cytarabine (arac) cytidine analogue all, aml. thioguanine guanine analogue aml watch...
TRANSCRIPT
cytarabine (araC)
Cytidine analogueALL, AML
thioguanineGuanine analogue
AMLWatch myelosuppression and GI perforation
cyclophosphamideAlkylating agent (binds DNA)
Autoimmune diseases, leukemias/lymphomasBeware hemorrhagic cystitis
vinblastinePrevents microtubule polymerization
Metastatic testicular cancer and lymphomaMarrow suppression is dose-limiting
dacarbazine
Alkylating agentHodgkin’s disease
irinotecan
Topoisomerase I inhibitorColorectal cancer
Beware life-threatening diarrhea
procarbazine
Alkylating agentHodgkin’s disease
5-FluoroUracil
Thymidylate synthase inhibitorBreast, GI, and skin cancer
(topical)
bleomycinBreaks DNA via oxidative intermediariesTesticular cancer and hodgkin’s disease
Pulmonary fibrosis is dose-limiting
mitomycin
Alkylating agentgastric and pancreatic cancer
capecitabine
Thymidylate synthase inhibitorMetastatic colorectal and breast
cancer
doxorubicin
Topoisomerase II inhibitorLeukemias and lymphomas
Watch heart failure
hydroxyureaInhibits ribonucleotide reductase
Hematologic malignancies, head & neck cancers, sickle cell (increases HbF)Watch out for secondary leukemia
carmustine
Alkylating agentBrain cancer
6-MercaptoPurineInhibitor of IMP dehydrogenase (purine construction)
ALL, AMLAllopurinol potentiates effectiveness and
pancreatic/marrow toxicity
azathioprineInhibitor of IMP dehydrogenase (purine
construction)Immunosuppression in renal transplants, RA
Allopurinol potentiates effectiveness and toxicity
etoposide
Topoisomerase II inhibitorTesticular and lung cancerWatch myelosuppression
altretamine
Alkylating agentOvarian cancer
thiopeta
Alkylating agentBladder cancer (instilled directly
into bladder)
vincristine
Prevents microtubule polymerizationLeukemias and Hodgkin’s disease
Peripheral neuropathy is dose-limiting
cladribine
Adenosine analogueHairy cell leukemia, MS
carboplatin
Cross-links guaninesGenitourinary & lung cancer
paclitaxel
Inhibits microtubule depolymerization
Ovarian and NSC lung cancer
topotecanTopoisomerase I inhibitor
Small cell lung cancer and cervical carcinomaBeware life-threatening diarrhea
cisplatinCross-links guanines
Genitourinary & lung cancerWatch nephrotoxicity; co-admin amifostine
docetaxel
Inhibits microtubule depolymerization
Breast and gastric cancer