nanotechnology & nanobiotechnology @ uic & nanobiotechnology @ uic (engineering &...

Nanotechnology & Nanobiotechnology @ UIC(Engineering & Science)

by

G.Ali Mansoori, PhD

mansoori@uic.edu

BioEngineering, Chemical Engineering & Physics Departments

atLivingston Nanotechnology Conference

Chicago, IL, December 2014

ABSTRACT• An overview of Speaker’s R&D work on design of

nanoparticles, nanoclusters, nanoconjugates andmolecular building blocks and their applications inscience, engineering and health.

Our Atomic Force Microscopes

Mansoori Group Research Topicswww.uic.edu/~mansoori/

1. Cancer nanotechnology:a. Melanoma prevention through nanotechnologyb. Applications of Azurin as an anti-cancer agent.c. Targeting the Folate Receptor.

2. Silver nanoparticles large-scale (industrial)production

3. Diamomdoids as molecular building block fornanotechnology

Mansoori Group Research Topics continued

• 4. Molecular based study of condensed matter in smallconfined systems

• 5. Applications of supercritical fluid technology forbioseparations

• 6. Environmental aspects of nanotechnology

• 7. Alzheimer’s disease detection & treatment throughnanotechnology.

Design, characterization and application of a folate-conjugated gold nanoparticle

• Gold Nanoparticles Conjugated with Folic Acid using Mercaptohexanol as the Linker JournalNanotechnology Progress International (JONPI), 1: 13-23, 2009.

• Structural and optical characterization of folate-conjugated gold-nanoparticlesPhysica E: Low-dimensional Systems and Nanostructures, doi:10.1016/j.physe.2009.10.039.

• Cancerous Cells Targeting and Destruction Using Folate Conjugated Gold Nanoparticles DynamicBiochemistry, Process Biotechnology and Molecular Biology, Vol. 4, 2010.(Article in Press)

• Folate-Conjugated Gold Nanoparticles (Synthesis, characterization and design for cancer cellsnanotechnology-based targeting) Int'l J of Nanoscience & Nanotechnology, 2010.(Article in Press)

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Design, characterization and application of a folate-conjugated gold nanoparticle continued

Melanoma prevention through nanotechnology

Acrobat Document

A patent pending.

Applications of Azurin as an anti-cancer agent

• Azurin: A NovelAnticancer Candidate

(Molecular Characteristics, Apoptosis Mechanism and Nanotechnology)

Prospects for Cancer Nanotechnology Treatment by Azurin Dynamic Biochemistry, Process Biotechnology and Molecular Biology, Vol. 4, 2010.

Silver Nanoparticles production and medical applications• Biosynthesis of Silver Nanoparticles by Fungus Trichoderma

Reesei (A Route for Large-Scale Production of SNP)

• (Left) TEM micrograph recorded from a drop-coated film of an aqueous solutionincubated with Trichoderma reesei and reacted with Ag+ ions for 72 hours.(Right) Selected area of electron diffraction pattern recorded from one of thesilver nanoparticles shown in the left Figure. The diffraction rings have beenindexed with reference to the fcc silver.

• Patented

Alzheimer’s Disease Nanotechnology:

RECENT PUBLICATIONS:Nanotechnology Building Blocks for Intervention with Alzheimer’s Disease Pathology: Implications in Disease Modifying Strategies J Bioanal. & Biomed., Vol.6, Issue 2, 6:009-014. doi: 10.4172/1948-593X.1000101, 2014

Nanotechnology for Alzheimer's disease detection and treatment (Invited paper) Nanotechnology Sec. / Insciences J. 2011, 1(4), 169-193;doi:10.5640/insc.0104169

Nanotechnology Solutions for Alzheimer's Disease: (Advances in research tools, diagnostic methods and therapeutic agents) Journal of Alzheimer's Disease, 13(2): pp. 199-223, 2008.

Early detection of AD through nanotechnology

Sequential formation of globular amyloid aggregates

Our tools

What we do

1. Ab initio calculations2. MD simulation3. Molecular self-assembly4. Scanning

probemicrocopy

1. THEORY: Generating & testing the basis sets. Structureoptimization. Comparing bond lengths with experiment.Creating and testing potentials for diamondoids &derivatives and pseudopotentials for metal tips. Testingdifferent density functionals (B3LYP, GGA, LSDA & LDA).Testing and comparing results from the ab initio codes (Molpro, Gaussian 03, etc.). Treating valence electronsexactly.

2. EXPERIMENTS: Preparing monolayers of diamondoids.Obtaining images with AFM and/or STM. Preparing samplesusing different solvents (THF, toluene, etc) with differentdegrees of concentration levels. Choosing substrates (Si,Mica, etc.). Choosing preparation techniques (drop,spinning, etc.). Force-distance calculations andcharacterization (through XPS, STM, and AFM). Testingversus THEORY results.

3. SIMULATIONS: Simulations to produce self-assemblies fornew materials with desired optoelectronic properties asMEMS, NEMS and other micro- and nano-gears anddevices. Utilizing the intermolecular potential data producedin the above sections.

Our team

Measurement, Simulation and Prediction of Intermolecular Interactions and Structural Characteristics of Organic Nanostructures (Diamondoids and Derivatives)

Diamomdoids as molecular building block for nanotechnology

Sense the hardness “See” the atoms

Our samples:

Feel the potential

Our findings:

Our goals:

Self-assembly

Supported by the U.S. Army Research Office

Applications of supercritical fluid technology for bio systems

• In this project we proposeto apply supercritical fluidtechnology forvaporization and ionizationof biological aerosolswhich will not requirecollection on a substrate orprobe.

The basics of the process

Supercritical fluid screening system to be used inthe experimental part of the project

Investigating Fate, Transport, Transformation, and Exposure of

Engineered NanomaterialsTransport, Reactivity, Transformation, and Toxicity of

Lactate-Modified Nanoscale Iron Particles In Field Contaminated Soils

Environmental Applications of Nanotechnology –Annual Review of Nano Research, Vol.2, Chapter 2, 2008.

Structure of nZVI particles SEM image of nZVI particles

Molecular based study of condensed matter in small confined systems

Behavior of confined fluids in nanoslit pores: the normal pressure tensor Microfluidics and Nanofluidics, 8(1): pp.97-104,January 2010; DOI: 10.1007/s10404-009-0449-

BEHAVIOR OF THE CONFINED HARD-SPHERE FLUID WITHIN NANOSLITS: A FUNDAMENTAL-MEASURE DENSITY-FUNCTIONAL THEORY STUDY Int'l J of Nanoscience, 7(4-5): pp. 245-253, 2008; DOI: 10.1142/S0219581X08005365.

An Analytic Model for Nano Confined Fluids Phase-Transition: Applications for Confined Fluids in Nanotube and Nanoslit J. Comput'l & Theor'l Nanoscience, 3(1):134-141, 2006.

BioE 505: NanoBioTechnologywww.uic.edu/classes/bioe/bioe505

BioE 405: Atomic & Molecular Nanotechnologywww.uic.edu/classes/bioe/bioe405

3 OR 4 hours. Nanoscale structures and phenomena. Simulation methods for nano systems, and molecular assemblies. Molecular building blocks, scanning probe and atomic force microscopy, quantum mechanical phenomena. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Senior standing or above. Recommended background: Engineering or physical science major.

4 hours. Nanotechnology theory and applications in biology and medicine. Molecular simulations, combinatorial chemistry. Nanoscale structures, molecular building blocks, integrated nano-bio complexes. Positional and self-assembly, self-replication. Recommended background: Engineering or physical sciences

Our Nano and Nanobio Courses at UIC

Our Nanotechnology & Nanobiotechnology

Completed Projects

Nanotechnology books we have published

Nanotechnology books we have published

Thank you for your attention!

Copy of this presentation is at:www.uic.edu/labs/trl/UIC-NANO.pdf