poc-final syllabus sem-1-2 -...

Saurashtra University

M

PHARMA(UGC Innovative Program sanction No.

Shree M. & N.

M.Sc.

Choice Based Credit

Effective from June 201

Shree M & N Virani Science College,

SYLLABUS

Saurashtra University

Master of Science

in

PHARMA . ORGANIC CHEMISTRYsanction No.F.14-30(A)/2012 (Inno/ASIST) Dt. 14

Shree M. & N. Virani Science College, Rajkot.)

M.Sc. Semester I-IV

Choice Based Credit System (CBCS)

Effective from June 2012

Shree M & N Virani Science College,

Rajkot

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ORGANIC CHEMISTRY Dt. 14-01-2012 to

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SaurashtraUniversity

CourseInformation

M.Sc.Pharmaceutical OrganicChemistry

Semester – I

PHARMACEUTICAL ORGANIC CHEMISTRY

Marks

POC-101 Pharmaceutical Engineering-I 100

POC -102 Inorganic Chemistry 100

POC -103 Organic Chemistry 100

POC -104 Physical Chemistry 100

POC -105 & 106 Practical + viva voce 150+50

M.Sc.Pharmaceutical OrganicChemistry

Faculty Name Science Duration in Month 510 hrs

Program Name M.Sc. Max.dur in Month 510 hrs

Faculty Code Total Semester 4

Semester I Course Code POC-101 to POC-104

POC-105 & POC-106

Total Credits 24

Sr.No Course SEM-I

Title of Course Name

Course Group Name

Total Marks Passing Std. Min.marks Credits

Duration Hours

Ext. Int. Total Ext. Int. Total

1 POC-101 Pharmaceutical Engineering -I

POC 70 30 100 28 12 40 4 60

2 POC-102 Inorganic Chemistry

POC 70 30 100 28 12 40 4 60

3 POC-103 Organic

Chemistry POC 70 30 100 28 12 40 4 60

4 POC-104 Physical

Chemistry POC 70 30 100 28 12 40 4 60

5 POC-105 Practical POC 150 - 150 60 - 60 6 270 6 POC-106 Viva-voce POC 50 - 50 20 - 20 2 -

Page | 3

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY

SEMESTER I

POC-101: Pharmaceutical Engineering - I

1. Flow of Fluids: Types of flow, Reynolds number, velocity distribution in pipes,

viscosity & its units), Bernoulli’s equation, loss due to sudden enlargement & sudden

contraction.

2. Transportation of Fluid : Positive displacement pumps, reciprocating pumps, rotary

pumps, centrifugal pumps, Diaphragm pump.

3. Heat & Mass Transfer: Modes of heat transfer, Conduction, Convection &

Radiation, Heat transfer by conduction, Heat transfer through a rectangular slab,

thermal resistance in series & parallel. Thermal conductivity. Heat transfer

Equipments, heat exchanger, shell & tube heat exchanger. Calculations involving heat

transfer coefficients. Fundamentals of Mass Transfer, Diffusion, Fick’s law.

4. Industrial Measuring Instruments:

a. Temperature measurement: Bimetallic thermometer, thermo electric sensors (thermo couple).

b. Viscosity Measurement: Capillary tube viscometer, Ostwald Viscometer, Saybolt Viscometer.

c. Specific gravity & Density measurement: Bubbler system, hydrometer method.

d. Liquid level measurement: Sight glass method, float gauge, Radiation level measurement, bubbler level measurement.

e. Pressure Measurements: Liquid column, manometers, purges system. f. Flow measurements: Venturimeter, Orificemeter, Pitot tube, rotameter.

5. Crystallization: Growth & Properties of crystals, Saturation, Nucleation,

Crystallization rate, fractional crystallization, types of crystallizers.

6. Mixing & Homogenization: Equipment for solid mixing, study of following

mixtures; planetary mixture, agitator, triple roller mill, propeller mixture,

pharmaceutical applications of mixing.

Reference Books

1. McCabe W. L. Smith J. C. unit operations of chemical engineering, 5th edition,

McGraw Hill International edition New York.

2. Peter Max, Elementary Chemical Engineering, Second Edition.

Page | 4

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY SEMESTER I

POC-102: INORGANIC CHEMISTRY

1. Quantum Mechanics and its Applications: MO-VB Theory: Born-Oppenheimer

approximation, Hydrogen Molecule ion. LCAO-Mo and VB treatments of hydrogen

molecule. Electron Density, forces and their role in chemical bonding. Hybridization

and valence MO’s of H2O, NH3 and CH4 .Huckel pi-electro theory and its applications

to Ethylene, Butadiene and Benzene. Idea of Self-consistent field method.

2. Magneto Chemistry: Definition of Magnetic Properties, Types of magnetic bodies,

Diamagnetism and Pascal’s Constant, Russell-Saunders or LS Coupling, Multiple

widths Large compared to kT, Multiple width small compared to kT, Stereo chemical

applications of Magnetic Properties of the First Transition Series, Lanthanides and

actinides, Determination of magnetic susceptibility by Gouy’s Method, Derivation of

Van Vleck formula for Susceptibility.

3. Mössbauer Spectroscopy: Introduction of Mössbauer effect, Isomer- Shift, Magnetic

hyperfine interactions. Quadrupole moment. Electric field gradient. Quadrupole

splitting. Applications in structure determination.

4. Electron Spin Resonance: Introduction to Electron Spin Resonance, technique of

electron spin resonance, interaction between nuclear spin and electron spin:- hyper

fine splitting, calculation and energies of Zeeman levels, calculations of energies,

frequency and the ESR spectrum when one electron influenced by a single proton and

one electron delocalize over two equivalent protons.

5. Uses of Organic Reagents in Inorganic Analysis: Cupferron, DMG, dithiozone,

aluminon, oxine, dithiooxamide, α-benzoinoxime, α-nitro-β-naphthol, α-nitroso- β-

naphthol, diphenyl carbazone, diphenyl carbazide, anthranilic acid, tannin, pyragallol,

benzidine, salicylaldoxime, o-phenanthroline

Reference Books

1. Physical Method in Chemistry, R.S.Drago, Saunders College Publishing.

2. Quantum Chemistry, R.K.Prasad, New Age.

3. Introductory Quantum Chemistry, A.K. Chandra, Tata MacGraw -Hill.

4. Quantum Mechanics, Chatwal&Anand, Himalya Publishing House.

Page | 5

5. Introduction ToMagnetochemistry, Alan Earnshaw, Academic Press.

6. Elements of Magnetochemistry, Dutta&Syamal, S. Chand & Company.

7. Textbook of Inorganic Chemistry Vol .I &II, A.Singh&R.Singh, Campus

International Publication

8. Advanced Inorganic Chemistry, Cotton Wilkinson, W S E Wiley.

9. Vogel’s Text book of Quantitative Inorganic Analysis, ELBS.

Page | 6

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY

SEMESTER I

POC-103: ORGANIC CHEMISTRY

1. Reaction path Way& Reactive Intermediates: Homolytic and Heterolytic fission,

Different types of arrow notation, Electrophile and Nucleophile. Carbonium ion,

Carbanion, Free radical, Carbene, Nitrene, Benzyne, Enamines.

2. Organic Named Reactions Like:

(1) Aldol, (2) Arndt-Eistert homologation, (3) Bylis-Hillman, (4) Baeyer-Villiger, (5)

Barbier-Wieland, (6) Barton, (7)Biginelli, (8) Birch, (9) Buchwald-hartwig cross

coupling, (10) Dieckmann, (11) Darzen, (12) Dess-Martin Oxidation, (13) Diels

Alder, (14) Ene, (15) Elbspersulphate, (16) Friedal-crafts, (17) Grignard, (18)

Hofmann Loffler Freytag, (19) Heck,(20) Kumada cross coupling, (21) Meerwien-

pondorf, (22) Michael addition, (23) Mitsunobu, (24) Negishi, (25) Oppenauer, (26)

Perkin, (27) Reimer-Tiemann, (28) Reformatsky, (29) Rosenmund, (30) Sonogashira

cross coupling (31) Stobbe, (32) Storkeenamine, (33) stille coupling, (34) Suzuki,

(35) Ugi, (36) Vilsmeier-Haack, (37) Wittig, (38) Mukaiyama reaction.

3. Molecular Rearrangements Like:

(1) Pinacol-pinacolone, (2) Wagner-Meerwein, (3) Demjanov, (4) Benzil-Benzilic

acid,(5) Favorskii, (6) Beckmann, (7) Hoffman, (8) Curtius, (9) Schmidt, (10) Baeyer-

Villiger.

4. Important Reagents:

(1)D.D.Q., (2) Dicyclohexylcarbodimide (DCC), (3)Diethylazodicarboxylate

(DEAD), (4) Gillman’s reagent, (5) Lithium diisopropylamine (L.D.A.), (6)

LiAlH 4(7) Selenium dioxide, (8)N-Bromosuccinimide (NBS),

(9)TriphenylPhosphene (TPP), (10) 1-Hydroxybenzotriazole (HOBT), (11)Triflets -

Sc(OTf)3, (12) EDCI, (13) Quaternary Ammonium salt- TBAB.

5. Advances in Organic Chemistry-Organocatalysis: Introduction, Aldol and Related

Reactions, Mannich and Related Reactions, Conjugate Addition Reactions (two

examples of each C-C, C-O, and C-N bond formations).

Reference Books

1. Organic Reaction Mechanism (II edition) - V. K. Ahluwalia, R. K.Parasar.

Page | 7

2. Reaction Mechanism and Reagents In Organic Chemistry -GurdeepRChatwa

3. Organic Chemistry (VI edition) - R.T Morrison- Boyd. Prentice Hall of India (2003)

4. Organic Chemistry - I.L. Finar, 6th Edition (Low price) Pearson Education, 2003

5. Organic Chemistry- (V edition) - John McMurry), Asian Book Pvt Ltd, New Delhi

6. Advanced organic chemistry (IV edition) - Jerry March

7. Reaction Mechanisms and Problems in Organic Chemistry–P.Chattopadhyay, Asian

Book Pvt Ltd, New Delhi (2003)

8. Reactive Intermediates in Organic Chemistry-J. P. Trivedi, Univ. Granth Nirman

Board

9. Principles of Reaction Mechanism in Organic Chemistry - Parmar-Chawla

10. A text book of Organic Chemistry, - Raj K. Bansal, New Age Inrternational (P) Ltd.

4th Edition 2003

11. Organic Chemistry, T.W. Graham Solomn, Craig B. Fryble, Low Price 8th Edition,

John Wiley & Sons, Inc.

12. Organic Chemistry, V. K. Ahluwalia&MadhuriGoyal, Narosa Pub. House, (2000).

13. Molecular Orbital Theory for Organic Chemists, A. Streitweiser, Jr, Wiley

International (1961) and Subsequent Edition.

Page | 8

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY

SEMESTER I

POC-104: PHYSICAL CHEMISTRY

1. Statistical Thermodynamics: Basic Terms: probability, cell, phase space, micro and

macro states, thermodynamic probability, statistical weight factor, assembly,

ensemble and its classification and statistical equilibrium. Derivation of Boltzmann-

Maxwell, Bose-Einstein and Fermi- Dirac statistics, Partition function and derivations

of translational, rotational, vibrational and electronic partition functions and

thermodynamic functions such as internal energy, heat capacity, entropy, work

function, pressure, heat content, etc. Partition function & third law of

thermodynamics. Applications of partition function to monoatomic gases, diatomic

molecules, equilibrium constant and equilibrium constants of metathetic reactions.

Problems.

2. The Debye-Huckel Theory: Ionic interactions in solutions. Electrical potential of

ionic atmosphere. Electrical free energy and activity coefficients. Mean ionic activity

coefficients (D-H limiting law).Applications of D-H theory: quantitative and

qualitative, solubility in presence of added electrolyte and osmotic coefficient. The D-

H theory in more concentrated solutions. D-H theory and equilibrium constant.

Problems.

3. The Properties of Solutions: Ideal solutions: Properties, the DuhemMargules

equation, vapour pressure curves. Composition of liquid and vapour in equilibrium

influence of temperature on gas solubility and solid-liquid equillibria. Non ideal

solutions: Deviation from ideal behaviour, vapour pressure curves, Liquid and vapour

compositions. General equations for liquid mixtures. Partially miscible liquids.Dilute

solutions: Henry’s law. Determination of molecular weights from freezing and

boiling points. Problems.

4. Free Energy and Chemical Reactions: Chemical equilibrium and the equilibrium

constant: Equilibrium in homogeneous gaseous systems. Homogeneous reactions in

liquid solutions. Homogeneous reactions in dilute solutions. Chemical equillibria in

heterogeneous systems. Free energy change in chemical reactions:The reaction

isotherm, standard free energy of reaction, the direction of chemical change. Variation

of equilibrium constant with pressure and temperature. Influence of temperature on

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heterogeneous reactions. Integration of the Van’t Hoff equation. Variation of standard

free energy with temperature. Simultaneous equillibria. Formation of standard free

energies and entropy changes and their applications, problems.

5. Homogeneous & Heterogeneous Catalysis: Types of catalysis (Homogeneous &

heterogeneous) & their characteristics. Theory of homogeneous & heterogeneous

catalysis. Autocatalysis, promoters or activators, Types of acid base catalysis.

Mechanism of acid-base catalysis & catalytic coefficients.

Reference Books

1. Thermodynamics for Chemists by Samuel Glasstone.

2. Statistical Thermodynamics by L. K. Nash.

3. Thermodynamics by Gurdeep and Rajesh.

4. Physical Chemistry by H.Snehi.

5. Physical Chemistry by Barrow.

6. Physical Chemistry by NegiAnand.

Page | 10

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY

SEMESTER I

POC-105: PRACTICALS

1. Organic Chemistry:

i) Organic preparation: Two stage preparation.

ii) Organic spotting:Multifunctional organic compounds

2. Inorganic Chemistry:

i) Qualitative Analysis: Analysis of a mixture containing six radicals including

one less common metal ion.

ii) Preparation & Estimation of Metal Complexes: Preparation of selected

inorganic metal complexes & their estimation by volumetric/ gravimetric/

colorimetric techniques to determine their percentage purity.

3. Physical Chemistry:

i) Instrumentation :

a. Conductometry: Mono and biprotic acids, mixtures of acids against

strong/weak bases, argentometric, complexometric, replacement

titrations, verification of Onsagar’s equation, dissociation of weak

acids.

b.Potentiometry: Acid-base, redox and argentometric titrations.

c. pH metry: Acid-base titration, pKa of acids and E0 QH2.

d.Ultrasonics: Acoustical parameters of liquids.

e. Refractometry: Binary mixtures and solids.

f. Polarimetry : Optically active compounds.

g.Spectrophotometry: Lambert-Beers Law, binary mixture, kinetics of

iodination, etc.

ii) Physicochemical Exercises:

a. Reaction Kinetics: First and second order reactions-order

determination, energy of activation.

b.Partition coefficient: Distribution of Benzoic acid/Ammonia in

organic solvent & aqueous phase.

c. Thermodynamics: Heat of Solution, Partial molar volume, etc.

4. Analytical Chemistry:

i) Calibration of equipments/instruments.

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ii) Food analysis: Honey, oil, tea-leaves, turmeric powder, etc.

iii) Drug analysis: Aspirin, Benzyl benzoate, etc.

iv) Environmental Analysis: Water parameter determination (anionic, cationic,

DO, COD etc.). Air pollution control apparatus cyclone separator.

5. Pharmaceutical Engineering:

i) Fluid Mechanics: Bernoulli’s equation, measurement of major & minor

losses, Reynolds experiment etc.

ii) Heat Transfer: Fourier’s law applicable to a composite slab, Heat transfer

through insulating powder, Stefan Boltzmann law verification, Natural

convection etc.

iii) Size Reduction: Jaw crusher, roll crusher, ball mill, Screening etc.

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SaurashtraUniversity CourseInformation

M.Sc.Pharmaceutical OrganicChemistry

M.Sc.Pharmaceutical OrganicChemistry

Faculty Name Science Duration in Month 510 hrs

Program Name M.Sc. Max.dur in Month 510 hrs

Faculty Code Total Semester 4

Semester II Course Code POC-201 to POC-204

POC-205 & POC-206

Total Credits 24

Sr.No Course SEM-II

Course Title Course Group Name

Total Marks Passing Std. Min. marks

Credits Duration Hour

Ext. Int. Total Ext. Int. Total 1 POC-201 Pharmaceutical

Engineering -II POC 70 30 100 28 12 40 4 60

2 POC-202 Organic Chemistry of

Natural Products

POC 70 30 100 28 12 40 4 60

3 POC-203 Organic Synthesis-A

disconnection approach

POC 70 30 100 28 12 40 4 60

4 POC-204 Selected Topics in

Pharmaceutical Chemistry

POC 70 30 100 28 12 40 4 60

5 POC-205 Practical POC 150 - 150 60 - 60 6 270 6 POC-206 Viva-voce POC 50 - 50 20 - 20 2 -

Semester – II

PHARMACEUTICAL ORGANIC CHEMISTRY

Marks

POC -201 Pharmaceutical Engineering-II 100

POC -202 Organic Chemistry of Natural Products 100

POC -203 Organic Synthesis- A Disconnection Approach 100

POC -204 Selected Topics in Pharmaceutical Chemistry 100

POC -205 & 206 Practical + viva voce 150+50

Page | 13

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY

SEMESTER II

POC-201: Pharmaceutical Engineering -II

1. Evaporation: Types of evaporation, heat transfer coefficient, boiling point rise due

to material in solutions, Mass & Energy balance over evaporator, single &multiple

effect evaporators.

2. Filtration : Introduction, classification of filters, Sand Filters, filter presses, Plate &

frame presses, leaf filters, filter aids, filtration theory, washing of filter cakes.

3. Centrifugation: Principles of centrifugation, advantages, disadvantages, & use of

perforated basket centrifuge, centrifuge filter.

4. Leaching &Extraction: Factors influencing the rate of extraction, equipment’s,

number of stages for counter-current washing, calculation of the number of theoretical

stages in extraction operation (Co-current contact with partially miscible solvents)

extraction Equipments.

5. Distillation: Vapour liquid equilibrium. Partial vaporization & partial condensation,

partial pressures, Dalton’s Raoult’s & Henry’s laws, relative volatility, the methods of

distillation, (two component mixtures), the fractionating column, (calculation of

number of plate, efficiency), steam distillation, packed columns, general description,

types of packing, flash distillation, fractional distillation.

6. Size Reduction & Screening: Objectives of comminution, factors affecting size

reduction, Principles of size reduction, Principles, construction & working of various

size reductions equipment’s such as Jaw Crusher, Roll Crusher, Ball mill. Screening

& Size distribution, determination of size, sieve analysis.

Reference Books

1. A. Martin, Physical Pharmacy, B. I. Waverly Pvt. Ltd., New Delhi (1994)

2. L. Lachman, H. A. Liebermin& J. L. Karling, Theory & Practise of Industrial

Pharmacy III eds. Varghese Publishing House, Bombay (1977).

3. Unit Operations-I by Gavhane, NiraliPrakashan.

4. Unit Operations-II by Gavhane, NiraliPrakashan

Page | 14

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY SEMESTER II

POC-202: CHEMISTRY OF NATURAL PRODUCTS

1. Steroids and Hormones: Constitution of cholesterol, Chemistry of Aldostrone,

Testosterone, (+)-Estradiol.

2. Vitamins: Synthesis and importance of vitamin A, B (folic acid, niacin, pentothenic

acid, riboflavin, pyridoxine), C and E (alpha and beta tocotrienols and tocopherols).

3. Alkaloids: Synthesis and importance of Morphine, (-)Strychnine, Reserpine, Codeine,

Quinine, Nicotine.

4. Amino acids, Peptides & Proteins, Nucleic acids: Classification & Nomenclature of

Amino Acids, Acid-base properties of Amino acids, Isoelectric point, separation of

amino acids, peptide & disulphide bonds, strategy of peptide bond synthesis: N-

protection & C-activation, Automate peptide synthesis, Protein structures: Primary,

secondary & tertiary. Introduction & synthesis of Nucleosides and Nucleotides.

5. Enzymes and its applications in organic synthesis: The discovery and importance

of enzymes and coenzymes, Methods for studying enzymatic reactions, Enzymatic

Hydrolysis and Group Transfer Reactions, Enzymatic C-C bond formation reactions,

Enzymatic addition & elimination reactions, Enzymatic Transformations of amino

acids (i.e. reactions at α,β & γ positions), Radicals in enzymatic reactions.

6. Total Synthesis of Selected Natural Products, Pharmaceutical Activity and

Occurance thereof: 7-methylomuralide, Agelastatin A, (-)Bursehemin, Carpanone,

Chelidonine, Fulvoplumierin, Griseofulvin, Janoxepin, Luoronin A, (-) Mersicarpine,

Taxol, (+)Vinblastine.

Reference Books

1. Some modern methods for organic synthesis - W. Carruthers.

2. Principles of organic synthesis - R. Norman & J. M. Coxon.

3. Advanced organic chemistry Part B – F.A. Carey & R. J. Sundberg.

4. Modern synthetic reactions - H.O. House, W.A. Benjamin.

5. Natural products: Chemistry & Biological significance – J. Madd, R. S. Davidson, J.

B. Hobbs, D.V. Banthrope.

Page | 15

6. Organic chemistry, Vol 2, - I..L. Finar.

7. Stereoselective synthesis: A practical approach - M. Nogradi.

8. Chemistry, Biological &Pharmacacological properties of medicinal plants from the

Americas - Ed. Kurt, M. P. Gupta & A. Marston.

9. Introduction to Enzyme & Co-enzyme Chemistry-T.D.H. Bugg.

10. New trends in Natural product chemistry – Alta – Ur- Rahman and

M.I. Choudhary.

Page | 16

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY

SEMESTER II

POC-203: ORGANIC SYNTHESIS – A DISCONNECTION APPROACH

1. A Disconnection Approach: Introduction to disconnection, concept of synthon,

synthetic equivalent, functional group inter-conversion, concept and design of

synthesis, criteria of good disconnection.

2. One Group Disconnection: Disconnection and synthesis of alcohols, olefins, simple

ketones, acids and its derivatives.

3. Two Group Disconnection: Disconnections in 1,3-dioxygenated skeletons,

preparation of 8-hydroxy carbonyl compounds, α,β-unsaturated carbonyl compounds,

1,3-dicarbonyls, 1,5-dicarbonyls and use of Mannich Reaction.

4. Illogical Two Group Disconnections: Disconnection and synthesis of 2-hydroxy

carbonyl compounds, 1,2-diols, 1,4 and 1,6-dicarbonyl compounds.

5. Disconnection and Synthesis of Acyclic and Cyclic Hetero-Compounds: Synthesis

of ethers, amines, nitrogen and oxygen containing five and six membered

heterocycles.

6. Ring Synthesis: Special methods for small rings preparations, synthesis of three and

four membered ring compounds.

7. Protecting Groups: Protection of organic functional groups, protecting reagents and

removal of protecting groups.

8. Umpolung of Reactivity: Umpolung of carbonyl group, synthesis based on umpoling

carbonyl group, synthesis of 1,2 and 1,3 diketones, cyclic ketones etc.

Reference Books

1. Designing organic synthesis - S. Warren, Wiley.

2. Some modern methods for organic synthesis - W. Carruthers.

3. Principles of organic synthesis - R. Norman & J. M. Coxon.

4. Advanced organic chemistry Part B – F.A. Carey & R. J. Sundberg.

5. Organic synthesis - concept, methods & starting materials – J. Fuhrhop.

6. Modern synthetic reactions - H.O. House, W.A. Benjamin.

7. Disconnection approach – S.Warren

Page | 17

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY

SEMESTER II

POC-204: SELECTED TOPICS IN PHARMA ORGANIC CHEMISTR Y

1. Environmental Chemistry: Introduction, classification and causes of Air & Water

pollution.

Air pollution control methods and equipments like:

Cyclone Separator,

Fabric Filter System,

Electrostatic Precipitator,

Wet Scrubber.

Water treatment methods & equipments like:

Screening,

Sedimentation, Floatation,

Activated Sludge Treatment, Trickling Filter,

Oxidation Pond, Aerated Lagoons, In Hoff’s Tanks.

2. Green Chemistry: Principles of Green Chemistry and its applications,

Environmentally benign reaction like strecker synthesis, Reformatsky

reaction,Grignard reaction, Diekmann condensation. Principles of microwave assisted

organic synthesis & Knoevenagel condensation, Beginelli reaction, Ugi Coupling,

Miyaura coupling, Stille coupling.

Reactions in ionic liquids: DielsAlderReactions, Knoevenagel Condensation,

FriedelCrafts Alkylation.

3. Pharma Regulatory Affairs: Introduction of regulatory affairs, SOPs, ICH

guidelines, GMP & GLP, Patent search tools and their usages, Brief IPR-Introduction,

Various Technical Terms (Up to 8), Legislation, IPA, Criteria for Patent.

4. Pharma-Analytical Chemistry: Statistical Data Analysis: a)Types of errors, b)

Accuracy & precision, c) Data processing, d) Confidence limit & interval, e) Test of

significance, f) t-test & F-test, g) Rejection of data, h) Control charts, i) Least square

analysis, j) problems.

Sample handling, RM-CRM, COA, Importance of Documentation.

Page | 18

5. Polymers used in Pharmaceuticals: Synthesis, properties and applications of Water

soluble synthetic Polymers: Poly (acrylic acid), Poly (vinyl pyrrolidone), Poly(vinyl

alcohol)Cellulose-Based Polymers: carboxymethyl cellulose,

Hydroxymethyl&Hydroxypropyle cellulose, Hydroxypropyle methyl cellulose,

cellulose acetate phthalateWater Insoluble Biodegradable Polymers: (Lactide-co-

glycolide) polymersStarch Based Polymer: Starch, Sodium starch glycolate Plastics &

Rubbers: Polyurethane, Silicones, Poly (vinyl acetate), Poly (methyl methacrylate),

Poly ( hydroxyethyl methacrylate)

6. Photo Chemistry: Introduction – Interaction of electromagnetic radiation with

matter, types of excitations, fate of excited molecules, quantum yield, transfer of

excitation energy, actinometry. Photo chemistry of carbonyl compounds –

Intramolecular reaction of the carbonyl compound-saturated, cyclic & acyclic, β,γ-

unsaturated & α,β - unsaturated compounds, cyclohexadienones. Intramolecular

cycloaddition reaction, dimerization & oxetane formation. Miscellaneous

Photochemical Reactions – Photo Fries reaction of anilides& esters, Barton reaction,

Singlate molecular oxygen reactions. Photochemical formation of smog. Photo

degradation of polymers.

Reference Books

1. Organic Photochemistry - J. Coxon& B. Halton

2. Introduction Photochemistry - A. Cox. & T. Camp.

3. Fundamentals of photochemistry - Rohtgi-Mukherjee

4. A First Course in Polymer Chemistry, Mir Publishers, Moscow.

5. Text-book of Polymer Science, F. W. Billmeyer, Willey Interscience.

6. Polymer Chemistry, Bruno Vollmert. Springer, New York.

7. Principles of Polymer Systems, F. Rodriguez, McGraw Hill.

8. Polymer Science, V. R. Gowariker, N. V. Vishwanathan and J. Shreedhar, Willey

Eastern Ltd., New Delhi.

9. Polymer Chemistry An Introduction, Malcolm P. Stevens, Addition-Wesley

Page | 19

10. Fundamentals of Analytical Chemistry, D.A. Skoog, D.M. West and F.J. Holler, W.B.

Saunders.

11. Vogel’s Textbook of quantitative Inorganic Analysis – L. Barrt et al. ELBS

12. Unit processes in organic synthesis - P.H. Groggins.

13. Environmental Chemistry by A. K. De.

14. An Introduction to air pollution by R. K. Trivedi and P. K. Goel.

15. Principles of Environmental Chemistry by H. Kolhandaraman and Geetha

Swaminathan.

16. Manual on water & waste water analysis by Neeri.

17. Water Pollution by Dr. V. P. Kudesia.

18. Basic concepts of Environmental Chemistry by Des W. Connell.

19. Manual on Water and Wastewater analysis by Dr. B. B. Sundarsan.

20. Liquid waste of Industry: Theories Practices and Treatment by Nelson L. Nemerow.

21. Guidelines on GMP/GLP by S. Lyer.

Page | 20

M.Sc. -PHARMACEUTICAL ORGANIC CHEMISTRY

SEMESTER II

POC-205: PRACTICALS

1. Organic Chemistry:

i) Organic preparation: Two stage preparation.

ii) Organic spotting:Multifunctional organic compounds

2. Inorganic Chemistry:

a. Qualitative analysis: Analysis of a mixture containing six radicals including

one less common metal ion.

b. Preparation & estimation of metal complexes: Preparation of selected

inorganic metal complexes & their estimation by volumetric/ gravimetric/

colorimetric techniques to determine their percentage purity.

3. Physical Chemistry:

a. Instrumentation :

i. Conductometry: Mono and biprotic acids, mixtures of acids against

strong/weak bases, argentometric, complexometric, replacement

titrations, verification of Onsager’s equation, dissociation of weak

acids.

ii. Potentiometry: acid-base, redox and argentometric titrations.

iii. pH metry: Acid-base titration, pKa of acids and E0 QH2.

iv. Ultrasonics: Acoustical parameters of liquids.

v. Refractometry: Binary mixtures and solids.

vi. Polarimetry : Optically active compounds.

vii. Spectrophotometry: Lambert-Beers Law, binary mixture, kinetics of

iodination, etc.

b. Physicochemical Exercises:

i. Reaction Kinetics: First and second order reactions-order

determination, energy of activation.

ii. Partition Co-efficient: Distribution of Benzoic acid/Ammonia in

organic solvent & aqueous phase.

iii. Thermodynamics: Heat of Solution, Partial molar volume, etc.

Page | 21

4. Analytical Chemistry:

a. Food Analysis: Honey, oil, tea-leaves, turmeric powder, etc.

b. Drug Analysis: Aspirin, Benzyl benzoate, etc.

c. Environmental Analysis: Water parameter determination (anionic, cationic,

DO, COD etc.)., Air pollution control apparatus cyclone separator.

5. Pharmaceutical Engineering:

a. Fluid Mechanics:Bernoulli’s equation, measurement of major & minor

losses, Reynolds experiment etc.

b. Heat Transfer: Fourier’s law applicable to a composite slab, Heat transfer

through insulating powder, Stefan Boltzmann law verification, Natural

convection etc.

c. Size Reduction:Jaw crusher, roll crusher, ball mill, Screening etc.

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