introduction to methods in neuroscience

Figure 5.5 Metabolism of small-molecule and peptide transmitters (Part 2)

Methodologies

Chapter 4

Figure 12-45b Essential Cell Biology (© Garland Science 2010)

Microscopy

Bright field, 400xHematoxylin stained

Bright field, 1000xHematoxylin stained

Fluorescence, 1000xMitoTracker Orange

Fluorescence, 1000xActin-labeled

Fluorescence, 400xActin-labeled + Nucleus-labeled

Fluorescence, 1000xActin-labeled + Nucleus-labeled

Scanning ElectronMicroscope

http://commons.wikimedia.org/wiki/File:Hela_Cells_Image_3709-PH.jpg

Patch Clamping

Figure 10-35 Essential Cell Biology (© Garland Science 2010)

Gene Knockout

Reporter Genes

Figure 10-29a Essential Cell Biology (© Garland Science 2010)

Figure 10-30 Essential Cell Biology (© Garland Science 2010)

Transgenic Animals

Figure 10-36 (part 1 of 2) Essential Cell Biology (© Garland Science 2010)

Figure 10-36 (part 2 of 2) Essential Cell Biology (© Garland Science 2010)

Figure 10-37 Essential Cell Biology (© Garland Science 2010)

Brainbows:Transgenic Mice + Fluorescence Microscopy

Towards Connectomics:Electron Microscopy + Human and Computer Labor

Computed Tomography(CT or CAT Scan)

Positron Emission Tomography(PET Scan)

Magnetic Resonance Imaging (MRI)

Functional Magnetic Resonance Imaging (fMRI)

BOLD effect:Blood oxygenation level-dependent effect

ratio of oxygenated to deoxygenated hemoglobin

Transcranial Magnetic Stimulation (TMS)

fMRI+TMS