1

TAIWAN ADVENTIST HOSPITAL

VOL.15, NO.03 100 07

http://www.tahsda.org.tw/pharmacy/pharmacypaper/

Glypressin

Q & A

() /

1 Cravit IV solution 250mg

ICRA2 Levofloxacin

Antibacterials-Fluoroquinolones

/ levofloxacin

(:)

Cravit Inj.

500mg/100mL

2 Glypressin Inj. 1mg

IGLYP Terlipressin

Posterior pituitary hormones /

Sandostatin Inj

0.1mg/1mL

3 Sevikar 5/20mg OSEV Amlodipine 5mg +

Olmesartan Medoxomil 20mg

Antihypertensive agents,

combination-CCB + ARB /

4 Onglyza 5mg OONG Saxagliptin

Antidiabetic agents-DPP IV inhibitors/

5 Ultracet 37.5/375mg

OULT Tramadol HCl 37.5mg + Acetaminophen 375 mg

Analgesics-Opioids + Paracetamol /

Tramtor 50mg

6

Rotarix Oral Suspension 1.5ml/dose

LROT2 Human Rotavirus, Live Attenuated, RIX4414 Strain

Vaccines / (G1 G1 G2G3G4 G9)

Rotarix 1 mL

/dose

7 Vimax Foaming Solution 25mL

EVIM Clobetasol Propionate 0.05%

/

Corticosteroids-very potent (group IV) /

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2

8 Arteoptic 2% oph. sol 5mL

EART2 Carteolol Antiglaucoma preparations -Beta blockors /

9 Polyxal silicone gel 15G

YPOLY Polysiloxane /

1 Cravit Inj. 500mg/100mL ICRA Cravit Inj. 250ml/50mL

2 Sandostatin Inj 0.1mg/1mL ISAN1

3 Sesden 30mg OSES

4 Avandamet 2mg/500mg OAVA2

5 Tramtor 50mg OTRAM

6 Rotarix 1 mL/dose LROT2

7 Tri-Luma cream 3g ETRI3

8 TRI-LUMA cream 15 GM ETRI

9 Pilocarpine oph soln 1%, 15mL EPIL1

10 Vitamin C 200mg OVC

11 Phyto Soya 60's/box YPHY

12 Isoflavone 30's/box YISO 7

13 Angeliq 28's/pk OANG

1 Prednisolone Prednisolone 5mg DONISON 5mg ODON5

2 Metronidazole Metronidazole 500mg/100mL Anegyn Inj 500mg/100mL IANEG

3 Clindamycin Eudamycin Inj 300mg/2mL Clindamycin Inj 300mg/2mL ICLI

4 Progesterone Progeffik 100mg Utrogestan 100mg OUTR /

Besins Healthcare

(1) 2

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1 Clobetasol Dermovate cream 5gm Dermovate Oint 0.05% 5gm EDERO

2 Atenolol Tenormin 100mg Tenormin 50mg OTEN5

3 Fentanyl Fentanyl Inj 0.5mg/10mL Fentanyl Inj 0.1mg/2mL IFEN2 TFDA

(1) 2 Tenormin 100mg

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3

1. [ODIA6] DIAMICRON MR 60mg (Gliclazide)

[ODIA3] Diamicron MR 30mg

2. Augmentin Syrup 457mg/5ml

3. [IKCL4] 20 mEq KCl in 5% D/W 500mLTPN

MOSS

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Drugs acting on the nervous system

1.3.2.6 Carbamazepine100/8/1 1.

(1) carbamazepine IC HLA-B 1502 carbamazepine

(2) carbamazepine HLA-B 1502

2. 4 Steven-Johnson

3. carbamazepine

1.3.4.(91/11/193/2/195/9/196/9/197/7/1100/6/1)

1.() 2. levodopa dopamine agonistropinirolepramipexolepergolidelisuride rotigotine amantadine levodopa COMT entacapone Comtan film-coated tab.

3.() 4.() 5.() 6.Rotigotine Neupro Patch dopamine agonist (100/6/1)

1.4. Drugs used in anesthesia

1.4.1.Propofol(91/2/1100/7/1) 1.(100/7/1) 2. 72 3.

1.4.2.Cis-atracuriumatracurium(91/2/1100/7/1) 1.(100/7/1) 2. 72 3.

1.4.3.Vecuroniumrocuronium(91/2/1100/7/1) 1.

(100/7/1) (1) (2)

2. 72 3.

1.6.2.Botulinum toxin type A

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(98/5/1)

1.6.2.1.Botox (90/1/193/1/194/6/198/3/198/5/1100/8/1) 1.~3.() 4.93/1/194/6/198/3/1100/8/1

(1)() (2)(94/6/1100/8/1) (3)~(6)()

1.6.2.2.Dysport (91/2/193/1/194/6/198/3/198/5/1100/8/1) 1.~3.() 4.93/1/194/6/198/3/1100/8/1

(1)() (2)(94/6/1100/8/1) (3)~ (6) ()

Cardiovascular-renal drugs

2.1. Antithrombotic agents 2.1.1 Platelet aggregation inhibitors100/7/1

2.1.1.1.Acetyl salicylic acid (Aspirin) 89/2/1

2.1.1.2.Ticlopidine ( ticlopidine acetylsalicylic acid )

(87/4/188/9/190/1/1100/7/1) 1. 2. acetylsalicylic acid (Aspirin) (87/4/190/1/1

3. (stent) 87/4/190/1/1100/7/1) 2.1.1.3.Tirofiban ( Aggrastat)91/2/199/10/1100/7/1)

1. 2.

2.1.1.4.Abciximab ReoPro(90/7/1100/7/1) 1. 2.

2.1.5. 2.1.3.1. (100/7/1) 2.1.1.5.Cilostazol Pletaal(90/6/1100/7/1)

2.1.1.6.Clopidogrel Plavix(90/1/193/4/194/8/196/10/1100/7/1)

1. 2. 3.

2.1.1.7.Eptifibatide Integrilin95/8/1100/7/1 1. 2.

2.1.9.Fondaparinux Arixtra(100/4/1) 2.1.4.1.(100/7/1) 2.1.2. Thrombolytic drugs (100/7/1)

2.1.2.1.r-TPA Actilyse Injtenecteplase ( Metalyse)(91/12/1100/7/1)

1.~8. 2.1.2.2.r-TPA Actilyse Inj(93/1/1100/7/1)

1.~4. 2.1.2.3.Recombinant Human Activated Protein C Xigris(93/11/195/2/1100/7/1)

1.~2. 2.1.3. Heparin group

2.1.3.1.Tinzaparin Innohep90/7/191/9/1100/7/1) 1.~3.

2.1.4. Other antithrombotic agents(100/7/1) 2.1.4.1.Fondaparinux Arixtra(100/4/1100/7/1)

5

2.2. Vasodilators

2.3. Vasoconstrictors

2.4. Agents used to treat urological disorders

2.5. Thrombolytic drugs 2.1.2. (100/7/1) 2.10. Antiarrhythmics100/8/1

2.10.1 Dronedarone ( Multaq) (100/8/1) 1.Multaq 6 (AF)

(AFL)sinus rhythm (1)70 AF(AFL) (2) 6570

50mm LVEF40

2.

Metabolic & nutrient agents 3.2.1.Mecobalamin (85/4/1100/8/1)

1. () 2. (NCV)

(chronic polyneuropathy)100/8/1 Hormones&drugs affecting hormonal mechanism

5.1. Drugs used in diabetes 5.1.1. Acarbose ( Glucobay)miglitol ( Diaban)86/1/187/4/189/6/191/7/198/12/1

5.1.2. Guar gum ( GuarinaGuarem ) 5.1.3 Exenatide ( Byetta)(100/5/1)

1. metformin / sulfonylurea

2. insulinDPP-4 sitagliptin 5.1.4.vildagliptin(100/8/1) sulphonylurea vildagliptin 50mg

Respiratory tract drugs

6.2.5.Montelukast sodium 4mg ( Singulair Chewable Tab. 4mgSingulair oral granules 4mg)(92/1/1100/7/1)

1. 2.Chewable Tab. 4mg ~oral granules 4mg 6 ~

3. 4.() 5. cromoglycate ketotifen

Immunologic agents

8.1. Vaccines and Immunoglobulins 8.1.2. TAT injTetanus Antitoxin

() T. toxoid cc

8.2. Immunomodulators

8.2.6. 8.2.6.1. Interferon alpha-2a Roferon-A interferon alpha-2b Intron A92/10/1;

6

peginterferon alfa-2a Pegasys92/11/1-C (94/11/1-B )96/10/198/11/1(99/5/1-B 100/6/1-B )

1. B C B C (1) B .~. () IV. IIIIII

IIIIII Interferon alpha-2ainterferon alpha-2b peginterferon alfa-2a lamivudine( Zeffix tablets 100mg) entecavir 0.5mgtelbivudine 600mg tenofovir 300mg 12~36 lamivudine( Zeffix tablets 100mg) entecavir 0.5mgtelbivudine 600mg tenofovir 300mg 12~36 98/11/199/5/1100/6/1

V. 10.7.3 3 5 3 6 IIIIII interferon alpha-2a interferon alpha-2b peginterferon alfa-2a lamivudine ( Zeffix tablets 100mg) entecavir 0.5mg telbivudine 600mg tenofovir 300mg 12~36 lamivudine( Zeffix tablets 100mg) entecavir 0.5mgtelbivudine 600mg tenofovir 300mg 12~36 98/11/1100/6/1

(2) C : ()

Antineoplastic drugs 9.16. Topotecan Hycamtin88/10/193/8/198/11/1100/6/1

9.16.1 Topotecan 88/10/193/8/198/11/1 1. 2. cisplatin IV-B 98/11/1

9.16.2 Topotecan 100/6/1

9.24.Gefitinib ( Iressa): (93/11/196/8/196/11/1100/6/1)

1. (1) EGFR-TK (B )

(100/6/1) (2) 70 ()

(96/11/1100/6/1) (2) platinum docetaxel paclitaxel

()(100/6/1) 2.

(1) EGFR-TK (100/6/1)

(2) 70 () X measurableevaluable(96/11/1100/6/1)

(2)

platinumcisplatin carboplatin taxanespaclitaxel docetaxel X measurableevaluable ()(100/6/1)

(3) X X

7

3. 4. erlotinib ( Tarceva) (96/8/1) 5. erlotinib ( Tarceva)

(96/8/1) () (100/6/1) 1

70 ()(96/11/1) () (100/6/1)

2() (100/6/1)

9.37. Bevacizumab ( Avastin)100/6/1

1.Bevacizumab irinotecan/ 5-fluorouracil/ leucovorin 5-fluorouracil/ leucovorin

2. 12 24

Antimicrobial agents

10.7. Antiviral drugs 10.7.1.

10.7.1.1. 1. Acyclovir(98/11/1100/7/1)

(1) VI

S2 ( 38) ()

85/1/1 (acute retina necrosis) 3 5

(86/1/187/4/1) acyclovir 87/11/1

A. B. (TBI) 30

(2) acyclovir 14 21 95/6/1100/7/1

2. Famciclovirvalaciclovir(100/7/1)

(1) VI (2) S2 (3) (4) (5) (acute retina necrosis) (6) 3 5

(7) acyclovir

A. B. (TBI) 30

3. AcyclovirFamciclovir valaciclovirt 1095/6/1100/7/1

8

10.7.1.2. Acyclovir tromantadine (97/12/198/11/1100/7/1

1.() 3 acyclovir tromantadine 5 (100/7/1

2.

10.7.3 Lamivudine ( Zeffix tablets 100mg)entecavir 0.5mg ( Baraclude)telbivudine 600mg ( Sebivo)tenofovir 300mg ( Viread)92/10/193/2/193/8/194/10/195/10/195/11/197/8/198/11/199/5/199/7/1100/6/1)

B C B 1.HBsAg (+) 98/11/1

(1) lamivudine( Zeffix tablets 100mg)entecavir 0.5mg telbivudine 600mg tenofovir 300mg 12~36 98/11/1100/6/1

(2) () 2.~6.()

10.8. Miscellaneous

10.8.3.Linezolid ( Zyvox Injection Tablets)(91/4/1100/7/1) 1.

(1) MRSA (methicillin-resistant staphylococcus aureus) vancomycin vancomycinteicoplanin vancomycinteicoplanin

(2) VRE (vancomycin- resistant enterococci) (3)

2.(osteomyelitis)(endocarditis) 3.

10.8.5. Tigecycline Tygacil (95/12/1100/7/1)

1. (1)

tigecycline (sensitivity)

(2)(100/7/1)

2.

Ophthalmic preparations 14.9. Miscellaneous

14.9.3 Cyclosporine ( Restasis) (100/08/1) Level 4 1. Schirmers test without anesthsia

2mm/5min 2.Tear Film Break-Up Time immediate 3.

4. 5.0.6 6.

9

100/04/08

benzocaine

(FDA)benzocaine

(methemoglobinemia)

2

FDA

2 (

)FDA

100/04/15

Orlistat

953orlistat

orlistat 9

100/06/01 (tumor

necrosis factorTNF)

B

(hepatitis B virusHBV)

TNF HBV

HBV

TNF HBV

HBV

TNF

HBV HBV

100/06/17

pioglitazone

FDA pioglitazone

FDA

10

pioglitazone

1

100/06/28

nimesulide

EMAEuropean Medicines Agency

nimesulide

EMAnimesulide

96

9718nimeslide

15

nimesulide

COX-2NSAIDs

4

100/06/28

Champix

FDA varenicline

FDA

MOSS ()

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11

98-100 (Adverse Drug Reactions, ADR)

98 99 100

ADR () 93 95 65

29% ~ 43 % 38% ~ 47%

ADR 68% ~ 84%

NSAIDs Diclofenac Ketorolac

2 Diclofenac

aspirin

()(anaphylactic-like reaction)

(1) (2)

(3)

100 NSAIDs

100 ADR Aspirin NSAIDs Pyrine

Ketorolac () 9 3 4 2

Diclofenac () 13 3 4 2

NSAIDs

ADR

12

1990 Felodipine (Plendil) 1

2

(bioavailability) ampicillin itraconazole ampicillin itraconazole

3

Ampicillin

Isoniazid

Azithromycin

Erythromycin

Isotretinoin

Itraconazole

Levodopa

Phenytoin

Digoxin

(bran fiber)

digoxin

Alendronate

Clodronate

Alendronate

Tetracycline

Ciprofloxacin

Levofloxacin

CYP450 4

13

3

Atorvastatin

Simvastatin

Atorvastatin

Simvastatin

Rosuvastatin

HMG-CoA reductase

inhibitors

Acitretin

etretinate

Amiodarone

N-DEA amiodarone

50%

CCBs (Nifedipine

Verapamil)

nifedipine

CCBs (Nifedipine

Nimodipine

Felodipine )

Benzodiazepines

Colchicine

colchicine

Colchicine colchicine

Metronidazole

Selegiline

Linezolid

( MAOI )

(tyramine)

MAOI

3, 5

Atorvastatin

Simvastatin

Rosuvastatin

HMG-CoA

reductase inhibitors

WarfarinClopidogrel

NSAIDs

Sulfonylurea

Warfarin K warfarin

K

INR

Warfarin Q-10

warfarin

Warfarin warfarin

14

Warfarin omega-3

warfarin

ACEIARB

()

Theophyllin

Aminophylline

( caffeine)

Caffeine

caffeine

BupropionSSRISNRI

()

Benzodiazepines

Atomoxetine

( caffeine)

JCAHO (1) (2) (3) (4) (5)

(6) 6

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1. Bailey DG, Malcolm J, Arnold O & Spence JD. Grapefruit juice-drug interactions. Br J Clin

Pharmacol 1998;46(2): 101-110.

2. Schmidt LE & Dalhoff K. Food-Drug Interactions. Drugs 2002;62(10): 1481-1502.

3. Lexi-Comp Online Interaction Monograph.

4. Sorrensen JM. HerbDrug, FoodDrug, NutrientDrug, and DrugDrug Interactions:

Mechanisms Involved and Their Medical Implications. The Journal of Alternative and

Complementary Medicine. 2002;8(3): 293 - 308.

5. (http://www.fda.gov.tw/content.aspx?site_content_sn=1849 )

6. Gauthier I & Malone M. Drug-Food Interactions in Hospitalised Patients: Methods of

Prevention. Drug Safety. 1998;18(6): 383-393.

7. Leibovitch ER, Deamer RL & Sanderson LA. Food Drug Interactions: Careful drug selection

and patient counseling can reduce the risk in older patients. Geriatrics. 2004;59 (3):19.

15

Glypressin ()

11 1 terlipressin acetate 0.86 terlipressin D-Mannitol hydrochloric acid 5 water for injectionsodium chloride hydrochloric acid pH

GlypressinGlypressin Glypressin

4 2mg 48 50 1mg 4 1mg 3 5 24 3-4mg 3 4 3 Glypressin Glypressin 130mole/L 30 10

- - - - - - - - 70 -

Terlipressin - 40ml/min 130mole/L - 500 1000 - 1.5L 60-80 albumin 130mole/L 40ml/min - 0.5g/ml

16

- - - - - - - 5-10 terlipressin

Glypressin clonidine 150g -

Q & A

Q.

A. 1. Adrenaline (Epinephrine, Bosmin)

adrenaline

2. Sodium bicarbonate (Jusomine)

3. 3 NaCl (hypertonic saline)

4. Ipratropium bromide (Atrovent)

5. Terbutaline sulfate (Bricanyl)beta 2 agonist

6. 0.45 saline

7. Steroid