lupus nephritis

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Lupus Nephritis

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Page 1: Lupus Nephritis

Lupus Nephritis

Page 2: Lupus Nephritis
Page 3: Lupus Nephritis

RBC Casts

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WHO Class I Lupus NephritisMinimal Mesangial

Immunoperoxidase staining shows C1q

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WHO Class II

Immunoperoxidase stain: Mesangial IgG deposits

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WHO Class II Lupus NephritisMesangial Proliferative

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WHO Class III Lupus Nephritis(Focal Proliferative)

Hematoxylin/Lissamine Green Stain: ≤50% of the glomerular tuft involvementWith areas of focal necrosis

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WHO Class III Lupus Nephritis

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WHO Class III Lupus Nephritis

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WHO Class IV Lupus NephritisDiffuse Proliferative

Immunoperoxidase Stain: ≥50% of the Glomerular Tuft involved

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WHO Class IV Lupus Nephritis

H & E Stain: Diffuse increase in matrix and hypercellularity

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WHO Class V Membranous

EM: Electron-dense immune deposits on the outer surface of BM, separated by“spikes” of exuberant BM-like material (mainly laminin)

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WHO Class V Lupus Nephritis

Silver Methenamine Stain: Silver positive spikes along the peripheral capillary wall

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WHO Class V Lupus Nephritis

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WHO Class VI Lupus NephritisAdvanced Sclerosis

Hematoxylin/Lissamine Green Stain: Sclerosis of ≥90% of the glomerulus

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WHO Class VI Lupus Nephritis