1 complement pathways - bio.umass.edu · 1 complement pathways complement activation proteins are...
Post on 18-Nov-2018
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Complement Pathways
Complement Activation
Proteins are normally inactive -need to be activated (or transient)
Activation - sequential proteolysis
Covalent Attachment - becomestably active after attaching tomicrobe (ab complexes)
Regulation! - important tominimize complement mediateddamage to host cells
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C1 Inhibitor Regulation
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Inhibition of C3 Convertase Formation
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Factor I mediated cleavage of C3b
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