cutaneous malignant melanoma

Cutaneous Malignant MelanomaCutaneous Malignant Melanoma

Surveillance, Epidemiology, and End Results Surveillance, Epidemiology, and End Results

(SEER) Program (www.seer.cancer.gov(SEER) Program (www.seer.cancer.gov))

M

F

Fears TR, Tucker MA.

J Natl Cancer Inst. 2005, 97:1789-90

Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS drmfpn@gwumc.edudrmfpn@gwumc.edu202-994-3970202-994-3970

Photobiology of Photobiology of melanomamelanoma

• Wavelengths Wavelengths responsible-UVA, responsible-UVA, UVB or both ? UVB or both ?

• Critical Critical UV-induced molecular UV-induced molecular alterationsalterations to melanocytes ? to melanocytes ?

• PigmentPigment- protective or - protective or promotional ?promotional ?

• Role of the Role of the immuneimmune system – UV system – UV effects on immunity?effects on immunity?

Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS

Melanoma induced by UV irradiation Melanoma induced by UV irradiation of HGF/SF transgenic miceof HGF/SF transgenic mice

Noonan et al., Nature, 2001; Recio et al, Cancer Res, 2002; in prep

Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS

Functional Mc1r is necessary for Functional Mc1r is necessary for UV-induced melanomaUV-induced melanoma

YELLOW

BLACK

BLACK

Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS

Neonatal host UV irradiation promotes melanoma outgrowth

Heather Poetschke-Klug et alHeather Poetschke-Klug et al Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS

AcknowledgementsAcknowledgements

• Photobiology lab, GWUMCPhotobiology lab, GWUMC– Ed De FaboEd De Fabo– J. Bahn; research assistants and studentsJ. Bahn; research assistants and students– Agnieszka Wolnicka-Glubisz; Stephanie Agnieszka Wolnicka-Glubisz; Stephanie

Constant; Jesse DamskerConstant; Jesse Damsker

• Glenn Merlino, NCI/NIHGlenn Merlino, NCI/NIH• Miriam Anver, SAIC, FCRFMiriam Anver, SAIC, FCRF• Funding- NCI/NIH; Elaine Snyder Funding- NCI/NIH; Elaine Snyder

Cancer Research Fund, GWUMCCancer Research Fund, GWUMC

Frances Noonan, EOH,SPHHSFrances Noonan, EOH,SPHHS