ppt _vitamin b₃ ( niacin )
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8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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VITAMIN B₃ (NIACIN)Oleh:
Muh.Ihsanuddin
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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Introduction
ac a! e an e coen*!e or!s o e a! n.Nicotina!ide is the actie &or!" which &unctions as a constituent o&twocoen*!es" na!el" nicotina!ide adenine dinucleotide (NA+) andnicotina!ide adeninedinucleotide 'hos'hate (NA+,). In the &or!s o& these coen*!es"niacin &unctions in!an biolo%ical redo reactions which actiate about dehdro%enases essential toelectron trans'ort and other cellular res'irator reactions. NA+&unctions as an electroncarrier &or intracellular res'iration as well as a co-&actor &or en*!esinoled in theoidation (catabolis!) o& &ats" 'roteins" carbohdrates and alcohol to'roduce ener%.NA+, &unctions as a hdro%en donor in reductie biosnthesis(anabolis!)" such as in
&att acid and steroid snthesis. /i#e NA+" NA+, is a co&actor &oren*!es" such as inthe oidation o& %lucose-0-'hos'hate to ribose-1-'hos'hate in the'entose 'hos'hate'athwa.In non-redo reactions" NA+ is the substrate &or two classes o&
en*!es thatse'arate the niacin !oiet &ro! NA+ and trans&er A+,-ribose to
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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2. 3i&at #i!ia dan stabilitas
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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3tru#tur 4i!iaNiacin
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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356A7A8 ......Asa! ni#tinattelah di#enal oleh 'ara
ahlibio#i!ia se9a# tahun 20;"teta'i 'en%enalanna seba%ai suatu
ita!in anti-'elar%a baru di!ulaitahun 2<$;. Terda'at dua stru#tur
!ole#ul an% !e!'unaibioa#tiitas ita!in ini" ialah sa!
ni#'tinat (ni#otinic acid)" dan a!ida
asa! ni#otinic (ni#otinic acida!ide). Tr'to'hane ternata!eru'a#an bentu# 'roita!in ba%iniacin= 0 !% tr'to'hane setara
den%an 2 !% niacin.
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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Absorbsi > si!'anan
AbsorbsiNiacin
+i dala! usus halus" niacin dihidroisis dan di absorbsi
seba%ai asa! ni#otinat"ni#otina!ida danni#otina!ida !ononuleotida( MMM )
!etabolis!e
Niacin dan 're#ursorna larutdala! air sehin%%a !udah disera'#e dala! !u#osa dindin% usus halusdan
+ialir#an lebih lan9ut #e dala! hati!elalui ena 'ortae % terda'atdala! 9arin%an berbentu# NA+, II
4dar Ni#otina!ida di dala! darahlen%#a' ( seba%ai NA+ dan NA+, )sebesar $1 ?%@!l
+i ala! 'las!a darah terda'at 0-< u%!l ,ada #ondisi ber'uasa terda'at
Nasin bebas da la! 'las!a darahsebesar "21 u%!l
+i dala hati seba%ai #adar niacin
tertin%%i 1 u% %" dan 9antun%"in al" otot scaleb > otot licin
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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Metabolis!e
Niacin die#s#resi#an didala! urine dala! bentu#
N!ehthl niacina!ide ( N-Me). +ala! #atabolis!aniacin" !etabolis!e N-Medi'ecah lebih lan9ut !en9adiberba%ai 9enis !etabolitan% belu! benar
identitasna. +i dala!urine" di sa!'in% N-Medie#s#resi#an 9u%a 'ridonedan bebera'a !etabolitelain dala! #uantu! #ecilan% bentu#na belu!
teridentiD#asi.
NetEE....
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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F?NG3I .....
Niacin ber&un%siseba%ai
4oen*i! NA+> NA+,
!etbolis!e 'rotein"
asa! le!a#"'erna&asan sel dan
deto#siD#asi"
rea#si o#sidasi-
redu#si 'ada%li#olisis"
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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3?MB57 .....
da%in%" aa!8atii#an"#acan% tanah.Gin9al
i#an"8ati#acan% tanah.Gin9alda%in%" aa!
Lihat tabel nilai niacin dalam berbagai bahan makanan....
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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Tabel Nilai niacin berbagai bahan makananmg/100 gram )
Bahanmaanan
Mg Bahan makanan mg
4acan tanahlo#al
2$" Aa! "
Teri nasi
#erin%
<"; +a%in% babi "0
3ardin ;"0 +a%in% sa'i "1
I#an #e!bun% 0"1 8ati sa'i 2"
I#an banden% 1" 8ati aa! 2"
I#an #e!bun% " Gin9al #a!bin% "
I#an selarse%ar
"< Gin9al sa'i 0";
I#an tawesse%ar
" Beras $"
?dan% se%ar " Te!'e H#acan% #edelai $"0
,eris udan% " 4acan% tanah "
8/17/2019 ppt _VITAMIN B₃ ( NIACIN )
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Food Niacin (mg/100g)
Peanut : 22.;Ancho!" dried : 2$.#ier : 22.1$heat %our" &hole'meal : 2.Bee etract : 1.0Pomret" black (ba&al hitam) : .*ardine" canned : $.1
Bee" lean : $.Mackerel (Tenggiri batang) : $. +hicken" brea,t meat : $.2
(Source: Tee et al.,
1997)
Net....
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4elebihan > #e#uran%an .....
4elebihan #e#uran%an niacinda'at !enebab#an:
4elebihan2. Meracuni siste! sara& . /e!a# darah$. Gula darah. Gan%%uan &un%ssi
hati1. Te#anan darahrendah
4e#uran%an2. 'rodu#si ener%i#uran%
#arena 'roser%li#olisis la!bat
. !enebab#an&un%si ota# le!ah
$. 'ela%ra. +iare1. de!entia
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T57IMA 4A3I8 .....
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