american institute for medical and biological …department of cell biology, the scripps research...

Curriculum Vitae, Gaudenz Danuser, Ph.D. July 18 UT Southwestern Medical Center

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INFORMATION GAUDENZ DANUSER Departments of Bioinformatics and Cell Biology UT Southwestern Medical Center Dallas, TX [email protected]

CURRENT POSITIONS 07/2013 – present Patrick E. Haggerty Distinguished Chair in Basic Biomedical Science

CPRIT Scholar for Cancer Research UT Southwestern Medical Center, Dallas, TX.

09/2015 – present Inaugural Chairman, Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX.

ACADEMIC DEGREES AND EDUCATION 07/1997 Ph.D. in Electrical Engineering (Dr. Sc.Techn), ETH Zurich, Switzerland

Mentor: Prof. Dr. Olaf Kuebler 01/1994 – 07/1997 Graduate studies in Electrical Engineering and Computer Science, ETH

Zurich, Switzerland 04/1995 – 07/1996 Company Start-up and Management, ETH Zurich, Switzerland. 03/1993 Diploma (equivalent to M.Sc.) in Measurement Engineering Sciences (Dipl.

Verm.-Ing.), ETH Zurich, Switzerland Mentor: Prof. Dr. Hans-Gert Kahle

10/1988 – 03/1993 Undergraduate studies in Geodesy and Photogrammetry, ETH Zurich, Switzerland

04/1983 – 10/1988 Music Academy of Berne, Switzerland HONORS AND AWARDS 2018 Blaffer Lecture, MD Anderson Medical Center 2018 Fellow, American Institute for Medical and Biological Engineering (AIMBE) 2017 Outstanding Educator Award, UT Southwestern Academy of Teachers (SWAT) 2015 Excellence in Postdoctoral Mentoring Award, Postdoctoral Association, UTSW 2014 Histochemical Society Lecturer 2013 Recruitment Awards by the University of Texas STARS program; and by the Cancer

Prevention Institute of Texas (CPRIT) 2011 Charles Edward Holt Memorial Lecture, Massachusetts Institute of Technology 2009 Transformative R01 grant award by the NIH Director’s office, jointly with K. Hahn 2009 Michael and Kate Barany Award for Young Investigators, The Biophysical Society 2008 Nikon Fellow at The Marine Biological Laboratory 2007 Summer Fellow at The Marine Biological Laboratory 1998 Swiss National Science Foundation Fellowship for Prospective Researchers 1997 Silver Medal of ETH for the PhD Thesis 1993 Silver Medal of ETH for the Master Thesis. 1992 Young Composer Award, State of Berne 1990 Composer Award, Editorial Musique Suisse, Geneva


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RESEARCH AND PROFESSIONAL EXPERIENCE 07/2015 – present Inaugural chairman, Lyda Hill Department of Bioinformatics, UT

Southwestern Medical Center (UTSW), Dallas, TX • The goal of the Department is to establish an internationally recognized

program in bioinformatics, defined as the scientific field concerned with the theory and implementation of computational algorithms for the recognition of patterns in clinical and experimental biomedical data. The department is planned to grow to a size of 16 faculty members over 10 years. Today, the Department is the primary home to 5 tenured/tenure-track faculty members, 1 distinguished fellow, and 2 research track faculty members. https://www.utsouthwestern.edu/departments/bioinformatics/

• As the inaugural chair, carries the ultimate responsibility for the development and implementation scientific structure, including prioritization of faculty appointments, investments in pilot grants that serve the integration of the Department with the campus; also, development and implementation of the administrative structure, including the recruitment of department administrators, definition of job titles appropriate for IT professionals, competitive pay plans, etc. Oversight of all financial decisions, including negotiation and distribution of faculty start-up packages, distribution of pilot grants, hardware/software investments.

• The Department is the leading entity in establishing high-performance computing on campus, accomplished by the BioHPC facility (see below); and in deploying first class services to other departments in biomedical data analysis, accomplished by the Bioinformatics Core Facility (BICF). https://www.utsouthwestern.edu/labs/bioinformatics/ Developed business plan that defines diverse modes of bioinformatics services to the community, including helpdesk support, bioinformaticist-on-demand program, and research program development. The plan also ensures sustainable growth of an intellectually diverse workforce. Acquired 6M USD grant from the Cancer Prevention Institute to launch BICF in 2015. Today, the facility consists of 18 team members with expertise in genomics, statistics, machine learning, and software engineering. 70% of the workforce is covered by fee-for-service programs.

• Other institutional initiatives: Initiated community-oriented programs, such as the BICF and BioHPC fellowships, Nanocourses, BioHPC Tech Talks, Artificial Intelligence in Medicine initiative (currently in nascent stages and in collaboration with Department of Radiation Oncology). Relationship building to local philanthropists through public and targeted talks.

07/2013 – present Professor of Cell Biology, UT Southwestern Medical Center, Dallas, TX • Supported by awards from the Cancer Prevention Institute of Texas

(CPRIT) and UT STARS program, established an internationally recognized research program in cancer cell morphogenesis and migration. The program combines state-of-the-art molecular cell biology in clinically-relevant models of lung, skin and pediatric cancers with innovative ex vivo and in vivo live cell imaging approaches and computational modelling to identify mechanisms of the intersection between morphogenesis, functional plasticity and survival in the metastatic cell. https://www.utsouthwestern.edu/labs/danuser/

https://www.utsouthwestern.edu/departments/bioinformatics/

https://www.utsouthwestern.edu/labs/bioinformatics/

https://www.utsouthwestern.edu/labs/danuser/


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• Recruited senior leadership (Fiolka, Noh, Jamieson, Welf) with expertise in optics engineering, financial mathematics, artificial intelligence, chemical engineering to build a uniquely composed, interdisciplinary research team focused on new approaches to quantitative cancer cell biology. All 4 individuals have been recognized by UTSW with promotions to faculty level positions. Since 2017, Fiolka is an independent CPRIT scholar, tenure track Assistant Professor in the Department if Cell Biology. The lab size overall varies between 20 and 25 members. About half of the lab members have background in mathematics and computer science, the other half in experimental biophysics and molecular cell biology.

• Research activity: Integrated experimental and computational workflows to unravel molecular mechanisms of cancer cell morphogenesis and their dependence on mechanical and chemical signalling processes. Some of the workflows are targeting translational research questions, e.g. the potential use of label free imaging of cell dynamics as diagnostic tools. Besides the combination of advanced molecular cell biology and computer vision, the lab spearheads innovative computer graphics methods for cell morphogenesis models in 3D, and adopts in a unique approach financial mathematics to infer causal relations between molecular processes. The foundation of this research is laid by new efforts in the lab to tailor 3D live cell microscopy to specific needs of a cell biological experiment.

• Institutional initiative: Launched the BioHPC initiative to establish high-performance computing at UTSW. Formulated design of integrated server and workstation architecture for distributed computing across campus. Started in summer 2013 with the financial commitment of ~1M USD by 2 PIs (Danuser and Jaqaman) and 3 department chairs, BioHPC today is the second largest academic computing facility in Texas, serving 16 departments and operating with annual budget >2.5M USD. Developed business plan to ensure sustainable growth of hardware and workforce. https://portal.biohpc.swmed.edu

09/2009 – 08/2014 Professor of Cell Biology, Harvard Medical School (HMS), Boston, MA. • Establish an internationally recognized research program in quantitative

imaging and computational modelling of cell dynamics. Lab size varies between 16 and 22 members. About half of the lab members have background in mathematics and computer science, the other half in experimental biophysics and molecular cell biology.

• Research activity: Quantitative light microscopy; computer vision of cell dynamics; numerical models of the integration of mechanical and chemical signals in cell migration, chromosome segregation, endocytosis, and axonal vesicle transport. First work on causal inference in nonlinear molecular processes from spontaneous image fluctuations.

• Build an Image and Data Analysis Core Facility (IDAC), including the development of a business plan for sustainable operation. IDAC is the first academic facility nationwide to support the growing needs in image analysis accompanying the rapid advances in light microscopy. The inaugural operating director of IDAC is former graduate student Hunter Elliott, who remains in this position until spring of 2018.

• Co-chair of IT Governance Committee, which oversaw the complete reorganization of high-performance and scientific computing at HMS.

https://portal.biohpc.swmed.edu/


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04/2009 – 08/2009 Professor of Cell Biology, Center of Integrative Molecular Biosciences, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA. • Continuation of research activity, as initiated in 2003.

11/2005 – 03/2009 Associate Professor of Cell Biology, Center of Integrative Molecular Biosciences, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA. • Expansion of lab to 7 postdocs, 6 Ph.D. students, and 3 support staff • Continuation of research activity, as initiated in 2003.

08/2003 – 10/2005 Assistant Professor of Cell Biology, Center of Integrative Molecular Biosciences, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA. • Established a computational cell biology lab embedded in cell biology.

Recruitment of 5 postdoctoral trainees and 2 Ph.D. students with background in Applied Mathematics, Computer Science, and Engineering.

• Research activity: Quantitative light microscopy; computer vision of cell dynamics; numerical models of cytoskeleton-generated forces in cell migration, chromosome segregation, endocytosis, and axonal vesicle transport.

02/2001 – 07/2003 Assistant Professor of Cell Biomechanics, Laboratory for Biomechanics, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland. • Expansion of BMMG to a team of 12 researchers. • Continuation of research activity with BMMG, as initiated in 1999. • Institutional initiative: Spearheaded concept and organized a group of >50

signing faculty from approx. 5 departments for a university-wide Light Microscopy Center. The Center was started, initially under the umbrella of the Institute of Biochemistry, in August 2003 by postdoctoral fellow, Dr. Gabor Csucs. Csucs is still the director of the by now university-wide Scientific Center for Optical and Electron Microscopy (ScopeM).

08/1999 – 01/2001 Lecturer (Obersassistent) at the Laboratory for Biomechanics (Director: Prof. Dr. E. Stüssi), Department of Materials, ETH Zurich. • Established BioMicroMetrics Group (BMMG) as an independent research

entity within the Laboratory of Biomechanics focused on cellular scale biomechanics.

• Research activity: Development of light microscopy of the architectural dynamics of living cells; mechanical modelling of cytoskeleton and biological tissue dynamics.

10/1997 – 07/1999

Postdoctoral Research Associate, Marine Biological Laboratory, Woods Hole, MA. Advisors: Dr. S. Inoué, Dr. R. Oldenbourg, Dr. P. Smith • Research activity: Development of computer vision methods for the

analysis of the architectural dynamics of living cells; machine vision based feedback control of micro-probes in electro-physiology.

06/1997 – 10/1997 Postdoctoral Fellow Image Science Laboratory, ETH Zurich. Advisor: Prof. Dr. G. Gerig • Research activity: Development of feature tracking for patient placement

in X-Ray portal imaging. 01/1994 – 06/1997 Doctoral student Advisor: Prof. Dr. O. Kübler, Image Science Laboratory,

ETH Zurich, Switzerland; Co-Advisor: Prof. Dr. H. Tiziani, Institute for Applied Optics, TU Stuttgart, Germany. • Research activity: Development of a machine vision system for the

feedback control of micro-manipulators using stereo light microscopy; Vision-based micro-mechanical testing of metallic substrates.


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04/1993 – 12/1997 Staff engineer, Swiss Federal Institute of Topography, Berne. • Surveillance of water dams, including the planning, execution, and

analysis of measurement protocols. 07/1991 – 09/1991 Internship BEDAG Computer Technology, Berne.

• Satellite remote sensing in GIS.

PROFESSIONAL AFFILIATIONS 2018 – present Fellow, American Institute for Medical and Biological Engineering 2002 – present Member, Biophysical Society of America 2000 – 2007 Member, The Royal Microscopical Society 1999 – present Member, American Society of Cell Biology 1997 – present Member, IEEE Computer Society and of IEEE (since October 2002)

ADVISORY BOARDS 07/2016 – present HHMI/Janelia Farms, Ashburn, VA. Advisory board Advanced Imaging Center. 01/2016 -- present Allen Institute of Cell Science, Seattle, WA. Advisory boards for Assay

Development and for Computational Data Modelling 11/2015 – present Keen Eye Technologies, Paris, France. Board of Directors. 08/2015 – present XCell Biosciences, Inc., San Francisco, CA. Scientific Advisory Board. 08/2015 – present Big Data 2K Center (BD2K), U. Southern California, Los Angeles, CA 08/2013 – present London Research Institute/The Francis Crick Institute, Computational Biology

Advisory Group to the Board of Directors 09/2012 – present INFORM Center, University of Marseille, France. Chairman of the External

Advisory Board. 07/2011 – present Carnegie Mellon – U. Pittsburgh joint program in Computational Biology.

External Advisory Board. 01/2006 – present Glencoe Inc., Dundee, UK; and Seattle, WA. Board of Directors. 03/2013 – 03/2014 DVS Sciences, Sunnyvale, CA. Scientific Advisory Board. 03/2008 – 12/2013 Applied Precision, Piscataway, NJ; Seattle, WA. Scientific Advisory Board. 03/2007 – 03/2009 Bitplane AG, Zurich, CH. Scientific advisor. 01/2004 – 02/2007 Bitplane AG, Zurich, CH. Inaugural Chair Advanced Imaging Centers.

EDITORIAL FUNCTIONS 2013 – present Editorial Board Developmental Cell 2012 Guest Editor (with Jason Swedlow) Current Opinion in Cell Biology “Scale

integration: the structure and dynamics of macromolecular assemblies, cells, tissues, and organisms”

2011 – present Editorial Board Journal of Cell Science 2010 – present Faculty 1000 2010 – 2016 Editor Journal of Cell Biology 2004 – 2008 Associate Editor IEEE Transaction on Image Processing 2005 Guest Editorial for special issue on Cellular and Molecular Imaging, IEEE

Transaction on Image Processing 2004 – 2008 Editorial Board Member Biophysical Journal

GRANT REVIEW PANELS 2013 – present Editor on NIH Director’s Transformative R01 review panel 2008 – 2012 Member of NIH study section MI (Microscopic Imaging); merged with EBIT

(Enabling Bioanalytical and Imaging Technologies) in 2010.


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Ad hoc reviews for NIH

NIH-NIBIB T32 training grants (October 2018); ZRG1 IMST-A (S10 equipment grants; November 2009); ZRG CDF-4 (October 2009); NIH Bioengineering Research Partnership (June 2004);

Other ad hoc reviews

ETH Zurich research commission; Institut Pasteur, Paris; Human Frontiers Science Program; AIRC (Italian Cancer Research); UK Medical Research Council, Wellcome Trust UK, Singapore Medical Research Council, Swiss National Science Foundation.

SERVICES TO THE SCIENTIFIC COMMUNITY 2011 – 2017 • Founding Director of the 10-day course ‘Computational Image Analysis in

Cell and Developmental Biology’. The course was held at The Marine Biological Laboratory in Woods Hole, MA. The first rendition was funded by a pilot grant from HHMI. Between 2013 and 2017 funding was provided by the grant R25GM103792 (PI: Danuser). The award allowed us to waive tuition and pay room and board for all students for the entire course period.

2011 • Co-Organizer (with G. Gundersen and T. Wittmann) of Special Interest Group on Microtubule Dynamics in Cell Migration at the Annual Meeting of the American Society of Cell Biology, Denver, CO

• Co-Organizer (with J.C. Olivo-Marin) of Symposium on Computer Vision in Cell Biology, European Molecular Biology Organization Meeting, Vienna.

2010 • Co-Organizer of Workshop on Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA.

2008 • Program committee ASCB Annual Meeting, San Francisco • Co-Organizer of Workshop on Bioimage Informatics, UC Santa Barbara,

CA. • Chair, Committee of Cell Biology Seminar Series, The Scripps Research

Institute 2006 • Organizer of session Computer Vision in Systems Biology, IEEE Int’l

Symposium in Biomedical Imaging, Arlington, VA. 2004 • Organizer of Concurrent Symposium Mechanics in Cell Biology, Annual

Meeting of the ASCB, Washington, D.C. 2003 • Co-Organizer of ETH Symposium Joining Forces – Biology meets

Chemistry and Engineering 2002

• Co-Chair mini-symposium Computational Approaches to Cell Biology. Annual Meeting of the American Society of Cell Biology, San Francisco, CA

• Co-Organizer of ETH Symposium Joining Forces – Biology meets Chemistry and Engineering

2001

• Spearheaded the formation of a group of more than 50 faculty members at ETH Zurich to request the funds for a campus-wide light microscopy imaging center. The facility was opened in 2004 under the directorship of my former postdoc Gabor Csucs, who has remained the director until today.

• Co-Organizer of ASCB Special Interest Subgroup Meeting on Quantitative Microscopy and Image Informatics, Washington D.C.

• Scientific Committee of BIOSURF IV, Lausanne, Switzerland. • Session chair Cellular biomechanics, International Society of

Biomechanics, Zurich, Switzerland. • Co-Organizer of Bioimaging Tutorial at the European Cells and Materials

Meeting, Davos, Switzerland


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RESEARCH SUPPORT Haggerty endowment annual distribution: US$ 150,000. Lyda Hill gift, annual support to the Department Chair: US$ 400,000 State of Texas Department Chair annual salary support: US$ 250,000 Current 04/2007 – 12/2020 The mechanics of actin-mediated cell protrusion (Danuser). R01

GM71868. Annual direct cost: US$ 200,000 01/2003 – 11/2020

Quantitative 3D Fluorescent Speckle Microscopy (Danuser). R01 GM67230. Annual direct cost: US$ 250,00.

06/2014 – 05/2020 Probing oncogenic functions of vimentin filaments by small molecule screens (Danuser). I-1840 Welch Foundation. Annual direct cost: US$ 90,000.

03/2016 – 02/2019 Computational Live Cell Histology. CPRIT RP160622. Annual direct cost: US$ 124,636

07/2015 – 06/2020 Bioinformatics Core Facility at UT Southwestern Medical Center. CPRIT RP150596. Total direct cost for 5 years: US$ 5,365,080

10/2013 – 09/2018 Spatio-temporal dynamics of GEF-GTPase networks (Program Project Hahn). P01 GM103723. Annual direct cost (Danuser only): US$ 175,000.

04/2006 – 04/2018 Mechanisms of clathrin-mediated endocytosis (MPI Schmid/ Danuser). R01 GM073165. Annual direct cost (Danuser only): ~US$ 120,000. Renewal pending.

06/2011 – 05/2016 Regulation and function of vimentin intermediate filaments (Program Project Goldman). P01 GM096971. Annual direct cost (Danuser only): US$ 180,000. Renewal pending. Bridge funded with US$68,100.

Completed

04/2000 – 03/2003 Automatic Tracking of Protein Mobility in Living Cells Using Fluorescent Light Microscope Movies (Danuser). Swiss National Science Foundation (SNF) 21-59452.99. Total direct cost: CHF 240,530.

06/2001 – 05/2004 Realization of a Grating Coupler Sensing Fluorescence Microscope and its Applications in Biomaterials Research (Danuser/Textor), ETHZ-internal (competitive) grant TH-28.3 01-1. Total direct cost: CHF 175,000.

01/2002 – 12/2003 Fluorescent Speckle Microscopy (Salmon). NIGMS. Subcontract to R01 GM60678 (Danuser). Total direct cost: US$ 63,683.

06/2002 – 05/2005 How cytoskeletal dynamics mediates cell motility. Human Frontiers in Sciences Program (HFSP). RGY5-2002. Young Investigator Award to C. Waterman-Storer, G. Danuser and I. Näthke. Total direct cost: US$ 250,000.

06/2002 – 12/2003 Conformation and Molecular Interaction of Proteins at Nanoscale Patterned Interfaces (Textor/Danuser). Commission for Technology and Innovation (CTI) TOP NANO21. 4597.1 (Co-PIs). Total direct cost: CHF 94,000.

01/2003 – 06/2004 Molecular control of single cell adhesion sites using sub-micron patterned substrates – A testbed for the manipulation of cell behavior via extra-cellular perturbation (Danuser). Commission for Technology and Innovation (CTI) TOP NANO21. 6209.1 Total direct cost: CHF 335,000.

01/2004 – 12/2007 Fluorescent Speckle Microscopy (Salmon). Subcontract to R01 GM60678. Total direct cost (Danuser only): US$ 480,000.

08/2007 – 07/2009 Morphodynamic profiling of tumor angiogenesis in 3D (Danuser). R21 CA124990. Total direct cost: US$ 225,000.

04/2010 – 03/2011 Total Internal Reflection Microscope. Shared instrumentation grant application for the Nikon Imaging Core Facility. US$ 316,000.


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08/2004 – 07/2011

Cell Migration Consortium (Horwitz). Subcontract to Consortium Glue Grant U54 GM64346. Total direct cost: US$ 614,000.

12/2009 – 11/2011 Orchestra: A high performance biomedical supercomputing collaborative (MPI Athanasoulis/Danuser). Shared instrumentation grant to expand high-performance computing at Harvard Medical School. Budget: US$ 3,700,000.

06/2003 – 12/2011

Computational analysis and mechanical modeling of chromosome dynamics in yeast (MPI Sorger/Danuser). R01 GM68956. Total direct cost (Danuser only): US$ 827,000.

09/2005 – 08/2013

Cell Decision Processes (Sorger). Subcontract to Center of Excellence in Complex Biomedical Systems Research Grant P50 GM68762. Total direct cost (Danuser only): US$ 335,000.

09/2010 – 08/2013 Spatio-temporal Rho GTPase signaling to the cytoskeleton during neuronal development and repair. HFSP application jointly with O. Pertz, U. Basel; and N.L. Jeon, Seoul National University. Total direct cost (Danuser only): US$ 250,000.

09/2009 – 08/2014 Quantitative Imaging of Signaling Network (MPI Danuser/Hahn). Transformative R01 GM090317; Total direct cost (Danuser only): US$ 1,100,000

09/2011 – 08/2016 Quantitative analysis of pharmacological mechanisms by intravital imaging (MPI Weissleder/Danuser/Mitchison/Sorger). R01 CA164448. Total direct cost (Danuser only): US$ 360,000.

09/2011 – 07/2016 Ultrastructural Basis of Mechanotransduction in Cell Matrix Adhesions (Program Project Hanein). P01 GM098412. Total direct cost (Danuser only): US$ 710,000.

12/2012 – 05/2018 Imaging and modeling the mechanical and chemical control of metastatic cell motility. CPRIT R1225. Total direct cost for 5 years: US$ 4,750,000

COLLABORATORS Current

2017 – James Amatruda, UT Southwestern Medical Center, Dallas, TX. Pediatric cancer systems biology.

2013 – Sean Morrison, UT Southwestern Medical Center, Dallas, TX. Cell biology of melanoma metastasis.

2013 – Jerry Shay, UT Southwestern Medical Center, Dallas, TX. Cellular effects of Ras-transformation in lung cancer. Telomere positioning effects.

2008 – Robert Goldman, Northwestern University Medical School, Chicago, IL; Intermediate filament dynamics in diverse cell functions.

2005 – Klaus Hahn, Dept of Pharmacology, University of North Carolina, Chapel Hill, NC; Rho GTPase signalling and multiplexing of biosensors.

2004 – Sandra Schmid, Dept of Biology, UT Southwestern Medical Center, Dallas,TX. Regulation of clathrin-mediated endocytosis

Past

2011 – 2016 Rick Horwitz, University of Virginia, Chorlottesville, VA; Dorit Hanein Burnham Institute, La Jolla, CA; Mark Ginsberg UC San Diego, La Jolla, CA; Martin Schwartz Yale U., New Haven, CT; Ultrastructural basis of adhesion signalling.

2013 – 2015 Alan Hall, Memorial Sloan Kettering, New York, NY. GEF function in collective migration.


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2011 – 2015 Ralph Weissleder, Tim Mitchison, Dept of Systems Biology, Harvard Medical School, Boston, MA. Quantitative Intravital Imaging of drug – tumor interactions.

2009 – 2014 David Pellman, Dana Farber Cancer Institute, Boston, MA; Regulation of microtubule dynamics in cell polarization.

2009 – 2013

Joan Brugge, Dept of Biology, Harvard Medical School, Boston, MA; Mechanochemical signaling in collective migration.

2009 -- 2013 Davie van Vactor, Dept of Biology, Harvard Medical School, Boston, MA; Regulation of microtubule dynamics in neurogenesis.

2007 – 2014 Denise Montell, Johns Hopkins University Medical School, Baltimore, MD; 3D migration of border cells.

2006 – 2010 Wilhelm Krek, ETH Zurich, Switzerland; Regulation of MT dynamics by oncogenes

2005 – 2011 Sergio Grinstein, Dept of Biochemistry, Hospital of Sick Kids, Toronto, Canada; Single-molecule imaging of CD36 receptor dynamics.

2005 – 2009 Jason Swedlow, Wellcome Trust Biocenter, Dundee, UK; Chromosome dynamics in HeLa cell mitosis.

2005 – 2008 Paul Forscher, Dept of Biology, Yale University, New Haven, CT; Cytoskeleton-mediated dynamics of neuronal growth cones.

2005 – 2008 Julie Theriot, Dept of Biochemistry, Stanford University, Palo Alto, CA; Mechanics keratocyte motility.

2005 – 2007 Tom Misteli, National Cancer Institute, Bethesda, MD; Chromosome repair. 2004 – 2011 Larry Goldstein, HHMI and Dept of Cell Biology, UC San Diego, CA;

Dynamics of motor-mediated vesicle transport in neuronal axons. 2004 – 2009 Tarun Kapoor, Rockefeller University, New York, NY; Microtubule dynamics

in Xenopus extract spindles. 2000 – 2004 Alexander Verkhovsky, Dept of Physics, EPF Lausanne, CH; Actin-mediated

motility of fish epidermal keratocytes. 2000 – 2003 Jeff Hubbell, Marcus Textor, Dept of Materials, ETH Zurich, CH.

Projects in biomaterial-design und cell-surface interactions. 2001 – 2013 Peter Sorger, Dept of Systems Biology, Harvard Medical School, Boston, MA

Chromosome dynamics in yeast mitosis. Single-molecule analysis of ErbB receptors family and interactors.

1999 – 2015 Clare Waterman, National Institutes of Health, Bethesda, MD; Quantitative Fluorescent Speckle Microscopy of actin and focal adhesion dynamics.

1999 – 2007 Edward. D. Salmon, Dept of Biology, University of North Carolina, Chapel Hill, NC; Quantitative Fluorescent Speckle Microscopy of mitotic spindle assembly and mechanics.

PREDOCTORAL AND POSTDOCTORAL TRAINEES 06/1999 – 02/2003 Dominik Thomann, M.Sc. Theoretical Physics, Ph.D. Biophysics; Left for:

Engineering Manager X-Rite, Regensdorf, Switzerland. 09/1999 – 07/2003 Gabor Csucs, M.Sc. Biophysics, Ph.D. Biochemistry from Hans-Rudolf

Bosshard lab, U. Zurich; Currently: Director of Microscopy Facility, ETH Zurich 05/2000 – 06/2003 Claude Berney, M.Sc. Physical Engineering, Ph.D. Biophysics; Left for: Field

Clinical Manager International at Boston Scientific, Fribourg, Switzerland. 12/2001 – 07/2003 Pascal Vallotton, M.Sc. Physical Engineering, Ph.D. Biophysics from Horst

Vogel lab, EPF Lausanne; Left for: Lab head, CSIRO, Sydney, Australia 09/2000 – 09/2004 Aaron Ponti, M.Sc. Molecular Biology, Ph.D. Biophysics; Left for: Senior

Research Scientist, Friedrich Miescher Institute, Basel, Switzerland. 10/2000 – 07/2004 Toru Fischbach, M.Sc. Materials Sciences, Ph.D. Biophysics; Left for: Product

manager at Synthes, Solothurn, Switzerland.


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09/2003 – 11/2006 Matthias Machacek, M.Sc. and Ph.D. Mechanical Engineering from Thomas Roesgen lab, ETH Zurich; Fellow of the Swiss National Science Foundation; Fellow of the Novartis Research Foundation. Left for: Senior Computational Biology Researcher, Novartis AG, Basel. Currently: Founder and Managing Director, LYO-X GmbH, Allschwil, Switzerland.

09/2002 – 08/2007 Jonas Dorn, M.Sc. Materials Sciences; Fellow of the Roche Research Foundation; Left for: Postdoc, Maddox lab, IRIC, Montreal, Canada. Currently: Project Lead, Digital Development Group, Novartis AG, Basel, CH.

08/2003 – 12/2007 Lin Ji, M.Sc. and Ph.D. Applied Mathematics from Steve Cox lab, Rice U. and Joyce McLaughlin lab, Rensellaer Polytech (1st Postdoc); Left lab for an Assistant Professor position, Einstein College of Medicine, Bronx, NY.

01/2004 – 12/2008 Ge Yang, M.Sc. Applied Mathematics and Ph.D. Mechanical Engineering from Bradley Nelson lab, U. Minnesota; Supported by R01 GM60678. Currently: Associate Professor (tenure track), Carnegie Mellon University, Pittsburgh, PA.

03/2004 – 08/2009 Dinah Loerke, M.Sc. Physics and Ph.D. Biophysics from Erwin Neher lab, MPI Goettingen; Supported by R01 GM73165. Currently: Associate Professor (with tenure), University of Denver, CO.

10/2007 – 06/2009 Shann-Ching Chen, Ph.D. Computer Science from Bob Murphy lab, Carnegie Mellon; Supported by U54 GM64346. Currently: Scientific Program Director Institute for Computational Health Sciences, UC San Francisco. Adjunct Associate Professor Tapei Medical University, Taiwan.

08/2003 – 08/2009 Khuloud Jaqaman, M.Sc. Physics, Ph.D. Computational Chemistry from Peter Ortoleva lab, Indiana U.; Paul Sigler/Agouron Fellow of the Helen Hay Whitney Foundation. Currently: Assistant Professor (tenure track), UT Southwestern Medical Center, Dallas, TX.

01/2006 – 12/2009 Mohsen Sabouri, M.Sc. and Ph.D. Physics (in Martin Grants lab, McGill, Toronto). Previous Postdoc in John Tyson lab, Virginia Tech.; Supported by P50 GM68762. Currently: Startup company consulting biotech and biopharma in data analysis.

02/2006 – 12/2009 Andrea Bacconi, M.Sc. and Ph.D. Cell Physiology from Heini Murer lab, U. Zurich, Fellow of the Swiss National Science Foundation, R01 GM71868

07/2002 – 03/2010 Alexandre Matov, M.Sc. Electrical Engineering; Supported by R01 GM60678. Left for: Postdoc in Torsten Wittman lab. UC San Francisco.

03/2005 – 03/2010 Kathryn Applegate, B.S. Bioinformatics; NSF pre-doctoral fellowship. Supported by R01 GM67230. Currently: Program Director BioLogos Forum.

01/2005 – 08/2010 James Lin, B.S. Cell Biology; Supported by R01 GM71868. Currently: Founder and CTO of XCell Biosciences. South San Francisco, CA.

04/2010 – 05/2011 Christian Dittrich, Ph.D. Chemistry, Previous Postdoc in Judith Steen lab, Children’s Hospital, Boston. Supported by fellowship from the Novartis Research Foundation. Currently: Project manager Merck Millipore, Schaffhausen, CH.

10/2009 – 09/2011 Achim Besser, Ph.D. Biophysics from Ulrich Schwartz, U. Heidelberg. R01 GM71868. Fellowship from the German Research Council. Currently: Research Scientist BASF Research, Ludwigshafen, Germany.

04/2007 – 12/2011 Allen Liu, Ph.D. Biophysics from Dan Fletcher lab, UC Berkeley, Supported by Leukemia and Lymphoma Society Fellowship. Currently: Associate Professor with Tenure, U. Michigan, Ann Arbor. MI. (joint postdoc with Sandy Schmid).

10/2008 – 12/2011 Sylvain Berlemont, Ph.D. Computer Science from Jean-Christophe Olivo-Marin lab, Pasteur Institute. Supported by U01 GM67230. Currently: Founder & CEO at Keen Eye Technologies


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04/2010 – 08/2012 Anindya Chanda, Ph.D Food Science and Environmental Toxicology from John Linz lab, Michigan State University, Lansing, MI. U01 GM67230. Currently: Assistant Professor, U. South Carolina, Columbia, SC.

04/2007 – 09/2012 Hunter Elliott, B.S. in Chemistry and Physics; Supported by R01 GM90317. Currently: Director of Machine Learning Research, PathAI, Boston, MA.

06/2010 – 02/2013 Uli Schmid, Ph.D. Biophysics from Matthias Weiss lab, German Cancer Research Center, Heidelberg. Fellowship from the German Research Council. Currently: Research manager at TWT Science and Innovation near Stuttgart, Germany.

12/2007 – 10/2013 Daniel Nunez, B.S. Mechanical Engineering; Supported by NIH predoctoral fellowship. Left for: Postdoc in Cai lab, U. Michigan, Ann Arbor, MI.

12/2007 – 11/2013 Pei-hsin Hsu, B.S. Mathematics and Molecular Biology; Supported by R01 GM68956. Left for: Postdoctoral fellow Angelika Amon lab, HHMI/MIT.

01/2011 – 12/2013 Laura-Anne Lowery, Ph.D. Developmental Biology from Hazel Sive lab, MIT, Cambridge, MA. K99/R00 award. (joint postdoc with Davie Van Vactor). Currently: Associate Professor with Tenure, Boston College, Boston, MA.

01/2011 – 12/2013 Michelle Mendoza, Ph.D. Cell Biology from Rick Firtel lab, UCSD, Cambridge, MA. K25 award. (joint postdoc with John Blenis). Currently: Assistant Professor, U. Utah/Huntsman Cancer Center.

06/2010 – 08/2014 Kwonmoo Lee, Ph.D. Physics from Marc Kirschner’s lab, Harvard Medical School and MIT, Boston. F32 fellowship. Currently: Assistant Professor Worcester Polytechnical Institute, MA.

02/2012 – 08/2014 Nancy Costigliola, Ph.D. Cell Biology from Ken Jacobson lab, UNC Chapel Hill, NC. Continuation of postdoc training in Tim Mitchison lab, HMS, Boston, MA. Currently: Image Scientist, Vertex, Boston, MA.

07/2010 – 08/2014 Alexis Lomakin, Ph.D. Cell Biology from Yuri Vasiliev’s lab, Moscow State University, Russia. Leukemia and Lymphoma Society fellowship. Currently: King’s Fellow, Kings College, UK.

08/2009 – 09/2014 Francois Aguet, Ph.D.. Computer Science from Michael Unser lab, EPF Lausanne. Swiss National Science Foundation fellowship and R01 GM073165. Left for: Senior Research Associate, Broad Institute, Boston, MA.

11/2011 – 09/2014 Youbean Oak, B.S. in Molecular Biology and Mathematics, Cornell U. Ithaca, NY. U01 GM67230. Left for: Consultant Simon-Kucher & Partners, Boston, MA.

06/2012 – 09/2014 Deepak Chitajallu, Ph.D. Computer Science from Ioannis Kakadiaris lab, University of Houston, TX. R01 CA164448. Left for: Kitware Inc. Chapel Hill, NC.

08/2010 – 08/2015 Marco Vilela, Ph.D. Biomathematics from Jonas S Almeida lab, University of Lisboa, Portugal. NIH F32 postdoctoral fellowship. Currently: Research Faculty in Biomedical Engineering, Brown University, Providence, RI.

11/2011 – 03/2016 Liya Ding, Ph.D. Computer Sciences from Aleix M. Martinez lab, Ohio State University, Columbus, OH. P01 GM096971. Currently: Research Associate, Allen Institute for Cell Science, Seattle, WA.

01/2013 – 02/2016 Claudia Schaefer, Ph.D. Molecular Cell Biology from Rudolf Merkel lab, University of Bonn, Germany. Previous postdoc in Victoria Bolotina lab, Boston University. CPRIT R1225. Left for: Senior Research Associate MIT/Koch Institute for Cancer Research, Boston, MA.

05/2011 – 10/2016 Nadia Halidi, Ph.D. Biophysics from Jean-Jaques Meister lab, EPF Lausanne, Switzerland. R01 GM90317 and P01 GM098412. Currently: Senior Research Associate, University of Oxford, UK.

06/2012 – 08/2017 Sangyoon Han, Ph.D. Mechanical Engineering from Nathan Sniadecki lab, University of Washington, WA. P01 GM098412. Currently: Assistant Professor, Mechanical Engineering, Michigan Tech Houghton, MI.


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06/2013 - 08/2017 Zhengwen (Tony) Zhang, Ph.D. Bioengineering from Bjoern Neu lab, Nangyan Technical University, Singapore. Welch Foundation. Currently: Masters Program in Computer Science, SMU, Dallas, TX.

01/2013 – 09/2017 Zhuo Gan, Ph.D. Bioengineering from Raimund Ober/Sally Ward lab. UT Southwestern Medical Center. P01 GM096971. Currently: Data Scientist

12/2014 – 03/2018 Andres Nevarez, B.S. in Biology, California State University, Fresno, CA. Ford Foundation fellowship (deferred) and HHMI Gilliam fellowship. Currently: graduate program at UCSD (left for family reasons)

10/2013 – 08/2018 Assaf Zaritzky, Ph.D. Computer Science from Lior Wolf lab, U. Tel Aviv,Israel. CPRIT RP160622. Currently: Assistant Professor, Computer Science, Ben Gurion University, Beer Sheva, Israel

05/2014 – 08/2018 Kevin Dean, Ph.D. Biochemistry from Amy Palmer lab, U Colorado, Boulder, CO. F32 fellowship from NIGMS. Currently: Assistant Professor, Director of Advanced Microscopy Initiative, UT Southwestern Medical Center, Dallas, TX.

10/2009 – Maria Bagonis, B.S. Biochemistry; M.Sc. Computational Chemistry. R01 GM090317 and CPRIT R1225.

10/2009 – Christoph Burckhardt, Ph.D. Cell Biology from Urs Greber lab, U. Zurich, Switzerland. Swiss National Science Foundation fellowship, Roche Research Foundation fellowship, R01 GM073165 and CPRIT R1225.

02/2013 – Erik Welf, Ph.D. Chemical Engineering from Babatunde A. Ogunnaike lab, U. Delaware. Previous postdoc in Jason Haugh lab, NC State University. K25 career development award from NCI.

10/2013 - Xiao Ma, Ph.D. Mechanical Engineering and Applied Mathematics from Pranav Shrotriya lab, Iowa State University, Ames, IA. P01 GM103723

02/2014 - Meghan Driscoll, Ph.D. Physics from Wolfgang Losert lab, U. Maryland, College Park, MD. F32 and K99/R00 fellowships from NIGMS.

05/2014 - Jin Suk Park, B.S. in Biology, U. Toronto. HHMI Mechanisms of Disease Training Grant and CPRIT R1225.

05/2014 - Ning Zhang, B.S. in Biotechnology. Zhejiang University, China. CPRIT Training Grant and CPRIT R1225.

07/2014 - Philippe Roudot, Ph.D. Computer Science from Charles Kervrann lab, INRIA, Rennes, France. Human Frontiers in Sciences Program fellowship.

10/2014 - Ashwati Mohan, B.S. in Molecular and Cell Biology, Texas A&M, College Station, TX. MD/Ph.D. program. F30 predoctoral fellowship from NCI.

09/2015 - Junsik Noh, Ph.D. Statistics from Sangyeol Lee lab, Seoul National U., Korea. P01 GM103723

04/2016 - Tadamoto Isogai, Ph.D. Cancer Cell Biology from Metello Innocenti lab, Dutch Cancer Institute. Holland. R01 GM071868.

05/2016 - Xinxin Wang, Ph.D. Physics from Anders Carlsson lab, WUSTL, St. Louis, MO. R01 GM073165

07/2016 - Xuexia Jiang, B.S. in Computer Science, Carnegie Mellon University, Pittsburgh, PA. MD/Ph.D. program. CPRIT R1225.

05/2017 - Jaewan Huh. Ph.D. Statistics from Sangyeol Lee lab, Seoul National U., Korea. Human Frontiers in Sciences fellowship.

09/2017 - Andrew Weems, Ph.D. in Cell Biology from Michael McMurray lab, U. Colorado, Anschutz Campus, Aurora, CO. Jane Coffin Child’s Foundation fellow.

09/2017 - Byron Weiss, B.S. in Bioengineering, Columbia University, New York, NY. MD/Ph.D. program. Welch Foundation.

02/2018 - Dagan Segal, Ph.D. in Developmental Biology from Beni Shilo lab, Weizmann Institute, Rehovot, Israel. EMBO long-term fellow.

08/2018 - Qiuyan Shao, Ph.D. in Biochemistry and Biophysics from Lanying Zheng lab, Texas A&M. P01 GM096971.


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TEACHING 03/2017 – Mathematics in Medicine, UT Southwestern Medical Center, Course

Director. Elective for medical students. 08/2016 – Biostatistics, UT Southwestern Medical Center, Lecture on ANOVA.

Compulsory for all incoming graduate students. 08/2015 – MATLAB Bootcamp, UT Southwestern Medical Center, Course Director. 1-

week intensive course for incoming graduate students (competitive 36 slots) with emphasis on basic programming, descriptive and predictive statistics, data visualization, and team-based learning.

01/2014 – UT Southwestern Medical Center, Topical lectures on cell migration (Cell Biology core course for medical students); mechanical signalling (Signal Transduction course); Image-based high-content screening (Omics course).

01/2012 – 05/2013 Protein Structure, Function and Catalysis, Course Co-Director, Harvard Medical School Graduate Program (with Steve Blacklow, Steve Harrison, Peter Sorger).

10/2011 – 10/2017 MBL Computational Image Analysis in Cell and Developmental Biology, Course director. Other faculty: Steve Altschuler, Lani Wu (UTSW), Khuloud Jaqaman (Harvard Medical School)

09/2010 – 12/2011 Fundamentals in Quantitative Cell Biology, Course Co-Director, Harvard Systems Biology Graduate Program (with Peter Sorger)

01/2010 – 05/2011 Cell Biology Core Course, Harvard Medical School, Topical lectures on cytoskeleton dynamics and cell migration (Dir: Sheila Thomas)

01/2010 – 05/2014 Principles of Optical Measurements, Massachusetts Institute of Technology, Elective for undergraduate students in physics and electrical engineering. Topical lectures on Fourier Optics and Super-resolution Microscopy. (Dir: Peter So)

07/2009 – 07/2010 MBL Physiology Course, The Marine Biological Laboratories, Woods Hole, MA (Dirs: Clare Waterman and Dyche Mullins). Faculty on one 2-week course module.

10/2008 LFD Workshop in Advanced Fluorescence Imaging and Dynamics, UC Irvine (Dir: Enrico Gratton). Two lectures on speckle microscopy and biosensor analysis

07/2008 MBL Physiology Course, The Marine Biological Laboratories, Woods Hole, MA (Dirs: Ron Vale and Tim Mitchison). Two lectures on integrated analysis of cell motility.

03/2007 – 06/2008 UC San Diego, Bioengineering Graduate Program. Course Director Advanced Biomechanics, focusing on the mechanics of molecular systems.

08/2004 – 06/2009 The Scripps Research Institute Graduate Program. Cell Biology. Topical lectures on Computational Modelling; Light microscopy; Cell Migration.

05/2003 – 06/2004 UC San Diego, Bioengineering Graduate Program, Advanced Biomechanics, Topical lectures on biopolymer dynamics.

02/2001 – 07/2003 ETH Zurich, Depts of Mechanical Engineering, Material Sciences, Computer Sciences Scientific Computing, and Biology, ETH Zurich: • Quantitative and Analytical Light Microscopy. Semester-long graduate

course including 14 lectures and a 1-week practical block course. Jointly with Andreas Stemmer.

• Energy conversion and transport in biosystems. 14-week undergraduate elective course. Jointly with Dimos Poulikakos and Yannis Ventikos.

• Computational Cell Biology. 14 week graduate elective course based on computer lab work. Jointly with Yannis Ventikos.

10/1999 – 01/2001 ETH Zurich, Dept of Material Sciences ETH Zurich • Trends in Quantitative Light Microscopy. Post-graduate seminar series. • Biomechanics of the Cell Graduate course (4 lectures)


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INVITED PRESENTATIONS Conference Talks 2018 • Enabling biological discovery through innovations in imaging and computation. NSF

Workshop at Marine Biological Lab, Woods Hole, MA. November 26 – 27. • Future of Algorithms in Biology. Workshop at Carnegie Mellon U. September 28 –

30. • Seeing the Invisible. Turku Finland. August 24 – 25. • Gordon Research Conference “Adhesion Signaling”. Biddeford, ME. June 24 – 29. • ETH Zurich Department of Biology Symposium. Davos, Switzerland. June 11 – 13

(Opening Keynote). • International Symposium on Bioimaging (ISBI), Washington, DC. April 4 – 7. • Tissue Organization, Challenging the Systems. EMBL/EMBO Conference,

Heidelberg, Germany. March 11-14. • Imaging of cancer Dynamics. II UNITO-POLITO Cancer Conference. Torino, Italy.

March 7-9. • NEUBIAS, European Imaging Consortium. Szeged, Hungary. January 31 – February

2 (Opening keynote lecture) 2017 • Seeing Is Believing. EMBL Heidelberg, Germany. October 4 – 7.

• Abercrombie Meeting, U. Oxford, UK. Sept 11 – 14. • UK Biophysical Society Meeting, Edinburgh, UK July 11 – 14. • Gordon Research Conference “Cell Contact and Adhesion”, Andover NH. June 18 –

23. • Yale Microscopy Workshop, New Haven, CT. June 6- 7. • Frontiers in Bioimaging. Janelia Farms, Ashburn, VA. April 2 – 4. • Advanced Imaging Workshop, UC Berkeley, CA. Feb 25 – 27.

2016 • Gordon Research Conference “Intermediate Filaments”. Stowe, VT. June 12 – 17. • 1st Annual Da Vinci Symposium. USC Bridge Institute. Malibu. Feb 18

2015 • Seeing is Believing. Heidelberg. Oct 6 – 10. • Quantitative Biology of Cell Signaling. Corsica, France. Sept 27 – Oct 2. • Physics of the Cell. Kloster Banz. Germany. Aug 30 – Sept 4. • System Biology of Human Disease. Heidelberg, Germany. July 6 – 8 (Keynote

Lecture). • Actin. Regensburg, Gemany. May 3 – 5. (Closing Keynote Lecture). • EMBO Workshop “Single Molecule Imaging”. Heidelberg, Germany. March 15 – 20. • Gordon Research Conference “Directed Cell Migration”. Galveston, TX. Jan 25 – 30.

2014 • Gordon Research Conference “Intermediate Filaments”. Mt Snow Resort, Dover, VT. June 15 – 20.

• Systems Biology of Mammalian Cells, Berlin, Germany. May 12 – 14. • Physics in Cancer. NCI, Bethesda, MD. April 1 – 3. • Quantitative Imaging. Albuquerque, NM. January 9 – 11.

2013 • Seeing Is Believing. EMBL Heidelberg, Germany. October 3 – 7. • British Society of Cell Biology/Developmental Biology. (Closing Plenary Lecture).

Warwick, UK March 17 – 21. • Gordon Research Conference “Extracellular Matrix Signalling”. Ventura, CA. Feb 10

– 15. 2012 • Turning Images To Knowledge, Janelia Farms, October 28 – 31.

• Imaging Cell Biology, Where Next?, Cumberland Lodge, UK. October 14 – 17. • Imaging 2020, Jackson Hole, WY, October 1 – 4. • FASEB Meeting “Mitosis: Spindle Assembly and Function”, Steamboat, CO, August

5 – 10.


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• Gordon Research Conference “Adhesion Signaling”. Colby College, ME. June 24 – 29.

• Gordon Research Conference “Intermediate Filaments”. Bates College, ME. June 17 – 22..

• Automated Microscopy and Phenotyping, Cold Spring Harbor Lab, April 10 – 14. • Imaging the Cancer Cell, Dana Farber Cancer Institute, March 28.

2011 • American Society of Cell Biology, Denver CO, December 3 – 7. (Symposium lecture) • EMBO Meeting. Vienna, Austria. September 10 – 13. • International Conference on Systems Biology. Heidelberg/Mannheim, Germany.

August 28 – September 1. Plenary Lecture. • Mathematical Biology of the Cell: Cytoskeleton and Motility. Banff, Canada. July 31

– August 5. • Gordon Research Conference “Directed Cell Migration and Chemotaxis”. Les

Diablerets, Switzerland. June 6 – 11. • Cell Migration and Mechanotransduction. NIH Bethesda, MD. May 24 – 26 (Keynote

lecture). • ISAC Annual Meeting. Special Session “Extracting Information from Images”.

Baltimore, MD. May 23. • Max Planck Society Symposium “Systems Biology of Cells and Tissues”, Dresden,

Germany. May 16. • Computational Cell Biology, Cold Spring Harbor Labs. March 28 – April 1.

2010 • INSERM Workshop, Advanced Quantitative Fluorescence Imaging of Host Cell Infection by Pathogens, Nice, FR. October 25 – 27.

• Imaging Approaches for Systems Biology, Warwick, UK. July 12 – 16. • Systems Biology of Human Disease, Boston, June 15 – 18. • Frontiers in Bioimaging, Janelia Farms, May 2 – 5.

2009 • ASCB Special Interest Group “Building the Cell”, San Diego, December 9. • Roche Lecture at the ESF/EMBO Meeting “Cell Polarity and Membrane Traffic”,

Santa Feliu, Spain, May 23 – 28. • Image Bioinformatics Workshop, HHMI Janelia Farms, April 5 – 8. • Biophysical Society Meeting. Awards Symposium, March 3. • Welcome Trust Strategic Meeting “Breaking the Limits [of Microscopy]”, Cambridge,

UK. Jan 14 – 17. 2008 • American Society of Cell Biology, Washington DC, December 13 – 17. Special

interest group session “At the limits”. • Nanophotonics, Bordeaux, France. October 23 – 27. • Cell Migration Symposium NIH, Bethesda, MD. September 16 – 18. • International Conference on Intelligent Systems for Molecular Biology (ISMB),

Toronto, Canada. July 20 – 23. • Max Planck Symposium “Future of Structural Biology”, Frankfurt, Germany. May 17

– 18. • IEEE International Symposium on Biomedical Imaging. Paris, France. May 15.

Opening Plenary Lecture. • American Society of Biochemistry and Molecular Biology Annual Meeting. San

Diego, CA. April 5 – 9. • 4th International Conference on Structural Analysis of Supramolecular Assemblies by

Hybrid Methods. Lake Tahoe, CA. March 12 – 15. • Institute for Mathematics and its Applications (IMA) Workshop “Network Analysis”,

St. Paul, MN. March 3 – 8. 2007 • Annual Meeting of Japanese Biophys. Soc. Tokyo, Japan, December 21.

• EPF Lausanne, Inauguration of BioImaging & Optics Platform. September 6.


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• Annual Meeting of Japanese Soc. Cell and Developmental Biology. Fukuoka, Japan. May 28.

• EMBO Workshop on Imaging for High-throughput Screening. Heidelberg, Germany. April 27.

• Gordon Research Conference Chemotaxis and Directed Cell Migration. Ventura, CA. Feb 1.

2006 • IMP, IMBA, and Boehringer Ingelheim, Vienna. Meeting on Cellular and In Vivo Imaging. Vienna, Austria, November 9 – 11.

• Wolfgang Pauli Workshop Cell Motility and Cytoskeletal Dynamics. Vienna, Austria, November 8.

• UCSF Nikon Imaging Center. Opening Symposium. San Francisco, CA. September 29.

• American Society of General Physiologists. Woods Hole, MA. September 6. • SIAM/SMB Life Sciences Meeting. Raleigh, NC. July 31. (Plenary Lecture) • Congress of the International Society for Analytical Cytology. Quebec City, Canada.

May 20. (Plenary Lecture) • NIH NIGMS Symposium Frontiers in Imaging Live Cells. Washington D.C. April 19. • La Jolla Cell Biology Meeting. Salk Institute, La Jolla, CA. April 11. • IEEE International Symposium on Biomedical Image Processing. Arlington, VA. April

6 • American Physical Society Meeting. Baltimore, MD. March 13. • Biophys. Soc. Annual Meeting, Motility Subgroup. Salt Lake City, UT. February 18. • DARPA Cell Signaling Workshop. Arlington, VA. January 24.

2005 • Annual Meeting of the American Soc. Cell Biology. San Francisco, CA. Special emphasis group on modeling cell migration. December 10.

• Wolfgang Pauli Workshop Cell Motility and Cytoskeletal Dynamics. Vienna, Austria, November 11.

• Biosciences 2005. Glasgow, UK. July 18. • European Light Microscopy Initiative. Semmering. Austria. June 5. • International Symposium on Computational Cell Biology. Lenox, MA. March 21. • Biophys. Soc. Annual Meeting. Long Beach, CA. February 13 (talk given by Lin Ji).

2004 • IEEE International Symposium on Biomedical Image Processing. Washington D.C. April 14.

• Multiscale Modeling Workshop. San Diego, CA. March 26. • Conference on Computational and Systems Biology, MIT. Cambridge, MA. January

8. 2003 • Optical 3D Measurement Techniques. Zurich, Switzerland. September 22. Keynote

Lecture. • EMBO Young Investigator Programme, Symposium on Fluorescence Microscopy.

Heidelberg, Germany. May 14. • Biophys. Soc. Annual Meeting. San Antonio, TX. March 1. • Conference on Computational and Systems Biology, MIT. Cambridge, MA. January

9. 2002 • Annual Meeting of the American Soc. Cell Biology, Minisymposium on

Computational Approaches to Cell Biology. San Francisco, CA. December 15 • Live Cell Imaging Workshop EPF Lausanne. Lausanne, Switzerland. October 9. • Joining Forces Symposium – Biology meets Chemistry, Engineering and Computer

Science, ETH Zurich. Zurich, Switzerland. March 22. • Biophys. Soc. Annual Meeting. San Francisco, CA. February 24 (talk delivered by

Dominik Thomann). 2001 • Annual Meeting of the American Soc. Cell Biology, Special Interest Group on

Quantitative Microscopy and Image Informatics. Washington D.C. December 9.


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• Workshop on New Directions in Cellular and Tissue Biomechanics. Les Diablerets, Switzerland, September 25.

• Biosurf IV. Lausanne, Switzerland. September 21. • Conference of the International Society for Biomechanics. Zurich, Switzerland. July

9. • European Cells and Materials Meeting. Davos, Switzerland. June. 25 • Bioinformatics Symposium, Biozentrum Basel. Basel, Switzerland. April 18.

2000 • Workshop on Image Sequence Analysis to Investigate Dynamic Processes. Heidelberg, Germany. September 19.

• Gordon Research Conference Developmental Physiology. Plymouth, NH. July 5. • Tissue Engineering Workshop. Davos, Switzerland. February 20. • SPIE Photonics West, Three-Dimensional Microscopy: Image Acquisition and

Processing VII. San Jose, CA. Jan. 24. 1999 • Annual Meeting of the American Soc. Cell Biology, Special Interest Group on

Quantitative Microscopy and Image Informatics. Washington D.C. December 11. • European Cells and Materials Meeting. Davos, Switzerland. August 23.

1998 • New England Society for Microscopy. Boston, MA. December 4. • Journees de Micro-Technique'98, Lausanne, Switzerland. October 1.

1997 • Deutsches Optik-Kolloquium’97. Stuttgart, Germany. February 19. 1996 • Int’l Soc. for Photogrammetry and Remote Sensing World Congress. Vienna,

Austria. July 13. • European Optical Society Symposium: Lasers, Optics and Vision for Productivity in

Manufacturing. Besancon, France. June 11. 1995 • ISPRS Intercommission Workshop From Pixels to Sequences. Zurich, Switzerland.

March 24. • SPIE Photonics West, Three-Dimensional Microscopy: Image Acquisition and

Processing III. San Jose, CA. February 10. Seminars 2018 • University of Zurich, Molecular Life Sciences, Zurich, Switzerland. June 8.

• University of Utah, Huntsman Cancer Research Institute. Salt Lake City. UT. April 26.

• Institute Pasteur and Curie, Bioinformatics Hub, Paris, France. February 21. 2017 • University of North Texas, Denton, TX. December 1.

• Yale Microscopy Workshop. New Haven, CT. June 6 – 7. • St Jude Children’s Hospital, Bioinformatics Symposium, Memphis, TN. April 25.

2016 • Institut Pasteur, Cell Biology Platform, Paris, France. Nov 28. • Symposium of the BioFrontiers Institute, U. Colorado Boulder, CO. Aug 12. • Stanford University, Center for Systems Biology, Keynote address to annual retreat.

Los Gatos, CA, June 28. • Biozentrum Basel, Switzerland. April 26. • Department of Molecular and Cell Biology. Yale University, New Haven, CT. March

28. • Joint Life Sciences Graduate Program, ETH Zurich and University of Zurich,

Switzerland, March 7. 2015 • Computational Biology Graduate Program, Carnegie Mellon U., Pittsburgh, PA,

November 13. • Department of Physics, Washington University St. Louis, MO, October 28. • Institute of Science and Technology, Vienna, Austria. July 9. • Cancer Imaging Program, UT Southwestern Medical Center, Dallas, TX, May 15. • Imaging Grand Rounds, UT Southwestern Medical Center, Dallas, TX, February 12.


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2013 • Biophysics and Biochemistry Center, NHLBI, June 5. • Purdue University, West Lafayette. January 23.

2012 • University of Marseille, FR, INFORM-LABEX kick-off meeting. December 5. • University of Chicago, Cell Biology and Physics. November 12. • Institute for Cancer Research, London, UK. October 17. • Rockefeller University, Biophysics Graduate Program. May 8. • Princeton University, Biophysics Seminar. May 7. • University of North Carolina, Chapel Hill. Department of Pharmacology. April 24. • UC San Diego. Bioengineering Department. April 10. • UT Southwestern Medical Center, Dallas. Cell Biology Department. March 5. • University of Connecticut, Storrs. Cell Biology Department. Feb 14 . • Northwestern University, Chicago. Molecular Cell Biology Department. January 18.

2011 • University of North Carolina, Chapel Hill. Pharmacology Graduate Retreat. November 8.

• Vanderbilt U., Nashville, TN. Department of Developmental and Cellular Biology. September 19.

• Nanobiology Summer School, Bad Herrenalp, Germany. September 9. • New York University. 10th Annual Symposium on Genomics and Systems Biology.

May 4. • Massachusetts Institute of Technology. Department of Biological Engineering.

February 10. • Massachusetts Institute of Technology. Department of Biology. March 1. (Holt

Lecture) 2010 • Massachusetts General Hospital. Division of Nephrology. December 7.

• University of Bordeaux. France. September 8. (Leica Life Science Forum Lecture) • Marie Curie Institute. Paris. France. September 6. (Leica Life Science Forum

Lecture) • Max Planck Institute for Biochemistry. Martinsried, Germany. March 22.

2009 • Cell Biology Department Retreat, Faculty Lecture. Boston. October 27. • Genentech Inc., South San Francisco. June 18. • Johns Hopkins University, Bioengineering Department. May 11. • Dalhousie University, Halifax, Canada. February 26. • University of Montreal, Canada. Cancer Research Institute. February 22. • Wellcome Trust Biocenter, Dundee, UK. January 19.

2008 • The Scripps Research Institute, Department of Cell Biology, November 17. • U. Virginia, Department of Bioengineering, September 22. • ETH Zurich, Department of Biology, June 26. • U. Virginia, Department of Cell Biology, April 30. • U. Connecticut, Department of Cell Biology, February 28. • U. Connecticut, Department of Physics, February 27. • UC San Francisco, Departments of Biophysics and Pharmacology, San Francisco,

CA, January 22. 2007 • U. Kyoto, Departments of Cell Biology and Biophysics, Kyoto, Japan. December 19.

• Harvard University, Department of Cell Biology, Cambridge, MA. October 22. • Tokyo University, Department of Cell Biology. Tokyo, Japan. June 1. • Riken Center for Developmental Biology. Kobe, Japan. May 31. • John Hopkins U., Department of Cell Biology, Baltimore, MD. April 4. • University of North Carolina, Department of Pharmacology. Chapel Hill, NC. April 2. • Laurence Berkeley National Laboratories, Berkeley, CA. March 29. • Stanford U. Molecular and Cellular Biology Lecture Series, Palo Alto, CA. March 28. • Harvard University, Department of Systems Biology, Cambridge, MA. March 16


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• Albert Einstein College of Medicine, Biophotonics Center, New York, NY. March 14. • San Diego State U., Interdisciplinary Program on Mathematics and Biology, San

Diego, CA. January 26. 2006 • UT Southwestern Medical Center, Dallas, TX. November 13.

• Yale University, Departments of Molecular and Developmental Cell Biology, and of Mechanical Engineering, New Haven, CT. October 4.

• ETH Zurich, Department of Cell Biology, Switzerland. September 1. • UC Los Angeles, Interdisciplinary Program on Advanced Mathematics (IPAM), Los

Angeles, CA. May 23. • EPF Lausanne, School of Life Sciences, Lausanne, Switzerland. April 27. • University of Pennsylvania, Department of Bioengineering. Philadelphia, PA.

January 24. 2005 • University of California Santa Barbara, Center for Bioimage Informatics. Santa

Barbara, CA. October 12. • Hospital for Sick Kids, Department of Biochemistry. Toronto, CA. August 3. • ETH Zurich, Department of Biochemistry, Switzerland. May 25. • Institute Pasteur, Department of Cell Biology, Paris, France. May 23. • University of California San Diego, Center for Theoretical Biological Physics, March

11. 2004 • Rockefeller University. New York, NY. November 14.

• University of North Carolina, Department of Cell Biology. Chapel Hill, NC. November 5.

• University of Pennsylvania, Department of Cell Biology. Philadelphia. November 1. • Carnegie Mellon University, Biomedical Engineering Seminar Series. Pittsburgh, PA.

February 26. • Burnham Institute, San Diego Actin Club. San Diego, CA. February 2.

2003 • University of California San Diego, Whitaker Institute of Bioengineering. San Diego, CA. October 31.

• The Scripps Research Institute, Advanced Molecular Imaging Forum. San Diego, CA. October 30.

• Swiss House Advanced Imaging Workshop organized by Bitplane Inc. Boston, MA. October 24.

• The Massachusetts Institute of Technology, Whitehead Institute for Bioimaging. Cambridge, MA. October 24.

• Swissnex Advanced Imaging Workshop organized by Bitplane Inc. San Francisco, CA. October 21.

• Max Planck Institute for Biochemistry. Martinsried, Germany. April 4. • Marine Biological Laboratory. Woods Hole, MA. January 7.

2002 • University of Zurich, Molecular Genetics Seminar Series. Zurich, Switzerland, December 3.

• Swiss Tissue Culture Society Workshop. Zofingen, CH. November 6. • Hoffmann-La Roche Research. Basel, CH. June 6. • ETH Zurich, Institut für Geodaesie und Photogrammetrie. Zurich, Switzerland. May

16. 2002. • ETH Zurich, Inauguration Lecture. Zurich, Switzerland. February 5.

2001 • ETH Zurich, Institute for Process Engineering. Zurich, Switzerland. December 18. • The Scripps Research Institute, Molecular and Cellular Biology Affinity Group

Seminar Series. La Jollas, CA. September 4. • Ludwig Maximilian University Munich, Center for Nanosciences. Munich, Germany.

July 24. • ETH Zurich, Institute for Biomedical Engineering. Zurich, Switzerland. May 4.


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2000 • Purdue University, Department of Biomedical Engineering. West Lafayette, IN. December 5.

• University of North Carolina, Department of Cell Biology. Chapel Hill, NC. December 3.

• ETH Zurich, Institute of Pharmacology. Zurich, Switzerland. November 7. • Wellcome Trust Biocenter. Dundee, UK. November 2. • Massachusetts Institute of Technology Advanced Microscopy Consortium,

Department of Biology. Cambridge, MA. July 11. • Massachusetts Institute of Technology, The NANONERD seminar series.

Cambridge, MA. July 11. • University of Michigan, Biophysical Seminars Series. Ann Arbor, MI. June 30. • ETH Zurich, Department of Materials. Zurich, Switzerland. May 24. • ETH Zurich, Image Science Laboratory. Zurich, Switzerland. May 11. • ETH Zurich, Department of Mechanical Engineering. Zurich, Switzerland. April 28. • The Scripps Research Institute, Department of Cell Biology. La Jolla, CA, Feb. 4.

1999 • ETH Zurich, Department of Materials. Zurich, Switzerland. June 14. • Columbia University, Departments of Microbiology and Cell Biology, New York, NY,

May 18. 1998 • ETH Zurich, Department of Materials. Zurich, Switzerland. December 17.

• Carl Zeiss Inc. Jena, Germany. August 20. • Ruhr Universitaet, Department of Analytical Chemistry. Bochum, Germany. August

17. • Yale University, Computer Science Department. New Haven, CT. March 27. • Marine Biological Laboratory, Boston University Marine Program Seminar. Woods

Hole, MA. March 11. 1997 • University of Stuttgart, Institute for Applied Optics. Stuttgart, Germany. January 15.

• Centre Suisse Electronique et Microtechnique CSEM. Neuchatel, Switzerland. March 19.

• Carnegie Mellon University, Department of Electrical Engineering. Pittsburgh, PA. September 16.

• Carnegie Mellon University, Institute of Robotics. Pittsburgh, PA. September 17. 1996 • Marine Biological Laboratory. Woods Hole, MA. September 17.

• Siemens Princeton Research Laboratory. Princeton, NJ. October 1.


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BIBLIOGRAPHY * indicates shared senior authorship Primary Research Articles 1. Mohan A., Dean K., Kasitinon S.K., Isogai T., Murali V.S., Han S.J., Roudot P., Groisman A., Welf

E. Danuser G. Hyperactive Rac1 drives MAPK-independent proliferation in melanoma by assembly of a mechanosensitive dendritic actin network. In revision.

2. Driscoll M., Welf E.S., Dean K.M., Fiolka R., Danuser G. Cell morphological motif detector for high-resolution 3D microscopy images. In revision.

3. Ding L., Danuser G. Structure-guided hysteresis thresholding by iterative graph matching applied to reconstruction of cytoskeleton networks. In revision.

4. Hsu P-H, Marco E., Tytell J., Sorger P.K., Jaqaman K.*, Danuser G.* In vivo evidence for Ndc80p regulated kinetochore-microtubule slippage. In revision.

5. David A., Roudot P., Legant W. , Betzig E., Danuser G., Gehrlich D. Augmin-mediated amplification of long-lived spindle microtubules directs plus-ends to kinetochores. In Revision.

6. Bagonis M., Fusco L., Pertz O. Danuser G. Automated profiling of growth cone heterogeneity defines relations between morphology and motility. In revision.

7. Ma X., Dagliyan O., Hahn K.M., Danuser G. Profiling Cellular Morphodynamics by Spatiotemporal Spectrum Decomposition. PLoS Comp. Biology. In Press

8. Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MC. Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. Proc Natl Acad Sci U S A. In Press.

9. Srinivasan S, Burckhardt CJ, Bhave M, Chen Z, Chen PH, Wang X, Danuser G, Schmid SL. A noncanonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells. PLoS Biol. 16(4):e2005377. 2018.

10. Roudot P., Ding L., Jaqaman K., Kervrann C., Danuser G. Piecewise-stationary motion modeling and iterative smoothing to track heterogeneous particle motion in dense environments. IEEE Trans Image Processing. DOI 10.1109/TIP.2017.2707803 In Press.

11. Lai TP, Zhang N, Noh J, Mender I, Tedone E, Huang E, Wright WE, Danuser G, Shay JW. A method for measuring the distribution of the shortest telomeres in cells and tissues. Nature Comm. 8(1):1356. 2017.

12. Werbin JL, Avendaño MS, Becker V, Jungmann R, Yin P*, Danuser G*, Sorger PK*. Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane. Sci Rep. 7(1):12150. 2017.

13. Costigliola N., Ding L., Burckhardt C.J., Han S., Gutierrez E., Mota A., Groisman A., Mitchison T.J., Danuser G. Vimentin fibers orient traction stress. Proc Natl Acad Sci U S A. 114(20):5195-5200 2017.

14. Zaritsky A., Tseng Y-Y., Rabadán M.A., Krishna S., Overholtzer M.*, Danuser G.*, Hall A. Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration. J. Cell Biol. . 2017.

15. Zaritsky A., Obolski U., Gan Z., Reis C.R., Kadlecova Z., Du Y., Schmid S.L., Danuser G. Decoupling global biases and local interactions between cell biological variables. eLife. doi: 10.7554/eLife.22323. 2017.

16. Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 27(22):3418-3435. 2016.

17. Schäfer C. Mohan A., Burford W., Driscoll M.K., Ludlow A.T., Wright W.E., Shay J.W., Danuser G. KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility. Convergent Science Physical Oncology. 2:035004. 2016.


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18. Wang H., Vilela M., Winkler A., Tarnawski M., Schlichting I., Yumerefendi H., Kuhlman B., Liu R., Danuser G.*, Hahn K.M.* LOVTRAP, A Versatile Optogenetic System, Reveals Resonator Motifs In Mammalian Mechano-chemical Signaling Pathways. Nature Methods. 13(9):755-758. 2016.

19. Gan Z., Ding L., Burckhardt C.J., Zaritsky A., Sitterley K., Mota A., Costigliola N., Starker C.G., Voytas D.F., Tytell J., Danuser G. Vimentin enhances directed cell migration by templating microtubule-mediated cell polarity. Cell Systems. 3(3):252-263. 2016.

20. Hodgson L., Spiering D., Sabouri M., Dagliyan O., DeMardirosian C., Danuser G.*, Hahn K.M.* Simultaneous imaging of Cdc42 activity and Cdc42-GDI binding in motility using Cdc42 modified with a novel FRET binding antenna. Nature Chem Bio. 12(10):802-809. 2016.

21. Welf E.S., Driscoll M.K., Dean K.M., Schäfer C., Chu J., Davidson M.W., Lin M.Z., Danuser G, Fiolka R. Quantitative multiscale cell imaging in controlled 3D microenvironments. Dev Cell. 36(4):462–475, 2016.

22. Zaritsky A., Welf E.S., Tseng Y., Rabadán M.Á., Serra-Picamal X., Trepat X., Danuser G.. Seeds of locally aligned motion and stress coordinate collective cell migration. Biophys. J. 109(12):2492-500. 2015.

23. Lomakin A.J., Lee K-C, Han S.J., Bui A., Davidson M., Mogilner A*, Danuser G*. Myosin-II controlled switch regulates cell polarization by balancing two competing actin networks. Nature Cell Biology. 17: 1435-1445, 2015. Cover Story.

24. Kwon M., Bagonis M., Danuser G., Pellman D. Overlapping Myo10-and Dynein dependent Cortical Microtubule Capture Mechanisms Promote Centrosome Positioning. Dev Cell. 34(3):323-37. 2015.

25. Lee K., Elliott H.L., Oak Y., Zee C.T., Groisman A., Danuser G. Functional hierarchy of redundant actin nucleators revealed by fine-grained registration of intrinsic image fluctuations. Cell Systems. 1, 37-50. 2015.

26. Dean K.M., Roudot P., Welf E.S., Danuser G., Fiolka R. Optimal Optical Sectioning Light-Sheet Microscopy. Biophys. J. 108(12):2807-2815. 2015. Cover Story.

27. Han S.J., Oak, Y., Groisman A., Danuser G. Traction microscopy to identify force modulation in sub-resolution adhesions. Nature Methods. 12(7):653-656. 2015

28. Mendoza M.C., Vilela M., Juarez J.C., Blenis J., Danuser G. ERK reinforces actin polymerization to power persistent edge protrusion during motility. Science Signaling. 8(377):ra47. 2015

29. Chittajallu D.R., Florian S., Kohler R.H., Iwamoto Y., Orth J.D., Weissleder R.*, Danuser G.*, Mitchison T.J.* In vivo cell cycle profiling in xenograft tumors by quantitative intravital microscopy. Nature Methods. 12(6):577-85. 2015.

30. Hookway C, Ding L, Davidson MW, Rappoport JZ, Danuser G, Gelfand VI. Microtubule-dependent transport and dynamics of vimentin intermediate filaments. . Mol. Biol. Cell. 2015.

31. Elliott H., Fischer R.A.*, Myers K.A., Desai R., Gao L., Chen C.S., Adelstein R., Waterman C.M.*, Danuser G*. Myosin II controls cellular branching morphogenesis and migration in 3D by minimizing cell surface curvature. Nature Cell Biology. 17(2):137-47. 2015

32. Ng M.R., Besser A., Brugge J.S., Danuser G. Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters. eLife. Dec 5;4. doi: 10.7554/eLife.03282.. 2015.

33. Martin K., Vilela M. Jeon N-L, Danuser G, Pertz O. Growth-factor-induced, persistent fibroblast migration is mediated by mechanical insulation of cell front and back. Dev Cell. 30(6):701-16. 2014

34. Yi J.J., Wang H., Vilela M., Danuser G., Hahn K.M. Manipulation of Endogenous Kinase Activity in Living Cells Using Photoswitchable Inhibitory Peptides. Synthetic Biology. 3(11):788-95. 2014.

35. Cai D., Chen S., Prasad M., He L., Wang X., Choesmel-Cadamuro V., Sawyer J.K., Danuser G., Montell D.J. Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration. Cell. 157(5):1146-59. 2014

36. Smole Z, Thoma CR, Applegate KT, Duda M, Gutbrodt KL, Danuser G*, Krek W*. Tumor suppressor NF2/merlin is a microtubule stabilizer. Cancer Research 74(1):353-62. 2014. [PMCID: PMC3929585]

http://hms.harvard.edu/WhitePagesPublic.asp?task=showperson&id=EFQwaWZJOTQ=&a=hms&r=1&kw=

http://hms.harvard.edu/WhitePagesPublic.asp?task=showperson&id=HVQ_Z2FDOzU=&a=hms&r=1&kw=

http://www.ncbi.nlm.nih.gov/pubmed/24282279



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37. Lowery LA, Stout A, Faris AE, Ding L, Baird MA, Davidson MW, Danuser G*, Van Vactor D*. Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth. Neural Dev. 8:22. 2013. [PMCID: PMC3907036]

38. Zawistowski J.S., Sabouri-Ghomi M., , Danuser G., Hahn K.M., Hodgson L.A. RhoC biosensor reveals differential activation of RhoA and RhoC in migrating cells. Plos One. 8(11):e79877. 2013. [PMCID: PMC3818223]

39. Marco E., Dorn J.F., Hsu P-H, Jaqaman K., Sorger P.K., and Danuser G. S. cerevisiae Chromosomes Biorient via Gradual Syntely Resolution from DNA Replication to Anaphase Onset. Cell. 154(5):1127-39. 2013. [PMCID: PMC3802543]

40. Aguet F, Antonescu C.N., Mettlen M., Schmid S.L.*, Danuser G.* Advances in low signal-to-noise imaging link Dynamin and AP2 to the functions of an endocytic checkpoint. Dev Cell. 26(3):279-91. 2013. [PMCID: PMC3939604]

41. Thievessen I, Thompson P.M., Berlemont S, Plevock K.M., Plotnikov S.V., Zemljic-Harpf A, Ross R.S., Davidson M.V., Danuser G, Campbell S.V., Waterman C.M. Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J. Cell Biology. 202(1):163-77. 2013. [PMCID: PMC3704983]

42. Long J.B., Bagonis M., Lowery L-A., Lee H., Danuser G., Van Vactor D. Multi-parametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics. Mol. Biol. Cell. 33(8):1528-1545. 2013. [PMCID: PMC3624261]

43. Ng M.R., Besser A., Danuser G*, Brugge J.S.*. Substrate Stiffness Regulates Cadherin-Dependent Collective Migration Through Myosin-II Contractility. J. Cell Biology. 199(3):545-563 2012. [PMCID: PMC3483134]

44. Nishimura Y., Applegate K., Danuser G., and Waterman C.M. Automated screening of microtubule growth dynamics identifies MARK2/Par1 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells. Plos One. 7(7):e41413. 2012. [PMCID: PMC3404095]

45. Loerke D., Le Duc Q., Blonk I., Kerstens A., Spanjaard E., Machacek M., Danuser G.*, and De Rooji J.* Quantitative imaging of epithelial cell scattering identifies specific inhibitors of cell motility and cell-cell dissociation. Science Signaling. 5(231):rs5. 2012.

46. Reis G.F., Yang G., Szpankowski L., Shah S.B., Robinson J.T., Hays T.S., Danuser G.*, Goldstein L.S.* Genetic Evidence for a Competition-Coordination Mechanism between Kinesin and Dynein in Axonal Transport of APP Vesicles. Mol. Biol. Cell. 23(9):1700-1714. 2012. [PMCID: PMC3338437]

47. Dittrich C., Burckhardt C.J., Danuser G. Peptide Nanoparticles Targeted by a Protein Corona Efficiently Deliver Membrane Impermeable Compounds into CHO Cells. Biomaterials. 33(9):2746-53. 2012. [PMCID: PMC3480320]

48. Nunez D., Antonescu C., Mettlen M., Schmid S.L., Loerke D., Danuser G. Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources. Traffic. 12(12):1868-1878. 2011. [PMCID: PMC3298691]

49. Gutierrez E., Tkachenko E., Besser A., Sundt P., Ley K., Danuser G., Ginsberg M.H., Groisman A. High Refractive Index Silicone Gels as Substrates with Physiological Rigidity for Simultaneous Total Internal Reflection Fluorescence and Traction Force Microscopy of Adherent Cells. Plos One. 6(9):e23807. 2011. [PMCID: PMC3178539]

50. Applegate K.T., Besson S., Matov A., Bagonis M.H., Jaqaman K., Danuser G. plusTipTracker: quantitative image analysis software for the measurement of microtubule dynamics. J. Struct. Biol. 176:168 – 184. 2011. [PMCID: PMC3298692]

51. Jaqaman K., Kuwata H., Touret N., Trimble W., Danuser G.*, Grinstein S.* Cytoskeleton control of CD36 diffusion promotes its receptor and signaling function. Cell. 146(4):593-606. 2011. [PMCID: PMC3160624]

52. Iwanicki M.P., Davidovitz R.A., Ng M.R., Besser A., Muranen T., Merritt M., Danuser G., Ince T. Brugge J.S. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discovery. 1:144-157. 2011. [PMCID: PMC3269166]


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53. Antonescu C., Aguet F., Danuser G., Schmid S.L. Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization and size. Mol Biol. Cell. 22(14):2588-600. 2011. [PMCID: PMC3135483]

54. Delorme-Walker V., Peterson J.R., Chernoff J., Waterman C.M., Danuser G., DerMardirossian C., Bokoch G. Pak 1 regulates focal adhesion strength, myosin IIA distribution and actin dynamics to optimize cell migration. J. Cell Biology. 193(7):1289-303. 2011. [PMCID: PMC3216326]

55. Loerke D., Mettlen M., Schmid S.L., Danuser G. Measuring the hierarchy of molecular events during clathrin-mediated endocytosis. Traffic. 12(7):815-25. 2011. [PMCID: PMC3115502]

56. Tkachenko E., Sabouri Ghomi M., Pertz O, Kim C., Gutierrez E., Machacek M., Groisman A., Danuser G., Ginsberg M.H. Protein Kinase A Governs a RhoA-RhoGDI-driven Protrusion-Retraction Pacemaker in Migrating Cells. Nat. Cell Biol. 13(6):661-8. 2011. [PMCID: PMC3746034]

57. Mendoza M.C., Er E.E., Zhang W., Ballif B.A., Elliott H.L., Danuser G., Blenis J. ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex. Mol Cell. 41(6):661-671. 2011. [PMCID: PMC3078620]

58. Matov A., Edvall M., and Danuser G. Optimal-flow minimum-cost correspondence assignment in particle flow tracking. Computer Vision Image Understanding. 115(4):531-540. 2011. [PMCID: PMC3123713]

59. Myers K.A., Applegate K.T, Danuser G.*, Fischer R.*, Waterman C.M.* Distinct compliance- and dimensionality-dependent pathways of extracellular matrix mechanosensing regulate microtubule dynamics to control endothelial cell branching morphogenesis. J. Cell Biology 192:321-334. 2011. [PMCID: PMC3172168]

60. Liu A.P., Aguet F., Danuser G.*, Schmid S.L.* Local clustering of transferrin receptors promotes clathrin-coated pit initiation. J. Cell Biology 191:1381-1393. 2010. [PMCID: PMC3010081]

61. Thoma C., Matov A., Gutbrodt K.L., Hoerner C.R., Smole Z., Krek W.*, Danuser G.* Quantitative Image Analysis Identifies pVHL as a Key Regulator of Microtubule Dynamic Instability. J. Cell Biology .190(6):991 – 1003. 2010. [PMCID: PMC3101603]

62. Matov A., Applegate K., Thoma C., Krek W., Danuser G.*, Wittmann T.* Analysis of microtubule dynamic instability using a growth marker. Nature Methods. 7:761-768. 2010. [PMCID: PMC3032800]

63. Antonescu C.N., Danuser G., Schmid S.L. Phosphatidic Acid Plays a Regulatory Role in Clathrin-mediated Endocytosis. Mol. Biol. Cell. 21(16):2944-2952. 2010. [PMCID: PMC2921119]

64. Lim J., Sabouri Ghomi M., Machacek M., Waterman C.M., Danuser G. Protrusion persistence and lamellipodial F-actin assembly in migrating epithelial cells are defined by the organization of contractile actomyosin structures in the lamella. Exp. Cell Research. 316(13):2027 - 2041. 2010. [PMCID: PMC2900543]

65. Wilson C.A., Tsuchida M.A., Allen G.M., Barnhart E.L., Applegate K.T., Yam P.T., Ji L., Keren K., Danuser G., Theriot J.A. Myosin II contributes to cell-scale actin network treadmilling via network disassembly. Nature 465, 373-377. 2010. [PMCID: PMC3662466]

66. Enulescu M., Sabouri-Ghomi M., Danuser G., Falcke M. Modeling of protrusion phenotypes driven by the actin-membrane interaction. Biophys. J. 98(8):1571 – 1581. 2010. [PMCID: PMC2856167]

67. Mettlen M., Loerke D., Yarar D. Danuser G., Schmid S.L. Cargo and adaptor specific mechanisms regulate clathrin-mediated endocytosis. J. Cell Biology .188(6):919- 933. 2010. [PMCID: PMC2845073]

68. Jaqaman K., King E.M., Amaro A.C., Winter J.R., Dorn J.F., Elliott H.L., McHedlishvili N., McClelland S.E., Porter I.M., Posch M., Toso A., Danuser G.*, McAinsh A.D.*, Meraldi P.*, Swedlow J.R.*. Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases. J. Cell Biology 188(5):665- 679. 2010. [PMCID: PMC2835940]

69. Gatlin J.C., Matov A., Danuser G., Mitchison Y.J., Salmon E.D. Directly probing the mechanical properties of the spindle and its matrix. J. Cell Biology 188(4): 481 – 489. 2010. [PMCID: PMC2828919]




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70. Houghtaling B.R., Yang G., Matov A. Danuser G.*, Kapoor T.M.* Op18 Reveals the Contribution of Non-Kinetochore Microtubules to the Dynamic Organization of the Vertebrate Meiotic Spindle. Proc. Natl Acad Sci USA. 106(36): 15338-15343. 2009. [PMCID: PMC2741252]

71. Liu A.P., Loerke D., Schmid S.L.*, Danuser G.* Global and Local Regulation of Clathrin-Coated Pit Dynamics Detected on Patterned Substrates. Biophys. J. 97(4):1038 – 1047. 2009. [PMCID: PMC2726330]

72. Machacek M., Hodgson L., Welch C. Elliott H., Pertz O., Nalbant P., Abell A., Johnson G.L., Hahn K.M.*, and Danuser G.* Coordination of Rho GTPase activities during cell protrusion. Nature. 461:99 – 103. 2009. [PMCID: PMC2885353]

73. Mettlen M., Stoeber M., Loerke D., Antonescu C.N., Danuser, Schmid S.L. Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol. Biol. Cell. 20(14):3251 - 3260. 2009. [PMCID: PMC2710825]

74. Kumar P., Lyle K.S., Gierke S., Matov A., Danuser G., and Wittmann T. GSK3[Beta] phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment. J. Cell Biology 184(6):895-908. 2009 [PMCID: PMC2699158]

75. Gatlin J.C., Matov A., Groen A.C., Needleman D.J., Maresca T.J., Danuser G., Mitchison T.J., Salmon E.D. Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr. Biol. 19(4):287-296. 2009. [PMCID: PMC2709244]

76. Loerke D., Mettlen M., Yarar D., Jaqaman K., Jaqaman H., Danuser G.*, and Schmid S.L.* Cargo and dynamin regulate clathrin-coated pit maturation. PLoS Biology. 7(3):e57. 2009. [PMCID: PMC2656549]

77. Gardel M. L., Sabass B., Ji L. Danuser G., Schwarz U.S., Waterman C.M. Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J. Cell Biology. 183(6): 999-1005. 2008. Cover Story. [PMCID: PMC2600750]

78. Ji L., Lim J., and Danuser G. Fluctuations of intracellular forces during cell protrusion. Nat. Cell Biol. 10, 1393 – 1400. 2008. Cover Story. [PMCID: PMC2597050]

79. Yang G., Cameron L.A., Maddox P.S., Salmon E.D., Danuser G. Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle. J. Cell Biology. 182(4):631 – 639. 2008. [PMCID: PMC2518697]

80. Jaqaman K., Loerke D., Mettlen M., Kuwata H., Grinstein S., Schmid S.L., Danuser G. Robust single particle tracking in live-cell time-lapse sequences. Nat. Methods. 5:695 - 702. 2008. Cover Story. [PMCID: PMC2747604]

81. Burnette D.T., Ji L., Schaefer A.W., Medeiros N.A., Danuser G., and Forscher P. Myosin II activity facilitates microtubule bundling in the neuronal growth cone neck. Dev Cell. 15:163 – 169. 2008. [PMCID: PMC2548298]

82. Schaefer A.W., Schoonderwoert V.T., Ji L., Danuser G., and Forscher P. Coordination of Actin Filament and Microtubule Dynamics during Neurite Outgrowth. Dev Cell. 15:146 – 162. 2008. [PMCID: PMC2595147]

83. Burnette D.T., Schaefer A.W., Ji L., Danuser G., and Forscher P. Filopodial actin bundles are not necessary for microtubule advance into the peripheral domain of Aplysia neuronal growth cones. Nat. Cell Biol. 9(12):1360 – 1369. 2007.

84. Yang G., Houghtaling B.R. Gaetz J., Liu J.Z., Danuser G.*, and Kapoor T.M.* Architectural Dynamics of the Meiotic Spindle Revealed by Single-Fluorophore Imaging. Nat. Cell Biol. 9(11):1233 - 1242. 2007.

85. Delorme V., Machacek M., DerMardirossian C., Andersen K.L., Wittmann T., Hanein D., Waterman-Storer C., Danuser G.*, and Bokoch G.M.* Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev Cell. 13:646 - 662. 2007. Cover Story. [PMCID: PMC2170459]

86. Csúcs G., Quirin K. and Danuser G. Locomotion of Epidermal Fish Keratocytes and Spatially Selective Adhesion Patterns. Cell Motil. Cytoskeleton. 64:856 - 867. 2007.

87. Yam P.T., Wilson C.A., Ji L., Hebert B., Barnhart E.L., Wiseman P.W., Danuser G., and Theriot J.A. Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility. J. Cell Biol. 178:1207-1221. 2007. [PMCID: PMC2064654]


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88. Jaqaman K., Dorn J.F., Marco E., Sorger, P.K., Danuser G. Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics. Bioinformatics. 23:1666-1673. 2007.

89. Soutoglou E., Dorn J.F., Sengupta K., Jasin M., Nussenszweig A., Ried T., Danuser G., and Misteli T. Positional stability of single double-strand breaks in mammalian cells. Nat. Cell Biol. 9(6): 675 – 682. 2007. [PMCID: PMC2442898]

90. Hu K., Ji L., Applegate K.T., Danuser G.*, and Waterman-Storer C.M.* Differential transmission of actin motion within focal adhesions. Science. 315: 111 - 115. 2007.

91. Jaqaman K., Dorn J.F., Jelson, G.S., Tytell J.D., Sorger, P.K., Danuser G. Comparative autoregressive moving average analysis of kinetochore microtubule dynamics in yeast. Biophys. J. 91: 2312-2325. 2006. [PMCID: PMC1557555]

92. Cameron L.A., Yang G., Cimini D., Canman J.C., Kisurina-Evgenieva O., Khodjakov A., Danuser G., and Salmon E.D. Kinesin 5-independent poleward flux of kinetochore microtubules in Ptk1 cells. J. Cell Biol. 173:173 – 179. 2006. Cover Story. [PMCID: PMC2063808]

93. Machacek M. and Danuser G. Morphodynamic profiling of protrusion phenotypes. Biophys. J. 90: 1439 – 1452. 2006.

94. Ji L. and Danuser G. Tracking quasi-stationary flow of weak fluorescent signals by adaptive multi-frame correlation. J. Microscopy. 220(3):150 - 167. 2005.

95. deRooij J., Kerstens A., Danuser G., Schwartz M.A. and Waterman-Storer C.M. Integrin-dependent actomyosin contraction regulates epithelial cell scattering. J. Cell Biol. 171 (1):153-164 2005.

96. Ponti A., Matov A., Adams M., Gupton S., Waterman-Storer C.M., and Danuser G. Periodic patterns of actin turnover in lamellipodia and lamellae of migrating epithelial cells analyzed by Quantitative Fluorescent Speckle Microscopy. Biophys. J. 89: 3456-3469. 2005.

97. Dorn J.F., Jaqaman K., Rines D.R., Jelson G.S., Sorger P.K., Danuser G. Yeast kinetochore microtubule dynamics analyzed by high-resolution three-dimensional microscopy. Biophys. J. 89:2835 – 2854. 2005.

98. Lussi J.W., Tang C., Kuenzi P.A., Staufer U., Csucs G., Voros J., Danuser G., Hubbell J.A., Textor M. Selective molecular assembly patterning at the nanoscale: a novel platform for producing protein patterns by electron-beam lithography on SiO2/indium tin oxide-coated glass substrates. Nanotechnology 16(9):1781-1786. 2005.

99. Kuenzi P.A., Lussi J., Aeschimann L., Danuser G., Textor M., de Rooij N.F., Staufer U. Nanofabrication of protein-patterned substrates for future cell adhesion experiments. Microelectron. Eng. 78-79:582 – 586. 2005.

100. Gupton S., Anderson K.L.., Kole T.P., Fischer R.S., Ponti A., Hitchcock-DeGregori S., Danuser G., Fowler V.M., Wirtz D., Hanein D., Waterman-Storer C.M. Cell migration without a lamellipodium: Translation of actin dynamics into cell movement mediated by tropomyosin. J. Cell Biol. 168:619-631. 2005.

101. Vallotton P., Danuser G.*, Bohnet S., Meister J.-J., and Verkhovsky A.B.* Tracking retrograde flow in keratocytes: news from the front. Mol. Biol Cell. 16:1223-1231 2005.

102. Adams M.C., Matov A., Yarar D., Gupton S.L., Danuser G., Waterman-Storer C.M. Signal analysis of Total Internal Reflection Fluorescent Speckle Microscopy (TIR-FSM) and wide-field epi-fluorescence FSM of the actin cytoskeleton and focal adhesions in living cells. J. Microscopy. 216(2):138 – 152. 2004.

103. Ponti A., Machacek M., Gupton S.L., Waterman-Storer C.M.*, and Danuser G.* Two distinct actin networks drive protrusion of migrating cells. Science. 305:1782 – 1786. 2004.

104. Vallotton P., Gupton S.L., Waterman-Storer C.M., and Danuser G. Simultaneous mapping of filamentous actin flow and turnover in migrating cells by Quantitative Fluorescent Speckle Microscopy. Proc. Natl Acad Sci USA. 101:9660 – 9665. 2004.

105. Thomann D., Dorn J., Sorger P.K., and Danuser G. Automatic fluorescent tag localization II: Improvement in super-resolution by relative tracking. J. Microscopy. 211: 230-248. 2003.

106. Vallotton P., Ponti A., Waterman-Storer C.M., Salmon E.D., and Danuser G. Recovery, visualization, and analysis of actin and tubulin polymer flow in live cells: A Fluorescent Speckle Microscopy study. Biophys. J. 85:1289-1306. 2003.


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107. Müller M., Vörös J., Csúcs G., Walter E., Danuser G., Merkle H.P., Spencer N.D., and Textor M. Surface modification of PLGA microspheres. J. Biomed. Materials Research. 66A (1): 55-61. 2003.

108. Berney C. and Danuser G. FRET or no FRET: a quantitative comparison. Biophys. J. 84:3992 – 4010. 2003.

109. Ponti A., Vallotton P., Salmon W.C., Waterman-Storer C.M., and Danuser G. Computational analysis of f-actin turnover in cortical actin meshworks using fluorescent speckle microscopy. Biophys. J. 84:3336 - 3352. 2003.

110. Csúcs G., Michel R., Lussi J.,W., Textor M., and Danuser G. Microcontact printing of novel co-polymers in combination with proteins for cell-biological applications. Biomaterials. 24(10):1713 – 1720. 2003

111. Scotchford C., Ball M., Winkelmann M., Vörös J., Csucs G., Brunette D., Danuser G., and Textor M. Chemically patterned, metal-oxide-based surfaces produced by photolithographic techniques for studying protein- and cell-interactions. Part II: Protein adsorption and early cell interactions. Biomaterials. 24(7):1147 – 1158. 2003.

112. Michel R., Reviakine I., Sutherland D., Fokas C., Csúcs G., Danuser G., and Textor M. A Novel Approach to Produce Biologically Relevant Chemical Patterns at the Nanometer Scale: Selective Molecular Assembly Combined with Colloidal Lithography. Langmuir. 18(22):8580 – 8586. 2002.

113. Thomann D., Rines D.R., Sorger P.K., and Danuser G. Automatic fluorescent tag detection in 3D with super-resolution: application to the analysis of chromosome movement. J. Microscopy. 208(1):49 - 64. 2002.

114. Denoth J., Stüssi E., Csúcs G., and Danuser G. Single Muscle Fibre Contraction is Dictated by Inter-sarcomere Dynamics. J. Theoretical Biol. 216(1):101 - 122. 2002.

115. Michel R., Lussi J., Csúcs G., Reviakine I., Danuser G., Ketterer B., Hubbell J. A., Textor M., and Spencer N. D. Selective Molecular-Assembly Patterning. A New Approach to Micro- and Nanochemical Patterning of Surfaces for Biological Applications, Langmuir. 18(8):3281 – 3287. 2002.

116. Danuser G. Super-resolution microscopy using normal flow decoding and geometric constraints. J. Microscopy. 204:136 – 149. 2001.

117. Danuser G. and Oldenbourg, R. Probing f-actin flow by tracking shape fluctuations of radial bundles in lamellipodia of motile cells. Biophys. J., 79(1):191 – 201. 2000.

118. Danuser G., Tran P., and Salmon E.D. Tracking differential interference contrast diffraction line images with nanometre sensitivity. J. Microscopy. 198(1):34 – 53. 2000.

119. Oldenbourg R., Katoh K., and Danuser G. Mechanism of lateral movement of filopodia and radial actin bundles across neuronal growth cones. Biophys. J., 78:1176 – 1182. 2000.

120. Messerli M.A., Danuser G., and Robinson K.R. Pulsatile influxes of H+, K+, and Ca2+ lag growth pulses of Lilium longiflorum pollen tubes. J. Cell Science, 112:1497 – 1509, 1999.

121. Danuser G. Photogrammetric Calibration of a Stereo Light Microscope. J. Microscopy, 193(1):62 – 83, 1999.

122. Danuser G. and Stricker M. Parametric Model Fitting: From Inlier Characterization to Outlier Detection. IEEE Trans. Pattern Analysis and Machine Intelligence, 20(3):263 – 280, 1998.

123. Mazza E., Danuser G., and Dual J. Light-optical deformation measurements in microbars with nanometer resolution. Microsystem Technologies, 2(2):83 – 91, 1996.

124. Kahle H., Mueller M., Geiger A., Danuser G., Mueller S., Veis G., Billiris H., and Paradissis D. The strain and stress in NW Greece and the Ionian Islands: First results from geodetic data. Tectonophysics, 249:41 – 52, 1995.

Review Articles

125. Isogai T., Danuser G. Discovery of functional interactions among actin regulators by analysis of

image fluctuations in an unperturbed motile cell system. Philos Trans R Soc Lond B Biol Sci. 373(1747). pii: 20170110. 2018.

https://www.ncbi.nlm.nih.gov/pubmed/29632262

https://www.ncbi.nlm.nih.gov/pubmed/29632262


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126. Mettlen M, Chen PH, Srinivasan S, Danuser G, Schmid SL. Regulation of Clathrin-Mediated Endocytosis. Annu Rev Biochem. doi: 10.1146/annurev-biochem-062917-012644. 2018

127. Isogai T, Park JS, Danuser G. Cell forces meet cell metabolism. Nat Cell Biol 31;19(6):591-593. 2017.

128. Driscoll M.K., Danuser G. Quantifying Modes of 3D Cell Migration. Trends in Cell Biol. 25(12):749-59. 2015

129. Welf E., Danuser G. Using fluctuation analysis to establish causal relations between cellular events without experimental perturbation. . Biophys. J., 107(11):2492-2498. 2014.

130. Mettlen M, Danuser G. Imaging and modeling the dynamics of clathrin-mediated endocytosis. Cold Spring Harb Perspect Biol. 6(12):a017038. 2014

131. Danuser G., Allard J., Mogilner A. Mathematical modeling of eukaryotic cell migration: insights beyond experiments. Ann. Rev. Cell Dev. Biol. 29:501-528. 2013.

132. Vilela M, Halidi N, Besson S, Elliott H, Hahn K, Tytell J, Danuser G. Fluctuation analysis of activity biosensor images for the study of information flow in signaling pathways. Methods Enzymol. 519:253-76. 2013

133. Mendoza MC, Besson S, Danuser G. Quantitative fluorescent speckle microscopy (QFSM) to measure actin dynamics. Current Protocols in Cytometry. Chapter 2:Unit2.18. 2012. [PMCID:PMC3688286]

134. Danuser G. Computer Vision in Cell Biology. Cell. 147:973 – 978. 2011. 135. Welch C.M., Elliott H., Danuser G.*, and Hahn K.M.* Imaging the coordination of multiple signalling

activities in living cells. Nature Rev. Mol. Cell Biol. 12:749 – 756. 2011. 136. Vilela M., and Danuser G. What’s wrong with correlative experiments? Nature Cell Biol.

13(9):1011. 2011. 137. Lim J., and Danuser G. Live cell imaging of F-actin dynamics via fluorescent speckle microscopy

(FSM). J. Visual Experiments. Aug 5 (30): 1325. 2009. [PMCID: PMC3149907] 138. Danuser G. Testing the lamella hypothesis: the next steps on the agenda. J. Cell Science.

122(12): 1959-1962. 2009. [PMID: 19494124] 139. Sabouri-Ghomi M., Wu Y., Hahn K., and Danuser G. Visualizing and quantifying adhesive signals.

Curr. Opinion in Cell Biology. 20(5):541-550. 2008. [PMCID: PMC2661108] 140. Jaqaman K. and Danuser G. Linking data to models: data regression. Nature Rev. Mol. Cell Biol.

7:813 – 819. 2006. 141. Danuser G. and Waterman-Storer C.M. Quantitative Fluorescent Speckle Microscopy of

Cytoskeleton Dynamics. Ann. Rev. Biophys. Biomol. Struct. 35: 361-387. 2006. 142. Meijering E., Smal I., and Danuser G. Tracking in Molecular Bioimaging. IEEE Signal Processing

Magazine Special Issue on Molecular and Cellular Bioimaging. 46 – 53. May 2006. 143. Danuser G. Coupling the dynamics of two actin networks - new views on the mechanics of cell

protrusion. Invited Minireview for Biosciences’05. Biochem. Soc. Trans. 33:1250-1253. 2005. 144. Danuser G. and Waterman-Storer C.M. Quantitative Fluorescent Speckle Microscopy: where it

came from and where it is going. J. Microscopy. 211: 191-207. 2003. 145. Waterman-Storer C.M. and Danuser G. New Directions for Fluorescent Speckle Microscopy.

Current Biology 12:R633-R640. 2002. 146. Luchinetti E., Thomann D., and Danuser G. Micro-Mechanical Testing of Bone Trabeculae –

Potentials and Limitations. J. Materials Science, 35:6057 - 6064. 2000. Book Chapters and Monographs 147. Mendoza MC, Besson S, Danuser G. Quantitative Fluorescent Speckle Microscopy (QFSM) to

Measure Actin Dynamics. Curr Protoc Cytom. Chapter 2:Unit2.18. 2012. 148. Jaqaman K. and Danuser G. Computational image analysis of cellular dynamics: a case study

based on particle tracking. CSHL Protoc. Eds Goldman R.D., Swedlow J.R., Spector D.L. Dec 2009.


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149. Applegate, K.T., Yang, G., and Danuser, G., “High Content Analysis of Cytoskeleton Functions by Fluorescent Speckle Microscopy,” Nanomedicine and Nanobiotechnology. Chapter 7:p. 167 – 206. Ed. V. Vogel. Wiley, Weinheim, 2008.

150. Dorn J.F., Danuser G., and Yang G. Computational processing and analysis of dynamic fluorescence image data. Methods in Cell Biology, GFP imaging. Ed. K. Sullivan 85:497 – 538. 2008.

151. Jaqaman K., Dorn J., and Danuser G. From live cell microscopy to molecular mechanisms: deciphering the functions of kinetochore proteins. Chapter 9. Imaging Cellular and Molecular Biological Function. Eds. Fischknecht F., Shorte S.. pp. 265 – 288. Springer, Heidelberg. 2007.

152. Ji L., Loerke D., Gardel, M. and Danuser G. Probing intracellular force distribution by high-resolution live cell microscopy and inverse dynamics. Chapter 16. Methods in Cell Biology, Cell mechanics. Eds Y.-L- Wang and D. Discher. 83:199 – 235. Academic Press. 2007.

153. Shah S., Yang G., and Danuser G., Goldstein L.S.B. Axonal transport: imaging and modeling of a neuronal process. Lecture Notes in Physics. 711:65 – 84. Springer. 2007.

154. Danuser G. Quantitative Stereo Vision for the Stereo Light Microscope: An Attempt to Provide Control Feedback for a Nanorobot System. Diss. ETH No. 12191 (O. Kübler, H. Tiziani, M. Stricker, advisors). ISBN 3-905588-00-5. 1997.

155. Danuser G., Geiger A., and Mueller, M. Modelling of Displacement and Strain Fields. Research Project at ETH Zurich, 1993. ISBN 3-906513-34-3. (monograph in German)

156. Danuser G. Robust Estimators with a High Break Point. Research Project at ETH Zurich, 1992. ISBN 3-906513-21-1. (monograph in German)

157. Danuser G., Schor U., Bagnaschi L., Cocard M., and Geiger A. Inference of the Kinematical Parameters from GPS Observations. Research Project at ETH Zurich, 1992. ISBN 3-906513-15-7. (monograph in German).

158. Danuser G. Time Transfer and Synchronization with GPS: Applications to the Control of Distributed Computer Systems. Joint Project ABB Research and ETH Zurich, 1991. ISBN 3-906513-10-6. (monograph in German).

Edited Conference Proceedings 159. Danuser G. Computer Vision for Systems Biology. In Proc. IEEE Symposium Biomedical Imaging.

Arlington, VA. IEEE Piscataway. April 2006. 160. Yang, G., Matov A., Danuser G. Reliable Tracking of Large Scale Dense Antiparallel Particle

Motion for Fluorescence Live Cell Imaging. In Comp. Vis. Patt. Rec. (CVPR'05). San Diego, CA. IEEE Computer Soc. 2005. (conference paper accepted based on double-blind full paper reviews).

161. Danuser G. Super-resolution tracking of weak fluorescent markers in 3D: Application in dissecting the mechanics of chromosome segregation using fluorescence imaging and molecular genetics in yeast. In Proc. IEEE Symposium Biomedical Imaging. p. 61 – 64. Arlington, VA. IEEE Piscataway, NJ. 2004.

162. Thomann D., Stüssi E., and Danuser G. One-step Calibration of Specimen Induced Focal Shifts and Spherical Aberration for Quantitative 3D Microscopy: Approach and First Results. In Proc. Three-Dimensional Microscopy: Image Acquisition and Processing VIII, Vol. 4261:69 – 80 SPIE. 2001. (conference paper accepted based on long abstract reviews).

163. Danuser G. Super-Resolution Stereo Light Microscopy for Real-Time Tasks Using Normal Flow and Geometric Constraints. In Proc. Three-Dimensional Microscopy: Image Acquisition and Processing VII, Vol. 3919:129 – 140 SPIE, San Jose, CA; Jan. 2000. (conference paper accepted based on long abstract reviews).

164. Berger M. and Danuser G. Displacement Measurements in Portal Images Using Deformable Multi Template Matching. In Proc. Comp. Vis. Patt. Rec. CVPR'97, p. 374 – 379, Puerto Rico. IEEE Computer Soc. 1997. (conference paper accepted based on double-blind full paper reviews)


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165. Mazza E., Dual J., Musil C., Danuser G., and Vetterli D. Measurement of the strain field in a micrometer sized region at a notch tip. In Optical Inspection and Micromeasurements, European Optical Society, Vol. 2782:160 – 168 SPIE, Becancon June 1996. (conference paper accepted based on long abstract reviews).

166. Danuser G. and Mazza E. Observing Deformations of 20 Nanometer with a Low Numerical Aperture Light Microscope. In Optical Inspection and Micromeasurements, European Optical Society, Vol. 2782:180 – 191 SPIE, Becancon, June 1996. (conference paper accepted based on long abstract reviews).

167. Danuser G. Stereo Light Microscope Calibration for 3D Submicron Vision. In Proc. 18th ISPRS Congress, Int'l Arch. on Photogrammetry and Remote Sensing 31(B5):101 – 108, Vienna, July 1996. (conference paper accepted based on triple-blind full paper reviews).

168. Danuser G. and Kuebler O. Calibration of CMO-stereo-microscopes in a micro robot system. In Proc. ISPRS Intercommission Workshop: From Pixels to Sequences, Int'l Arch. on Photogrammetry and Remote Sensing 30(5W1):345 – 353, Zurich, March 1995. (conference paper accepted based on long abstract reviews).

169. Danuser G. and Kuebler O. Calibration Procedure for light-optical and scanning electron stereo microscopy in micro- and nanorobotics. In Three-Dimensional Microscopy: Image Acquisition and Processing II, Vol. 2412:174 – 185 SPIE, San Jose, Feb. 1995. (conference paper accepted based on long abstract reviews).

Patents U.S. Patent 8,237,786. Danuser G. and Goodwyn P. System and Method for dense-stochastic-sampling

imaging. August 7, 2012. U.S. Patent 8,828,928 Dittrich C. and Danuser G. Amphiphilic peptides and peptide particles. September

9, 2014.

american institute for medical and biological …department of cell biology, the scripps research...

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