alcat test_food allergy and chemical sensitivity tests

Download Alcat Test_Food Allergy and Chemical Sensitivity Tests

Post on 19-May-2015



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If you think you are allergic to any kind of food, then use our Food Allergy testing procedure to determine the food that is not for you. With a food allergy test, you don’t have to down something that you can’t take also called Food intolerance! Food sensitivity can be dangerous. You won’t know it, but it might end up being your worst foe! for more details visit


  • 1. Anxiety and Your Patient A holistic, integrative approach for the general practitioner- Copyright 9/11/2012

2. Epidemiology Journal Clinical Psychiatry- most common psych disorder 15.7 million in the US 30% seek treatment Present to general practitioners more than psychiatrist Copyright 9/11/2012 3. What is Anxiety Persistent fear response without identifiable specific trigger or Prolonged response Starts fight or flight response Anxiety increases risk of inflammatory diseases More prone to mistakes, less productive Copyright 9/11/2012 4. Genetic? Studies show may be genetic susceptibility with variants of retinoid- related orphan receptor alpha (RORA) gene to PTSD Gene primary function to protect brain from stress Gene Variant of BDNF gene Met66Met- smaller hippocampus on imaging and higher response amygdala to emotional stimuli with Copyright 9/11/2012 5. Mediators- B.I.G Brain (neuroendocrine) Immune System- surveillance, Gut Vagus nerve 2 way communication system between brain and gut All interact to form super information highway Copyright 9/11/2012 6. Brain-Theories and Substances Trigger Arrives amygdala To Locus Cereleus Activation of sympathetic system Prefrontal lobe Response Copyright 9/11/2012 7. Brain Connection- Pathway r Trigger Amygdala Locus Cereleus NE CRH ACTH Adrenal Stimulation Copyright 9/11/2012 8. Theories and Substance Amygdala stores fear memories Used Pavlovian conditioned and unconditioned stimulus Substances affect amygdala can escalate or ameliorate anxiety Copyright 9/11/2012 9. Brain Connection Locus Cereleus primary NE center in brain LC can be affected by other NT LC connects to all parts of brain including hypothalamus NE play role in HTN, behavioral changes and modulates HPA axis Increased cytokines increase NE in hypothalamus via LC neurons Copyright 9/11/2012 10. Brain Connection Several factors seem to play a role here NT such as GABA, Serotonin and Norepinephrine and glutamate have been assigned significant roles The HPA with CRF axis gets activated as well Cytokines can form de novo in the brain and trigger responses Copyright 9/11/2012 11. Brain Connection The major neurotransmitters implicated in the anxiety response GABA NE Serotonin Glutamate Copyright 9/11/2012 12. Brain Connection Serotonin is known as inhibitory NT Derived from trytophan Majority found in gut (90%) Rest brain and platelets Foods that irritate gut can caused excess release of serotonin leading to diarrhea (goal is to expel substance causing issue) Copyright 9/11/2012 13. Copyright 9/11/2012 14. Brain Connection Serotonin depletion in prefrontal cortex leads to anxiety symptoms Serotonin has 7 subtype receptors 5HT1a- related to anxiety 5HT3 in the chemoreceptor center brain can be stimulated by excess serotonin and cause nausea and vomiting Copyright 9/11/2012 15. Brain Connection GABA major inhibitory in the brain Also found in Gut Regulation of GABA system in amygdala important part of anxiety pathology Pathway conversion excitatory Glutamate to GABA via enzyme glutamate decarboxylase Copyright 9/11/2012 16. Copyright 9/11/2012 17. Brain Connection- GABA 3 types GABA receptors- A, B. C Deficiency in GABA receptors (A)- led to hyper activation of HPA axis GABA-A (fast) binding increase cl conductance so hyperpolarize post synaptic neurons to decrease excitation GABA-B- inhibit Ca channels to reduce NT release, and K channels to decrease excitability Copyright 9/11/2012 18. Glutamate Excitatory NT (most abundant) Several studies indicate that modulating glutamate receptors can improve anxiety Mechanism not fully elucidated Glial cells responsible removal of glutamate Dysfunction or reduction leads to glutamate toxicity Copyright 9/11/2012 19. Glutamate Thought to be mediated through NDMA receptor Needs glutamate, glycine and voltage for activation and opening channels Open- Calcium influx Excess calcium- neuronal injury Fine line because activation NDMA needed for memory and learning Copyright 9/11/2012 20. Norepinephrine Increases symptoms of anxiety When administered symptoms of anxiety- HR, diaphoresis, etc. Controversy if NE from LC causative Copyright 9/11/2012 21. Brain Connection- Other substances CCK 4- provokes anxiety BDNF- responsible for health, growth and plasticity of nerves (adaptability) BNDF protects neurons from glutamate toxicity Oxytocin- role in social phobias Copyright 9/11/2012 22. Brain Connection- BDNF Human study showed depressed individuals with lower BDNF Those with lowest BDNF levels did not respond as well to anti-depressant treatment Several studies show BDNF facilitates function of anti-depressant esp. SSRI Copyright 9/11/2012 23. Immune Connection The immune system is thought to be trigger Chronic GI inflammation increases inflammatory cytokines and anxiety behavior Immune system and neuroendocrine share many receptor sites and ligands Cytokines (produced by immune system and also by brain) can regulate stress response in brain as well as endocrine system and behavior Copyright 9/11/2012 24. Immune connection Immune system when triggered produce cytokines Ex. IL-6, IL-1, IL-2, IFN-gamma, TNF, Peripheral cytokines can cross BBB Stimulate HPA axis as well as cause brain (glial Cells) to produce de novo cytokines Excess IL-6 act on neurons increase anxiety and cognitive deficits Copyright 9/11/2012 25. Immune Connection Cytokine can activate HPA axis Increase CRH CRH sensitize cells and facilitate effect of cytokines like TNF TNF alpha injected in amygdala facilitated ETOH withdrawal anxiety Inhibitor of CRH receptor decreased magnitude of anxiety response Copyright 9/11/2012 26. Immune Connection Interferon gamma stimulates enzyme indoleamine2,3 dioxygenase (IDO). This degrades Tryptophan (responsible for serotonin formation) to other inflammatory substances such as Kynurenine 17 B-estradiol could increases INF gamma thereby potentially increasing inflammation Copyright 9/11/2012 27. Immune Connection Aging increases Cytokines such as INF gamma, TNF alpha Dysregulates HPA feedback mechanism thereby increasing cortisol levels Cortisol affects metabolism of tryptophan towards inflammatory along with direct effect hippocampus Theorized one of reasons elderly more prone to depression/anxietyCopyright 9/11/2012 28. Immune Connection Studies show that TCA like imipramine and SSRI have anti-inflammatory effect Decreases levels of IL-2, IL-1, TNF, IL- 6, INF gamma These substances have immediate effect on NE and Serotonin but takes longer for clinical benefits (about time that it takes to have effect on cytokines Copyright 9/11/2012 29. Gut Connection Gut has over 100 million neurons 90% visceral neurons have connection with brain 95% all serotonin found in gut Copyright 9/11/2012 30. Gut Connection Studies showed that changing bacterial flora in mice changed behavior Colonized germ free mice with gut flora from active or passive mice would change behavior accordingly Mice treated with antibiotics- anxiety reduction. Stopped antibiotics flora and anxiety returned to baseline Copyright 9/11/2012 31. Gut Connection Changes seem to be associated with change in BDNF (linked to anxiety and depression) Stressor exposure changed bacterial flora in gut (decrease genus Bacteroides and increase Clostridium) Stressor also increased inflammatory cytokines (IL-6, MCP-1) further affected other bacterial flora IL-6 inflammatory cytokine Copyright 9/11/2012 32. Gut Connection Evidence that Lactobacillus Rhamnosus augments GABA function in brain via vagus nerve from gut (results lost with vagotomy) Also lowered corticosterone levels Copyright 9/11/2012 33. Gut Connection Infectious colitis induces anxiety Bifidobacterium longum NCC3001 improved anxiety (results lost with vagotomy) Bifidobacterium longum normalized behavior and BDNF mRNA but did not affect cytokine or kynurenine levels Enbrel- decreased cytokines and improved anxiety but did not affect BDNF Copyright 9/11/2012 34. Gut Connection Since inflammation can directly affect flora of gut and flora can affect behavior Could anything such as food sensitivities cause inflammation in gut and thereby exacerbate anxiety symptoms Personal food sensitivity such as ALCAT may be an important adjunct as testing looks at immune response Copyright 9/11/2012 35. Gut Connection Study showed stress contributed to development of food allergies by increasing gut permeability therefore increased uptake of food antigen Bacteria like H. Pylori has been shown to do the same in gastric mucosa, also increasing food sensitivity Activation of immune system and cytokines Copyright 9/11/2012 36. Gut Connection Food sensitivities trigger gut permeability Part treatment remove triggers Heal gut Bifidobacterium Animalis Lactis LKM 512 found to help to keep tight junction gut and decrease permeability Decreased inflammation in elderly Seems to suppress inflammatory bacteria Copyright 9/11/2012 37. What to do? When and if possible identify trigger Gut symptoms- know can be variety of things from food sensitivity, to infectious or inflammatory trigger such as IBD to emotional stress (remember changes flora) ALCAT may be helpful Remove and or treat trigger Consider probiotics with neuromodulatory effect Copyright 9/11/2012 38. What to do Consider other substances to decrease inflammatory cytokines while treatment is on going (curcumin, fish oil, and resveratrol, andrographis)- ?medical food Tea Tree Oil (inhalation)- decreases TNF alpha, IL 1 If over weight start weight loss Remember Adipocytes can generate cytokines as well Copyright 9/11/2012 39. What to do German Chamomille- inhibited release lipopolysaccharide which induce macrophage prostaglandin E2 (


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