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Curriculum Vitae Martin Lotz, M.D.

CURRICULUM VITAE

MARTIN LOTZ, M.D. THE SCRIPPS RESEARCH INSTITUTE

LA JOLLA, CA 92037 Tel 858-784-8960 Fax 858-784-2744

Email: [email protected]

January 2020


PERSONAL INFORMATION

Name: Martin Karl Gerhard Lotz Date/Place of Birth: November 23, 1955; W. Germany Citizenship: Germany, USA CURRENT APPOINTMENTS

Professor Head, Arthritis Research Department of Molecular Medicine The Scripps Research Institute, La Jolla, California Date of Appointment: 1997 Program Director Clinical Research Services Scripps Health, La Jolla, California Date of Appointment: 1997 EDUCATION

1974-1980 Medical School, Universities of Marburg, Vienna and Heidelberg Degrees: University of Heidelberg - MD, 1981 University of Heidelberg - Doctor of Medicine (Dr. med.), 1982 POSTGRADUATE TRAINING

1980-1982 Residency in Internal Medicine University Hospital, Heidelberg, Germany 1983-1987 Research Fellowship Department of Basic and Clinical Research Scripps Clinic and Research Foundation, La Jolla, California 1986-1988 Clinical Rheumatology Fellowship University of California, San Diego, California PREVIOUS APPOINTMENTS

1987-1990 Assistant Professor Department of Molecular and Experimental Medicine Scripps Clinic and Research Foundation, La Jolla, California

1990-1996 Associate Professor Department of Medicine University of California, San Diego, California 1997-2014 Research Professor Department of Medicine University of California, San Diego HONORS


Arthritis Foundation Investigator Award 1988 American Society for Clinical Investigation 1994 Kappa Delta Award, Orthopedic Research Society 2005 Basic Science Award, Osteoarthritis Research Society International 2010 Lee Howley Sr. Prize for Arthritis Research, Arthritis Foundation 2019 EDITORIAL BOARDS Biotherapy 1996-2002 Revue de Rhumatisme 1996-2004 Journal of Immunology, Associate Editor 2001-2005 Arthritis and Rheumatism 1998-2006 Arthritis Research and Therapy, Associate Editor 2006- Journal of Orthopaedic Research 2014- Modern Rheumatology 1998- Osteoarthritis and Cartilage 1994- OTHER PROFESSIONAL ACTIVITIES Board of Directors, Osteoarthritis Research Society International 2001-2008 President, Osteoarthritis Research Society International 2004-06 Scientific Advisory Board, Arthritis National Research Foundation 2011- Medical and Scientific Advisory Committee Co-Chair, Arthritis Foundation 2015- Board of Directors, Arthritis Foundation 2017- CLINICAL ACTIVITIES UCSD Rheumatology outpatient service 1985-1996 Attending Physician, UCSD Rheumatology service 1990-1996 RESEARCH INTEREST My research interest is in joint biology, joint aging, arthritis pathogenesis, preclinical and clinical drug development. Since 1989 I directed a program on joint aging and osteoarthritis. Our studies identified aging-related changes in cartilage and other joint tissues that determine risk for osteoarthritis. We discovered that cellular homeostasis mechanisms are compromised in aging and that this represents an early event leading to tissue damage. We initiated a ‘Joint Omics’ project which uses next generation sequencing technologies to uncover aging and disease associated changes in the transcriptomes in joint tissues. Data from this project are being used to identify key regulators of the abnormal phenotypes of cells, with focus on transcription factors. Our current studies address the role of FOXO, KLF and MKX transcription factors and the circadian rhythm pathway in cartilage homeostasis and osteoarthritis pathogenesis. These transcription factors are also being investigated in meniscus, ligaments and spine. Efforts are ongoing to discover small molecules and genetic approaches to target transcription factors in the treatment of joint diseases and in tissue engineering.


PUBLICATIONS (>300) 2020 Baek J, Lee E, LOTZ MK, D’Lima DD. Bioactive proteins delivery through core-shell nanofibers for meniscal tissue regeneration. Nanomedicine 23:102090, 2020. 2019 Baek J, LOTZ MK, D'Lima DD. Core-Shell Nanofibrous Scaffolds for Repair of Meniscus Tears. Tissue Eng Part A. 2019. Tissue Eng Part A 25:1577-90, 2019. Sueishi T, Akasaki Y, Goto N, Kurakazu I, Toya M, Kuwahara M, Hayashida M, Nakaya M, Kurose H, Bekki H, LOTZ MK, and Nakashima Y. GRK5 inhibition attenuates cartilage degradation via decreased NF-κBα signaling. Arthritis Rheum Nov 2019. [Epub ahead of print]. Otsuki S, Alvarez-Garcia O, LOTZ M. Neo M. Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis. Histology and Histopathology 34:1051-1060, 2019. Carlson AK, Rawle RA, Wallace CW, Brooks EG, Adams E, Greenwood MC, Olmer M, LOTZ MK, Bothner B, June RK. Characterization of metabolomic phenotypes of osteoarthritis using global metabolomic profiling of human synovial fluid. Osteoarthritis Cartilage. 27:1174-1184, 2019. Nogueira-Recalde U, Lorenzo Gómez I, Blanco FJ, Loza MI, Grassi D, Shirinsky V, Shirinsky I, LOTZ M, Robbins PD, Domínguez E, Caramés B. Identification of Fibrates as Drugs with Senolytic and Autophagic Activity as Osteoarthritis Therapeutics. EBioMedicine 45:588-605, 2019. Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Saton T, Miyata K, Inui M, Olmer M, Sugiyama E, LOTZ M, Asahara H. Wwp2 maintains cartilage homeostasis through regulation of Adamts5. Nature Comm 10:2429, 2019. Wyseure T, Yang T, Jenny Y. Zhou JY, Cooke EJ, Wanko B, Olmer M, Agashe, R, Morodomi Y, LOTZ M, Morser J, von Drygalski A, Mosnier LO. TAFI Deficiency Causes Maladaptive Vascular Remodeling After Hemophilic Joint Bleeding. J Clin Invest Insight 4:e128379, 2019. Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, LOTZ MK, Nakashima Y. FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling. J Biol Chem. 2019 Oct 10 Bekki H, Duffy T, Okubo N, Olmer M, Lamia K, Kay SA, LOTZ MK. Suppression of Circadian Clock Protein Cryptochrome 2 Promotes Osteoarthritis. Osteoarthritis Cartilage 2019. Under revision Lee KI, Gamini, R, Olmer M, Ikuta Y, Hasei J, Baek J, Alvarez-Garcia O, Grogan SP, D’Lima DD, Asahara H, LOTZ MK. Mohawk is a meniscus-enriched transcription factor that promotes meniscus cell phenotype, tissue repair and prevents osteoarthritis. 2019. Under revision Duffy T, Bekki H, LOTZ MK. Genome-wide occupancy profiling reveals critical roles of FoxO1 in regulating extracellular matrix and circadian rhythm genes in human chondrocytes. Arthritis Rheum 2019. Under revision Sasho T, Akagi R, Aharam T, Sato Y, Taro T, Aishi T, Tozawa R, LOTZ M, Satoshi Y, Ono Y. Clinical implications and detection of osteophytes at the posterior femoral condylar notch by radiograph: A proposal for a Kellgren/Lawrence 1.5 grade. 2019 submitted


2018 Fisch KM, Gamini R, Alvarez-Garcia O, Akagi R, Saito M, Muramatsu Y, Sasho T, Su A, LOTZ M. Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis. Osteoarthritis Cartilage 2018, 26:1531-8. Kumar P, Yao LJ, Saidin S, Paleja B, van Loosdregt J, Chua C, Arkachaisri T, Consolaro A, Gattorno M, Martini A, Pischel KD, Williams GW, LOTZ M, Albani S. Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis. J Autoimmun 2018; 94:90-98. Alvarez-Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H, LOTZ M. FOXO are required for intervertebral disc homeostasis during aging and their deficiency promotes disc degeneration. Aging Cell 2018; 18:e12800. Lee D, Taniguchi N, Sato K, Choijookhuu N, Hishikawa Y, Kataoka H, Morinaga H, LOTZ M, Chosa E. HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles. Sci Rep. 2018 8:9601. Chen LY, LOTZ M, Terkeltaub R, Liu-Bryan R. Modulation of Matrix Metabolism By ATP-Citrate Lyase In Articular Chondrocytes. J Biol Chem 2018; 293:12259-12270. Lee K, Olmer M, Baek J, D’Lima DD, LOTZ MK. Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears. Acta Biomater 2018; 76:125-134. Ishitobi H, Sanada Y, Kato Y, Ikuta Y, Shibata S, Yamasaki S, LOTZ MK, Matsubara K, Miyaki S, Adachi N. Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes. Eur J Pharmacol. 2018; 830:1-8. Miyaki S, LOTZ MK. Extracellular vesicles in cartilage homeostasis and osteoarthritis. Curr Opin Rheumatol 2018; 30:129-135. Taniguchi N, Kawakami Y, Maruyama I, LOTZ M. HMGB proteins and arthritis. Hum Cell 2018; 1:01-09. Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, LOTZ MK. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis. Science Transl Med. 2018 10:eaan0746. Grogan SP, Duffy S, Pauli C, LOTZ MK, D’Lima DD.Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering. J Orthop Res. 2018 36:1947-1958. Serrano RL, Chen LY, LOTZ MK, Liu-Bryan R, Terkeltaub R. Impaired proteasomal function in human osteoarthritic chondrocytes can contribute to decreased levels of Sox9 and aggrecan. Arthritis Rheum 2018 70:1030-1041. 2017 Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, LOTZ MK. Regulated in development and DNA damage response 1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases severity of experimental osteoarthritis. Arthritis Rheumatol 2017; 69:1418-1428. Grogan SP, Pauli C, LOTZ MK, D'Lima DD. Relevance of meniscal cell regional phenotype to tissue engineering. Connect Tissue Res 2017; 58:259-270. Hasei J, Teramura T. Takehara T, Onodera Y, Hori T, Olmer M, Hatada I, Fukuda K, Ozaki T, LOTZ MK, Asahara H. TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes. Sci Rep 2017; 21:42990.


Alvarez-Garcia O, Matsuzaki T, Olmer M, Masuda K, LOTZ MK. Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. J Orthop Res 2017; 35:2682-2691. Asahara H, Inui M, LOTZ, M. Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis, J Bone Miner Res 2017; 32:1773-1782. Peeters J, De Graeff N, LOTZ M, Albani S, De Roock S van Loosdregt J. Increased autophagy contributes to the inflammatory phenotype of Juvenile Idiopathic Arthritis synovial fluid T cells. Rheumatology 2017; 10:1694-1699. Matsuzaki T, Akasaki Y, Olmer M, Oscar M, Alvarez-Garcia O, Reixach N, Buxbaum J, LOTZ MK. Transthyretin deposition promotes progression of osteoarthritis. Aging Cell 2017; 16:1313-1322. Meckes JK, Carames B, Olmer M, Kiosses WB, Grogan SP, LOTZ MK, D’Lima D. Compromised autophagy precedes meniscus degeneration and cartilage damage in mice. Osteoarthritis Cartilage 2017; 25:1880-1889. Akagi R, Akatsu Y, Fisch KM, Alvarez-Garcia O, Teramua T, Muramatsu Y, Saito M, Sasho T, Su A, LOTZ MK. Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes. Osteoarthritis Cartilage 2017; 25:943-951. Shen T, Alvarez-Garcia O, Li Y, Olmer M, LOTZ MK. Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism. Osteoarthritis Cartilage 2017; 25:287-296. Hasegawa A, Yonezawa T, Taniguchi N, Otabe K, Akasaki Y, Matsukawa T, Saito M, Neo M, Marmostein LY, LOTZ MK. Fibulin-3 in joint aging and osteoarthritis pathogenesis. Arthritis Rheumatol 2017; 69:576-585. Yu X, Kawakami H, Tahara N, Olmer M, Hayashi S, Akiyama F, Bagchi A, LOTZ M, Kawakami Y. Expression of Noggin and Gremlin1 and its implications in fine-tuning BMP activities in mouse cartilage tissues. J Orthop Res 2017; 35:1671-1682. 2016 Kwok J, Onuma H, Olmer M, LOTZ MK, Grogan SP, D’Lima DD. Histopathological analysis of murine menisci: implications for joint aging and osteoarthritis. Osteoarthritis Cartilage 2016; 24:709-18. Temple-Wong MM, Ren S, Quach P, Hansen BC, Chen AC, Hasegawa A, D'Lima DD, Koziol J, Masuda K, LOTZ MK, Sah RL. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. Arthritis Res Ther 2016; 21:18. Loeser R, Lotz M, Osteoarthritis in the elderly. In: Advances in Geroscience. Sierra F, Kohanski R [Eds.] Springer NY, p. 309-353, 2016. Alvarez-Garcia O, Olmer M, Akagi R, Akasaki Y, Fisch KM, Shen T, Su AI, Lotz MK. Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy. Osteoarthritis Cartilage 2016; 24:1639-1647. Alvarez-Garcia O, Fisch KM, Akagi R, Su AI, LOTZ MK. Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage. Arthritis Rheumatol 2016; 68:1876-1886. D’Adamo S, Alvarez-Garcia O, Muramatsu Y, Flamigni F, LOTZ MK. MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins. Osteoarthritis Cartilage 2016; 6:1082-1091.


Loosdregt J, Rossetti M, Spreafico R, Moshref M, Olmer M, Williams GW, Venkatanarayanan HB, Kumar P, Copeland D, Pischel K, LOTZ M, Albani S. Increased autophagy in CD4+ T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance. Eur J Immunol 2016; 46:2862-2870. Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, LOTZ MK, Sakai D, Masuda K, Ozaki T, Asahara H. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun 2016; 16:12503. Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, LOTZ MK, Okawa A, Asahara H. Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis. Proc Natl Acad Sci U S A 2016; 113:7840-7845. 2015 Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe F, Onizuka N, Inui M, Takada S, Ito Y, Sekiya I, Muneta T, LOTZ M, Asahara H. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. J Orthop Res 2015; 33:1-8. Hoshiyama Y, Otsuki S, Oda S, Kurokawa Y, Nakajima M, Jotoku T, Tamura R, Okamoto Y, LOTZ MK, Neo M. Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells. J Orthop Res 2015; 33:548-55. Caramés B, Olmer M, Kiosses WB, LOTZ M. The relationship of autophagy defects and cartilage damage during joint aging in a mouse model. Arthritis Rheumatol 2015; 67:1568-76. López de Figueroa P, LOTZ M, Blanco FJ, Caramés B. Autophagy activation protects from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol 2015; 67:966-76. Akasaki Y, Reixach N, Matsuzaki T, Alvarez-Garcia O, Olmer M, Iwamoto Y, Buxbaum JN, and LOTZ MK. Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis. Arthritis Rheumatol 2015 67:2097-107. Loeser RF, Ferguson CM, LOTZ MK. Aging and Post-Traumatic Arthritis. In: Post-Traumatic Arthritis, Pathogenesis, Diagnosis and Management. Olson SA, Guilak F [Eds.] Springer NY 2015, p.165-83. Grogan SP, LOTZ MK, D’Lima DD. Potential Mechanisms of PTA: Cell Death. In: Post-Traumatic Arthritis, Pathogenesis, Diagnosis and Management. Olson SA, Guilak F [Eds.] Springer NY 2015, p.185-99. Yamanaka Y, Faghihi MA, Magistri M, Alvarez-Garcia O, LOTZ M, Wahlestedt C. Antisense RNA controls LRP1 sense transcript expression through interaction with a chromatin-associated protein, HMGB2. Cell Rep 2015; 11:967-76. Wang Y, Zhao X, LOTZ M, Terkeltaub R, Liu-Bryan R. Mitochondrial biogenesis is impaired in osteoarthritic chondrocytes but reversible via peroxisome proliferator-activated receptor-γ coactivator 1α. Arthritis Rheumatol 2015; 67:2141-53. Takada T, Miyaki S, Ishitobi H, Hirai Y, Nakasa T, Igarashi K, LOTZ M, Ochi M. Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1. Arthritis Res Ther 2015; 13:285. 2014 Grogan S, Chen X, Sovani S, Taniguchi N, Colwell C Jr, LOTZ M, D’Lima D. Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation. Tissue Eng Part A 2014; 20:264-74.


Olee T, Grogan SP, LOTZ M, Colwell CW, Snyder E, D'Lima D. Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells. Tissue Eng Part A 2014; 20:683-92. Onizuka N, Ito Y, Takada S, Nakahara H, LOTZ M, Toyama Y, Asahara H. The Mohawk homeobox transcription factor regulates the differentiation of tendons, tendon sheaths and volar plates. J Orthop Sci 2014; 19:172-80. Akasaki Y, Hasegawa A, Saito M, Asahara H, Iwamoto Y, LOTZ MK. Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis. Osteoarthritis Cartilage 2014; 22:162–170, 2014. Alvarez-Garcia O, Rogers NH, Smith RG, LOTZ MK. Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1. Arthritis Rheumatol 2014; 66:1779-88. Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, LOTZ MK, Ochi M. Exosomes from IL-1 stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res Ther 2014; 16:R163. Zhao X, Petursson F, Viollet B, LOTZ M, Terkeltaub R, Liu-Bryan R. Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase. Arthritis Rheumatol 2014; 66:3073-82, 2014. Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS Jr. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J Allergy Clin Immunol 2014; 134:698-705. Akasaki Y, Alvarez-Garcia O, Saito M, Caramés B, Iwamoto Y, and LOTZ MK. FOXO transcription factors support oxidative stress resistance in human chondrocytes. Arthritis Rheumatol 2014; 66:3349-58. 2013 Shapiro I, Layfield R, LOTZ M, Settembre C, Whitehouse C. Boning up on autophagy. The role of autophagy in skeletal biology. Autophagy 2013; 10:1-13. Grogan SP, Duffy S, Pauli C, Koziol JA, Su A, D’Lima DD, LOTZ MK. Zone specific gene expression patterns in articular cartilage. Arthritis Rheum 2013; 65:418-28. Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, LOTZ MK, Asahara H, Ishiguro N. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. Arthritis Res Ther 2013;15:R28. Hasegawa A, Nakahara H, Asahara H, Kinoshita M, Koziol J, LOTZ MK. Cellular and extracellular matrix changes in anterior cruciate ligament during human knee aging and osteoarthritis. Arthritis Res Ther 2013; 15:R29. van Loosdregt J, Spreafico R, Rossetti M, Prakken BJ, LOTZ M, Albani S. Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells. J Allergy Clin Immunol 2013; 131:1443-6. Grogan SP, Chung PH, Soman P, Chen P, LOTZ MK, Chen S, D’Lima DD. Digital-Micromirror-Device projection printing system for meniscus tissue engineering. Acta Biomater 2013; 9:7218-26. LOTZ M, Martel-Pelletier J, Christiansen C, Brandi M-L, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier J-P, Raynauld J-P, Reiter-


Niesert S, Rizzoli R, L. Sandell LJ, Spector T, Van Spil WE, Reginster J-Y. Value of biomarkers in osteoarthritis: current status and perspectives. Ann Rheum Dis 2013; 72:1756-63. Petursson F, Husa M, June R, LOTZ M, Terkeltaub R and Liu-Bryan R. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to Biomechanical Injury in Chondrocytes. Arthritis Res Ther 2013; 15:R77. Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, LOTZ MK, Asahara H. Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. Arthritis Rheum 2013; 65:2081-9. Caramés B, Kiosses WB, Akasaki Y, Brinson D, Koziol J, LOTZ M. Glucosamine activates autophagy in vitro and in vivo. Arthritis Rheum 2013; 65:1843-52. Husa M, Petursson F, LOTZ M, Terkeltaub R, Liu-Bryan R. C/EBP homologous protein drives pro-catabolic responses in chondrocytes. Arthritis Res Ther 2013; 15:R218. Yoshitaka T, Kawai A, Miyaki S, Numoto K, Kikuta K, Ozaki T, LOTZ M, Asahara A. Analysis of microRNAs expressions in chondrosarcoma. J Orthop Res 2013; 31:1992-8. Levy YD, Hasegawa A, Patil S, Koziol J, LOTZ MK, D’Lima D. Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis. Ann Rheum Dis 2013; 72:271-7. 2012 LOTZ M, Caramés B. Autophagy, a new therapeutic target in cartilage injury and osteoarthritis. J Am Acad Orthop Surg 2012; 20:261-2. Caramés B, Hasegawa A, Taniguchi N, Blanco F, LOTZ M. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis, Ann Rheum Dis 2013; 71:575-81. Caramés B, Taniguchi N, Seino D, Blanco F, D’Lima DD, LOTZ M. Mechanical injury suppresses autophagy regulators and its pharmacological activation results in chondroprotection. Arthritis Rheum 2012; 64:1182-92. Hasegawa A, Otsuki S, Pauli C, Miyaki S, Patil S, Steklov N, Kinoshita M, Koziol J, D’Lima DD, LOTZ M. Anterior cruciate ligament changes in human joint in aging and osteoarthritis. Arthritis Rheum 2012; 64:696-704. Chan EF, Harjanto R, Asahara H, H, Nozomu I, Masuda K, Bugbee WD, Firestein GS, Hosalkar H, LOTZ M, Sah RL. Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice. Orthop Clin North Am 2012; 43:173-85. LOTZ M. Osteoarthritis year 2011 in review: biology. Osteoarthritis Cartilage 2012 20:192-6. Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, LOTZ M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M. Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. Arthritis Rheum 2012; 64:1551-61. Cui X, Breitenkamp K, Finn MG, LOTZ M, D'Lima D. Direct human cartilage repair using three-dimensional bioprinting technology. Tissue Eng Part A 2012; 18:1304-12. Grogan SP, Pauli C, Chen P, Du J, Chung CB, Kong SD, Colwell Jr CW, LOTZ M, Jin S, D'Lima D. In situ tissue engineering using magnetically guided 3D cell patterning. Tissue Eng Part C Methods 2012; 18:496-506.


Cui X, Hasegawa A, LOTZ M, D’Lima D. Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes meniscal phenotype without hypertrophy. Biotechnol Bioeng 2012; 109:2369-80. Cui X, Boland T, D'Lima DD, LOTZ MK. Thermal inkjet printing in Tissue Engineering and regenerative medicine. Recent Pat Drug Deliv Formul 2012; 6:149-55. LOTZ M, Loeser R. Effects of aging on articular cartilage homeostasis. Bone 2012; 51:241-8. Pauli C, Whiteside R, Las Heras F, Nesic D, Koziol J, Grogan SP, Matyas F, Pritzker KPH, D’Lima D, LOTZ M. Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development. Osteoarthritis Cartilage 2012; 20:476-85. Grogan SP, Sovani S, Pauli C, Chen J, Hartmann A, Colwell CW, LOTZ MK, D’Lima DD. Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels. Tissue Engineering 2012; 18:1784-92. Cui X, Breitenkamp K, LOTZ M, D'Lima D. Synergistic action of fibroblast growth factor-2 and transforming growth factor-beta1 enhances human neocartilage formation in bioprinted 3D hydrogels. Biotechnol Bioeng 2012; 109:2357-88. Pauli C, Lee M, Bae W, LOTZ M, Bydder G, D’Lima D, Chung C, Du J. Ultrashort-echo time MR Imaging of the patella with bicomponent analysis: Correlation with histopathologic and polarized light microscopic findings. Radiology 2012; 264:484-93. 2011 LOTZ M. Chondrocyte differentiation and osteoarthritis. OARSI Primer, 2011. www.OARSI.ORG. Terkeltaub R, Yang B, LOTZ M, Liu-Bryan R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to inflammatory cytokines IL-1β and TNFα. Arthritis Rheum 2011; 63:1928-37. Itou J, Taniguchi N, Oishi I, Kawakami H, LOTZ M, Kawakami Y. HMGB factors are required for posterior digit development through enhancing ß-catenin pathway activity, Dev Dyn 2011; 240:1151-62. Pauli C, Grogan SP, Patil S, Otsuki S, Hasegawa A, Koziol J, LOTZ M, D’Lima D. Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis. Osteoarthritis Cartilage 2011; 19:1132-41. LOTZ MK, Caramés B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and osteoarthritis, Nature Rev Rheumatol 2011; 7:579-87. Taniguchi N, Caramés B, Cherqui S, Kawakami Y, LOTZ M. Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation. J Biol Chem 2011; 286:41489-98. 2010 Temple-Wong MM, Bae WC, Chen MQ, Bugbee WD, Amiel D, Coutts RD, LOTZ M, Sah RL. Biomechanical, structural, and biochemical indices of degenerative and osteoarthritic deterioration of adult human articular cartilage of the femoral condyle. Osteoarthritis Cartilage 2009; 17:1469-76. Otsuki S, Grogan SP, Miyaki S, Kinoshita M, Asahara H, LOTZ M. Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage. J Orthop Res 2010; 28:96-102.


Haudenschild DR, Chen J, Pang N, LOTZ M, D’Lima DD. Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum 2010; 62:191-200. Bae WC, Payanal MM, Chen AC, Hsieh-Bonassera ND, Ballard BL, LOTZ M, Coutts RD, Bugbee WD, Sah RL. Topographic patterns of cartilage lesions in knee osteoarthritis. Cartilage 2010; 1:10-19. Higashiyama R, Miyaki S, Yamashita S, Yoshitaka T, Lindman G, Ito Y, Sasho T, Takahashi K, LOTZ M, Asahara H. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Modern Rheumatol 2010; 20:11-17. Caramés B, Taniguchi N, Otsuki S, Blanco F, LOTZ M. Autophagy is a protective mechanism in normal cartilage and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum 2010; 62:791-01. Oyama Y, Hashiguchi T, Taniguchi T, Tancharoen S, Uchimura T, Biswas KK, Kawahara K, Nitanda T, Umekita Y, LOTZ M, Maruyama I. High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. Lab Invest 2010; 90:853-66. Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, LOTZ M, Ueno-Kudo H, Asahara H. MicroRNA-140 plays dual roles both in cartilage development and homeostasis. Genes Dev 2010; 24:1173-85. Otsuki S, Hanson SR, Miyaki S, Grogan SP, Kinoshita M, Asahara H, Wong C-H, LOTZ M. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc Natl Acad Sci USA 2010; 107:10202-07. Haudenschild, D, Chen J, Steklov N, Grogan S, LOTZ M, D’Lima DD. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis. J Orthop Res 2010; 29:20-25. LOTZ M, Otsuki S, Grogan SP, Sah R, Terkeltaub R, D’Lima D. Cartilage cell clusters. Arthritis Rheum 2010; 62:2206-18. LOTZ M, Kraus V. Posttraumatic Osteoarthritis: Pathogenesis and pharmacological treatment options. Arthritis Res Ther 2010; 12:408. Schelwies M, Brinson D, Hong Y-H, LOTZ M, Wong C-H, Hanson S. Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases. ChemBioChem 2010; 11:2393-97. 2009 Garcia-Gonzalez A, LOTZ M, Ochoa JL. Anti-inflammatory activity of superoxide dismutase obtained from from Debaryomyces hansenii on type II collagen induced arthritis in rats. Rev Invest Clin 2009; 61:212-20. Taniguchi N, Caramés B, Ronfani L, Ulmer U, Komiya S, Bianchi ME, LOTZ M. Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Proc Natl Acad Sci U S A 2009; 106:1181-6. Steklov N, Srivastava A, Sung KLP, Chen PC, LOTZ M, D’Lima DD. Aging-related differences in chondrocyte viscoelastic properties. Mol Cell Biomech 2009; 6:113-20. Grogan SP, Miyaki S, Asahara H, D’Lima DD, LOTZ M. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther 2009; 11:R85. Haudenschild DR, Chen J, Steklov N, LOTZ M, D’Lima DD. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli. Mol Cell Biomech 2009; 6:135-44.


Shikhman AR, Brinson DC, Valbracht J, LOTZ M. Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes. Osteoarthritis Cartilage 2009; 17:1022-8. Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, LOTZ M, Asahara H. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum 2009; 60:2723-30. Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M, Ozaki T, LOTZ M, Bedford MT, Asahara H. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol 2009; 9:47. Taniguchi N, Caramés B, Kawakami Y, Amendt BA, Komiya S, LOTZ M. Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathways. Proc Natl Acad Sci U S A 2009; b:16817-22. 2008 Otsuki S, Nakajima M, LOTZ M, Kinoshita M. Hyaluronic acid and chondroitin sulfate content of osteoarthritic human knee cartilage: site-specific correlation with weight-bearing force based on femorotibial angle measurement. J Orthop Res 2008; 26:1194-8. Otsuki S, Brinson DC, Creighton L, Kinoshita M, Sah RL, D’Lima D, LOTZ M. The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants. Arthritis Rheum 2008; 58:1076-85. Grogan SP, Olee T, Hiraoka K, LOTZ M. Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site. Arthritis Rheum 2008; 58:2754-63. Otsuki S, Taniguchi N, Grogan SP, D’Lima D, Kinoshita M, LOTZ M. Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage. Arthritis Res Ther 2008; 10:R61. Wong BL, Bae WC, Chun J, Gratz KR, LOTZ M, Sah RL. Biomechanics of cartilage articulation: effects of lubrication and degeneration on shear deformation. Arthritis Rheum 2008; 58:2065-74. Haudenschild DR, Nguyen B, Chen J, D’Lima DD, LOTZ M. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes. Arthritis Rheum 2008; 58:2735-42. Mishima Y, LOTZ M. Chemotaxis of human articular chondrocytes and mesenchymal stem cells. J Orthop Res 2008; 26:1407-12. Haudenschild DR, D’Lima DD, LOTZ M. Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton. Biorheology 2008; 45:219-228. 2007 Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, LOTZ M, Bianchi ME, Asahara H. Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol 2007; 27:5650-63. Temple MM, Bae WC, Chen MQ, LOTZ M, Amiel D, Coutts RD, Sah RL. Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle. Osteoarthritis Cartilage 2007; 15:1042-52. LOTZ M. Nitric oxide and other radicals in the pathogenesis of osteoarthritis. In: Osteoarthritis, Inflammation and Degradation: A Continuum. Buckwalter J, LOTZ M, Stoltz JF [Eds.] IOS Press 2007, p.182-91.


Stoltz JF, LOTZ M, Buckwalter J. Cartilage engineering. In: Osteoarthritis, Inflammation and Degradation: A Continuum. Buckwalter J, LOTZ M, Stoltz JF [Eds.] IOS Press 2007, p.280-86. Buckwalter J, LOTZ M, Stoltz JF. Therapeutics and osteoarthritis. In: Osteoarthritis, Inflammation and Degradation: A Continuum. Buckwalter J, LOTZ M, Stoltz JF [Eds.] IOS Press 2007, p.287-98. 2006 D’Lima D, Hermida J, Hashimoto S, Colwell C, LOTZ M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 2006; 54:1814-21. Hiraoka K, Grogan S, Olee T, LOTZ M. Mesenchymal progenitor cells in adult human articular cartilage. Biorheology 2006; 43:447-54. 2005 Daouti S, Latario B, Nagulapalli S, Buxton F, Uziel-Fusi S, Chirn GW, Bodian D, Song C, Labow M, LOTZ M, Quintavalla J, Kumar C. Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis. Osteoarthritis Cartilage 2005; 13:508-18. Shikhman AR, Amiel D, D’Lima D, Hwang SB, Hu C, Xu A, Hashimoto S, Kobayashi K, Sasho T, LOTZ M. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis 2005; 64:89-94. Kinney RC, Schwartz Z, Week K, LOTZ M, Boyan BD. Human articular chondrocytes exhibit sexual dimorphism in their responses to 17beta-estradiol. Osteoarthritis Cartilage 2005; 13:330-7. Kawakami Y, Tsuda M, Takahashi S, Taniguchi N, Esteban CR, Zemmyo M, Furumatsu T, LOTZM, Belmonte JC, Asahara H. Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Proc Natl Acad Sci U S A 2005; 102:2414-9. Cecil DL, Johnson K, Rediske J, LOTZ M, Schmidt AM, Terkeltaub R. Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products. J Immunol 2005; 175:8296-302. 2004 Shikhman AR, Brinson DC, LOTZ M. Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses. Am J Physiol Endocrinol Metab 2004; 286:E980-5. Kühn K, D’Lima DD, Hashimoto S, LOTZ M. Cell death in cartilage. Osteoarthritis Cartilage 2004; 12:1-16. Alsalameh S, Amin R, Gemba T, LOTZ M. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum 2004; 50:1522-32. D'Lima DD, Kuhn K, LOTZ M. Detection of apoptosis in cartilage in situ and in isolated chondrocytes. Methods Mol Med 2004; 100:275-90. Sen M, Cheng YH, Goldring MB, LOTZ M, Carson DA. WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum 2004; 50:488-97. D’Lima D, LOTZ M, Colwell CW Jr. Cartilage mechanical properties after injury. J ASTM Intl 2004; 67-76.


D’Lima DD, Bergula A, Chen PC, Colwell CW Jr, LOTZ M. Age related differences in chondrocyte viability and biosynthetic response to mechanical injury. J ASTM Intl 2004; 77–83. 2003 LOTZ M. Neuropeptides, free radicals and nitric oxide. In: Rheumatology, 3rd Edition. Hochberg M et al [Eds.]. Keyword Publishing Services Ltd, Essex UK 2003. Kühn K, Shikhman AR, LOTZ M. Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis. J Cell Physiol 2003; 197:379-87. Zemmyo M, Meharra EJ, Kühn K, Creighton-Achermann L, LOTZ M. Accelerated, aging-dependent development of osteoarthritis in alpha 1 integrin-deficient mice. Arthritis Rheum 2003; 48:2873-80. Kühn K, LOTZ M. Mechanisms of sodium nitroprusside-induced death in human chondrocytes. Rheumatol Intl 2003; 23:241-7. Seitz M, Valbracht J, Quach J, LOTZ M. Gold sodium thiomalate and chloroquine inhibit cytokine production in monocytic THP-1 cells through distinct transcriptional and posttranslational mechanisms. J Clin Immunol 2003; 23:477-84. 2002 Yamada K, Healy R, Amiel D, LOTZ M, Coutts R. Subchondral bone of the human knee joint in aging and osteoarthritis. Osteoarthritis Cartilage 2002; 10:360-9. Hashimoto S, Creighton-Achermann L, Takahashi K, Amiel D, Coutts RD, LOTZ M. Development and regulation of osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage 2002; 10:180-7. Gemba T, Valbracht J, Alsalameh S, LOTZ M. Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment. J Biol Chem 2002; 277:907-911. 2001 D'Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, LOTZ M. Impact of mechanical trauma on matrix and cells. Clin Orthop Relat Res 2001 391:S90-9. D’Lima DD, Hashimoto S, Chen PC, LOTZ M, Colwell CW Jr. Cartilage injury induces chondrocyte apoptosis. J Bone Joint Surg Am 2001 83-A Suppl:19-21. D’Lima DD, Hashimoto S, Chen PC, LOTZ M, Colwell CW Jr. In vitro and in vivo models of cartilage injury. J Bone Joint Surg Am 2001; 83-A Suppl 2:22-24. D’Lima DD, Hashimoto S, Chen PC, LOTZ M, Colwell CW Jr. Prevention of chondrocyte apoptosis. J Bone Joint Surg 2001; 83-A Suppl 2:25-6. Johnson K, Hashimoto S, LOTZ M, Pritzker K, Goding J, Terkeltaub R. Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification. Arthritis Rheum 2001; 44:1071-81. Colwell CW Jr, D'Lima DD, Hoenecke HR, Fronek J, Pulido P, Morris BA, Chung C, Resnick D, LOTZ M. In vivo changes after mechanical injury. Clin Orthop Relat Res 2001; 391:S116-23.


Johnson K, Hashimoto S, LOTZ M, Pritzker K, Terkeltaub R. Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa. Am J Pathol 2001; 159:149-63. Jin G, Sah RL, Li YS, LOTZ M, Shyy JY, Chien S. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res 2001; 18:899-908. LOTZ M. Cytokines and their Receptors. In: Arthritis and Allied Conditions. Koopman W. [Ed.] Lippincott Williams & Wilkins, New York, 436-77, 2001. Johansen JS, Olee T, Price PA, Hashimoto S, Ochs RL, LOTZ M. Regulation of YKL-40 production by human articular chondrocytes. Arthritis Rheum 2001; 44:826-37. Shikhman AR, Kühn K, Alaaeddine N, LOTZ M. N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes. J Immunol 2001; 166:5155-60. Liu J, Shikhman AR, LOTZ MK, Wong CH. Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis. Chem Biol 2001; 8:701-11. Alaaeddine N, Olee T, Hashimoto S, Creighton-Achermann L, LOTZ M. Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum 2001; 44:1633-43. Kühn K, LOTZ M. Regulation of CD95 (Fas/Apo-1)-induced apoptosis in human chondrocytes. Arthritis Rheum 2001; 44:1644-53. LOTZ M. Cytokines in cartilage injury and repair. Clin Orthop Relat Res 2001; 391:S108-15. Kobayashi K, Mishima H, Hashimoto S, Goomer RS, Harwood FL, LOTZ M, Moriya H, Amiel D. Chondrocyte apoptosis and regional differential expression of nitric oxide in the medial meniscus following partial menisectomy. J Orthop Res 2001; 19:802-8. Komuro H, Olee T, Kühn K, Quach J, Brinson DC, Shikhman A, Valbracht J, Creighton-Achermann L, LOTZ M. The osteoprotegerin/receptor activator of nuclear factor kappaB/receptor activator of nuclear factor kappaB ligand system in cartilage. Arthritis Rheum 2001; 44:2768-76. Shikhman AR, Brinson DC, Valbracht J, LOTZ M. Cytokine regulation of facilitated glucose transport in human articular chondrocytes. J Immunol 2001; 167:7001-8. Takahashi K, Hashimoto S, Kubo T, Hirasawa Y, LOTZ M, Amiel D. Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model. J Orthop Res 2001; 19:500-3. D’Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, LOTZ M. Human chondrocyte apoptosis in response to mechanical injury. Osteoarthritis Cartilage 2001; 9:712-9. 2000 Kühn K, Hashimoto S, LOTZ M. IL-1 beta protects human chondrocytes from CD95-induced apoptosis. J Immunol 2000; 164:2233-9. Shikhman AR, Brinson DC, LOTZ M. Profile of glycosaminoglycan-degrading glycosides and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation. Arthritis Rheum 2000; 43:1307-14. Dudler J, Renggli-Zulliger N, Busso N, LOTZ M, So A. Effect of interleukin-17 on proteoglycan degradation in murine knee joints. Ann Rheum Dis 2000; 59:529-32. Takahashi K, Hashimoto S, Kubo T, Hirasawa Y, LOTZ M, Amiel D. Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis. J Rheumatol 2000; 27:1713.


1999 LOTZ M, Hashimoto S, Ochs R, Kühn K. Chondrocyte Apoptosis. In: Apoptosis and Inflammation. Winkler JD [Ed.] Birkhäuser, Basel, 1999 p.101-19. Olee T, Hashimoto S, Quach J, LOTZ M. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J Immunol 1999; 62:1096-100. LOTZ M. The role of nitric oxide in articular cartilage damage. Rheum Dis Clin North Am 1999; 25:269-82. LOTZ M, Hashimoto S, Kühn K. Mechanisms of chondrocyte apoptosis. Osteoarthritis Cartilage 1999 7:389-91. Kühn K, Hashimoto S, LOTZ M. Cell density modulates apoptosis in human articular chondrocytes. J Cell Physiol 1999; 180:439-77. Hashimoto S, Takahashi K, Ochs RL, Coutts RD, Amiel D, LOTZ M. Nitric oxide production and apoptosis in cells of the meniscus during experimental osteoarthritis. Arthritis Rheum 1999; 42:2123-31. 1998 LOTZ M. Mechanisms of pain in arthritis. In: Anesthesia: Biologic Foundations. Biebuyck JF, Lynch C, Maze M, Saidman LJ, Yaksh TL, and Zapol W [Eds.] Lippincott-Raven Publishers, Philadelphia, PA, 1998 p. 819-28. LOTZ M. Mechanisms of tissue destruction in rheumatoid arthritis. In: Rheumatology, 2nd Edition. Klippel JH and Diepe PA [Eds.] Mosby London, 1998 p.1-10. Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, Seegmiller JE, Terkeltaub R, LOTZ M. Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci U S A 1998; 95:3094-9. Hashimoto S, Takahashi K, Amiel D, Coutts RD, LOTZ M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 1998; 41:1266-74. Hashimoto S, Ochs RL, Komiya S, LOTZ M. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 1998; 41:1632-8. Geng Y, Zhou L, Thompson WJ, LOTZ M. Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes. J Biol Chem 1998; 273:27484-91. Terkeltaub R, LOTZ M, Johnson K, Deng D, Hashimoto S, Goldring MB, Burton D, Deftos LJ. Parathyroid hormone-related proteins is abundant in osteoarthritic cartilage, and the parathyroid hormone-related is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of inorganic pyrophosphate. Arthritis Rheum 1998; 41:2152-64. Shalom-Barak T, Quach J, LOTZ M. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. J Biol Chem 1998; 273:27467-73. 1997


LOTZ M. Cytokines and Their Receptors. In: Arthritis and Allied Conditions, 13th Edition. Koopman W [Ed.] Williams and Wilkins, Baltimore, MD 1997, p 439-78. Zvaifler NJ, Tsai V, Alsalameh S, von Kempis J, Firestein GS, LOTZ M. Pannocytes: distinctive cells found in rheumatoid arthritis articular cartilage erosions. Am J Pathol 1997; 150:1125-38. Rosen F, McCabe G, Quach J, Solan J, Terkeltaub R, Seegmiller JE, LOTZ M. Differential effects of aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate production and decreased cell proliferation. Arthritis Rheum 1997; 40:1275-81. Schwarz H, Arden K, LOTZ M. CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies. Biochem Biophys Res Comm 1997; 235:699-703. Cai J, Zheng T, LOTZ M, Zhang Y, Masood R, Gill P. Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-beta. Blood 1997; 89:1491-500. Shiraishi A, Dudler J, LOTZ M. The role of IFN regulatory factor-1 in synovitis and nitric oxide production. J Immunol 1997; 159:3549-54. Hashimoto S, Setareh M, Ochs R, LOTZ M. Fas/Fas ligand expression and induction of apoptosis in chondrocytes. Arthritis Rheum 1997; 40:1749-55. von Kempis J, Schwarz H, LOTZ M. Differentiation-dependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin. Osteoarthritis Cartilage 1997; 5:394-406. 1996 Maier R, Wisniewski HG, Vilcek J, LOTZ M. TSG-6 expression in human articular chondrocytes. Possible implications in joint inflammation and cartilage degradation. Arthritis Rheum 1996; 39:552-9. Schwarz H, Blanco FJ, von Kempis J, Valbracht J, LOTZ M. ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family regulates T-lymphocyte proliferation and survival. Blood 1996; 87:2839-45. LOTZ M, Setareh M, von Kempis J, Schwarz H. The nerve growth factor/tumor necrosis factor receptor family. J Leukoc Biol 1996; 60:1-7. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, Silverman GJ, LOTZ M, Carson DA, Raz E. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996; 273:352-4. LOTZ M, Villiger PM. Cellular Responses to Cytokines. In: Cytokines and the CNS. Ransohoff RM and Benveniste EN [Eds.] CRC Press, 1996 p. 47-62. Geng Y, Valbracht J, LOTZ M. Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest 1996; 98:2425-30. 1995 Blanco FJ, Ochs RL, Schwarz H, LOTZ M. Chondrocyte apoptosis induced by nitric oxide. Am J Pathol 1995; 146:75-85. LOTZ M, Blanco FJ, von Kempis J, Dudler J, Maier R, Villiger PM, Geng Y. Cytokine regulation of chondrocyte functions. J Rheumatol Suppl 1995; 43:104-8.


Schwarz, H, Valbracht J, Tuckwell J, von Kempis J, LOTZ M. ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood 1995; 85:1043-52. Blanco FJ, Geng Y, LOTZ M. Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression. J Immunol 1995; 154:4018-26. Geng Y, Maier R, LOTZ M. Tyrosine kinases are involved with the expression of inducible nitric oxide synthase in human articular chondrocytes. J Cell Physiol 1995; 163:545-54. Blanco FJ, LOTZ M. IL-1 induced nitric oxide inhibits chondrocyte proliferation via PGE2. Exp Cell Res 1995; 218:319-25. Guerne PA, Blanco F, Kaelin A, Desgorges A, LOTZ M. Growth factor responsiveness of human articular chondrocytes in aging and development. Arthritis Rheum 1995 38:960-8. Geng Y, LOTZ M. Increased intracellular Ca2+ selectively suppresses IL-1-induced NO production by reducing iNOS mRNA stability. J Cell Biol 1995; 129:1651-7. Raz E, Dudler J, LOTZ M, Baird SM, Berry CC, Eisenberg RA, Carson DA. Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 1995; 4:286-92. Geng Y, Blanco FJ, Cornelisson M, LOTZ M. Regulation of xygenase-2 expression in human articular chondrocytes. J Immunol 1995; 155:796-801. LOTZ M, Rosen F, McCabe G, Quach J, Blanco F, Dudler J, Solan J, Goding J, Seegmiller JE, Terkeltaub R. Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes. Proc Natl Acad Sci U S A 1995; 92:10364-8. Setareh M, Schwarz H, LOTZ M. A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family. Gene 1995; 164:311-5. LOTZ M. Interleukin-6. In: Cytokines: Interleukins and Their Receptors. Kurzrock R and Talpaz M. [Eds.] Kluwer Academic Publishers, Norwell, MA. 1995 p. 209-34. LOTZ M. Interleukin-6: a comprehensive review. Cancer Treat Res 1995; 80:209-33. 1994 LOTZ M. Clinical value and limitations of measuring cytokines in the diagnosis and management of autoimmune rheumatic diseases. In: Advanced Immunoassays in Rheumatology. Teodorescu, M, Froehlich, C.J [Eds.] CRC Press, Boca Raton, 1994 p. 267-82. Woods VL, Schreck P, Amiel D, Akeson WH, LOTZ M. The role of integrin adhesion receptors in aging of cartilage and osteoarthritis. In: Musculoskeletal Soft-Tissue Aging: Impact on Mobility. Am Acad Orthop Surg 1994 p. 165-78. LOTZ M, Clark-Lewis I, Ganu V. HIV-1 transactivator protein Tat induces proliferation and TGF-beta expression in human articular chondrocytes. J Cell Biol 1994; 124:365-71. LOTZ M, Ranheim E, Kipps TJ. Transforming growth factor-beta as endogenous growth inhibitor of chronic lymphocytic leukemia cells. J Exp Med 1994; 179:999-1004. Woods VL Jr, Schreck PJ, Gesink DS, Pacheco HO, Amiel D, Akeson WH, LOTZ M. Integrin expression by human articular chondrocytes. Arthritis Rheum 1994; 37:537-44.


LOTZ M. Experimental models of arthritis. Rationale for using topical capsaicin to suppress substance P in order to manage arthritis pain. Seminars Arthritis Rheum 1994; 23:10-7. Weisman MH, Flynn P, Yaksh TL, LOTZ M. Effects of topical capsaicin on substance P and prostaglandin E2 levels in synovial fluid: a double blind study. Sem Arthritis Rheum 1994; 23:18-24. Guerne PA, Sublet A, LOTZ M. Growth factor responsiveness of human articular chondrocytes: distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts. J Cell Physiol 1994; 58:476-84. Schwarz H, Villiger PM, von Kempis J, LOTZ M. Neuropeptide Y is an inducible gene in the human immune system. J Neuroimmunol 1994; 51:53-61. Broor S, Kusari AB, Zhang B, Seth P, Richman DD, Carson DA, Wachsman W, LOTZ M. Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor. J Acquir Immune Defic Syndr 1994; 7:647-54. Rediske JJ, Koehne CF, Zhang B, LOTZ M. The inducible production of nitric oxide by articular cell types. Osteoarthritis Cartilage 1994; 2:199-206. LOTZ M, Villiger P, Hugli T, Koziol J, Zuraw BL. Interleukin-6 and interstitial cystitis. J Urol 1994; 152:869-73. Zuraw BL, Sugimoto S, Parsons CL, Hugli T, LOTZ M, Koziol J. Activation of urinary kallikrein in patients with interstitial cystitis. J Urol 1994; 152:874-8. Geng Y, Gulbins E, Altman A, LOTZ M. Monocyte deactivation by interleukin-10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. Proc Natl Acad Sci U S A 1994; 91:8602-6. Maier R, Bilbe G, Rediske J, LOTZ M. Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression. Biochim Biopys Acta 1994; 1208:145-50. Schwarz H, Blanco FJ, LOTZ M. Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. J Neuroimmunol 1994; 55:107-15. Maier R, Geng Y, Zhang B, Rediske J, Bilbe G, LOTZ M. Inducible nitric oxide synthesis in human joint tissue cells. In: The Biology of Nitric Oxide Volume 4 Enzymology, Biochemistry and Immunology. Moncada S, Freelisch M, Busse R and Higgs EA [Eds.] Portland Press, 1994 London.


1993 LOTZ M. The cytokine network. In: Inflammatory Bowel Diseases, Pathophysiology as a Basis of Treatment. Schölmerich J, Kruis W, Goebell H, Hohenberger W, and Gross V. [Eds.] Kluwer Academic Publishers, Dordrecht, Boston, London. p. 1993 103-13. LOTZ M, Seth P. TGFbeta and HIV infection. Ann NY Acad Sci 1993; 685:501-11. LOTZ M. Prospects for immunotherapy of rheumatoid arthritis. Rev Rheum Ed Fr 1993; 60:3-9. Villiger PM, Geng Y, LOTZ M. Induction of cytokine expression by leukemia inhibitory factor. J Clin Invest 91:1575-81. Machold KP, Carson DA, LOTZ M. Transforming growth factor-beta (TGF beta) inhibition of Epstein-Barr virus (EBV)- and interleukin-4 (IL-4)-induced immunoglobulin production in human B lymphocytes. J Clin Immunol 1993; 13:219-27. Delcayre AX, LOTZ M, Lernhardt W. Inhibition of Epstein-Barr virus-mediated capping of CD21/CR2 by alpha interferon (IFN-alpha): immediate antiviral activity of IFNalpha during the early phase of infection. J Virol 1993; 67:2918-21. Raz E, Watanabe A, Baird SM, Eisenberg RA, Parr TB, LOTZ M, Kipps TJ, Carson DA. Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc Natl Acad Sci U S A 1993; 90:4523-7. Gross V, Villiger PM, Zhang B, LOTZ M. Retinoic acid inhibits interleukin-1 induced cytokine synthesis in human monocytes. J Leukoc Biol 1993; 54:125-32. Gross V, Zhang B, Geng Y, Villiger PM, LOTZ M. Regulation of interleukin-6 (IL-6) expression: evidence for a tissue-specific role of protein kinase C. J Clin Immunol 1993; 13:310-20. Villiger PM, Kusari AB, ten Dijke P, LOTZ M. IL-1beta and IL-6 selectively induce transforming growth factor-beta isoforms in human articular chondrocytes. J Immunol 1993; 151:3337-44. Maier R, Ganu V, LOTZ M. Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases. J Biol Chem 1993; 268:21527-32. Gross V, Villiger PM, LOTZ M. Retinoic acid inhibits IL-1-induced IL-6 synthesis in epithelial cells. Inflammopharmacology 1993; 2:111-112. LOTZ M. Interleukin-6. Cancer Investigation 1993; 11:732-742. Wisniewski HG, Maier R, LOTZ M, Lee S, Klampfer L, Lee TH, Vilcek J. TSG-6: a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis. J Immunol 1993;151:6593-601. Schwarz H, Tuckwell J, LOTZ M. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor necrosis factor receptor family. Gene 1993; 134:295-298. Geng Y, Zhang B, LOTZ M. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J Immunol 1993; 151:6692-700. 1992 LOTZ M, Roudier J. Epstein Barr virus and rheumatoid arthritis. In: Rheumatoid arthritis. Smolen JS, Kalden JR, Maini RN [Eds.] Springer Verlag, Berlin, Heidelberg, New York. 1992 p. 257-80.


Mandler RN, Kerrigan DP, Smart J, Kuis W, Villiger P, LOTZ M. Castleman’s disease in POEMS syndrome with elevated interleukin-6. Cancer 1992; 69:2697-703. Broide DH, LOTZ M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992; 89:958-67. LOTZ M. Regulation of the chondrocytes in aging. In: Biological regulations of the chondrocytes. Adolphe M. [Ed.] CRC Press, Boca Raton. p. 1992 237-73. LOTZ M, Terkeltaub R, Villiger PM. Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes. J Immunol 1992; 148:466-73. Villiger PM, LOTZ M. Expression of prepro-enkephalin by human articular chondrocytes is linked to cell proliferation. EMBO J 1992; 11:135-43. Villiger PM, LOTZ M. Differential expression of TGFbeta isoforms by human articular chondrocytes in response to growth factors. J Cell Physiol 1992; 151:318-25. Villiger PM, Terkeltaub R, LOTZ M. Production of monocyte chemoattractant protein-1 by inflamed synovial tissue and cultured synoviocytes. J Immunol 1992; 149:722-7. Villiger PM, Terkeltaub R, LOTZ M. Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid. J Clin Invest 1992; 90:488-96. LOTZ M, Moats T, Villiger PM. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis. J Clin Invest 1992; 90:888-96. LOTZ M. Inflammatory mediators in osteoarthritis. Internal Medicine 1992; 13:56-66. Villiger PM, Fey MF, LOTZ M, Tobler A. IgG2 and IgG4 subclass deficiency and Evan's syndrome in an adult patient. J Allergy Clin Immunol 1992; 90:693-4. 1991 Villiger PM, Cronin MT, Amenomori T, Wachsman W, LOTZ M. IL-6 production by human T-lymphocytes. Expression in HTLV-1-infected but not in normal T cells. J Immunol 1991; 146:550-9. LOTZ M, Guerne PA. Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA). J Biol Chem 1991; 266:2017-20. Kekow J, Wachsman W, McCutchan JA, Gross WL, Zachariah M, Carson DA, LOTZ M. Transforming growth factor-beta and suppression of humoral immune responses in HIV infection. J Clin Invest 1991; 87:1010-6. Delcayre AX, Salas F, Mathur S, Kovats K, LOTZ M, Lernhardt W. Epstein Barr virus/complement C3d receptor is an interferon alpha receptor. EMBO J 1991; 10:919-26. Kekow J, Gross WL, Carson DA, LOTZ M. Modulation of immunocompetent cells in the synovial fluid TGF-beta. Immun Infekt 1991; 9:60-1. Kuis W, Villiger PM, Leser HG, LOTZ M. Differential processing of proenkephalin-A by human peripheral blood monocytes and T lymphocytes. J Clin Invest 1991; 88:817-24. LOTZ M, Guerne PA. Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA). J Biol Chem 2017; 266:2017-2020, 1991.


LOTZ M, Villiger PM. Neuroimmune interactions in homeostasis and pathophysiology of connective tissues. EBSCO Media 1991; 261-7. Maisel AS, Murray D, LOTZ M, Rearden A, Irwin M, Michel MC. Propranolol treatment affects parameters of human immunity. Immunopharmacol 1991; 22:157-64. 1990 Guerne PA, Carson DA, LOTZ M. IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. J Immunol 1990; 144:499-505. LOTZ M, Kekow J, Carson DA. Transforming growth factor-beta and cellular immune responses in synovial fluids. J Immunol 1990; 144:4189-94. Zuraw BL, LOTZ M. Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating factors interleukin 6 and interferon gamma. J Biol Chem 1990; 265:12664-70. Carrera CJ, Terai C, LOTZ M, Curd JG, Piro LD, Beutler E, Carson DA. Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy. J Clin Invest 1990; 86:1480-8. Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, LOTZ M. Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci U S A 1990; 87:8321-5. Tighe H, Silverman GJ, Kozin F, Tucker R, Gulizia R, Peebles C, LOTZ M, Rhodes G, Machold K, Mosier DE, et al. Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients. Eur J Immunol 1990; 20:1843-8. 1989 Jirik FR, Podor TJ, Hirano T, Kishimoto T, Loskutoff DJ, Carson DA, LOTZ M. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol 1989; 142:144-7. Guerne PA, Zuraw BL, Vaughan JH, Carson DA, LOTZ M. Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest 1989; 83:585-92. Podor TJ, Jirik FR, Loskutoff DJ, Carson DA, LOTZ M. Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. Ann NY Acad Sci 1989; 557:374-87. LOTZ M, Vaughan JH. Neuroimmunological interactions. In: Yearbook of Science and Technology. 1989 p. 169-71, McGraw-Hill. Carrera CJ, Yamanaka H, Piro LD, LOTZ M, Carson DA. Profound toxicity of deoxyadenosine and 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. Adv Exp Med Biol 1989; 253B:219-25. LOTZ M, Zuraw B, Carson D, Jirik FR. Hepatocytes produce interleukin-6. Ann NY Acad Sci 1989; 557:509-11. LOTZ M, Roudier J. Epstein-Barr virus and rheumatoid arthritis: cellular and molecular aspects. Rheumatol Intl 1989; 9:147-52. Guerne PA, Vaughan JH, Carson DA, Terkeltaub R, LOTZ M. Interleukin-6 (IL-6) and joint tissues. Ann NY Acad Sci 1989; 557:558-61.


Guerne PA, Terkeltaub R, Zuraw B, LOTZ M. Inflammatory microcrystals stimulate interleukin-6 production and secretion by human monocytes and synoviocytes. Arthritis Rheum 1989; 32:1443-52. 1988 LOTZ M, Jirik F, Kabouridis P, Tsoukas C, Hirano T, Kishimoto T, Carson DA. B cell stimulating factor 2/Interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med 1988; 167:1253-8. Fox RI, LOTZ M, Carson DA. Structure and function of synoviocytes. In: Arthritis and Allied Conditions, McCarty, DJ [Ed.] Philadelphia, Lea & Febiger, 11th Edition, 1988 p. 273-88. LOTZ M, Vaughan JH. Rheumatoid Arthritis. In: Immunological Diseases, Samter M, Talmadge DW, Frank MM, Austen KF, Claman HN [Eds.] Vol. II, 1988 p. 1365-416, Little, Brown and Co., Boston. LOTZ M, Vaughan JH, Carson DA. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 1988; 241:1218-21. 1987 LOTZ M, Carson DA, Vaughan JH. Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science 1987; 235:893-5. LOTZ M, Tsoukas CD, Curd JG, Carson DA, Vaughan JH. Effects of recombinant human interferons on rheumatoid arthritis B lymphocytes activated by Epstein-Barr virus. J Rheumatol 1987; 14:42-5. LOTZ M, Tsoukas CD, Carson DA, Vaughan JH. Interleukins and interferons during EBV infection. In: Epstein-Barr Virus and Human Diseases, Levine PH, Ablashi DV, Nonoyama M and Pearson GR [Eds.] Clifton, New Jersey, The Humana Press, 1987 p. 349-53. Kurki P, LOTZ M, Ogata K, Tan EM. Proliferating cell nuclear antigen (PCNA)/cyclin in activated human T lymphocytes. J Immunol 1987; 138:4114-20. LOTZ M, Zuraw BL. Interferon-gamma is a major regulator of C1-inhibitor synthesis by human blood monocytes. J Immunol 1987; 139:3382-7. 1986 Valentine M, LOTZ M, Dinarello CA, Carson DA, Vaughan JH. Lymphoblastoid B cell lines produce an interleukin-1-like activity that can be serologically distinct from macrophage interleukin-1. Lymphokine Res 1986; 5:173-83. LOTZ M, Tsoukas CD, Fong S, Dinarello CA, Carson DA, Vaughan JH. Release of lymphokines after Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans. J Immunol 1986; 136:3636-42. LOTZ M, Tsoukas CD, Fong S, Dinarello CA, Carson DA, Vaughan JH. Release of lymphokines after infection with Epstein Barr virus in vitro. II. A monocyte-dependent inhibitor of interleukin 1 downregulates the production of interleukin 2 and interferon-gamma in rheumatoid arthritis. J Immunol 1986; 136:3643-8. LOTZ M, Tsoukas CD, Robinson CA, Dinarello CA, Carson DA, Vaughan JH. Basis for defective responses of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3 (T3) antibodies. J Clin Invest 1986; 78:713-21. LOTZ M, Tsoukas CD, Hench PK, Carson DA, Vaughan JH. Release of lymphokines following Epstein-Barr virus infection in vitro of blood lymphocytes from patients with autoimmune diseases. Trans Assoc Am Phys 1986; 99:114-24.


1985 Tsoukas CD, Valentine M, LOTZ M, Vaughan JH, Carson DA. The role of the T3 molecular complex on human T lymphocyte-mediated cytotoxicity. Adv Exp Med Biol 1985; 184:365-85. Fox RI, LOTZ M, Rhodes G, Vaughan JH. Epstein-Barr virus in rheumatoid arthritis. Clin Rheum Dis 1985; 11:665-88. Tsoukas CD, Landgraf B, Bentin J, Valentine M, LOTZ M, Vaughan JH, Carson DA. Activation of resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes. J Immunol 1985; 135:1719-23. LOTZ M, Tsoukas CD, Fong S, Carson DA, Vaughan JH. Regulation of Epstein-Barr virus infection by recombinant interferons. Selected sensitivity to interferon-gamma. Eur J Immunol 1985; 15:520-5. 1984 Tsoukas CD, Valentine M, LOTZ M, Vaughan JH, Carson DA. The role of the T3 molecular complex in antigen recognition and subsequent activation events. Immunol Today 1984; 5:311-3. Tsoukas CD, Lambris J, LOTZ M, Valentine MA, Vaughan JH, Carson DA. Lymphocyte mitogenesis induced by monoclonal antibodies to the T3 complex. Differential modulation by human IgG. Cell Immunol 1984; 89:66-74. 1982 LOTZ M. Psychosomatische Aspekte beim Mammakarzinom. Dissertation, University of Heidelberg, 1982.

Research Gate (RG) Score 47.44 (higher than 97.5% of Research Gate Members) Google Scholar: Citations: 29,428

h-index: 95 i10-index: 240


POSTDOCTORAL FELLOWS AND VISITING INVESTIGATORS Name Dates of Training Current Affiliation Nobuo Negoro, MD, PhD 1988 – 1989 Osaka University, Japan Pierre-André Guerne, MD 1988 – 1990 University of Geneva, Switzerland Jörn Kekow, MD 1989 – 1990 University of Lübeck, Germany Wietse Kuis, MD 1989 – 1990 Children's Hospital Utrecht, The Netherlands Peter Villiger, MD 1989 – 1991 Chief of Rheumatology, University Bern, Switzerland Hans-Georg Leser, MD, PhD 1990 – 1991 University of Regensburg, Germany Pradeep Seth, MD 1990 – 1991 All India Institute of Medical Sciences, New Delhi, Volker Gross, MD, PhD 1990 – 1991 University of Regensburg, Germany Shoba Broor, MD 1991 – 1992 All India Institute of Medical Sciences, New Delhi, Rainer Maier, PhD 1992 – 1994 Novartis Corp., Basel, Switzerland Johannes von Kempis, MD 1992 – 1994 University of Freiburg, Germany Herbert Schwarz, PhD 1991 – 1994 University of Regensburg, Germany Francisco Blanco, MD 1993 – 1994 Hospital Universitario, Madrid, Spain Ursula Pirzer, MD 1993 – 1994 Technische Universität, München, Germany Jean Dudler, MD 1993 – 1997 University Lausanne, Switzerland Akihiro Shiraishi, PhD 1994 – 1997 Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan Yu Geng, MD 1992 – 1999 Pro-Sci Inc., La Jolla, CA Morey Setareh, PhD 1994 – 1999 Pierce Inc., La Jolla, CA Tali Shalom-Barak, DVM 1995 – 1999 Jackson Laboratories, Ben Harbor, ME Dalun Deng, PhD 1997 – 2000 University of California San Diego, San Diego, CA Kazushige Tanaka, PhD 1998 – 2000 Shionogi Corp., Osaka, Japan Hiroshi Chantaphakul, MD 1998 – 2000 Rheumatology, Bumrungrad Hospital, Thailand Saifeddin Alsalameh, MD 1999 – 2000 Internal Medicine and Rheumatology, Germany Nada Alaeddine, PhD 1998 – 2001 University Balamand Med. School, Tripoli, Lebanon Hajime Komuro, MD 1999 – 2001 Hanwa Sumiyoshi General Hospital, Osaka, Japan Takefumi Gemba, PhD 1999 – 2001 AnGes MG, Inc., Osaka, Japan Michael Seitz, MD, PhD 2001 – 2001 University Hospital of Berne, Switzerland Angel Isidro Campa, PhD 2001 – 2001 Unit of Marine Pathology, CIBNOR, La Paz, Mexico Shigeru Takahashi, PhD 2002 – 2003 Tokyo University of Pharmacy & Life Science, Japan Michihisa Zemmyo, MD 2002 – 2003 Kurume University, Japan Koji Hiraoka, MD, PhD 2002 – 2004 Kurume University, Japan Megumi Hashimoto, MD 2003 – 2004 National Center for Child and Health, Japan Takayuki Furumatsu, PhD 2003 – 2005 Okayama Medical Center, Japan Sanshiro Hashimoto, MD 1995 – 2005 Hashimoto Clinic, Japan Ajay Srivastava, PhD 2003 – 2005 McLaren Regional Medical Center, Arkansas Hirohito Mitsuyama, MD, PhD 2004 – 2005 Nagoya University, Japan Kenji Yoshida, PhD 2004 – 2006 Otsuka Pharmaceuticals, Japan Francisco Blanco, MD, PhD 2006 – 2006 Hospital Juan Canalejo, La Coruna, Spain Klaus Kühn, PhD 1997 – 2007 Invitrogen Corporation, Carlsbad, CA Tsaiwei Olee, PhD 1997 – 2007 Scripps Health, La Jolla, CA


Shawn Grogan, PhD 2005 – 2007 Scripps Health, La Jolla, CA Masanao Tsuda, PhD 2003 – 2007 The Burnham Institute, La Jolla, CA Tatsuo Ito, MD, PhD 2004 – 2007 Memorial Sloan-Kettering, NY Yasunori Mishima, MD 2005 – 2007 Kurume University, Japan Dominik Haudenschild, PhD 2005 – 2008 University of California Davis, Sacramento, CA Sung Won Lee, MD, PhD 2006 – 2008 Dong-A University, Busan, Korea Reiji Higashiyama, MD 2007 – 2009 Chiba University, Japan Daisuke Seino, MD 2008 – 2009 Hyogo College of Medicine, Japan Christopher Verioti, DO 2007 – 2008 McLaren Regional Medical Center, MI Young-Hoon Hong, MD 2008 – 2010 Yeungnam University Hospital, Korea Hideki Mizuuchi, MD, PhD 2007 – 2010 Kyushu University, Fukuoka, Japan Shuhei Otsuki, MD, PhD 2006 – 2010 Osaka Medical College, Japan Lina Ching, MD 2009 – 2010 Tri-Valley Medical Group, Murrieta, CA Noboru Taniguchi, PhD 2002 – 2011 Chief, Orthopaedics, Kagoshima University, Japan Shigeru Miyaki, PhD 2007 – 2011 Hiroshima University Hospital, Japan Atsushi Inoue, PhD 2009 – 2011 Astellas Pharma Inc., Japan Chantal Pauli, MD 2010 – 2011 Weill Cornell, New York, USA Yadin Levy, MD 2011 – 2012 Tel Aviv University Hospital, Israel Tomo Yonezawa, PhD 2011 – 2011 Nagasaki University, Japan Beatriz Caramés Perez, PhD 2007 – 2012 CH Universitario Juan Canalejo, La Coruna, Spain Xiaofeng Cui, PhD 2011 – 2012 Stemorgan Research, Albany, NY Akihiko Hasegawa, MD 2010 – 2013 Osaka Medical College, Japan Tetsuya Matsukawa, MD 2012 – 2013 Nagoya University, Japan Hiroyuki Nakahara, MD, PhD 2011 – 2013 Nat’l Institute for Child Health & Dev, Japan Fumiyaki Ayabe, PhD 2011 – 2013 Otsuka Pharmaceutical Co., Ltd., Japan Masahiko Saito, MD 2012 – 2013 Chiba University, Japan Koji Otabe, MD 2012 – 2013 Tokyo Medical and Dental University Jorg van Loosdregt, PhD 2012 – 2013 University Medical Center Utrecht, The Netherlands Min-Chan Park, MD, PhD 2012 – 2014 Yonsei University, Seoul, Korea, Japan Ryuichiro Akagi, MD 2013 – 2014 Chiba University, Japan Hiroyuki Onuma, MD, PhD 2014 – 2014 St. Marianna University, Kawasaki, Japan Shantanu Patil, MD 2001 – 2014 SRM University, Chennai, India Yukio Akasaki, MD 2012 – 2015 Kyushu University Hospital, Fukuoka City, Japan Kathleen Fisch, PhD 2012 – 2015 University of California, San Diego Takeshi Teramura, MD 2014 – 2015 Kobe University School of Medicine, Kobe, Japan Yuta Muramatsu, MD, PhD 2014 – 2015 Chiba University, Japan Wonchul Choi, MD, PhD 2013 – 2015 CHA University School of Medicine, Korea Tao Shen, MD, PhD 2014 – 2015 Shenjing Hospital of CMV, China Jeanie Kwok, PhD 2015 – 2016 Northwestern University, Feinberg School of Medicine Yorikazu Akatsu, MD 2015 – 2016 Chiba University, Japan Taisuke Fukawa, MD 2015 – 2016 Chiba University, Japan Joe Hasei, MD 2014 – 2016 Okayama University Hospital, Japan Ramya Gamini, PhD 2014 – 2017 The Scripps Research Institute


Kavitta Allem, MD 2014 – 2017 Scripps Health, La Jolla, CA Yohei Yamamoto, PhD 2016 – 2017 Chiba University, Japan Luis Passarelli Tirico, MD, PhD 2016 – 2017 University of São Paulo, Brazil Naoki Okubo, MD 2016 – 2017 Kyoto University, Japan Keita Nagira, MD 2016 – 2017 Tottori University Hospital, Japan Seunghan Oh, PhD 2017 – 2018 Wonkwang University, South Korea Takehito Hananouchi, MD, PhD 2016 – 2018 Osaka Sangyo University, Japan Sungwook Choi, MD, PhD 2016 – 2018 Jeju National University Hospital, South Korea Oscar Alvarez-Garcia, PhD 2013 – 2016 The Scripps Research Institute, Sr. Staff Scientist Sho Mokuda, MD 2015 – 2018 Hiromshima University, Japan Yasunari Ikuta, PhD 2016 – 2018 Hiromshima University, Japan Haruhisa Kanaya, MD 2017 – 2018 Tottori University Hospital, Japan Tomoko Miyata, MD, PhD 2016 – 2017 Fukuoka University, Japan Kohei Miyata, MD, PhD 2015 – 2018 Fukuoka University, Japan Florian Gaul, MD 2016 – 2018 Ilan Eskinazi, PhD 2016 – 2018 University of Florida Dae Hee Lee, MD, PhD 2017 – 2018 Samsung Medical Center, South Korea Sang Hak Lee, MD, PhD 2017 – 2018 Kyung Hee University, South Korea Tokio Matsuzaki, MD, PhD 2014 – 2019 University of California San Diego Hirofumi Bekki, MD 2017 – 2019 Kwang-IL Lee, PhD 2015 – Present Ho Jong Ra, MD, PhD 2017 – Present Tomas Duffy, PhD 2018 – Present Gary Yao, PhD 2019 – Present Yoshinobu Saito, MD, PhD 2019 – Present Manabu Kawata, MD, PhD 2019 – Present

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