4/30/2008 dr. abdullah saleh 1 - hashemite university · pdf filepotassium tert-butoxide is an...
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E2 Mechanism
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• The E2 Reaction
• E2 reaction involves concerted removal of the proton, formation of the double bond, and
departure of the leaving group
• Both alkyl halide and base concentrations affect.
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E1 Mechanism
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• The E1 Reaction• The E1 reaction competes with the SN1 reaction and likewise
goes through a carbocation intermediate
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Potassium tert-butoxide is an extremely bulky
base and is routinely used to favor E2 reaction
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• If the base is small, SN2 competes strongly
because approach at carbon is unhindered
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END OF CHAPTER 6
Dr. Abdullah I. Saleh
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