cytarabine (arac) cytidine analogue all, aml. thioguanine guanine analogue aml watch...

cytarabine (araC)

Cytidine analogueALL, AML

thioguanineGuanine analogue

AMLWatch myelosuppression and GI perforation

cyclophosphamideAlkylating agent (binds DNA)

Autoimmune diseases, leukemias/lymphomasBeware hemorrhagic cystitis

vinblastinePrevents microtubule polymerization

Metastatic testicular cancer and lymphomaMarrow suppression is dose-limiting

dacarbazine

Alkylating agentHodgkin’s disease

irinotecan

Topoisomerase I inhibitorColorectal cancer

Beware life-threatening diarrhea

procarbazine

Alkylating agentHodgkin’s disease

5-FluoroUracil

Thymidylate synthase inhibitorBreast, GI, and skin cancer

(topical)

bleomycinBreaks DNA via oxidative intermediariesTesticular cancer and hodgkin’s disease

Pulmonary fibrosis is dose-limiting

mitomycin

Alkylating agentgastric and pancreatic cancer

capecitabine

Thymidylate synthase inhibitorMetastatic colorectal and breast

cancer

doxorubicin

Topoisomerase II inhibitorLeukemias and lymphomas

Watch heart failure

hydroxyureaInhibits ribonucleotide reductase

Hematologic malignancies, head & neck cancers, sickle cell (increases HbF)Watch out for secondary leukemia

carmustine

Alkylating agentBrain cancer

6-MercaptoPurineInhibitor of IMP dehydrogenase (purine construction)

ALL, AMLAllopurinol potentiates effectiveness and

pancreatic/marrow toxicity

azathioprineInhibitor of IMP dehydrogenase (purine

construction)Immunosuppression in renal transplants, RA

Allopurinol potentiates effectiveness and toxicity

etoposide

Topoisomerase II inhibitorTesticular and lung cancerWatch myelosuppression

altretamine

Alkylating agentOvarian cancer

thiopeta

Alkylating agentBladder cancer (instilled directly

into bladder)

vincristine

Prevents microtubule polymerizationLeukemias and Hodgkin’s disease

Peripheral neuropathy is dose-limiting

cladribine

Adenosine analogueHairy cell leukemia, MS

carboplatin

Cross-links guaninesGenitourinary & lung cancer

paclitaxel

Inhibits microtubule depolymerization

Ovarian and NSC lung cancer

topotecanTopoisomerase I inhibitor

Small cell lung cancer and cervical carcinomaBeware life-threatening diarrhea

cisplatinCross-links guanines

Genitourinary & lung cancerWatch nephrotoxicity; co-admin amifostine

docetaxel

Inhibits microtubule depolymerization

Breast and gastric cancer