lupus nephritis
Post on 07-May-2015
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Lupus Nephritis
RBC Casts
WHO Class I Lupus NephritisMinimal Mesangial
Immunoperoxidase staining shows C1q
WHO Class II
Immunoperoxidase stain: Mesangial IgG deposits
WHO Class II Lupus NephritisMesangial Proliferative
WHO Class III Lupus Nephritis(Focal Proliferative)
Hematoxylin/Lissamine Green Stain: ≤50% of the glomerular tuft involvementWith areas of focal necrosis
WHO Class III Lupus Nephritis
WHO Class III Lupus Nephritis
WHO Class IV Lupus NephritisDiffuse Proliferative
Immunoperoxidase Stain: ≥50% of the Glomerular Tuft involved
WHO Class IV Lupus Nephritis
H & E Stain: Diffuse increase in matrix and hypercellularity
WHO Class V Membranous
EM: Electron-dense immune deposits on the outer surface of BM, separated by“spikes” of exuberant BM-like material (mainly laminin)
WHO Class V Lupus Nephritis
Silver Methenamine Stain: Silver positive spikes along the peripheral capillary wall
WHO Class V Lupus Nephritis
WHO Class VI Lupus NephritisAdvanced Sclerosis
Hematoxylin/Lissamine Green Stain: Sclerosis of ≥90% of the glomerulus
WHO Class VI Lupus Nephritis
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