eye selectivity peaks in middle layers of poster print

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•  Functionaldataweremotion-anddistortion-correctedusingAFNI8.Distortion-matchedT1-weightedEPI(greenoverlay:GM)guidedthenonlinearwarpingoffunctionaltoanatomicaldata.

•  Regressionanalysis(GLM)assessedfMRIresponsemodulationfortwostimulusconditions(allLandallR)ineachvoxel.ControlGLMassessedresponsestoM-andP-targetedstimuli(collapsingacrossLandR).Voxelsnearpialvesselswereexcludedfromanalysis.•  GMinreferenceanatomywassegmentedusinganequivolume9solution.Eachfunctionalvoxelwasthenassignedadepth,anddepth-dependentfMRIprofileswereformedbyaveragingresponsein6bins.

•  Neuronsinprimaryvisualcortexaredrivenprimarilybyvisualinputfromeithertheleftortherighteye.Theseneuronsareorganizedinalternatingleft-rightstripesknownasoculardominancecolumns(ODCs).

•  Inmonkeys,oculardominanceisstrongestinmiddlecorticallayers1.Cellsarelessmonocularinsuperficialanddeeplayers1.

•  High-fieldfMRIcanrevealinformationaboutcorticalstructureonthescaleofcolumns2andlayers3.ODCshavebeendemonstratedinhumans2,4,5,6.

•  UsingGEEPI,weusedknowncytoarchitectureofODCsandeyeselectivitytotestthefidelityof7TfMRIinhumansubjects.

Participants.Sevenhealthyadults(2male,meanage=33±11years)participatedintwoscanningsessions.

Stimuli.Flickeringcheckerboardswerepresentedtoeitherleft(L)orright(R)eye.Thecheckerboardstargetedeitherparvocellular(P)pathways(0.5Hz,highspatialfrequency,chromaticisoluminant)ormagnocellular(M)pathways(12Hz,lowspatialfrequency,achromatic).Design.Fourstimulusconditions(L/RxM/P)repeated4timesineachscan,randomlyinterleaved.

Dataacquisition.•  7TSiemensscannerwithacustom-made32-channelreceive,4-channeltransmitheadcoil

•  GEEPIimagesat0.8mmisotropicresolution(TR/TE:2s/22.6ms;FOV=168x200mm;R=3;echospacing=1.01ms,6/8PartialFourier)

•  T1-weighedGEEPIsequences7wereobtainedineachsession.3Tstructuralscanswereacquiredseparately.

Eyeselectivitypeaksinmiddlelayersofhumanvisualcortex:Evidencefrom7TfMRIdata

KimberlyB.Weldon1,MarisaJ.Sanchez1,2,PhilipC.Burton1,3,andCherylA.Olman1,3

1CenterforMagneticResonanceResearch,UniversityofMinnesota;2DepartmentofPsychiatry,UniversityofMinnesota;3DepartmentofPsychology,UniversityofMinnesota

Contact:kweldon@umn.edu

Results

•  Columnarstructurewasevidentineye-selectivitymaps.•  EyeselectivityinV1wasenhancedinthemiddlelayers,butnotdeeporsuperficiallayers,comparedtoacontrolanalysisinV2.

•  Eyeselectivitywasweakerthanexpected;thiscanbeexplainedbyblurringinthedata.

•  IncreasedeyeselectivityindeeperGMwasnotanticipated.Controlanalysisofcolorselectivityindicatesitisnotanon-specifichemodynamicorpartialvolumingeffect.

Discussion

Introduction Analysis

1.  Hubel,D.H.,&Wiesel,T.N.(1968).Receptivefieldsandfunctionalarchitectureofmonkeystriatecortex.TheJournalofphysiology,195(1),215-243.2.  Nasr,S.,Polimeni,J.R.,&Tootell,R.B.(2016).Interdigitatedcolor-anddisparity-selectivecolumnswithinhumanvisualcorticalareasV2andV3.JournalofNeuroscience,36(6),1841-1857.3.  Olman,C.A.,Harel,N.,Feinberg,D.A.,He,S.,Zhang,P.,Ugurbil,K.,&Yacoub,E.(2012).Layer-specificfMRIreflectsdifferentneuronalcomputationsatdifferentdepthsinhumanV1.PloSone,7(3),

e32536.4.  Horton,J.C.,&Hedley-Whyte,E.T.(1984).Mappingofcytochromeoxidasepatchesandoculardominancecolumnsinhumanvisualcortex.PhilosophicalTransactionsoftheRoyalSocietyofLondon.B,

BiologicalSciences,304(1119),255-272.5.  Yacoub,E.,Shmuel,A.,Logothetis,N.,&Uğurbil,K.(2007).RobustdetectionofoculardominancecolumnsinhumansusingHahnSpinEchoBOLDfunctionalMRIat7Tesla.Neuroimage,37(4),1161-1177.6.  Cheng,K.,Waggoner,R.A.,&Tanaka,K.(2001).Humanoculardominancecolumnsasrevealedbyhigh-fieldfunctionalmagneticresonanceimaging.Neuron,32(2),359-374.7.  vanderZwaag,W.,Buur,P.F.,Fracasso,A.,vanDoesum,T.,Uludağ,K.,Versluis,M.J.,&Marques,J.P.(2018).Distortion-matchedT1mapsandunbiasedT1-weightedimagesasanatomicalreferencefor

high-resolutionfMRI.NeuroImage,176,41-55.8.  Cox,R.W.(1996).AFNI:softwareforanalysisandvisualizationoffunctionalmagneticresonanceneuroimages.ComputersandBiomedicalresearch,29(3),162-173.9.  Waehnert,M.D.,Dinse,J.,Weiss,M.,Streicher,M.N.,Waehnert,P.,Geyer,S.,...&Bazin,P.L.(2014).Anatomicallymotivatedmodelingofcorticallaminae.Neuroimage,93,210-220.

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Acknowledgements:NIHgrantsR01MH111447,R21EY025731,P41EB015894,P30NS076408,S10RR026783,WMKECKFoundation

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