80

10.4

" 1 1 # 1 $#!3

G 5 1 10 10 29

PA!T"#$% S"&% AS MO!% T'A( 1 )


4/17


D-1 10 1 10 10 40

"-# 1 1 # 1 5#


D-1 10 1 10 10 35

"-# 1 1 # 1 $1

PA!T"#$% S"&% AS MO!% T'A( 1 )


5/17

*+ ,ar+ing GMSPP ratio

Batch GMS DMA AOT PP EE ( %)

A # 2 20 10 AOT & DMA 31

B 1 1 20 10 AOT & DMA 3

C 5 1 20 10 AOT & DMA 3#


6/17

. Primaquine phosphate - 10 mg

. AOT - 20 mg

.$utrol / - 10 mg. GMS - 10 mg

. DMA - 03 ml

. P%G 400 - 03 ml

. DD - 4 ml

%% - 0

PS 5 1 nm

PD" 5 06


7/17


A 10 1 20 10 AOT, PP in a. !"a#$ $

B 10 1 20 10 AOT, PP in DMA '

C 10 1 20 10 Wi%" 10 m& l'%()l * +8 ina. !"a#$

'#!$

D 10 1 25 10 PP in a. P"a#$ AOT

in DMA

$3!3

PA!T"#$% S"&% AS MO!% T'A( 1 )


8/17


9/17

Batch DMA AOT PP GMS EE (%) PS PDA 1 20 10 10 51 '## !

Bi%" l'%()l * +8

1 20 10 10 5$ '33 !1*$

Batch DMA AOT PP GMS EE (%) PS PD

A – 1 1 20 10 10 ' +# !$

B – #

i%" l'%()l * +8

1 20 10 10 '$!$ # !$


10/17

Ba%" DMA / DDW AOT PP M EE P PDI

A 0.95 / 0.05 20 10 10 '+!* # µ

Bi%" l'%()l * +8

0.95 / 0.05 20 10 10 3$!3 # µ


11/17

Different sol,ents

. Pharmasol,e

. Transcutol

. Soluphor P

. Solutol 'S 13

Batch So.ent /0e AOT PP GMS EE (%) PS PD

A DMA 1 m 20 10 10 43 552 0.05

B Pharma0o.e 1 m 20 10 10 27 472 0.015


12/17

B6 a(6in& AOT/PP (a%i)


A 1 15 1 10 32 800 0.7

B 1 # 1 10 47.3 530 0.1

C 1 #5 1 10 5+ 472 0.2

D 1 3 1 10 55 4+8 0.01

B6 in($a#in& (' )n$n%(a%i)n


E 1 # 15 1 33 # µ

" 1 # # 1 - -


13/17

B6 in($a#in& M )n$n%(a%i)n


G 1 # 1 15 #!3 # µ

2 1 # 1 # 5!3 1 µ


14/17

Batch DMA AOT PP GMS EE (%)

C – 1 1 25 10 10 5$!$

C – # 1 25 10 10 5'


15/17

Ba%" DMA DDW AOT PP M EE P PDI

A 1 1 m 25 10 10 20 400 1.1

B !5 1 m 25 10 10 5$ 31 !3

Ba%" DMA DDW AOT PP M EE P PDI

B – 1 !5 1 m 25 10 10 5+ 3+ !1

B – # !5 1 m 25 10 10 5 '5 !#


16/17

T) im!()$ EE,

Ai%i)n ): #mall am)'n% ): a%$( %) DMA ; n)% #%a


17/17

Batch DMA DD AOT PP GMS EE (%)

A !5 !5 m 25 10 10 17.8

A ; 1 !5 !5 m 25 10 10 20.3

Batch DMA DD AOT PP GMS EE (%)

B !5 1 m 25 10 10 +'!

B - 1 !5 1 m 25 10 10 +3

self nanoprecipitating preconcentrate of primaquine phosphate

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