gynekologisk kreft i norge - legeforeningen...eggstokkreft 520 (66 år) 49% livmorkropp 702 (68 år)...

Eggstokkreft 520 (66 år) 49%

Livmorkropp 702 (68 år) 84%

Livmorhals 316 (45 år) 81%

Andre 139

Totalt 1677

Alle tilfeller kvinner 15443

Bryst 3589

Kreftregisteret 2017

GYNEKOLOGISK KREFT I NORGE

Endometrial cancer

• The most common gynecological

cancer in industrialised countries

• > 90 % of cases in women > 50 years

• 80 % of cases diagnosed in stage I

Endometrial hyperplasia

Type Premalignant

potential

(% cancer)

Simple < 5%

Komplex without

atypia

5 – 15%

Komplex with atypia ~ 30%

Postmenopausal bleeding - etiology

Factor % forekomst

Østrogen behandling 30

Atrofisk endometritt/vaginitt 30

Endometrie cancer 15

Endometrie hyperplasi 5

Endometrie/cervix polypp 10

Diverse (cx.cancer, uterussarkom,

urinveier, traume) 10

Cancer corp. uteri - pathology

• Endometroid adenocarcinoma (80%)

• Serous papillary carcinoma (5-10%)

• Clear cell carcinoma (3-5%)

• Carcinosarcoma (3-4 %)

• Mucinous carcinoma (< 3%)

• Squamous cell carcinoma (<1%)

• Leiomyosarcoma (58%)

• Endometrial stroma sarcoma (32%)

93%

7%

Endometriecancer

Risikogrupper

Lymphadenectomy in

endometrial cancerPRO

• Proper staging

according to FIGO

• Prognostication

• Triage for further therapy

after surgery

• Potential therapeutic

effect of

lymphadenectomy

CON

• Increased risk of per-

and post-operative

complications

• Time- and money-

consuming procedure

• Therapeutic effect

undocumented

3

1

8

Benedetti Panici 2008 Kitchener 2009

May 2010

6

Injection of dye into the cervix

at 9 and 3 o’clock

9

HE, 20 X CKAE1/AE3, 20 X12

Hereditary endometrial cancer

• HNPCC carriers + site specific form (?)

• 5-8% of all endometrial cancer

• ~ 50% life time risk for HNPCC carriers,

2nd. most frequent HNPCC cancer form

Aarnio et al. Int J Cancer 1999

• Stage- and grade distribution equal sporadic

• Screening plaucible: endom. biopsy + ultrasound