accelerating clinical and translational research new bone growth substance for treatment of...
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ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
New Bone Growth Substance for Treatment ofOsteoporosis and Bone Fracture Healing
Hiroki Yokota, PhDBiomedical Engineering, IUPUI
Make bone strong!
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
rest/recoveryphosphorylated
eIF2eIF2
stress to endoplasmic
reticulum (ER)
damage/aging
oxidation
variousstress
sources
hypoxiaischemia
nutrientdeprivation
salubrinal
Rationale
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
salu
brin
al
pla
ceb
o
anterior surgical hole (day 20)
day
1 2 3 4 5 6 7 8 9 10 20
salubrinalinjection harvestharvest
surgery
anterior hole
posterior hole
salubrinalinjection
side
10 days 20 days
control salubrinal
2.0
0
ante
rio
r w
ou
nd
siz
e (m
m)
1.0
******1.0
0
0.5
10 days 20 days
*
**
po
ster
ior
cort
ical
th
ickn
ess
(mm
)
Rat Experiment
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Selection of vehicles (RISC support)
• Non toxic• Good solubility
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
diffusion
convection
circulation
subcutaneoustissue
blood
moleculartransport
molecularturnoverinjection
Pharmacokinetics
ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH
www.indianactsi.org
Acknowledgements
• Ping Zhang, IUSOM; Andy Chen, UCSD; Guofeng Wang, U. Pittsburg
• Matt Rubin, IURTC
• IU Kelly School of Business, Business of Life Sciences students
• DoD Congressionally Directed Medical Research Program
• Teresita Bellido, Anatomy & Cell Biology, IUSOM
• Munro Peacock, Endocrinology, IUSOM
• Jeffrey Anglen, Orthopedic Surgery, IUSOM
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