cardiovascular effects of anti-hyperglycemic therapy edoardo mannucci diabetes agency
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Cardiovascular effects of anti-hyperglycemic
therapy
Edoardo Mannucci
Diabetes AgencyCareggi teaching hospital,
Firenze, Italy
ADVANCE
MACE
CV mort.
Effects of intensified glycemic control on CV mortality
MYOCARDIAL ISCHEMIA
Adrenercic activation could have a negative impact on the
prognosis of
MACE
Secondary prevention of macrovascular events in patientswith type 2 diabetes:The PROACTIVE Study
Dormandy JA et al., Lancet 2005; 366: 1279
Relative risk SU vs other therapies
vs. Conventional
vs. Insulin
vs. Metformin
Mortality 0.96 1.03 1.53
MI 0.83 0.91 1.24
Stroke 1.19 1.40 2.12
Effect of SU on MACE
Monami M, Ganovese S, Mannucci E – 2013 [in press]
Effect of SU on mortality
Monami M, Ganovese S, Mannucci E – 2013 [in press]
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