agilent 7500 icp-ms date: 28jul2005. page 2 what is icp-ms? 123456789101112131415161718 1hhe1...
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Agilent 7500 ICP-MSAgilent 7500 ICP-MS
Date: 28JUL2005
Page 2
What is ICP-MS?What is ICP-MS?
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
1 HHe
1
2 Li Be B C N O FNe
2
3 Na
Mg
Al Si P S Cl Ar 3
4 K Ca Sc Ti V CrMn
Fe Co NiCu
Zn Ga Ge AsSe
Br Kr 4
5 Rb
St Y ZrNb
Mo Tc Ru RhPd
Ag
Cd In Sn SbTe
IXe
5
6 Cs Ba L Hf Ta W Re Os Ir PtAu
Hg
Tl Pb BiPo
AtRn
6
7 Fr Ra A RfDb
Sg Bh Hs Mt 7
L LaCe
PrNd
Pm
Sm
Eu GdTb
Dy
Ho
ErTm
Yb Lu
A AcTh
Pa
U Np PuAm
Cm
Bk
Cf EsFm
Md
No
Lr
Page 3
Atomic Spectroscopy (I)Atomic Spectroscopy (I)
Atomic Absorption Spectroscopy
Graphite Furnace AAS
Inductively Coupled Plasma -
Optical Emission Spectroscopy
Nucleus
Electron
ICP-Mass Spectroscopy
Page 4
Atomic Spectroscopy (II)Atomic Spectroscopy (II)
ICP-MSFAASHigh Precision
GFAAS
High Sensitivity
Low Detection Limits
ICP-OES
Multi-element Simultaneous Analysis
Spectral Interferences
Quantitation
Sensitivity
Page 5
ICP-MS Schematic DiagramICP-MS Schematic Diagram
1. Nebulizer
2. Spray Chamber3. Plasma
4. Off-axis Lens 6. ORS7. Mass Filter
8. Detector5. Isolation Valve
Page 6
Sample Introduction DeviceSample Introduction Device
To ICPBabingtonNebulizer
Sample solution
Ar carrier gas
Peltier cooling device
Cooling water
Al insulation
cover
Ar blend gas
Page 7
Mass flow ControlMass flow Control
2. Spray Chamber 4. Interface6. Ion Lenses
Plasma Gas (15~16L/min)
Carrier Gas (1.2L/min) +
Sample Blend Gas (0.6L/min)
Auxiliary Gas (1L/min)
Page 8
Ionization by PlasmaIonization by Plasma
2. Spray Chamber
+1. Drying
2. Decomposition
3. Atomization
4. Ionization
ID 2.5mm, Flow 0.2~0.4ml/min
Page 9
Distribution of PlasmaDistribution of Plasma
-8 -6 -4 -2 0 2 4 6 8
Distance from Center(mm)
Inte
nsi
ty(%
) Sample27.12MHz
40MHz
27.12MHz
40MHz
S
S
Page 10
Work coil
Shield plate
Cool PlasmaCool Plasma
Torch
Interference
39K 38Ar1H
40Ca 40Ar
56Fe 40Ar16O
0
6
12
18
K Ca Fe Ar
Element
Pote
ntia
l
Page 11
Cool PlasmaCool Plasma
Normal Plasma Cool Plasma
• Forward Power: 1300W
• Sampling Depth: 7mm
• Carrier Gas Flow: 1.2ml/min
• Forward Power: 900W
• Sampling Depth: 13mm
• Carrier Gas Flow: 1.7ml/min
Shield plate
Page 12
Ionization EfficiencyIonization Efficiency
0.0000001
0.000001
0.00001
0.0001
0.001
0.01
0.1
1
10
100
4,500 5,000 5,500 6,000 6,500 7,000 7,500
Electron Temperature(K)
Ioniz
ation E
ffici
ency
(%)
Mg
Fe
As
Cl
Ar
Mg, Fe, As
Cl
Ar
Page 13
Optimum gas flowOptimum gas flowS
en
sit
ivit
y
Co
ArH
ArO
Carrier gas flow
Page 14
Extraction LensExtraction Lens
Skimmer cone
Twin Extraction LensesSampling cone
Page 15
Why need ORS?Why need ORS?
There are some applications where
cool plasma does not meet current and
future required performance levels for
certain analytes:
several interfered analytes in high
(100-1000ppm) Si matrices
interfered analytes (Ti, Zn) in high
matrix acids H2SO4 and H3PO4
Interference Matrix39K 38Ar1H UPW
40Ca 40Ar UPW56Fe 40Ar16O UPW51V 35Cl16O HCl
52Cr 35Cl16O1H HCl75As 40Ar35Cl HCl48Ti 32S16O H2SO4
64Zn 32S16O16O H2SO4
63Cu 31P16O16O H3PO4
68Zn 31P18O18O1H H3PO4
24Mg 12C12C Organics52Cr 40Ar12C Organics
Agilent’s Octopole Reaction Cell can remove these interferences…
Page 16
Off-axis LensOff-axis Lens
Page 17
DissociationDissociation
As
Ar
Cl
ArCl
75amu
ArCl
75amu
75amu
40amu
35amu
He
Page 18
Energy TransferEnergy Transfer
As75amu
ArCl
75amu
Electric Potential
(Quadrupole)
He
Page 19
Reaction modeReaction mode
Charge Transfer
Ar+ + H2 H2+ + Ar
(neutral)
Proton Transfer
Ar2+ + H2 Ar2H+ + H
(80amu) (81amu)
Page 20
Mass FilterMass Filter
3MHz
• True Hyperbolic Quadrupole
• 3MHz RF Generator
• Peak Shape
• Abundance Sensitivity
Page 21
Dual Electron MultiplierDual Electron Multiplier
Dynode
ee
M+
Fast Analogue
Detection
Pulse Counting
Detection
Page 22
Wide Dynamic RangeWide Dynamic Range
1ppt
1000ppm
• Dynamic Range: 9 orders
• Analog Mode
• Pulse Counting Mode
• Solid type Multiplier
Page 23
ICP-MS Schematic DiagramICP-MS Schematic Diagram
1. Nebulizer
2. Spray Chamber3. Plasma
4. Off-axis Lens 6. ORS7. Mass Filter
8. Detector5. Isolation Valve
Page 24
FlexibilityFlexibility
[HPLC-ICP-MS]
[GC-ICP-MS] [Organic Kit]
[ORS Technology]
[I-Autosampler]
Page 25
Sample TypeSample Type
• Waters
• Chemicals
• Semiconductor
• Food
• Geological
• Clinical
• Forensic
• Petrochemical
• Nuclear