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TAIWAN ADVENTIST HOSPITAL
VOL.15, NO.03 100 07
http://www.tahsda.org.tw/pharmacy/pharmacypaper/
Glypressin
Q & A
() /
1 Cravit IV solution 250mg
ICRA2 Levofloxacin
Antibacterials-Fluoroquinolones
/ levofloxacin
(:)
Cravit Inj.
500mg/100mL
2 Glypressin Inj. 1mg
IGLYP Terlipressin
Posterior pituitary hormones /
Sandostatin Inj
0.1mg/1mL
3 Sevikar 5/20mg OSEV Amlodipine 5mg +
Olmesartan Medoxomil 20mg
Antihypertensive agents,
combination-CCB + ARB /
4 Onglyza 5mg OONG Saxagliptin
Antidiabetic agents-DPP IV inhibitors/
5 Ultracet 37.5/375mg
OULT Tramadol HCl 37.5mg + Acetaminophen 375 mg
Analgesics-Opioids + Paracetamol /
Tramtor 50mg
6
Rotarix Oral Suspension 1.5ml/dose
LROT2 Human Rotavirus, Live Attenuated, RIX4414 Strain
Vaccines / (G1 G1 G2G3G4 G9)
Rotarix 1 mL
/dose
7 Vimax Foaming Solution 25mL
EVIM Clobetasol Propionate 0.05%
/
Corticosteroids-very potent (group IV) /
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8 Arteoptic 2% oph. sol 5mL
EART2 Carteolol Antiglaucoma preparations -Beta blockors /
9 Polyxal silicone gel 15G
YPOLY Polysiloxane /
1 Cravit Inj. 500mg/100mL ICRA Cravit Inj. 250ml/50mL
2 Sandostatin Inj 0.1mg/1mL ISAN1
3 Sesden 30mg OSES
4 Avandamet 2mg/500mg OAVA2
5 Tramtor 50mg OTRAM
6 Rotarix 1 mL/dose LROT2
7 Tri-Luma cream 3g ETRI3
8 TRI-LUMA cream 15 GM ETRI
9 Pilocarpine oph soln 1%, 15mL EPIL1
10 Vitamin C 200mg OVC
11 Phyto Soya 60's/box YPHY
12 Isoflavone 30's/box YISO 7
13 Angeliq 28's/pk OANG
1 Prednisolone Prednisolone 5mg DONISON 5mg ODON5
2 Metronidazole Metronidazole 500mg/100mL Anegyn Inj 500mg/100mL IANEG
3 Clindamycin Eudamycin Inj 300mg/2mL Clindamycin Inj 300mg/2mL ICLI
4 Progesterone Progeffik 100mg Utrogestan 100mg OUTR /
Besins Healthcare
(1) 2
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1 Clobetasol Dermovate cream 5gm Dermovate Oint 0.05% 5gm EDERO
2 Atenolol Tenormin 100mg Tenormin 50mg OTEN5
3 Fentanyl Fentanyl Inj 0.5mg/10mL Fentanyl Inj 0.1mg/2mL IFEN2 TFDA
(1) 2 Tenormin 100mg
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1. [ODIA6] DIAMICRON MR 60mg (Gliclazide)
[ODIA3] Diamicron MR 30mg
2. Augmentin Syrup 457mg/5ml
3. [IKCL4] 20 mEq KCl in 5% D/W 500mLTPN
MOSS
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Drugs acting on the nervous system
1.3.2.6 Carbamazepine100/8/1 1.
(1) carbamazepine IC HLA-B 1502 carbamazepine
(2) carbamazepine HLA-B 1502
2. 4 Steven-Johnson
3. carbamazepine
1.3.4.(91/11/193/2/195/9/196/9/197/7/1100/6/1)
1.() 2. levodopa dopamine agonistropinirolepramipexolepergolidelisuride rotigotine amantadine levodopa COMT entacapone Comtan film-coated tab.
3.() 4.() 5.() 6.Rotigotine Neupro Patch dopamine agonist (100/6/1)
1.4. Drugs used in anesthesia
1.4.1.Propofol(91/2/1100/7/1) 1.(100/7/1) 2. 72 3.
1.4.2.Cis-atracuriumatracurium(91/2/1100/7/1) 1.(100/7/1) 2. 72 3.
1.4.3.Vecuroniumrocuronium(91/2/1100/7/1) 1.
(100/7/1) (1) (2)
2. 72 3.
1.6.2.Botulinum toxin type A
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(98/5/1)
1.6.2.1.Botox (90/1/193/1/194/6/198/3/198/5/1100/8/1) 1.~3.() 4.93/1/194/6/198/3/1100/8/1
(1)() (2)(94/6/1100/8/1) (3)~(6)()
1.6.2.2.Dysport (91/2/193/1/194/6/198/3/198/5/1100/8/1) 1.~3.() 4.93/1/194/6/198/3/1100/8/1
(1)() (2)(94/6/1100/8/1) (3)~ (6) ()
Cardiovascular-renal drugs
2.1. Antithrombotic agents 2.1.1 Platelet aggregation inhibitors100/7/1
2.1.1.1.Acetyl salicylic acid (Aspirin) 89/2/1
2.1.1.2.Ticlopidine ( ticlopidine acetylsalicylic acid )
(87/4/188/9/190/1/1100/7/1) 1. 2. acetylsalicylic acid (Aspirin) (87/4/190/1/1
3. (stent) 87/4/190/1/1100/7/1) 2.1.1.3.Tirofiban ( Aggrastat)91/2/199/10/1100/7/1)
1. 2.
2.1.1.4.Abciximab ReoPro(90/7/1100/7/1) 1. 2.
2.1.5. 2.1.3.1. (100/7/1) 2.1.1.5.Cilostazol Pletaal(90/6/1100/7/1)
2.1.1.6.Clopidogrel Plavix(90/1/193/4/194/8/196/10/1100/7/1)
1. 2. 3.
2.1.1.7.Eptifibatide Integrilin95/8/1100/7/1 1. 2.
2.1.9.Fondaparinux Arixtra(100/4/1) 2.1.4.1.(100/7/1) 2.1.2. Thrombolytic drugs (100/7/1)
2.1.2.1.r-TPA Actilyse Injtenecteplase ( Metalyse)(91/12/1100/7/1)
1.~8. 2.1.2.2.r-TPA Actilyse Inj(93/1/1100/7/1)
1.~4. 2.1.2.3.Recombinant Human Activated Protein C Xigris(93/11/195/2/1100/7/1)
1.~2. 2.1.3. Heparin group
2.1.3.1.Tinzaparin Innohep90/7/191/9/1100/7/1) 1.~3.
2.1.4. Other antithrombotic agents(100/7/1) 2.1.4.1.Fondaparinux Arixtra(100/4/1100/7/1)
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2.2. Vasodilators
2.3. Vasoconstrictors
2.4. Agents used to treat urological disorders
2.5. Thrombolytic drugs 2.1.2. (100/7/1) 2.10. Antiarrhythmics100/8/1
2.10.1 Dronedarone ( Multaq) (100/8/1) 1.Multaq 6 (AF)
(AFL)sinus rhythm (1)70 AF(AFL) (2) 6570
50mm LVEF40
2.
Metabolic & nutrient agents 3.2.1.Mecobalamin (85/4/1100/8/1)
1. () 2. (NCV)
(chronic polyneuropathy)100/8/1 Hormones&drugs affecting hormonal mechanism
5.1. Drugs used in diabetes 5.1.1. Acarbose ( Glucobay)miglitol ( Diaban)86/1/187/4/189/6/191/7/198/12/1
5.1.2. Guar gum ( GuarinaGuarem ) 5.1.3 Exenatide ( Byetta)(100/5/1)
1. metformin / sulfonylurea
2. insulinDPP-4 sitagliptin 5.1.4.vildagliptin(100/8/1) sulphonylurea vildagliptin 50mg
Respiratory tract drugs
6.2.5.Montelukast sodium 4mg ( Singulair Chewable Tab. 4mgSingulair oral granules 4mg)(92/1/1100/7/1)
1. 2.Chewable Tab. 4mg ~oral granules 4mg 6 ~
3. 4.() 5. cromoglycate ketotifen
Immunologic agents
8.1. Vaccines and Immunoglobulins 8.1.2. TAT injTetanus Antitoxin
() T. toxoid cc
8.2. Immunomodulators
8.2.6. 8.2.6.1. Interferon alpha-2a Roferon-A interferon alpha-2b Intron A92/10/1;
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peginterferon alfa-2a Pegasys92/11/1-C (94/11/1-B )96/10/198/11/1(99/5/1-B 100/6/1-B )
1. B C B C (1) B .~. () IV. IIIIII
IIIIII Interferon alpha-2ainterferon alpha-2b peginterferon alfa-2a lamivudine( Zeffix tablets 100mg) entecavir 0.5mgtelbivudine 600mg tenofovir 300mg 12~36 lamivudine( Zeffix tablets 100mg) entecavir 0.5mgtelbivudine 600mg tenofovir 300mg 12~36 98/11/199/5/1100/6/1
V. 10.7.3 3 5 3 6 IIIIII interferon alpha-2a interferon alpha-2b peginterferon alfa-2a lamivudine ( Zeffix tablets 100mg) entecavir 0.5mg telbivudine 600mg tenofovir 300mg 12~36 lamivudine( Zeffix tablets 100mg) entecavir 0.5mgtelbivudine 600mg tenofovir 300mg 12~36 98/11/1100/6/1
(2) C : ()
Antineoplastic drugs 9.16. Topotecan Hycamtin88/10/193/8/198/11/1100/6/1
9.16.1 Topotecan 88/10/193/8/198/11/1 1. 2. cisplatin IV-B 98/11/1
9.16.2 Topotecan 100/6/1
9.24.Gefitinib ( Iressa): (93/11/196/8/196/11/1100/6/1)
1. (1) EGFR-TK (B )
(100/6/1) (2) 70 ()
(96/11/1100/6/1) (2) platinum docetaxel paclitaxel
()(100/6/1) 2.
(1) EGFR-TK (100/6/1)
(2) 70 () X measurableevaluable(96/11/1100/6/1)
(2)
platinumcisplatin carboplatin taxanespaclitaxel docetaxel X measurableevaluable ()(100/6/1)
(3) X X
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3. 4. erlotinib ( Tarceva) (96/8/1) 5. erlotinib ( Tarceva)
(96/8/1) () (100/6/1) 1
70 ()(96/11/1) () (100/6/1)
2() (100/6/1)
9.37. Bevacizumab ( Avastin)100/6/1
1.Bevacizumab irinotecan/ 5-fluorouracil/ leucovorin 5-fluorouracil/ leucovorin
2. 12 24
Antimicrobial agents
10.7. Antiviral drugs 10.7.1.
10.7.1.1. 1. Acyclovir(98/11/1100/7/1)
(1) VI
S2 ( 38) ()
85/1/1 (acute retina necrosis) 3 5
(86/1/187/4/1) acyclovir 87/11/1
A. B. (TBI) 30
(2) acyclovir 14 21 95/6/1100/7/1
2. Famciclovirvalaciclovir(100/7/1)
(1) VI (2) S2 (3) (4) (5) (acute retina necrosis) (6) 3 5
(7) acyclovir
A. B. (TBI) 30
3. AcyclovirFamciclovir valaciclovirt 1095/6/1100/7/1
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10.7.1.2. Acyclovir tromantadine (97/12/198/11/1100/7/1
1.() 3 acyclovir tromantadine 5 (100/7/1
2.
10.7.3 Lamivudine ( Zeffix tablets 100mg)entecavir 0.5mg ( Baraclude)telbivudine 600mg ( Sebivo)tenofovir 300mg ( Viread)92/10/193/2/193/8/194/10/195/10/195/11/197/8/198/11/199/5/199/7/1100/6/1)
B C B 1.HBsAg (+) 98/11/1
(1) lamivudine( Zeffix tablets 100mg)entecavir 0.5mg telbivudine 600mg tenofovir 300mg 12~36 98/11/1100/6/1
(2) () 2.~6.()
10.8. Miscellaneous
10.8.3.Linezolid ( Zyvox Injection Tablets)(91/4/1100/7/1) 1.
(1) MRSA (methicillin-resistant staphylococcus aureus) vancomycin vancomycinteicoplanin vancomycinteicoplanin
(2) VRE (vancomycin- resistant enterococci) (3)
2.(osteomyelitis)(endocarditis) 3.
10.8.5. Tigecycline Tygacil (95/12/1100/7/1)
1. (1)
tigecycline (sensitivity)
(2)(100/7/1)
2.
Ophthalmic preparations 14.9. Miscellaneous
14.9.3 Cyclosporine ( Restasis) (100/08/1) Level 4 1. Schirmers test without anesthsia
2mm/5min 2.Tear Film Break-Up Time immediate 3.
4. 5.0.6 6.
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100/04/08
benzocaine
(FDA)benzocaine
(methemoglobinemia)
2
FDA
2 (
)FDA
100/04/15
Orlistat
953orlistat
orlistat 9
100/06/01 (tumor
necrosis factorTNF)
B
(hepatitis B virusHBV)
TNF HBV
HBV
TNF HBV
HBV
TNF
HBV HBV
100/06/17
pioglitazone
FDA pioglitazone
FDA
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10
pioglitazone
1
100/06/28
nimesulide
EMAEuropean Medicines Agency
nimesulide
EMAnimesulide
96
9718nimeslide
15
nimesulide
COX-2NSAIDs
4
100/06/28
Champix
FDA varenicline
FDA
MOSS ()
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98-100 (Adverse Drug Reactions, ADR)
98 99 100
ADR () 93 95 65
29% ~ 43 % 38% ~ 47%
ADR 68% ~ 84%
NSAIDs Diclofenac Ketorolac
2 Diclofenac
aspirin
()(anaphylactic-like reaction)
(1) (2)
(3)
100 NSAIDs
100 ADR Aspirin NSAIDs Pyrine
Ketorolac () 9 3 4 2
Diclofenac () 13 3 4 2
NSAIDs
ADR
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1990 Felodipine (Plendil) 1
2
(bioavailability) ampicillin itraconazole ampicillin itraconazole
3
Ampicillin
Isoniazid
Azithromycin
Erythromycin
Isotretinoin
Itraconazole
Levodopa
Phenytoin
Digoxin
(bran fiber)
digoxin
Alendronate
Clodronate
Alendronate
Tetracycline
Ciprofloxacin
Levofloxacin
CYP450 4
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3
Atorvastatin
Simvastatin
Atorvastatin
Simvastatin
Rosuvastatin
HMG-CoA reductase
inhibitors
Acitretin
etretinate
Amiodarone
N-DEA amiodarone
50%
CCBs (Nifedipine
Verapamil)
nifedipine
CCBs (Nifedipine
Nimodipine
Felodipine )
Benzodiazepines
Colchicine
colchicine
Colchicine colchicine
Metronidazole
Selegiline
Linezolid
( MAOI )
(tyramine)
MAOI
3, 5
Atorvastatin
Simvastatin
Rosuvastatin
HMG-CoA
reductase inhibitors
WarfarinClopidogrel
NSAIDs
Sulfonylurea
Warfarin K warfarin
K
INR
Warfarin Q-10
warfarin
Warfarin warfarin
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Warfarin omega-3
warfarin
ACEIARB
()
Theophyllin
Aminophylline
( caffeine)
Caffeine
caffeine
BupropionSSRISNRI
()
Benzodiazepines
Atomoxetine
( caffeine)
JCAHO (1) (2) (3) (4) (5)
(6) 6
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1. Bailey DG, Malcolm J, Arnold O & Spence JD. Grapefruit juice-drug interactions. Br J Clin
Pharmacol 1998;46(2): 101-110.
2. Schmidt LE & Dalhoff K. Food-Drug Interactions. Drugs 2002;62(10): 1481-1502.
3. Lexi-Comp Online Interaction Monograph.
4. Sorrensen JM. HerbDrug, FoodDrug, NutrientDrug, and DrugDrug Interactions:
Mechanisms Involved and Their Medical Implications. The Journal of Alternative and
Complementary Medicine. 2002;8(3): 293 - 308.
5. (http://www.fda.gov.tw/content.aspx?site_content_sn=1849 )
6. Gauthier I & Malone M. Drug-Food Interactions in Hospitalised Patients: Methods of
Prevention. Drug Safety. 1998;18(6): 383-393.
7. Leibovitch ER, Deamer RL & Sanderson LA. Food Drug Interactions: Careful drug selection
and patient counseling can reduce the risk in older patients. Geriatrics. 2004;59 (3):19.
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Glypressin ()
11 1 terlipressin acetate 0.86 terlipressin D-Mannitol hydrochloric acid 5 water for injectionsodium chloride hydrochloric acid pH
GlypressinGlypressin Glypressin
4 2mg 48 50 1mg 4 1mg 3 5 24 3-4mg 3 4 3 Glypressin Glypressin 130mole/L 30 10
- - - - - - - - 70 -
Terlipressin - 40ml/min 130mole/L - 500 1000 - 1.5L 60-80 albumin 130mole/L 40ml/min - 0.5g/ml
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- - - - - - - 5-10 terlipressin
Glypressin clonidine 150g -
Q & A
Q.
A. 1. Adrenaline (Epinephrine, Bosmin)
adrenaline
2. Sodium bicarbonate (Jusomine)
3. 3 NaCl (hypertonic saline)
4. Ipratropium bromide (Atrovent)
5. Terbutaline sulfate (Bricanyl)beta 2 agonist
6. 0.45 saline
7. Steroid
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