Capabilities – QuebecLiquids

Alcrea Health & LiquiFab

LiquiFab

• Founded in 1995

• Located in Quebec City, Quebec

• Began operations as the

manufacturing arm of both Aeterna

Laboratories and Atrium Innovations

Aeterna Laboratories

• Biopharmaceutical company

• Extensive product portfolio in

Oncology, Endocrinology, and

Infectious Diseases

Alcrea Health & LiquiFab

• Under Alcrea Health umbrella

• Utilizes 15+ years of liquid manufacturing

experience within the health and nutrition

to develop finished nutraceuticals:

– Simple vitamin and mineral supplements

– Complex fish oil emulsions

– Herbal extractions

– Energy drinks

• Alcrea’s experts in product design, formulation and

manufacturing of well-crafted nutritional supplements

LiquiFab Today

Expertise & Certifications

FormulationCertifications

• Formulation and manufacturing

experts on hand to help create

custom liquid supplements

• Flavor system development

• Expertise in absorption,

bioavailability, content uniformity,

regulatory submission and

dosage requirements

• Strict compliance with FDA and

NHPD good manufacturing

practices (GMPs)

• Finished products are tested

in accordance with USP/AOAC

methods where applicable

• Organic certified by

CARTV/ECOCERT

Quality Control & Assurance

GMP programs for personnel, plant and grounds, sanitation, equipment,

quality operations, production and process controls and warehouse

Implementation of internal and external

audit programs

Supplier Qualification Program (SQP)

Regulatory affairs specifications and controls for

raw material, packaging and labeling material/product licensing

Unique Technologies

Sonification

• Ultrasonic extraction and

preservation – Disintegration of cell structures

(LYSIS) by means of ultrasound

– Used for the extraction of intra-cellular

compounds

• Ultrasound has a potential

benefit in the extraction and

isolation of novel, potentially

bioactive components

Air Quality

• HVAC system designed to

prevent contamination – Controls the direction of air and

the differential pressures between

production areas

• High number of air changes per

hour reduces airborne dust and

controls air quality

• Main production rooms– Airlock protection & positive

pressure protection to maintain

the surroundings

Purified Water System

• The purified water system USP grade is composed of three sections:

– Pretreatment

– Processing

– Purification/distribution

• Meets USP specifications for TOC, conductivity and microorganisms

• Water is in continuous circulation in the distribution loop with a TOC

detector to follow the quality of water, ensuring the most pure water

source for our formulations

Unique Technologies

Manufacturing

Facility Overview

Capacity

• Facility Size: 26,000 Square Feet

• Building Type: Pharmaceutical Grade

• Manufacturing Suites: 4

• Small batch sizes: Flexible manufacturing for small to large runs

• 22,000,000 bottles (60ML) annually

• Bottling rate of 5,000 bottles per hour

• Mixing: 100,000 kgs per month

• Multi-level batch size capabilities(from 50L to 5,000L)

• Multi-level conditioning capabilities(from 5ML to tons)

• Large pressure filter capacity

• Microfiltration

• Oil filling capacity

• Bottling Lines: 3

• Air Quality: Differential air pressureH/T controlled

Production Process

• Closed manufacturing suites

• Pure water based extraction that meets

USP standards

• Extraction at any temperature from

4°C - 90°C

• Molecular fractionation to purify small to

large batches (Ultra filtration)

• Inline crushing generating particles size

from 1 micron

• USP-Grade purified water system

Production Process

• Handling for products and materials of

ranging viscosities

• Adaptable production lines from low speed

test batches to high speed, high volume batches

• Clean in place systems – sterilization

(Absence of harsh solvents)

• Oil filing capacity (Nitrogen flushed, proprietary

antioxidant blending)

• Paperless tracking bar code technology –

from ingredient to finished product

Production Solutions

Delivery Forms

• Oil based liquids

• Water based liquids

• Emulsions

• Liquid suspensions

• Liquid plant extracts

• Frozen products

Production Solutions

Packaging

• Glass bottles

• Plastic bottles

• Straight liquids

• Droppers

• Sprays

• Pumps

• Shots

• Full-body sleeve labels

• Pressure sensitive labels

Benefits

A liquid delivery system has proven to be one of the most effective ways

to supply nutrients to the human body.

Delivery: Scientifically sound way to deliver many beneficial

nutrients in one convenient dose.

Compliance: Well formulated supplements with a good taste

increase compliance among consumers.

Absorption: Available for rapid absorption, as they do not need

to be dissolved first like tablets and pills.

Bioavailability: Two opportunities for digestive absorption: the stomach

and the small intestine.

Benefits

Combinations: Optimization of nutrient quantities and ratios, maximize

synergistic nutrient combinations.

Purity: Limit the need for fillers, binders, disintegrators

and coloring.

Alternative: Practical alternatives to pills for infants, toddlers

and others who prefer or require liquids. Capsules and tablets may be

difficult to chew or swallow.

Versatility: Nutrients can be delivered by the spoonful or as drops, or stirred

into other liquids and consumed as part of a beverage.

Production Orders & Volume Price Breaks

Liquid Fill WeightMinimum Quantity

Price Break 1 Price Break 2 Price Break 3

500 ml and < 1,000 2,500 5,000 10,000

501 ml and > 500 1,000 2,000 5,000

120 ml and < shot 25,000 80,000 125,000 250,000

121 ml and > functional beverage

12,000 20,000 40,000 80,000

Sample fees of $200 will be requested for new formulations.

For additional questions or to discuss a project, please contact:

Jessi Mingo, Manager, Business Development and Marketing

jmingo@alcrea-health.com • 412-722-0314