also in this issue: 20th american peptide symposium … in this issue: 2007 young investigator’s...

Volume 4, Number 5 Autumn 2007

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Also In This Issue:

2007 Young Investigator’sMini-Symposium Awards

2007 Young Investigator’s PosterCompetition Awards

2007 APS Election Results

2007 Makineni Lectureship

2008 Vincent du Vigneaud Awards

Murray Goodman Memorial Prize

GRC -- Biology & Chemistry in Peptides

Research Internships in Science andEngineering

Peptide Breakthrough --Editor-in-Chief’s Choice

Biopolymers-Peptide Science Update

Upcoming Worldwide Events

APS Member Benefits

FASEB Member Benefits

4th International PeptideSymposium Report

NIH Pioneer and New InnovatorAwards

20th American Peptide Symposium ReportThe Twentieth American Peptide Society Symposium, Peptides for Youth, was held on

June 26 – 30, 2007 in Montréal, Québec, Canada. The third APS meeting to come toCanada, and the first time in Montréal, Peptides for Youth celebrated the past history andpioneers of the society and launched new initiatives directed at enhancing memberparticipation at the meeting. With over 1,000 participants, Peptides for Youth was asuccess, and provided high-impact scientific content with a balance of industrial andacademic speakers and posters.

The Symposium was filled with excellent lecture sessions and workshops, organized bythe Scientific Advisory Board and often dedicated to the pioneers of the field. For example,two memorable lectures werepresented on the firstevening, as Dr. Isabella Karledelivered the MerrifieldAward Lecture and ProfessorRonald Raines gave theMakineni Award Lecture.Many of the presentationswill be published in theSymposium’s Proceedings,which will for the first timebe cited on the ISI Web ofScience.

The valued history of ourSociety was portrayed in tenPortraits of the Pioneers ofthe American Peptide Society, that were prepared by student volunteers from the Universi-ties of Montréal, Sherbrooke and Montpellier, and displayed at the entrance to theExposition. On the middle day of the meeting, the students also presented a historical slideshow scored to the Cole Porter song “Experiment,” featuring a retrospective with NorthAmerican bias of the growth of our field, from the first peptide synthesis of Fischer morethan a hundred years ago to Peptides for Youth.

By attempting new things such as placing the Young Investigator Oral Presentationsinto the heart of the meeting, Peptides for Youth highlighted the importance and power ofthe next generation of peptide scientists. In particular, Peptide Idol, a new format forselecting the winner of the Young Investigator poster competition, was a hit that illustrated

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American Peptide Society Newsletter

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the strength of the Society’s future. Moreover, Peptides for Youth marked the launch of the“Molecules of Life Project” with the debut of the “Peptides of Life,” in which art andscience were employed together to teach a syllabus of twelve peptides to elementary schoolstudents.

The format was fresh and included new innovations such as the General Assembly, inwhich members had an open forum to voice their opinion on Society activities; theNetworking Lunch, in which Young Investigators were given opportunity to network withsenior members, and the Session on Complementary and Alternative Medicine, featuringnew avenues for developing peptide science. Some enjoyed a morning yoga session on theroof of the Hyatt Hotel and others gazed at fireworks from Club 737 at the top of one ofMontréal’s tallest buildings, during new complementary social venues that balanced thetraditional Opening Reception, Merrifield and Speakers Dinners and Closing Banquet.

The co-chairs thank the many symposium committee members who volunteered theirservices and helped make the 20th APS symposium such a successful meeting!

William Lubell and Emanuel EscherSymposium Co-chairs

20th APS Co-Chairs William Lubell(top) and Emanuel Escher (bottom)

WINNERS:Masa Cemazar, University of QueenslandArianna Rath, University of Toronto

THANKS TO ALL PARTICIPANTS:Chris Armishaw, Copenhagen University

Monica Branco, University of Delaware

Marie-Stephanie Camus, EcolePolytechnique Federale de Lausanne

Pawell Czechura, University of Ottowa

Zvi Hayouka, Hebrew University

Kai Hilpert, University of British Columbia

Manoj Kurian Jacob, Rajiv Gandhi Centrefor Biotechnology

Kazuki Kawahara, Osaka University

Jennifer Lanning, University of Chicago

Jeffrey-Tri Nguyen, Kyoto PharmaceuticalUniversity

The Dr. Bert L. Schram2007 Young Investigator’s Mini-Symposium AwardsSponsored by the ESCOM Science Foundation

Bettina Proneth, University of Florida

Nir Qvit, Hebrew University

Shai Rahimipour, Bar Ilan University

Nicole Van der Weerden, La TrobeUniversity

Larisa Yeomans, University of Arizona

THANKS TO THE YIMS JUDGES:Lila GieraschErnest GiraltMibel AguilarChris SoareNeal ZondloJesse DongOliver ZerbeHelma WennemersRobert Ben

20th American Peptide Symposium Report(continued from Page 1)

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FIRST PLACE WINNER:Meritxell Teixido, University of Barcelona

SECOND PLACE WINNER:Swapna Bagwanth,University of Minnesota

THANKS TO ALL PEPTIDE IDOLPARTICIPANTS:Jennifer Chaytor, University of Ottowa

Bhaswati Dattachowdhury,University of Kansas

Feliciana Real Fernandez, University ofFlorence

Norman Metanis, The Scripps ResearchInstitute

Theresa Tiefenbrunn, The ScrippsResearch Institute

The 2007 Young Investigators’Poster Competition Awards -- Sponsored by C.S. Bio

THANKS TO ALL POSTERCOMPETITION JUDGES:Paolo GriecoLaszlo OtvosJohn TolleAnna DiezJeff BodeCarsten BaldaufYvonne AngellHee-Seung LeeAnnelise BarronAjoy BasakJeff BeckerMatt BogyoAle NarvanenRobert HondalKenneth RotondiFernando FormaggioGilles GuichardMark McLaughlinPhil DawsonClaudio MapelliChris SchafmeisterJohn MayerWolfgang MaisonFelix PolyakPierre LavigneAnna Maria PapiniMark JarosinskiJesse DongMichael CarrascoDavid Perrin

2007 APS Election ResultsCongratulations to the following success-ful candidates in the 2007 APS election:¨ President Elect: Gregg Fields

¨ Secretary: Robin Offord

¨ Two new Councilors: Phil Dawsonand Hank Mosberg

¨ Five Nominating Committee mem-bers: Deborah Heyl-Clegg, MichaelPennington, Robert Hammer, ClaudioMapelli, and Maria Bednarek

The changes to the Constitution andBylaws passed with 98% of the vote.

Congratulations to all of the newlyelected officers, councilors and Nominat-ing Committee members, and ourheartfelt thanks to all of the candidateswho agreed to run for election.

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The 2007 Makineni Lectureship –Endowed by PolyPeptide Laboratories, Inc., andMurray and Zelda Goodman (2003)

The American Peptide Society is pleased to announce the selection of Dr. Ron Rainesas the Rao Makineni Lecturer for 2007. Dr. Raines delivered his lecture as part of theprogram at the 20th APS Symposium this past June in Montréal.

Ron Raines is the Henry Lardy Professor of Biochemistry and a Professor of Chemistryat the University of Wisconsin–Madison. Ron received Sc.B. degrees in chemistry andbiology at MIT, and A.M. and Ph.D. degrees in organic chemistry at Harvard University. Hewas a Helen Hay Whitney postdoctoral fellow in the Department of Biochemistry andBiophysics at the University of California, San Francisco. He joined the faculty at theUniversity of Wisconsin–Madison in 1989.

Ron has contributed broadly to our understanding of the chemistry and biology ofpeptides and proteins. He discovered fundamental attributes of the collagen triple helix,enabling him to assemble triple helices that are stronger and longer than any found innature. Ron demonstrated that mammalian ribonucleases can become potent cytotoxinsand potential cancer chemotherapeutics. He developed the traceless Staudinger ligation asa means to couple synthetic peptides and thus synthesize proteins.

Ron has trained more than 70 doctoral and postdoctoral students. He is an author ofmore than 200 research papers, and an inventor on more than 10 US patents.

Ron has received the Pfizer Award in Enzyme Chemistry and the Arthur C. CopeScholar Award from the American Chemical Society, the Emil Thomas Kaiser Award fromThe Protein Society, and a Guggenheim Fellowship. He is a fellow of the AmericanAssociation for the Advancement of Science and the Royal Society of Chemistry.

The Makineni Lectureship is dedicated to Rao Makineni, a longtime supporter ofpeptide science, peptide scientists, and the American Peptide Society. The Lectureshiphonors an individual who has made a recent contribution of unusual merit to research inthe field of peptide science, and is intended to recognize original and singular discoveriesrather than cumulative or lifetime contributions. The Lecture is presented at the biennialAmerican Peptide Symposia.

Ron Raines

2008 Vincent du Vigneaud Awards –Sponsored by Bachem

The American Peptide Society’s Vincent du Vigneaud Awards, recognizing outstandingachievements in peptide research, will be presented to Jeff Kelly (Scripps ResearchInstitute) and Tom Muir (Rockefeller University) on February 21, 2008 as part of theGordon Research Conference on the Chemistry and Biology of Peptides, chaired by Drs.Carrie Haskell-Luevano (University of Florida) and Kit Lam (University of California –Davis).

Tom Muir (left) and Jeff Kelly (right)


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GRC – Biology & Chemistry in PeptidesVentura, California, February 17 – 22, 2008

The scientific program for the 2008 Gordon Research Conference on Biology andChemistry in Peptides is nearing completion. We anticipate an exciting meeting withsessions focused on infectious diseases, material sciences and nanotechnology, foldingand dynamics, new chemistry approaches in peptide sciences, chemical biology andmolecular imaging, peptide/protein design strategies, ligand-receptor interactions, as wellas a wide array of topics to be included in poster and oral presentations selected fromsubmitted abstracts.

We strongly encourage all participants to present their most recent findings or resultsas a poster. In the past, poster sessions have been lively exchanges of information andideas. We have set aside ample time for the poster sessions and will select a number ofposters for short oral presentations during the conference.

We recommend early application to the Peptides GRC as attendance is limited. Wewelcome applications from graduate students and young postdoctoral scientists. Prefer-ence will be given to those who submit a poster abstract to the chairs. For more informa-tion, please see http://www.grc.org/programs.aspx?year=2008&program=peptides

Carrie Haskell-Luevano and Kit LamConference Chairs

Murray Goodman Memorial PrizeThe Biopolymers Murray Goodman Memorial Prize was presented for the first time

during the fall 2007 meeting of the American Chemical Society to Dr. Christopher T. Walshfor seminal contributions to the understanding of the complex catalytic chemistry ofbiopolymers of profound physiological significance. This annual award was established inmemory of Dr. Murray Goodman, founding editor of Biopolymers, one of the AmericanPeptide Society founders and its President from 2001 to 2003, and an enormouslyinfluential force in the field of peptide chemistry for more than 50 years.

Christopher T. Walsh

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Peptide Breakthrough – Editor-in-Chief’s ChoiceA number of breakthrough manuscripts involving the use of peptides have been

published within the past six months highlighting the importance of the field in today’sresearch arena. While it is impossible to list all the recent great advancements, thefollowing articles were selected to illustrate the broad applicability of peptides in biomedicalresearch and encourage young scientists to pursue this exciting field.

“Selective inhibition of NF-kappa B activation prevents dopaminergic neuronal loss ina mouse model of Parkinson’s disease.” Ghosh A. et al., PNAS, 2007, Nov 13. Parkinson’sdisease (PD) affects about 1.2 million patients in the US and Canada and represents thesecond most common neurodegenerative disorder with no available effective therapy. Afterdemonstrating that NF-kappa B is increased in the midbrain of PD patients and mice,Ghosh et al. successfully inhibited NF-kappa B activation and improved motor functions inmice with PD pathology following i.p. injection of NBD peptide, a peptide corresponding tothe NF-kappa B essential modifier-binding domain of I-kappa B kinase alpha.

“Self-assembled templates for polypeptide synthesis.” Ryadnov MG. & Woolfson DN., J.Am. Chem. Soc., 2007, 129:14074. Ryadnov and Woolfson took advantage of the ability ofpeptides to self-assemble to develop a novel method for synthesis of long peptide chains,which combine native chemical ligation and peptide self-assembly.

“Potent D-peptide inhibitors of HIV-1 entry.” Welch BD. et al., PNAS, 2007, 104:16828.Using phage display technology and structure-assisted design, Welch et al. identified D-peptides having hundred picomolar range inhibitory activity of HIV-1 entry process.Crystallographic studies indicate the formation of specific and high affinity interactionswith HIV glycoproteins, illustrating the ability of D-peptide to bind with high affinity tonaturally occurring proteins.

“Peptides selected for the protein nanocage pores change the rate of iron recoveryfrom the ferritin mineral.” Liu XS. et al., J. Biol. Chem., 2007, 282:31821. By searching acombinatorial library of ferritin-binding peptides, Liu et al. discovered heptatpeptidescapable of modulating the rate of iron release. Such peptides have potential uses asregulators of ferritin demineralization rates in vivo or peptide regulators of gated pores inmembranes.

Sylvie E. BlondelleEditor-in-Chief, APS Newsletter

Biopolymers-Peptide Science UpdateAs most American Peptide Society members know, Biopolymers-Peptide Science is a

specialized off-shoot of Biopolymers emphasizing the fields of peptide chemistry andbiology. Importantly, Biopolymers-Peptide Science is the official journal of our Society.Biopolymers-Peptide Science offers several issues and article formats to its readership andto prospective authors. For many years, the focus was on topical reviews—called “CurrentTrends in Peptide Science.” We continue to solicit and welcome proposals for these usefulperspectives on important themes in the peptide field, and we find that these articles areamong the most cited in the journal.

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Research Internships inScience andEngineering (RISE)

Attention faculty members: do youknow talented undergraduate students(RISE) and graduate students (RISEProfessional) who might be interested ininternships in Germany? The GermanAcademic Exchange Service (DAAD) isagain offering scholarships to provide aunique combination of study-abroadexperience and participation in an actualfirst-rate research project at top researchinstitutions and universities. Germanlanguage skills are not required for mostpositions. The working language willgenerally be English.

RISE undergrads are paired withGerman Ph.D. students in a uniquementoring partnership to ensureimmediate integration into hands-on labwork and built-in social network with anexcellent opportunity to develop newtechnical skills.

RISE professionals (recent graduates,Master’s and Ph.D. students, and RISEalumni) are matched with a Germancompany, where they gain insight intothe professional applications of scienceand engineering and develop practicalskills.

More information on summerresearch opportunities can be found athttp://www.daad.de/rise and http://www.daad.de/rise-pro, respectively.Application deadline is January 15, 2008.


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A few years back, Biopolymers-Peptide Science began to accept original researcharticles, and this decision has allowed the journal to have a balanced blend of reviews andnew research findings. It is clear from the healthy rate of submission of high qualitypapers that this decision was a good one.

In addition to this mix, Biopolymers-Peptide Science fills another key role for itsreadership: we have welcomed thematic issues organized by peptide scientists across theglobe. These issues have allowed the journal to honor the passing of major figures in ourfield whose careers have had great impact on peptide science, such as Murray Goodmanand Arno Spatola. As we all are so acutely aware, we recently lost one of our most distin-guished colleagues and a great friend, Bruce Merrifield. As of this writing, a special issuededicated to Bruce is coming to closure. Svetlana Mojsov and George Barany are guesteditors of this issue, and it will appear as the second issue in 2008. There will be abouttwo-dozen articles in this issue, including perspectives from those who worked closely withBruce or benefited from his mentorship. The outpouring of interest for this issue is atestimony to Bruce’s huge presence and impact, as well as his personal qualities.

We look forward to several other special issues in Biopolymers-Peptide Science in thenext months, interspersed with regular issues. Look for one particularly exciting and novelupcoming project: Jungmo Ahn and Jeff Bode are guest-editing an issue entirely made upof articles written and reviewed by young investigators. It will be exciting to see what thepeptide chemists and biologists of the future have to offer!

In the final issue of 2007 we introduced two new features that we feel will be of interestand use to our readers. First, we included a book review by Vic Hruby highlighting LeoBenoiton’s terrific treatise on peptide synthesis. We will be on the lookout for other books ofparticular interest and will solicit reviews. Second, we have begun to offer information onarticles published in our sister journal, the Journal of Peptide Science. We share manyreaders and authors with this journal, and it makes sense to provide alerts to each other’scontents.

We are also delighted to report that Biopolymers-Peptide Science will publish articlesbased on the award lectures of the 2008 du Vigneaud Award winners, Jeff Kelly and TomMuir. These two outstanding peptide scientists will receive their awards and present theirlectures at the Gordon Conference on the Chemistry and Biology of Peptides, this comingFebruary.

As the official journal of the American Peptide Society, Biopolymers-Peptide Sciencestrives to serve our community—peptide researchers. We also ask that you, the readersand prospective authors, tell us what the journal can best do for you. Grassroots feedbackand proposals for thematic issues are essential for the journal to serve its scientificcommunity optimally. We cherish the unique niche of this journal, and we realize that ourrole relies on being aware and responsive to the needs and preferences of the communitywe serve. We ask for help to do this as well as possible.

Lila M. GieraschEditor-in-Chief, Biopolymers-Peptide Science

Biopolymers-Peptide Science Update(continued from Page 6)

UpcomingWorldwide EventsABRF Enabling Technologiesin the Life SciencesFebruary 9-12, 2008Salt Lake City, UtahFor more information:http://www.abrf2008.org/exhibits

Peptides, Chemistry & Biology GordonResearch ConferenceFebruary 17 - 22, 2008Ventura Beach, CaliforniaFor more information:http://www.grc.org/programs.aspx?year=2008&program=peptides

BIT’s 1st Annual Protein and PeptideConference (PepCon-2008)April 22-24, 2008Shenzhen, ChinaFor more information:http://www.bitlifesciences.com/Pepcon2008/index.htm

11th Naples Workshop: New Frontiers inthe Search of Bioactive Molecules: fromPeptides to DrugsMay 24 - 27, 2008Napoli, ItalyFor more information:http://www.cirpeb.unina.it/naples2008

Protein Society 22nd Annual SymposiumJuly 19-23, 2008San Diego, CaliforniaFor more information:http://www.proteinsociety.org

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American Peptide SocietyMember Benefits¨ A subscription to Biopolymers –

Peptide Science.

¨ Discounted subscription rates for thefollowing journals:

- Chemical Biology & Drug Design- International Journal for Peptide Research & Therapeutics- Protein and Peptide Letters- Current Protein & Peptide Science- Current Proteomics

¨ Free professional position and resumeposting on the website.

¨ Membership in the Federation ofAmerican Societies for ExperimentalBiology (FASEB).

For more information, please visit ourwebsite at http://www.AmPepSoc.org.

Benefits of Membershipin FASEB

Your American Peptide Societymember benefits also include member-ship in FASEB.

The Federation of American Societiesfor Experimental Biology (FASEB) existsto advance biological sciences throughadvocacy and education to lead toimprovements in human health. Thestrength of FASEB comes from the 21Member Societies (including the Ameri-can Peptide Society) and the more than80,000 individuals who belong to theseorganizations. In Washington, DC, FASEBis the voice of the bench scientist inbiology and is the primary liaisonbetween the biomedical researchcommunity and the federal government.


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4th International Peptide Symposium:in conjunction with the7th Australian Peptide Symposium and the2nd Asia-Pacific International Peptide SymposiumOctober 21-25, 2007, Cairns, Queensland, Australia

The 4th International Peptide Symposium was held at The Cairns Convention Centrein far north tropical Queensland from 21st to 25th October, 2007. The meeting, which hadthe theme “Discovery to Drugs: The Peptide Pipeline” was organised by the AustralianPeptide Association with Profs. Ian Smith and John Wade as the co-chairs. The meetingattracted over 400 delegates from all over the world, with large delegations from theJapanese, Korean, US and European peptide communities. In total there were 74 oral and212 poster presentations. A number of student bursaries were awarded and two studentposter prizes were awarded for each poster session. Specialist workshops were organisedby ABI, Agilent, Thermo Scientific, Beckman Coulter and Bruker and there was anexcellent trade display with 30 companies represented.

The Peptide Symposium opened on the Sunday evening with a stimulating plenarylecture by Brian Chait (Rockefeller University, New York, USA) entitled Proteomic Ap-proaches for Analysing Complex Biological Machines, in which he presented a focusedproteomics approach to dissect Nuclear Pore Complexes.

The remaining oral presentations were organised into individual sessions in themorning with parallel sessions running in the afternoons. Session titles were: ProteinMisfolding and Disease; Peptidomimetics and Drug Design; New Developments in PeptideDrug Delivery; Chemical Peptide Synthesis: Innovations and Applications; Peptidomics:Towards Therapeutics; Peptides-to-Clinic; Clinical Proteomics; Toxins and Targets: NewTherapetic and GMO leads; Molecular Interactions- Exploring Affinity and Specificity;Emerging Technologies for Studying Peptide Structure and Function; New Concepts inBioactive Peptide Design; Peptidomics; Biomarker Analysis and Characterisation; Peptideand Protein Engineering; Peptides as Drugs in Infectious Diseases and Neuropeptides andPain. As at previous meetings in this series the role of emerging technologies in peptideand protein research and modern drug discovery was well demonstrated and a number ofdifferent disease states addressed including cancer, diabetes, rhematoid arthritis andAlzheimers.

Three very successful specialists satellite meetings were also held immediately prior tothe Symposium, which focussed on Advances in Solid Phase Peptide Synthesis (PortDouglas, Chair Prof John Wade), Protein Misfolding (Dunk Island, Chair Dr KevinBarnham), and Chemical Protein Synthesis and Ligation (Heron Island, Chair, Prof PaulAlewood).

We would like to thank all participants and our sincere appreciation for the support ofthe Japanese, Korean, Chinese, European and American Peptide Societies. The friendlyambience of the meeting stimulated much discussion and cross fertilisation of ideasbetween the participants which will surely lead to some exciting further developments andcollaborations in the future. We look forward to welcoming everyone to the 8th AustralianPeptide Conference in October 2009 which will be again located in a relaxing and sunnyNorth Queensland location.

Mibel AguilarConference Secretary


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American PeptideSociety NewsletterPublished quarterly by the American Peptide Society,http://www.americanpeptidesociety.com.

President . . . . . . . . . . . . . . . . Dr. Richard A. HoughtenPresident-elect . . . . . . . . . . . . . . . . Dr. Gregg B. FieldsTreasurer . . . . . . . . . . . . . . . . . . . . Dr. Thomas J. LoblSecretary . . . . . . . . . . . . . . . . . . . . . Dr. Robin E. OffordImmediate Past President . . . . . . . . Dr. Jane V. AldrichEditor-in-Chief . . . . . . . . . . . . . . Dr. Sylvie E. BlondelleEditor . . . . . . . . . . . . . . . . . . . . . . . . . Ellen T. Brenner

We are always seeking items for your society’s newsletter--either scientific or personal, as long as they are relevantto the field of peptide science, the Society, and itsmembers. Please email your news items, along with anyphotos or graphics, to Editor Ellen Brenner [email protected]. Items should be either MicrosoftWord document attachments, or plain text included inthe body of the email. Photos should preferably be ineither JPEG or EPS format, and not embedded in aWord document.

NIH Pioneer and New Innovator AwardsGot bold, innovative research ideas with high-impact potential? Apply for an NIH

Director’s Pioneer Award. If you’re a new investigator, you’re also eligible for an NIHDirector’s New Innovator Award.

Both programs are part of the NIH Roadmap for Medical Research, and supportexceptionally creative scientists who propose highly innovative-and often unconventional-approaches to major challenges in biomedical or behavioral research.

Women and members of groups that are underrepresented in NIH research areas areespecially encouraged to apply.PIONEER AWARD¨ $2.5 million in direct costs over 5 years

¨ 5-10 awards expected in September 2008

¨ Applications accepted December 16, 2007-January 16, 2008

¨ For more information see http://grants1.nih.gov/grants/guide/rfa-files/RFA-RM-08-013.html and http://nihroadmap.nih.gov/pioneer

¨ E-mail questions to [email protected]

NEW INNOVATOR AWARD¨ $1.5 million in direct costs over 5 years

¨ Up to 24 awards expected in September 2008

¨ Applications accepted March 3-31, 2008

¨ For more information see http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-08-007.html, http://grants.nih.gov/grants/new_investigators/innovator_award, andhttp://grants.nih.gov/grants/guide/rfa-files/RFA-RM-08-014.html.

¨ E-mail questions to [email protected]

also in this issue: 20th american peptide symposium … in this issue: 2007 young investigator’s...

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