genome-based healthcare for the workplace
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Improving Health, Performance and Productivity
Personalised Genome-based Healthcare in the Workplace
Dr Paul Beaver - Director (Science), Co-founder
The Current Health Crisis
There are 3 trends that significantly
influence workplace health and
performance.
Influencing Workplace Health and Performance
Recent Australian Government data shows1
1) Life Expectancy:
Increasing but Health Expectancy decreasing.
Men - last 18.6 years and women - last 20.7 years with disabilities.
2) Obesity Epidemic:Australians overweight or obese68% of men (over 7.3 million ) & 55% of women (over 6.0 million)
3) Ageing Population:Baby Boomers
By 2020 approximately 20% of Australians will be over 65 years old
1 References available on request
The Current Health Crisis Influencing Workplace Health and Performance
1. Stress
2. Exercise- lack of
3. Food- quantity & quality
4. Smoking
5. Alcohol / drugs
6. Environmental factors- air, water
NOW the most important factor is:
7. Interaction of our genes with our lifestyle choices
Factors Contributing to Current Health Crisis
Importance of Gene and Environment/Lifestyle Interactions
The recent Federal Government report released in May 2009, titled
“Weighing it up – Obesity in Australia”, stated that:
1.Environmental and Lifestyle Factors
contribute about 30% to an individual’s body weight, and;
2. Genetics contributes the other 70%
(Similarly, research indicates the ratio for Heart Health is approx. 50 % and 50%.)
Personalised Genome-based Healthcare
Genetics in the Workplace*
Major technological advances in the last few decades have increased our knowledge of the role that genetics plays in occupational diseases
Combined with knowledge of other factors that contribute to occupational morbidity and mortality, genetic information will play an increasing role in preventing occupational disease.
Understanding the role of genetic factors and their interaction with environmental/occupational exposures is important in occupational health and could lead to further prevention and control efforts, the identification of novel therapeutic targets and educational strategies for better management of work-related diseases.
*Recent On-line article from the Centers for Disease Control and Prevention -National Institute for Occupational Health and Safety ,USA, http://www.cdc.gov/niosh/topics/genetics/ ,
Genetics in the Workplace
“In summary, the use of genetic information in the workplace has the potential to affect every worker in the United States.”
*Genetics in the Workplace - Implications for Occupational Safety and Health, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, NIOSH, 2010
Nutrigenetics and Nutrigenomics
Nutrigenetics
Nutrigenomics
Nutrigenomics – What is it?
Studies the interaction between our genes, diet and
lifestyle choices.
It’s true you can’t change your genes, HOWEVER,
you can compensate for their influence by making
the right nutritional, exercise and lifestyle choices.
Nutrigenomics+ =
The Fitgenes ‘Multi-disciplinary’ Convergence Approach
Exercise &Movement
Behavioural& Lifestyle Choices
Genetic Factors
Nutrition
CA Support Announced: “Healthy Solutions Win Backing”
On 29 June 2012, Commercialisation Australia (CA) announced
another $9 million in funding to support 24 new participants and
extend additional funds to two existing participants on the
program.
Commercialisation Australia
Where to From Here?
Our Vision
To help people maximise their potential
for
Healthy Living – Healthy Ageing©
> Disease
> Symptoms
Birth Death
Personalised, Strategic and Targeted Interventions
> Improve health expectancy and live disease free.
> Maximise health potential:
Genetic predispositions
Nutrition
Exercise
Lifestyle Choices
Stress Management
Health
Exp
ecta
ncy
Life E
xp
ecta
ncy
Goal: Avoid Poor Health:
?But how?
The Fitgenes Philosophy
TrGenotype
& Cell
Function
Gene Expression
Maximise your Potential forHealthy Living - Healthy Ageing
5) Optimise metabolism
7) Burn fat 1)Reduce Inflammation
6) Remove toxins (detox)
3) Improve circulation
4) Healthy nutrition
2) Redox Balance
Cell Health
Why Inflammation is the #1 Focus
15 Risk Factors for Heart Health
1. Genetic factors
2. Diabetes
3. Smoking
4. Hypertension
5. Lack of exercise
6. Depression/Lack of optimistic thinking
7. Obesity
8. Stress
9. Elevated cholesterol, triglycerides
10.Elevated Homocysteine
11.Lack of faith
12.Inadequate intake of fruits and
vegetables
13.C-Reactive Protein
14.Hypothyroid
15.Inadequate Omega-3
15 Risk Factors for Heart Health
1. Genetic factors ↑CRP
2. Diabetes ↑CRP
3. Smoking ↑CRP
4. Hypertension ↑CRP
5. Lack of exercise ↑CRP
6. Depression/Lack of optimistic
thinking ↑CRP
7. Obesity ↑CRP
8. Stress ↑CRP
9. Elevated cholesterol, triglycerides ↑CRP
10.Elevated Homocysteine ↑CRP
11.Lack of faith ↑CRP
12.Inadequate intake of fruits and
vegetables ↑CRP
13.C-Reactive Protein ↑CRP
14.Hypothyroid ↑CRP
15.Inadequate Omega-3 ↑CRP
Inflammation and Cardiovascular Disease:Is Abdominal Obesity the Missing Link?
TNFα
IL-6
↑ CRP
Atherogenic Insulin-Resistant “Dysmetabolic
Milieu” ↑ Risk of Coronary Syndrome
Adipose Tissue
CRP = C-reactive protein; IL-6 = interleukin 6; TNFα = tumor necrosis factor alphaAdapted from Després JP. Int J Obes Relat Metab Disord.2003;27:S22-S24,
?
Example
Personal Genetic Profile
Health Destiny(Health Potential + Pre-disposition to Risk)
Nutrition, Exercise & Lifestyle Assessment
Investigate Medical
Biomarkers
Health Pre-disposition(identify potential for
health or risk)
Family History
Recommend Personalised Gene-matched Nutrition, Exercise and Lifestyle
Interventions
Fitgenes Health Program - Overview
Fitgenes 12 Week Program OutlineProgram Item Baseline
Data Collection
Week 1
Week 4
Week 8
Week 12
Week 16
Next Phase of Treatment
DNA Profile Yes
Pathology Tests(Panel Options)
Yes Retest pathology
Initial Questionnaire
Yes
Review Questionnaire
Yes
Treatment Plan and Protocol
Yes
In-clinic anthropometric tests
Yes Yes Yes Yes
Program Summary Report
Yes
Clinic Appointment Yes 30 min
Yes 60 min
Yes 30 min
Yes 30 min
Yes 30 min
Yes 30 min
Weight Loss Case
Study: “Jenny”Practitioner - Sharon Palmer
> 6 years ago weighed 140 kgs.
> Has had significant weight loss in the past:- Lost 60 kg: regained- Lost 50 kg: regained
> Went to GP for weight loss:- Put onto Optifast Shakes: - 3 shakes per day- No food at all for 10 months
> GP also put on drugs to increase metabolism and suppress appetite:- Use for 3 months but couldn’t tolerate.- Caused anxiety and panic attacks.- Had also used T3, but also stopped this as didn’t like the
effect.
Jenny’s Weight Loss History
Jenny’s Rebound Weight Gain
> When stopped the Optifast shakes went back to being careful with diet.
> Regained 5 kgs per week, and ended back at starting weight.
> Was so unhappy she ‘wanted to die’.
– GP recommended a gastric bypass but Jenny didn’t want this.
– Decided to have a gastric sleeve. Done Feb 2007.
– Initially lost a lot of weight.
– Weight loss has now stopped and Jenny is beginning to gain weight
again.
– She is afraid she will gain all her weight back again.
Jenny DNA Fat Metabolism
Jenny’s Data Follow up Follow up
Date 14/9/11 16/1/12 8/3/12
Patient Actual AgeBiological Age
4861.54 H
4851.63 H
4846.73 Lost 14.81 yrsFirst time younger than actual age
Weight kg
85 kg 72 kg-13 kg totalNever been this weight
73.5 kg
Fat Mass:Difference from ideal
35.14 kg+15.43
24.93 kg+2.23 kgTotal loss -10.21kg
23.85-1.08Total loss-11.29kg
Muscle Mass:Difference from ideal
21.78 kg-4.97 kg
21.38 kg-0.04 kgTotal loss -0.40kg
23.85+2.47Total gain+2.07
IntraCellular Fluid %(Aim 50-60%)
42.02 L 45.72 L 48.23L
ExtraCellular Fluid %(Aim 40-50%)
57.98 H 54.28 H 51.77 H
Cellular Fluid Balance:(Ideal -20 to 0)
36.30 H 26.27 HBest reading
17.06Best reading
Waist (cm)Aim F <80 M <94
95 74Total loss of 21 cm
72Total loss of 23 cm
Inflammation decreasing Inflammation decreasing
.
“Doing my Fitgenes DNA profile
has helped me gain information
that has helped me on a
number of levels.”
Jenny B. 2012Firstly, I felt better about my previous struggles,
knowing there was an underlying genetic reason
for my obesity and yo-yo weight gains. I felt
better about the fact that it had a root cause. I
suppose I could have felt powerless to do much
about it but instead it energised me to fight
against it. …..
Testimonial February 2012
› Doing my Fitgenes DNA profile has helped me gain information that has helped me on a number of
levels.
› Firstly, I felt better about my previous struggles, knowing there was an underlying genetic reason for
my obesity and yoyo weight gains. I felt better about the fact that it had a root cause. I suppose I could
have felt powerless to do much about it but instead it energised me to fight against it. I am actually
proud of myself for losing weight. My genetic profile would indicate this is very difficult for me, and I am
prone to rebound weight gain.
› It also encourages me to fight harder to not allow myself to regain. I don’t think I can get away with
things anymore. Also, there was always a point in the past when I assumed I could eat normally. Now I
have much more information and it enables me to talk straight to myself.
› In food terms it has changed my whole way of eating. I found that I cannot tolerate a high intake of
saturated fats and my body is designed to store these. As a result, I do not generally eat meat or animal
fats like hard cheese. I love cheese and wine, I just don’t eat the cheese any more. (I am still working
on the wine). It makes it much easier to maintain my weight loss. There are times when I do eat them
but very rarely. The point is I can now make an informed choice.
› Overall, I would say that this is the best decision I have made as it has given me information that has
helped me make sense of my struggles and gives me tools to make decisions for the future. I just can’t
kid myself anymore as I know the truth!!!
Case Studies – High Blood Pressure
Client: A B C D Age (years) 50 34 50 54 Gender Male Male Male Male FT Program Start Date 24/02/2012 5/11/2011 23/11/2011 16/04/2010 FT Program Week # 1 5 1 9 1 12 1 6
Blood Pressure (BP) 155/99 1 130/85 130/80 2 120/65 183/84 3 117/77 190/110 140/80
Weight (Wt) Kg 106 101 124 108 - 4 - 82 76Change in Wt 5 14 6 Waist Circumf. (WC) cm 119 114 111 98 - - - - 5 13
Notes:1. BP had been at 172/119 before starting the program
2. BP had been at 158/100 before starting the program
3. BP had been at 213/110 before starting the program
4 Weight Management was not a health goal for this client as his % body fat was in the superfit range
Pracware
In Conclusion…
Personalised, genome-based
healthcare has an important role to
play in improving workplace:
> Health
> Performance
> Productivity
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