4/30/2008 dr. abdullah saleh 1 - hashemite university · pdf filepotassium tert-butoxide is an...

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E2 Mechanism

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• The E2 Reaction

• E2 reaction involves concerted removal of the proton, formation of the double bond, and

departure of the leaving group

• Both alkyl halide and base concentrations affect.

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E1 Mechanism

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• The E1 Reaction• The E1 reaction competes with the SN1 reaction and likewise

goes through a carbocation intermediate

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Potassium tert-butoxide is an extremely bulky

base and is routinely used to favor E2 reaction

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• If the base is small, SN2 competes strongly

because approach at carbon is unhindered

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END OF CHAPTER 6

Dr. Abdullah I. Saleh

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