enhancing myosin activation and cardiac contractility: implications for heart failure
Post on 23-Feb-2016
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Enhancing Myosin Activation and Cardiac Contractility: Implications for
Heart Failure
Heart Failure
Traditional Treatment for Acute Decompensated Heart Failure
Traditional Treatment for Acute Decompensated Heart Failure
(cont)
Traditional Treatment for Acute Decompensated Heart Failure
(cont)
Traditional Positive Inotropic Agents
Omecamtiv Mecarbil: A Novel Selective Cardiac Myosin
Activator
Omecamtiv Mecarbil
Omecamtiv Mecarbil: Echocardiogram Changes in
Healthy Volunteers
Omecamtiv Mecarbil: Echocardiographic Changes in Patients With Stable Heart Failure
and LV Dysfunction
ATOMIC-AHF: Study DesignRandomized, Double-blind, Placebo-controlled, Sequential
Cohort Study
ATOMIC-AHF-Primary End Point:Dyspnea Response
Paired Placebo
Safety Concerns
Supraventricular and Ventricular Tachyarrhythmias
COSMIC-HF: Chronic Oral Study of Myosin Activation to
Increase Contractility in Heart Failure
References
Abbreviations
Abbreviations (cont)
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