Enhancing Myosin Activation and Cardiac Contractility: Implications for

Heart Failure

Heart Failure

Traditional Treatment for Acute Decompensated Heart Failure

Traditional Treatment for Acute Decompensated Heart Failure

(cont)

Traditional Treatment for Acute Decompensated Heart Failure

(cont)

Traditional Positive Inotropic Agents

Omecamtiv Mecarbil: A Novel Selective Cardiac Myosin

Activator

Omecamtiv Mecarbil

Omecamtiv Mecarbil: Echocardiogram Changes in

Healthy Volunteers

Omecamtiv Mecarbil: Echocardiographic Changes in Patients With Stable Heart Failure

and LV Dysfunction

ATOMIC-AHF: Study DesignRandomized, Double-blind, Placebo-controlled, Sequential

Cohort Study

ATOMIC-AHF-Primary End Point:Dyspnea Response

Paired Placebo

Safety Concerns

Supraventricular and Ventricular Tachyarrhythmias

COSMIC-HF: Chronic Oral Study of Myosin Activation to

Increase Contractility in Heart Failure

References

Abbreviations

Abbreviations (cont)