Why Polyphenolics__________________

About Polyphenolics

Founded in 1996, Polyphenolics is a science driven organization dedicated to researching and developing innovative products using grape seed derived polyphenols to deliver specific, documented health benefits.

Division of Constellation Brands

Polyphenolics is a division of Constellation Brands, Inc., the world’s largest premium wine company and owner of famous brands, such as Franciscan, Simi, and the legendary Robert Mondavi Winery. As our parent company strives for excellence in making premium wines, Polyphenolics strives for excellence in making premium grape seed extracts. As a division of Constellation Brands, Polyphenolics has access to an abundant supply of California wine grapes.

All Grape Seed Extracts are not created equal.

Quality

Polyphenolics goes beyond federally mandated traceability requirements, documenting all aspects of growing, treating, and processing the grapes. Through painstaking supply chain documentation and laboratory testing, Polyphenolics can substantiate freshness, identity, domestic origin, and absence of chemical contaminants and genetic modification. Polyphenolics controls the entire manufacturing process, from the initial selection of grapes to the final extraction of finished material that is MegaNatural® grape seed extracts.

• MegaNatural® grape seed extracts are adulterant free. They come from 100% California grown grapes traceable to the fields they were grown in.

• The consistency of every batch is verified through specialized HPLC testing. Consistent activity guarantees consistent results in your finished product.

Why You Should Not Use or Consider Less Expensive/Inferior Quality Grape Seed Extract in Your Product.

What Differentiates MegaNatural® Grape Seed Extracts From Others?

•Four US Patents Issued•World-Wide Patents Pending•Unique Composition•Original Research•Clinically Proven•Condition-Specific

•100% California-Grown Grapes•100% Pure Grape Seed Extract•100% Water Soluble•No Chemical Solvents•Relentlessly Tested•FDA No-Objection GRAS

Identifying a NeedThe Stealth Killer

America’s HIGH BLOOD PRESSURE

crisis is spinning out of control. Learn

about it, treat it and maybe save your life.

TimeDecember 6, 2004

Prevalence of high blood pressure in adults age 20 and older, by age and sex.

Source: NCHS and NHLBI.

12.2

24.4

38.8

53.2

65.4 64.6

6.616.2

38.4

54.1

70.877.3

0102030405060708090

20-34 35-44 45-54 55-64 65-74 75+

Perc

ent o

f Pop

ulat

ion

Men Women

• 31% of US population (132 Million)• 39% of men and 23% of women• Between the ages of 20-39 yr:

• 37.4% in African Americans 32.2% in Whites• 30.9% in Hispanics • 9 out of 10 of these people will

develop hypertension by 65

Pre-Hypertensive people createa large market

Major Breakthrough in the Development of

MegaNatural®-BP through original research

Original Research

Polyphenolics has invested heavily in original research at both the laboratory and clinical levels. Original research is important because multiple factors, from the grape varietals chosen, to the time of harvest, and the extraction technique, can influence the profile of the finished product. The only way to know if a particular extract has biological efficacy is to test the specific composition of the extract.

Mechanism of Action Study

How does MegaNatural®-BP Work?Research using animal models indicates that it activates the enzyme nitric oxide synthase (eNOS) to produce nitric oxide (NO). NO is a gaseous compound that acts as a cellular messenger. When NO is present in the inner lining of the blood vessels, known as the endothelium, it causes the surrounding smooth muscle to relax. This endothelium-dependent relaxation of the blood vessels then supports healthy blood flow.*

MegaNatural®-BP causes a relaxation of the blood vessels

This is similar to that elicited by acetylcholine – a known vasodilator.

Human Clinical Trial #1MegaNatural®-BP was found to help maintain blood pressure levels within the normal range.

Human Clinical Trial #2MegaNatural®-BP was found to help maintain blood pressure levels within the normal range.

GSE PlaceboSystolic

BPDiastolic

BPSystolic

BPDiastolic

BPInitial 134 ± 2 79 ± 2 133 ± 1.9 79 ± 2

Final 126 ± 2 74 ± 2 133 ± 2.3 81 ± 2

Difference -8 -5 0 +2P 0.003 <0.05 NS NSPower (α at 0.05)

0.86 0.50

N = 15 for both groups

Human Clinical Trial #3MegaNatural®-BP was found to help maintain blood pressure levels within the normal range in a beverage.

Results: Consumption of MegaNatural®-BP beverage for six weeks led to a significant reduction in systolic BP compared to placebo beverage that returned to baseline after four week discontinuation of GSE beverage. Similar findings were apparent for diastolic BP showing 4.7% reduction in DBP that returned to baseline after discontinuation of GSE beverage. Subjects with higher starting BP experienced greater BP reduction.

Publications

1. Sivaprakasapillai et.al., Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Journal of Metabolism Clinical and Experimental, (2009) 58 (12), 1743-1746.

2. Edirisinghe et.al., Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clinical Science (2008) 114, 331-337.

3. Robinson et.al., Effect of Grape Seed Extract in Subjects with Pre-Hypertension, Recent Advances in Cardiovascular Disease (2007) 13th World Congress on Heart Disease, 239-242.

4. Robinson et. al., Effect of Grape Seed Extract in Subjects with Pre-Hypertension. Journal of Pharmacy and Nutrition Sciences(2012) 2, 155-159.

Normal Phase HPLC Chromatogram of MegaNatural®-BP

MegaNatural®-BP is Structurally Unique, providing 90-95% total polyphenols

(as monomers, oligomers, and polymers).

GRAS Notification to FDA

Polyphenolics conducted a subchronic three month oral toxicity study of MegaNatural® seed and skin extracts and micronucleus assay • FDA “No Objections”GRAS for use in food and

beverages (August 2003)• GRAS Extension in 2007

1/3 of Americans could benefit from MegaNatural®-BP

• Nearly 1 in 3 adults has high blood pressure• 71.8% of adults with high blood pressure are

aware of their condition• 64.9% of people with high blood pressure do

not have it under control

Patents

Structure Function Claims

• MegaNatural®-BP is a unique form of grape seed extract that has been clinically shown to help maintain healthy blood pressure levels within the normal range.

• MegaNatural®-BP, a unique form of grape seed extract, is an antioxidant that helps support endothelial function by maintaining healthy nitric oxide levels that are within the normal range. This helps support healthy vasodilation and blood flow.

“

”

“If a formulator begins with a branded ingredient that has endured vigorous R&D already, it could ultimately save time, and give confidence because a company’s R&D is backed by additional studies.” Anil Shrikhande, President, Polyphenolics

NATURAL PRODUCTS INSIDER, JUNE 2014

Our Customers

Polyphenolics believes in forming close partnerships with our customers and remains available to customer partners during all phases of product development for technical questions and support.

MegaNatural® grape seed extracts are now included in formulations targeting heart health, sports nutrition, blood pressure maintenance, blood sugar maintenance, and various prevention lines for men and women from some of the most successful supplement companies in the world.

www.polyphenolics.com

QUESTIONS?