neurological (emergencies) treatment trials by william meurer
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Neurological (Emergencies) Treatment TrialsWilliam J. Meurer MD, MSAssistant Professor of Emergency Medicine and NeurologyWilliam G. Barsan Research Forum 27 April 2016
Disclosures• Grant Funding• NIH – NINDS• NIH – NIDCD• AHRQ
• Editorial• Methodology statistics reviews for Academic Emergency Medicine
Journal• Expert Witness• Medical liability consulting
• Financial• No companies or patents• Diversified index funds only
• Sports• Ohio State Fan
Outline• Part 1: Neurological Emergencies Treatment Trials• Pre-history• The launch• The current trials• Why I do this
• Part 2: Clinical Trials Methodology Course• Pre-history• The launch• The current model• Why I do this
• Part 3: DIZTINCT
Part 1: Neurological Emergencies Treatment Trials
A long time ago (1990) in a galaxy (Cincinnati) far, far away…
EPISODE IVA New Hope
Stroke physicians have been stymied for decades without any acute treatments to improve outcomes by reducing the damage from stroke. They have looked to their colleagues, the cardiologists for help, but have met many roadblocks.
John Marler, MD – NINDS
Bill Barsan, MD
NETT – The beginning
NETT – Ongoing Trials
Randomized Controlled Trials
•Not easy•Barriers to entry•Site principal investigator “props”•Not enough being done•Best way to get definitive answers
NINDS Clinical Trials Methodology Course
•Not easy•Barriers to entry•Small clinical trials are the hardest• Junior / new investigators under-resourced•Not enough being done
05/01/2023 R25 NS088248 11
April – July
August 7-11 Ann Arbor
August - October
MarchInstruments / Pre-Review
WebinarsSmall Group Meetings
Travel / Logistics
Didactics / Workshops /Small Groups MANDATORY
Small Groups / Mock Study Sections
PRO
TOCO
L D
EVEL
OPM
ENT
PRO
POSA
L D
EVEL
OPM
ENT
Part 3 - DIZTINCT
www.dizztinct.org
Questions• Thank you• Thank you• Thank you
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