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  • 8/13/2019 Age and socioeconomic inequalities in health

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    Age  and  socioeconomic  inequalities  in  health:  Examining  therole  of   lifestyle  choices

    Arnstein Øvrum a,b,*,  Geir Wæhler Gustavsen a, Kyrre Rickertsen a,b

    aNorwegian    Agricultural  Economics  Research  Institute,   P.O.  Box  8024   Dep,   NO-0030   Oslo,   NorwaybUMB  School  of   Economics  and  Business,  Norwegian   University   of   Life   Sciences,   P.O.  Box  5003,   NO-1432    Å s,   Norway

    1.  Introduction

    A  large  and  growing  body  of   literature  seeks  to  improve

    our  understanding  of   why  indicators  of   socioeconomic

    status  and  health  are  so  strongly  associated  (Cutler,  Lleras-

    Muney,  &  Vogl,  2011;  Marmot,  Friel,  Bell,  Houweling,  &

    Taylor,  2008).  Acknowledging  the  dynamic  nature  of 

    health  production,  this  literature  has  partly  focused  on

    how  socioeconomic  inequalities  in  health  evolve  over  the

    adult  life  course.  The  current  empirical  evidence  on  thisimportant  issue  is  mixed,  in   part  because  different

    indicators  of   socioeconomic  status  and  health  have  been

    investigated  (Kim  &  Durden,  2007).  However,  three  main

    patterns  of   results  stand  out.

    In   some  studies,  health  differences  by  socioeconomic

    status  are  found  to  be  increasing  in  age  throughout  the

    adult  life  course  (Benzeval,  Green,  &  Leyland,  2011;   Kim  &

    Durden,  2007;   Ross  &  Wu,  1996;  Wilson,  Shuey,  &  Elder,

    2007).  Such  results  correspond  with  the  cumulative

    advantage  hypothesis.  This  hypothesis  asserts  that

    throughout  the  adult  life  course,  socioeconomic  status  is

    closely  associated  with  our  daily  investments  into  the

    production  of   poor   and  good  health.  Gradually,  these

    investments  result  in  a  relatively  more  rapid  deteriorationof   health  among  lower  than  higher  socioeconomic  status

    groups.

    In   other  studies,  health  differences  by  socioeconomic

    status  are  found  to  be  increasing  in  age  until  late  midlife,  or

    pre-retirement  (50–60   years  of   age),  after  which  they  level

    off   or  begin  to  decrease  (Beckett,  2000;   Huijts,  Eikemo,  &

    Skalická,  2010;   van  Kippersluis,  O’Donnell,  van  Doorslaer,

    &  van   Ourti,  2010).  Such  results  are  in  line  with  the

    cumulative  advantage  hypothesis  until  late  midlife,  but

    with  an  age-as-leveler  hypothesis  thereafter.  More  partic-

    ularly,  biological  factors  become  increasingly  important

    Advances   in  Life  Course  Research   19  (2014)  1–13

    R  

    L  

    O

     Article history:

    Received  27   June  2013

    Received in revised form 24 October 2013

    Accepted   31  October  2013

    Keywords:

    Socioeconomic  status

    Inequality

    Life   course

    Lifestyles

    Health

    Norway

    R  

    T

    The role of lifestyle choices in explaining how socioeconomic inequalities in health vary

    with age has received little attention. This study explores how the income and education

    gradients inboth important lifestyle choices andself-assessed health (SAH) vary with age.

    Repeatedcross-sectionaldatafromNorway (n = 25,016)andlogistic regressionmodelsare

    used to track the income and education gradients in physical activity, smoking,

    consumption of fruit and vegetables and SAH over the age range 25–79 years. The

    education gradient in smoking, the income gradient in consumption of fruit and

    vegetables and theeducationgradient inphysical activityamongmales become smaller at

    older ages. Physical activity among females is the only lifestyle indicator in which the

    income and education gradients grow stronger at older ages. In conclusion, this study

    shows that income and education gradients in lifestyle choices may not remain constant,

    but vary with age, and such variationcould be important in explaining corresponding age

    patterns of inequality in health.  2013 Elsevier Ltd. All rights reserved.

    *  Corresponding  author  at:  Norwegian  Agricultural   Economics

    Research  Institute,  P.O.  Box  8024.  Dep,  N-0030   Oslo,  Norway.

    Tel.:  +47  22367200;  fax:  +47  22367299.

    E-mail  addresses:   [email protected]  (A.  Øvrum),

    [email protected]  (G.W.  Gustavsen),  [email protected]

    (K.  Rickertsen).

    Contents  lists  available  at  ScienceDirect

    Advances in Life Course Research

    jo u rn al   h omepage:  ww w.e ls ev ier .co m/locat e /a lcr

    1040-2608/$  –  see  front   matter    2013  Elsevier  Ltd.   All  rights  reserved.http://dx.doi.org/10.1016/j.alcr.2013.10.002

    http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002mailto:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]://www.sciencedirect.com/science/journal/10402608http://dx.doi.org/10.1016/j.alcr.2013.10.002http://dx.doi.org/10.1016/j.alcr.2013.10.002http://www.sciencedirect.com/science/journal/10402608mailto:[email protected]:[email protected]:[email protected]://dx.doi.org/10.1016/j.alcr.2013.10.002http://crossmark.crossref.org/dialog/?doi=10.1016/j.alcr.2013.10.002&domain=pdfhttp://crossmark.crossref.org/dialog/?doi=10.1016/j.alcr.2013.10.002&domain=pdf

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    with  older  age  in  determining  health,  thus   downplaying

    the  role  of   socioeconomic  status  (Herd,  2006).   Also  other

    factors  have  been  found  to  contribute  to  age-as-leveler

    effects  in  health.  These  factors  include  the  effects  of 

    mortality  selection  (Kim  &  Durden,  2007),  cohort  effects

    (Lynch,  2003)  and  labor  market  participation  status  (Case

    &  Deaton,  2005;   van  Kippersluis  et  al.,  2010).

    Finally, 

    some 

    studies 

    have 

    found 

    that, 

    for 

    selectedhealth  and  socioeconomic  status  indicators,  health  differ-

    ences  by  socioeconomic  status  do  not  vary  significantly

    with  age  (Beckett,  2000;   Kim  &  Durden,  2007).   We  refer  to

    such  patterns  of   results  as  being  in   line  with  the  persistent

    health  inequality  hypothesis  (Ferraro  &  Farmer,  1996).

    To  the  best  of   our  knowledge,  no  studies  have  yet

    explicitly  examined  the  potential  role  of   healthy  lifestyle

    choices  in  explaining  these  competing  hypotheses  for  the

    dynamics  of   socioeconomic  inequalities  in  health.  This  is

    surprising  for  at  least  three  reasons.  First,  there  is

    convincing  evidence  for  the  protective  effect  of   certain

    lifestyle  choices,  including  physical  activity,  not  smoking

    and 

    consumption 

    of  

    fruit 

    and 

    vegetables, 

    against 

    adversehealth  outcomes  such  as  type  2  diabetes,  cardiovascular

    disease  and  certain  types  of   cancer  (Gandini  et  al.,  2008;

    He,  Nowson,  Lucas,  &  MacGregor,  2007;   Jeon,  Lokken,  Hu,  &

    Van  Dam,  2007;   Sofi,  Capalbo,  Cesari,  Abbate,  &  Gensini,

    2008;   World  Health  Organization,  2003).  Second,  similar  to

    most  health  outcomes,  the  probability  of   making  healthy

    lifestyle  choices  is  closely  associated  with  socioeconomic

    status  indicators  such  as  education  and  income  (Cutler  &

    Lleras-Muney,  2010;   Pampel,  Krueger,  &  Denney,  2010).

    Third,  the  effects  of   healthy  lifestyle  choices  on   the

    incidence  of   adverse  health  outcomes  are  often  character-

    ized  by  cumulative,  long-processes  (Kuh  &  Shlomo,  2004),

    which 

    highlights 

    the 

    importance 

    of  

    taking 

    life 

    courseperspective  with  respect  to  the  dynamic  relationship

    between  socioeconomic  status,  lifestyle  choices  and

    health.

    As  noted,  we  often  implicitly  assume  that  lifestyle

    choices  differ  systematically  by  socioeconomic  status  and

    thereby  contribute  to  patterns  of   cumulative  advantage

    effects  in  health.  This  is  a  reasonable  assumption  to  the

    extent  that  the  socioeconomic  gradients  in  lifestyle  choices

    remain  stable  or  increase  over  the  adult  life  course.  But

    what   if   the  socioeconomic  gradients  in   lifestyle  choices

    become  smaller  with  older  age?  For  example,  people  of 

    lower  socioeconomic  status  may  grow  more  health

    conscious 

    and 

    thus 

    engage 

    in 

    healthier 

    lifestyles 

    whenthey  reach  late  midlife  and  realize  that  good  health

    investments  are  important  for  longevity.

    We  use  repeated  cross-sectional  data  from  Norway

    from  1997  to  2011  to  explore  how  the  income  and

    education  gradients  in  both  important  lifestyle  choices  and

    SAH  vary  with  age.  Repeated  cross-sectional  data  are  often

    referred  to  as  pseudo-panel  data  because  although  not

    tracking  the  same  individuals  as  they  age,  such  data  allow

    for  tracking  the  average  age  patterns  for  groups  of 

    individuals  as  they  age  while  controlling  for  possibly

    confounding  cohort  and  period  effects  (Deaton,  1997).

    However,  note  that  our  study  is  not  a  pure  ‘life  course’

    study 

    in 

    the 

    sense 

    that 

    we 

    do 

    not 

    follow 

    the 

    sameindividuals  as  they  age.

    Our lifestyle  indicators  are  physical  activity,  smoking

    and  consumption  of   fruit  and  vegetables.  We  use  these

    lifestyle  indicators  because  they  are  different  in  nature  and

    because  of   their  close  association  with  both  socioeconomic

    status  indicators  and  the  risk  of   major  health  outcomes,  as

    described  above.  Our  research  questions  are  as  follows.

    First,  to  what  extent  are  the  observed  age  patterns  of 

    inequality 

    in 

    lifestyle 

    choices 

    consistent 

    with 

    (i) 

    the 

    age-as-leveler,  (ii)  the  persistent  health  inequality,  and  (iii)  the

    cumulative  advantage  hypothesis  in  health?  Second,  to

    what  extent  do  age  patterns  of   inequality  vary  across

    different  lifestyle  choices,  education  and  income,  and

    gender?

    2.  Methods

     2.1.  Data  source

    The  Norwegian   Monitor   Survey   is  a  nationally   represen-

    tative   and  repeated   cross-sectional   survey   of   adults   aged

    15–95 

    years. 

    The 

    survey 

    has 

    been 

    conducted 

    every 

    secondyear   since   1985  and  is  one  of   Norway’s   most  comprehensive

    consumer   and  opinion   surveys.   The  institution   behind   the

    survey   (Ipsos   Norway)   recruits   respondents   through   a  short

    telephone   interview,   and  those  who  accept   to  participate

    receive  a  paper-based   questionnaire   by  mail.   Ethical

    approval   was  not  required for this  research;   we  represent

    a  third  party   user  of   the  data   in  question,   and  we  only  have

    access   to a data  filethat  contains  anonymous  data,   i.e., we do

    not  have  access   to  any  information   that   can  be  used  to

    identify   specific   individuals.

    The  question  about  SAH  was  not  included  in  the  survey

    before  1997,  and  therefore  data  from  1997  to  2011   are

    used. 

    For 

    two 

    reasons, 

    only 

    respondents 

    between 

    the 

    agesof   25  and  79  years  were  included.  First,  we  want  to  study

    individuals  who  have  completed  most  of   their  education

    and  started  earning  their  own  income.  Second,  the  sample

    includes  relatively  few  respondents  between  the  ages  of   80

    and  95  years.  After  deleting  observations  with  missing

    information  for  any  of   the  variables  included  in  this  study

    (3066  observations),  we  obtain  our  sample  of   25,016

    observations.  Based  on  statistical  tests  comparing  group

    means,  the  deleted  respondents  were  on  average  signifi-

    cantly  older,  more  likely  female,  less  educated  and  had

    lower  incomes  than  the  respondents  that  are  included  in

    the  sample.

     2.2.  Outcome  variables

    The  survey  questions  related  to  physical  activity,

    smoking,  consumption  of   fruit  and  vegetables  and  SAH

    are  based  on  various  types  of   categorical  scales.  The

    respondents  were  asked  to  indicate  their  frequency  of 

    intake  for  nine   different  fruit  and  vegetables  on  the

    following  scale;  ‘‘daily’’;  ‘‘3–5   times  per  week’’;  ‘‘1–2   times

    per  week’’;  ‘‘2–3   times  per  month’’;  ‘‘about  once  per

    month’’;  ‘‘3–11   times  per  year’’;  ‘‘rarer’’;  or  ‘‘never’’.

    Similarly,  physical  activity  has  an  8-point  frequency  scale

    ranging  from  ‘‘never’’  to  ‘‘once  or  more  per  day’’.  The

    respondents 

    also 

    indicated 

    if  

    they 

    smoked 

    tobacco 

    ‘‘daily’’,‘‘sometimes’’  or  ‘‘never’’  at  the  time  of   the  survey,  whereas

     A.  Øvrum  et   al.  /   Advances  in   Life   Course  Research  19  (2014)  1–132

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    SAH  is  based  on  the  typical  5-point  scale  ranging  from

    ‘‘very  poor’’  to  ‘‘very   good’’  health.  To  facilitate  the

    comparison  of   how  income  and  education  gradients  vary

    with  age,  we  have  dichotomized  each  of   these  categorical

    variables.  We define  being  physically  active  at  least  twice

    per  week,  not  a  daily  smoker  (non-smoking),  eating  fruit

    and  vegetables  at  least  twice  per  day  and  reporting  one’s

    SAH 

    to 

    be 

    ‘‘good’’ 

    or 

    ‘‘very 

    good’’ 

    as 

    binary 

    indicators 

    of healthy  lifestyles  and  good  health.

     2.3.  Explanatory  variables

    We  categorize   education   into  four   groups   using   dummy

    indicators,   ranging   from   having   completed   only  lower

    secondary   education   (9  years  of   education)   or  less,  to

    having   obtained   a  university   or  college   degree.   We divide

    household   income   into  age-group  survey-year   specific

    income   quartiles,   with   each   age group  comprising   a  5-year

    interval   (e.g.,  people   aged   25–29  years).   The  original   survey

    question   on  household   income   included   nine  response

    alternatives, 

    each 

    representing 

    specific 

    income 

    interval.Before   dividing   income   into  age-group   survey-year   specific

    quartiles,   we  (i)  set  household   income   to  the  midpoint   value

    of   each   income   interval,   and  (ii)   adjusted   for  household   size

    by  dividing   the  resulting   income   measure   by  the  square   root

    of   household   size  (OECD,   2008).

    We define  age  as  a  continuous  variable,  but  center  it  at

    age  30   to  reduce  multicollinearity  between  age  and  age-

    squared  in  the  later  statistical  analyses  (Kim  &  Durden,

    2007).  Dichotomous  indicators  for  gender,  survey  years

    and  5-year  birth  cohorts  are  also  included  in   the  statistical

    analyses,  which  we  describe  next.

     2.4. 

    Statistical 

    analyses

    We  employ  multivariate  logistic  regression  models  to

    predict  how  the  income  and  education  gradients  in

    lifestyles  and  SAH  vary  with  age  and  to  assess  whether

    such  age  variation  is  statistically  significant.  The  income

    models  control  for  age,  age-squared,  the  second,  third  and

    fourth  income  quartiles,  interactions  between  each  of 

    these  age  and  income  indicators,  as  well  as  education,

    gender,  survey  years  and  5-year  birth  cohorts.  In   cases

    where  no  age-squared   income  interactions  are  statisti-

    cally  significant  at  the  95%  level,  the  model  is  simplified  by

    removing  these  interactions  to  allow  for  the  income

    gradient 

    to 

    possibly 

    change 

    linearly 

    instead 

    of  

    non-linearlyin  age  (Beckett,  2000).  The  corresponding  education

    models  are  obtained  by  replacing  the  second,  third  and

    fourth  income  quartiles  with  the  education  dummies  for

    having  completed  upper  secondary  education,  some

    university  and  university  with  a  degree,  respectively.

    In   our  models,   we  treat   age,  period  and  cohort   effects  as

    fixed   effects.   The  linear   dependence   between   a  respondent’s

    age,  birth  year  and  the  survey   year   (Deaton, 1997) is handled

    by  allowing   for  non-linear   effects   in  ageand  by  using   5-year

    birth  cohort  dummies,  while period  effects  areaccounted  for

    by  including   dummy  indicators   for  each   survey   year  except

    the  first   (reference   year)   (Sarma,   Thind,  &  Chu,  2011).  There

    were 

    no 

    major 

    changes 

    in 

    health 

    policy 

    during 

    the 

    studyperiod   1997–2011  that   should  affect   our  results.   We  also

    tested   alternative   strategies for  estimating   age,   period   and

    cohort   effects,   including   the  random   intercept   model

    (O’Brien,   Hudson,  &  Stockard,   2008) and  the  cross-classified

    model   (Reither,   Hauser,   &  Yang,   2009). The  estimated   age

    effects,   which   are  the  focus   of   this   study, were  very  similar

    across   these  alternative   model  specifications.

    We  also  estimate  SAH   models  in  which  we  add  the  three

    lifestyle 

    indicators 

    as 

    explanatory 

    variables. 

    This 

    allows 

    forassessing  whether  the  lifestyle  indicators  are  significantly

    associated  with  SAH,  and  whether  the  income  and

    education  gradients  in  SAH   become  smaller  once  we

    control  for  lifestyle  choices.  Age  patterns  of   health

    inequalities  may  differ  by  gender  (Corna,  2013), and

    therefore  we  also  estimate  our  models  separately  by

    gender.  We comment  on  the  results  of   gender  specific

    models  when   they  are  relevant.  All  the  statistical  models  in

    this  study  are  estimated  using  survey  weights  and  robust

    standard  errors.  The  survey  weights  are  provided  by  the

    institution  behind  the  survey  and  account  for  sampling

    differences  with  respect  to  age,  gender  and  geographic

    region, 

    such 

    that 

    the 

    statistical 

    results 

    are 

    made 

    represen-tative  of   the  overall  population  within  each  survey  year.

    Our  four  outcome  variables  are  binary,  but  three  of 

    them  contain  more  information.  As  a  robustness  check,  we

    have  estimated  ordered  logit  models  with  alternative

    variable  definitions  for  physical  activity  (frequency  scale

    1–8),  consumption  of   fruit  and  vegetables  (frequency  scale

    1–9)  and  SAH  (likert  scale  1–5).  The  results  of   these

    alternative  model  specifications  suggest  that  the  conclu-

    sions  of   this  study  are  not  sensitive  to  how  we  define  the

    dependent  variables  in  our  models.

    Finally,  as  described  above,  in  this  study  we  decided  to

    delete  observations  with  missing  values  rather  than  use

    imputation 

    techniques. 

    The 

    main 

    reason 

    for 

    this 

    decision 

    isthat  nearly  seventy  percent  of   the  3066  observations  with

    missing  values  are  due  to  missing  information  on   one  or

    several  of   the  four  outcome  variables.  However,  as  a

    robustness  check,  we  have  re-estimated  the  models  for

    each  lifestyle  indicator  and  SAH   after  adding  observations

    for  which  we  have  data  on  all  explanatory  variables  and

    the  outcome  variable  in   question,  but  missing  information

    on  at  least  one  of   the  remaining  three  outcome  variables

    that  are  not  part  of   the  model.1 The  results  from  these

    models  with  additional  observations  were  nearly  identical

    to  the  results  of   the  models  to  follow  in  the  results  section

    below.  Therefore,  we  believe  that  the  results  of   this  study

    are 

    not 

    sensitive 

    to 

    left-out 

    observations.

    3.  Results

     3.1.  Descriptive  statistics

    Table  1  provides  the  descriptions  and  sample  means  for

    the  outcome  and  explanatory  variables  of   this  study.

    1 We thereby  add  1804  observations  to  the  physical   activity  model,

    1381  observations  to  the  non-smoking   model,  619   observations  to  the

    fruit   and  vegetables  model  and  1679  observations  to  the  SAH  model

    compared 

    to 

    the 

    models 

    in 

    the 

    results 

    section, 

    which 

    all 

    include 

    25,016observations.

     A. Øvrum  et   al.   /   Advances  in   Life   Course  Research  19   (2014)   1–13   3

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    Approximately 

    54% 

    of  

    the 

    respondents 

    exercise 

    at 

    leasttwice  per  week,  72%  are  non-smokers,  50%  eat  fruit  and

    vegetables  at  least  twice  per  day  and  69%  report  their

    health  status  as  either  ‘‘good’’  or  ‘‘very  good’’.

    Figs.  1  and  2  depict  age  variation  in  lifestyles  and  SAH

    by  income  and  education,  respectively.  The  figures

    illustrate  the  development  in   sample  means  for  physical

    activity,  non-smoking,  consumption  of   fruit  and  vegetables

    and  SAH  for  each  income  quartile  and  each  education

    group  at  each  5-year  age  interval.  The  figures  indicate  that

    lifestyle  habits  become  healthier  with  increasing  age  until

    at  least  late  midlife,  while  SAH   is  decreasing  in  age.  There

    are  clear  income  and  education  gradients  in   lifestyles  and

    SAH 

    in 

    most 

    age 

    groups. 

    The 

    main 

    exceptions 

    are 

    the 

    smallincome  gradients  in  lifestyles  at  age  25–29   years  and  the

    small  income  and  education  gradients  in  non-smoking  at

    age  75–79  years.  Age  variation  in  the  gradients  are  most

    evident  in   the  case  of   income  and  SAH,  with  the  gradient

    clearly  peaking  at  age  55–59  years,  and  in  the  case  of 

    education  and  non-smoking,  with  the  gradient  clearly

    declining  with  higher  age.

     3.2.  Logistic   regression  models

    Table  2  reports  the  results  of   the  income  models  for

    physical  activity,  non-smoking,  consumption  of   fruit  and

    vegetables 

    and 

    SAH, 

    and 

    Table 

    reports 

    the 

    results 

    of  

    thecorresponding  education  models.  The  tables  show  odds

    ratios  (ORs)  and  indicate  the  significance  of   different  ORs

    using  asterisks.

    Table  2  shows  that  at  30  years  of   age,  there  are  clear

    income  gradients  in  all  outcome  variables  except  con-

    sumption  of   fruit  and  vegetables,  and  Table  3  shows  that

    there  are  clear  education  gradients  in   all  outcome  variables

    –  and  in  particular  non-smoking  –  at  this  age  (recall  that

    the  age  variable  is  centered  at  30   years  of   age).  Thus,  the

    results  in  Tables  2  and  3  confirm  the  patterns  observed  in

    Figs.  1  and  2  with  respect  to  the  income  and  education

    gradients  in  lifestyles  and  SAH   in  young  adulthood.

    The 

    SAH 

    models 

    in 

    the 

    rightmost 

    column 

    of  

    Tables 

    and3  suggest  that  SAH  is  significantly   associated   with   all three

    lifestyle 

    choices, 

    and 

    in 

    particular 

    physical 

    activity 

    and 

    non-smoking.   Furthermore,   comparing   the  two  SAH  models  in

    Table  2,  the  education   gradient   in  SAH  becomes   smaller

    once   we  control   for lifestyles  (e.g.,  the  OR   of   university

    degree   is  reduced   from  1.88  to  1.61  when   we  add  lifestyles

    as  control   variables).   Similarly,   Table   3   shows   that   also   the

    income  gradient   in SAH becomes  smalleronce  we control   for

    lifestyles.2 The  cross-sectional   nature   of   our  data  do  not

    allow  for  any  casual   inference.   However,   these   results

    indicate,   at  least,   that  our  lifestyle   indicators   might  be

    important   in  affecting   health   (World Health  Organization,

    2003),  and  in  mediating   the  relationship   between   socioeco-

    nomic   status  and  health   (Cutler  et  al.,  2011).

     3.3.  Predicted  income  and  education   gradients

    Our  main  interest  is  to  explore  how  the  income  and

    education  gradients  in  lifestyles  and  health  vary  with  age.

    To  facilitate  interpretation,  we  will  in  the  following  focus

    mainly  on  comparing  results  across  the  lowest  and  the

    highest  income  and  education  groups,  and  focus  less  on

    results  for  the  two  intermediate  income  and  education

    groups.

    Fig.  3  is  based  on   the  results  of   the  first  four  income

    models  in   Table  2  and  shows  how  the  predicted

    probabilities  for  healthy  lifestyles  and  good  health  vary

    with 

    age 

    for 

    people 

    in 

    the 

    first 

    and 

    the 

    fourth 

    incomequartiles.  The  figure  also  shows  the  absolute  differences  in

    predicted  probabilities  between  these  two  income  groups,

    which  we  refer  to  as  the  income  gradient.  The  predictions

    were  calculated  at  the  mean  values  of   the  other

    explanatory  variables  that  are  included  in  the  models

    (i.e.,  variables  that  do  not  involve  age  and  income).

    Similarly,  Fig.   4  is  based  on  the  results  of   the  first  four

     Table  1

    Variable  descriptions  and  summary   statistics.

    Variablea Description  Percentage/mean

    Physical   activity  Undertake  physical   activity  at  least  twice   per  week   54%

    Non-smoking   Not  a  daily  smoker   72%

    Fruit  and  vegetables  Eat  fruit,   berries  and/or  vegetables  at  least  twice   per  day  50%

    Self-assessed  health  Self-assessed  health   is  ‘‘good’’  or  ‘‘very  good’’  69%

    Lower   secondary  education  Completed  lower  secondary  education  (9  years)  or  less   15%

    Upper  secondary  education  Completed  upper  secondary  education  35%Some   university   Attended  some  university   or  college  20%

    University   degree   Obtained  a  university  or  college  degree  29%

    Income   quartile  1  Age-group  survey-year  specific  income   quartile   1  26%

    Income   quartile  2  Age-group  survey-year  specific  income   quartile   2  25%

    Income   quartile  3  Age-group  survey-year  specific  income   quartile   3  25%

    Income   quartile  4  Age-group  survey-year  specific  income   quartile   4  24%

    Age  Respondent  ageb 48.07

    Female   Respondent  is  female   54%

    Norwegian  Monitor  Survey  (1997–2011).  Summary   statistics  based  on  25,016  observations.a All  variables  except   age  are  dummy  indicators  taking   a  value  of   one  if   the  response   to  the  variable  description  is  yes,   and  zero   otherwise.b Age  is  centered   at  age  30  in  the  later  statistical  analyses   to  reduce   multicollinearity  between  age  and  age-squared.

    2 We find  similar  patterns   when   we  instead  estimate   the  lifestyle

    models  with   current   SAH  added  as  explanatory  variable.  That  is,  all  three

    lifestyle  choices  are  positively  associated  with   SAH  (P  

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    education  models  in   Table  3  and  shows  how  the  predicted

    probabilities  for  healthy  lifestyles  and  good  health  vary

    with  age  for  people  who  have  completed  only  lower

    secondary  education  or  less  and  for  those  with  a  university

    degree,  along  with  the  absolute  differences  in  predicted

    probabilities  between  these  two  education  groups,  which

    we  refer  to  as  the  education  gradient.

    Fig.  3  shows  that  the  income  gradients  in   consumption

    of   fruit  and  vegetables  and  SAH  are  concave  in  age,  i.e.,

    income  differences  are  stronger  during  late  midlife  –  and  at

    their  strongest  at  60  and  61  years  of   age,  respectively  –

    than 

    at 

    younger 

    and 

    older 

    ages. 

    Table 

    shows 

    that 

    this 

    agevariation  (Age   Income  quartile  4  and  Age2  Income

    quartile  4)   is  statistically  significant  at  the  95%  level.  The

    strongest  predicted  income  gradient  across  the  four

    outcome  variables  is  found  in  SAH   at  61  years  of   age,

    where  only  52.3%  of   those  in   the  first  income  quartile  are

    predicted  to  report  being  in  good  or  very  good  health,

    compared  with  75.0%   of   those  in  the  fourth  income

    quartile.  As  discussed,  the  age  pattern  of   cumulative

    advantage  effects  in   SAH   by  income  until  late  midlife

    followed  by  age-as-leveler  effects  at  older  ages  have  been

    reported  in  several  earlier  studies  (Beckett,  2000;   Huijts

    et  al.,  2010;   van  Kippersluis  et  al.,  2010).

    The 

    income 

    gradient 

    in 

    physical 

    activity 

    is 

    convex 

    inage,  and  this  age  variation  is  statistically  significant,  i.e.,

    income  differences  in  physical  activity  are  smaller  during

    midlife  than   at  younger  and  older  ages.  However,  this

    result  seems  to  reflect  gender  differences;  when  we

    estimate  the  models  separately  by  gender,  the  income

    gradient  in  physical  activity  is  decreasing  linearly  in  age

    among  males  (P  

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    in  Fig.  4. However,  when  we  estimate  the  models

    separately  by  gender,  we  find  that  while  the  education

    gradients  in  physical  activity  and  SAH  do  not  vary

    significantly  with  age  among  males,  they  are  convex  in

    age  among  females,  i.e.,  the  education  gradients  in  these

    variables  among  females  are  smaller  during  late  midlife  –

    and  at  their  smallest  at  51  and  58   years  of   age,  respectively

    –  than  at  younger  and  older  ages  (see  Fig.   A4  in

    Appendix  A).

    We summarize  our  results  in   Table  4. Based  on   the

    above  statistical  and  graphical  analysis,  we  indicate  how

    the 

    income 

    and 

    education 

    gradients 

    in 

    physical 

    activity,non-smoking,  consumption  of   fruit  and  vegetables  and

    SAH  vary  with  age,  including  whether  this  age  variation  is

    statistically  significant.  We  separate  the  results  by  gender

    where  relevant.

    4.  Discussion

    The  relationship  between  socioeconomic  status  and

    health  is  dynamic  and  may  vary  with  age.  Our  analysis  has

    explored  the  potential  role  of   lifestyle  choices  in   explaining

    some  of   these  dynamics.  Wefind  that  in   Norway,  there  are

    clear  income  and  education  gradients  in  the  probability  of 

    being 

    physically 

    active, 

    smoking 

    and 

    eating 

    fruit 

    andvegetables  throughout  most  stages  of   the  adult  life  course.

    However,  the  predicted  age  patterns  of   inequality  are

    found  to  vary  across  different  lifestyle  choices,  education

    and  income,  and  to  some  extent  gender  (see  Table  4).

    The  income  gradient  in  smoking,  the  education  gradient

    in  consumption  of   fruit  and  vegetables  and  the  education

    gradient  in  physical  activity  among  males  do  not  vary

    significantly  with  age.  These  results  suggest  that   lifestyle

    choices  are  expected  to  contribute  to  cumulative  advan-

    tage  effects  in  health  by  socioeconomic  status  (Benzeval  et

    al.,  2011;   Kim  &  Durden,  2007;   Ross  &  Wu,1996;  Wilson  et

    al.,  2007);   throughout  the  life  course,  socioeconomic  status

    is 

    closely 

    associated 

    with 

    our 

    daily 

    investments 

    into 

    theproduction  of   poor  and  good  health.  Because  many  adverse

    health  outcomes  are  the  result  of   long-term,  cumulative

    processes  (Kuh  &  Shlomo,  2004),  these  daily  health

    investments  eventually  result  in  a  relatively  more  rapid

    deterioration  of   health  among  lower  than  higher  socioeco-

    nomic  status  groups.

    The  education  gradient  in  smoking,  the  income  gradient

    in  consumption  of   fruit  and  vegetables  and  the  income

    gradient  in  physical  activity  among  males  become  smaller

    as  people  grow  older.  These  results  suggest  that,  in   some

    cases,  the  income  and  education  gradients  in  lifestyle

    choices  may  not  be  constant,  but  vary  with  age.  To  the

    extent 

    that 

    lifestyle 

    habits 

    are 

    converging 

    with 

    older 

    age,as  found  in  these  examples,  this  may  contribute  to  patterns

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       M

      e  a  n

     

    25 30 35 40 45 50 55 60 65 70 75

    Age group

    Physical activity

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       M

      e  a  n

     

    25 30 35 40 45 50 55 60 65 70 75

    Age group

    Non−smoking

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       M  e  a

      n

     

    25 30 35 40 45 50 55 60 65 70 75

    Age group

    Fruit and vegetables

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       M  e  a

      n

     

    25 30 35 40 45 50 55 60 65 70 75

    Age group

    Self−assessed health (SAH)

    Lower secondary education Upper secondary education

    Some university/college University/college degree

    Fig.  2.  Sample   means   split  by  5-year  age  groups  and  the  four   education  groups.

     A.  Øvrum  et   al.  /   Advances  in   Life   Course  Research  19  (2014)  1–136

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    of   age-as-leveler  effects  in   health  (Beckett,  2000;   Huijts

    et  al.,  2010;   van  Kippersluis  et  al.,  2010),  persistent  health

    inequalities  (Ferraro  &  Farmer,  1996),  or  a  slowing  down  of 

    cumulative  advantage  effects  in   health  by  socioeconomic

    status  at  older  ages.

    Our 

    analysis 

    is 

    based 

    on 

    repeated 

    cross-sectional 

    data,and  thus   we  are  not  able  to  directly  assess  whether

    converging  lifestyle  habits  in  age  contribute  to  a  slowing

    down  of   cumulative  advantage  effects  in  health  by

    socioeconomic  status.  We  find  that  current  lifestyle

    choices  are  significantly  associated  with  the  probability

    of   reporting  good  health,  as  represented  by  SAH,  and  that

    the 

    income 

    and 

    education 

    gradients 

    in 

    SAH 

    becomesmaller  once  we  control  for  these  lifestyle  indicators.

     Table  2

    Logistic  regressions  for  lifestyle  choices  and  health–income  models.

    Physical   activity  Non-smoking   Fruit  and  vegetables  Self-assessed

    health  (SAH)

    Self-assessed

    health  (SAH)

    OR   OR   OR   OR   OR 

    Agea 1.17  0.98  1.47*** 0.73** 0.69***

    Age2 0.96** 1.05*** 0.95*** 1.03  1.03

    Income   quartile  2b 1.19** 1.26*** 1.05  1.60*** 1.55***

    Income   quartile  2   age  0.85* 1.02  1.15  0.98  1.00

    Income   quartile  2   age2 1.05** –c 0.97  1.00  1.00

    Income   quartile  3  1.39*** 1.38*** 1.11  1.83*** 1.74***

    Income   quartile  3   age  0.92  1.00  1.19* 1.11   1.10

    Income   quartile  3   age2 1.02  –c 0.97  0.98  0.98

    Income   quartile  4  1.68*** 1.49*** 1.07  2.01*** 1.85***

    Income   quartile  4   age  0.77*** 0.95  1.34*** 1.29** 1.31**

    Income   quartile  4   age2 1.07*** –c 0.95** 0.95** 0.95**

    Female  1.33*** 0.93** 2.73*** 1.03  0.97

    Upper  secondary  educationb 1.21*** 1.26*** 1.20*** 1.18*** 1.13**

    Some   university  1.57*** 1.97*** 1.65*** 1.54*** 1.37***

    University   degree  1.71*** 3.09*** 1.86*** 1.88*** 1.61***

    Physical   activity  1.63***

    Non-smoking   1.57***

    Fruit  and  vegetables  1.11***

    Norwegian  Monitor  Survey   (1997–2011).  All  models  based  on  25,016  observations.  OR,  odds  ratio.a Age  and  Age2 have   been  centered   at  age  30  and  divided  by  10  and  102,  respectively.b Income  quartile  1  and  Lower  secondary  education  are  the  reference   groups.c No  Age2  income-interactions   had  P  

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    We further  find  patterns  of   age-as-leveler  effects  in  SAH  by

    income,  persistent  inequalities  in   SAH   by  education  among

    males,  and  after  decreasing  until  late  midlife,  cumulative

    advantage  effects  in  SAH  by  education  among  females  after

    58  years  of   age.

    As  noted,  our  results  are  relatively  mixed  across

    different  lifestyle  choices,  education  and  income,  and  to

    some  extent  gender.  For  example,  while  the  education

    gradient  in  physical  activity  and  consumption  of   fruit  and

    vegetables  for  the  total  sample  do  not  vary  significantly

    with 

    age, 

    the 

    education 

    gradient 

    in 

    non-smoking 

    movesfrom  being  very  strong  at  younger  ages,  to  almost  zero  at

    older  ages.  This  age  pattern  in  smoking  appears  too

    pronounced  to  be  explained  fully  by  sample  selection

    because  of   high  mortality  rates  among  people  in  the  lower

    education  groups  (Beckett,  2000).   Instead,  different  age

    patterns  for  the  above  education  gradients  might  in  part

    reflect  systematic  variation  across  different  lifestyle

    choices  in  terms  of   perceived  health  risks.  That  is,  people

    with  low  levels  of   formal  education  quit  smoking  at  faster

    rates  as  they  grow  older  because  they  learn  that  not  doing

    so  can  seriously  damage  their  health  (Gandini  et  al.,  2008).

    While  eating  fruit  and  vegetables  and  being  physically

    active 

    are 

    also 

    clearly 

    associated 

    with 

    good 

    healthoutcomes  (He  et  al.,  2007;    Jeon  et  al.,  2007;   World  Health

    Organization,  2003), this  evidence  may  be  less  accessible

    or  perceived  as  less  striking  than  the  corresponding

    evidence  on  smoking  (Sanderson,  Waller,   Jarvis,  Humph-

    ries,  &  Wardle,  2009).

    Physical  activity  among  females  is  the  only  lifestyle

    indicator  for  which  income  and  education  differences  are

    increasing  in  age;  the  income  gradient  increases  linearly  in

    age  and  the  education  gradient  is  convex  in  age  and  at  its

    smallest  at  51  years  of   age.  This  result  could  reflect  the

    effect  of   time  constraints  as  a  result  of   combining  a  career

    with 

    raising 

    children 

    during 

    the 

    earlier 

    stages 

    of  

    the 

    adultlife  course  (Sørensen  &  Gill,  2008).   These  time  constraints

    may  be  particularly  pronounced  among  women  in  the

    highest  socioeconomic  status  groups.  For  example,  studies

    from  the  USA  find  that  both  number  of   working  hours  in

    the  labor  market  and  time  spent  with  the  children

    increases  markedly  with  length  of   education  (Aguiar  &

    Hurst,  2007;   Guryan,  Hurst,  &  Kearney,  2008),  which  leaves

    less  hours  available  for  time-consuming  leisure  activities

    such  as  physical  activity  (Welch,  McNaughton,  Hunter,

    Hume,  &  Crawford,  2009). Thus,  income  and  education

    differences  in   physical  activity  among  females  may  be

    smaller  until  about  50  years  of   age,  when  time  constraints

    are 

    likely 

    to 

    be 

    important, 

    particularly 

    among 

    highersocioeconomic  status  women,  than  at  older  ages,  when

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       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

     

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Physical activity

       0

     .   1

     .   2

     .   3

     .   4

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     .   7

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       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

     

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Non−smoking

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p

      r  o   b  a   b   i   l   i   t  y

     

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Fruit and vegetables

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p

      r  o   b  a   b   i   l   i   t  y

     

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Self−assessed health (SAH)

    First income quartile Fourth income quartile

    Absolute difference (Income gradient)

    Fig.  3.  Predicted  age  variation  in  the  income   gradients  in  lifestyles  and  self-assessed  health   (SAH).   Predicted  probabilities  based  on  results  of   the  models  in

    Table 

    and 

    calculated 

    at 

    the 

    mean 

    values 

    of  

    the 

    additional 

    explanatory 

    variables 

    that 

    are 

    included 

    in 

    these 

    models.

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    time  constraints  are  likely  to  become  increasingly  less

    important.

    To  some  extent,  our  results  are  sensitive  to  choice  of 

    education  or  income  as  socioeconomic  status  indicator.

    While  education  and  income  are  usually  highly  correlated,

    previous  life  course  studies  have  shed  light  on  some  of   the

    fundamental  differences  between  these  two  leading

    socioeconomic  status  indicators  (Cutler  et  al.,  2011). For

    example,  while  education  is  more  or  less  fixed  at  an   early

    stage  of   the  adult  life  course,  income  may  be  affected  by

    many  factors  throughout  the  adult  life  course,  including

    health  shocks  and  the  gradual  deterioration  of   health  in

    age  (Smith,  2004).   We  find,  for  example,  that  while  the

    income  gradient  in   SAH   is  clearly  peaking  around  pre-

    retirement  (50–60   years  of   age),  this  is  not  the  case  for  the

    education  gradient  in  SAH.  According  to  previous  studies

    that  find  similar  patterns  of   results,  the  income  gradient  in

    SAH  peaks  around  pre-retirement  mostly  because  of   the

    effect  of   poor  health  on  premature  exit  from  the  labor

    force,  which  in  turn  negatively  affect  incomes  because  of 

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       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Physical activity

       0

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       1

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    Age

    Non−smoking

       0

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     .   9

       1

       P  r  e   d   i  c   t  e   d  p

      r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Fruit and vegetables

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p

      r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Self−assessed health (SAH)

    Lower secondary education University/college degree

    Absolute difference (Education gradient)

    Fig.  4.  Predicted  age  variation  in  the  education  gradients  in  lifestyles  and  self-assessed  health  (SAH).  Predicted  probabilities  based  on  results  of   the  models   in

    Table 

    and 

    calculated 

    at 

    the 

    mean 

    values 

    of  

    the 

    additional 

    explanatory 

    variables 

    that 

    are 

    included 

    in 

    these 

    models.

     Table  4

    Lifestyle  choices  and  SAH  –  summary   of   age  variation  in  income   and  education  gradients.

    Age  variation  in  income   gradienta Age  variation  in  education  gradienta

    Total  sample   Male   Female  Total  sample  Male  Female

    Physical   activity  Convex  Decreasing   Increasingb Constantc Constant  Convex

    Non-smoking   Constant  Decreasing

    Fruit  and  vegetables  Concave  Constant

    SAH  Concave  Constant   Constant  Convex

    The  table  summarizes   the  results  in  Tables  2  and  3  and  Figs.  3  and  4  and  corresponding  results  by  gender   (Figs.  A1–A4)  where   relevant.a The  income   gradient   refers   to  absolute  differences  in  predicted  probabilities  for  lifestyles  and  SAH  between  people  in  the  first  and  fourth   income

    quartiles,  while  the  education  gradient   refers   to  such   differences  between  people  with   lower  secondary  education  (or  less)  and  people  with   a  university   or

    college  degree.b

    P  

    0.10. 

    Other 

    age 

    variation 

    in 

    income 

    and 

    education 

    gradients 

    that 

    is 

    not 

    ‘‘Constant’’ 

    has 

    P  

    0.05.c ‘‘Constant’’  refers  to  linear  or   non-linear   age  variation  in  the  income   or  education  gradient  that   is  not  statistically  significant.

     A.   Øvrum  et   al.   /   Advances  in   Life   Course  Research  19   (2014)   1–13   9

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    the  shift  from  wage  earning  to  a  reliance  on  social  security

    payments  (van   Kippersluis  et  al.,  2010).

    We  find  that  there  are  strong  education  and  income

    gradients  in  lifestyles  and  health  in   Norway,  which  is

    considered  an  egalitarian  country,  with  a  strong,  well-

    funded  welfare  state  and  a  low  level  of   income  inequality

    (OECD,  2011).  However,  this  result  is  not  surprising

    considering 

    that 

    similar 

    results 

    have 

    been 

    found 

    in 

    severalother  studies  from  Norway  and  other  Scandinavian

    countries  (e.g.,  Huijts  et  al.,  2010;   Mackenbach  et  al.,

    2008;   Shkolnikov  et  al.,  2012).While  strong  welfare  states

    may  not  be  sufficient  to  avoid  socioeconomic  inequalities

    in  health,  it  may  influence  the  way  in   which  such

    inequalities  evolve  over  the  life  course.  For  example,

    Lundberg  et  al.  (2008)  found  that  countries  with  generous

    basic  security  pension  systems,  including  Norway,  experi-

    ence  lower  rates  of   excess  mortality  among  elderly  people

    than  other  countries.  However,  in   general,  the  evidence  on

    the  role  of   social  policies  and  different  types  of   welfare

    states  in  shaping  life  course  patterns  of   health  inequalities

    is 

    scarce 

    (Corna, 

    2013), and 

    thus 

    more 

    studies 

    that 

    addressthis  issue  are  needed.

    The  results  of   this  study  must  be  considered  in  light  of 

    its  limitations.  In   particular,  our  analysis  employs  repeated

    cross-sectional  data,  and  thus   we  are  not  able  to  fully

    capture  the  dynamic  nature  of   health  production,  nor  are

    we  able  to  capture  possible  feedbacks  between  socioeco-

    nomic  status,  lifestyle  choices  and  health.  Thus,  the  results

    of   this  study  are  mainly  of   a  descriptive  nature,  since  our

    data  do  not  allow  for  any  causal  inference.  Some  of   our  key

    variables  may  also  include  measurement  error  because  of 

    incompleteness  and  the  reliance  on   self-reported  data,

    although,  for  example,  SAH  has  been  shown  to  be  highly

    correlated 

    with 

    several 

    objective 

    health 

    measures 

    (Idler 

    &Benyamini,  1997).  Biases  may  also  arise  from  mortality

    selection,  as  discussed,  and  from  the  fact  that  10.9%   of   the

    respondents  were  excluded  from  our  final  sample  because

    of   missing  information  on  one  or  more  relevant  variables.

    Factors  such  as  mortality  selection  (Beckett,  2000),  the

    increasing  importance  of   biological  factors  relative  to

    socioeconomic  status  in   determining  health  at  older  ages

    (Herd,  2006),  cohort  effects  (Lynch,  2003) and  labor  market

    participation  status  (Case  &  Deaton,  2005)  may  all  be

    important  in  explaining  why  we  sometimes  observe  that

    socioeconomic  inequalities  do  not  continue  to  widen,  or

    accumulate,  into  older  age.  However,  our  results  suggest

    that  also  dynamics  in  the  relationship  between  socioeco-

    nomic  status  and  health  affecting  lifestyle  choices  may  be

    important  in  explaining  such  patterns.  Given  the  results

    and  limitations  of   this  study,  there  is  a  need  for  more

    similar 

    research. 

    Studies 

    based 

    on 

    long 

    panel 

    data 

    thattrack  important  lifestyle  and  health  indicators  as  well  as

    socioeconomic  status  in  the  same  individuals  over  most

    stages  of   the  adult  life  course  would  be  particularly

    relevant.  Studies  on  other  lifestyle  indicators,  such  as

    alcohol  use  and  the  consumption  of   unhealthy  foods,

    would  also  be  interesting,  as  would  further  analyses  of   the

    three  lifestyle  indicators  used  in  this  study,  but  possibly

    using  alternative  variable  definitions  (e.g.,  physical  activity

    accounting  for  intensity  level).

    Our  results   suggest   that,   except   for  physical   activity

    among   females,   income   and  education   gradients   in   lifestyle

    choices   either   remain   constant   in  age  or  become   smaller

    with 

    older 

    age. 

    While 

    policies 

    for 

    reducing 

    health 

    inequal-ities   and  its  sources   are  important   at  all stages  of   the  life

    course,   from  birth  to  old  age,  policies   for  improved   lifestyle

    habits   may  benefit   especially   from  targeting   young   people,

    and particularly   young  people   with   low  levelsof   income  and

    formal  education.  Health   information  policies  aimedtoward

    making   people  more   health   consciousness   at  younger   ages

    may  be  efficient.   This  type   of   health   information   could  focus

    on  the  long-term,   cumulative   nature   of   health   production

    and  thus  the  importance   of   making   healthy   lifestyle   choices

    already   at  younger   ages.

     Acknowledgements

    Funding  for  this  research  was  provided  by  the  Research

    Council  of   Norway,  Grant  Nos.  182289  and  184809.   We

    thank  two  anonymous  reviewers  for  their  helpful  com-

    ments  and  suggestions.

     Appendix    A

    Figs.  A1–A4.

     A.  Øvrum  et   al.  /   Advances  in   Life   Course  Research  19  (2014)  1–1310

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       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e

       d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Physical activity male

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e

       d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Non−smoking male

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Fruit and vegetables male

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Self−assessed health (SAH) male

    First income quartile Fourth income quartile

    Absolute difference (Income gradient)

    Fig.   A1.  Predicted  age  variation  in  the  income   gradients  in  lifestyles  and  SAH  among  males.  Predicted  probabilities  based  on  results  of   logistic  regression

    models   that  are  equivalent  to  the  models   in  Table  2, but  estimated  only  for  the  male  subsample.

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Physical activity female

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Non−smoking female

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Fruit and vegetables female

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Self−assessed health (SAH) female

    First income quartile Fourth income quartile

    Absolute difference (Income gradient)

    Fig. 

     A2. 

    Predicted 

    age 

    variation 

    in 

    the 

    income 

    gradients 

    in 

    lifestyles 

    and 

    SAH 

    among 

    females. 

    Predicted 

    probabilities 

    based 

    on 

    results 

    of  

    logistic 

    regressionmodels   that  are  equivalent  to  the  models   in  Table  2, but  estimated  only  for  the  female   subsample.

     A. Øvrum  et   al.   /   Advances  in   Life   Course  Research  19   (2014)   1–13   11

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       0

     .   1

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     .   9

       1

       P  r  e

       d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Physical activity male

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e

       d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Non−smoking male

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Fruit and vegetables male

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Self−assessed health (SAH) male

    Lower secondary education University/college degree

    Absolute difference (Education gradient)

    Fig.  A3.  Predicted  age  variation  in  the  education  gradients  in  lifestyles  and  SAH  among  males.   Predicted  probabilities  based  on  results  of   logistic  regression

    models   that   are  equivalent  to  the  models   in  Table  3, but  estimated  only  for  the  male   subsample.

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Physical activity female

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Non−smoking female

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Fruit and vegetables female

       0

     .   1

     .   2

     .   3

     .   4

     .   5

     .   6

     .   7

     .   8

     .   9

       1

       P  r  e   d   i  c   t  e   d  p  r  o   b  a   b   i   l   i   t  y

    25 30 35 40 45 50 55 60 65 70 75 80

    Age

    Self−assessed health (SAH) female

    Lower secondary education University/college degree

    Absolute difference (Education gradient)

    Fig. 

     A4. 

    Predicted 

    age 

    variation 

    in 

    the 

    education 

    gradients 

    in 

    lifestyles 

    and 

    SAH 

    among 

    females 

    Predicted 

    probabilities 

    based 

    on 

    results 

    of  

    logistic 

    regressionmodels   that   are  equivalent  to  the  models   in  Table  3, but  estimated  only  for  the  female   subsample.

     A.  Øvrum  et   al.  /   Advances  in   Life   Course  Research  19  (2014)  1–1312

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    References

    Aguiar, M., & Hurst, E. (2007). Measuring trends in leisure: The allocation of time  over five decades. The Quarterly Journal of Economics, 122,  969–1006.

    Beckett,M. (2000). Converging health inequalities in later life: An artifact of mortality  selection? Journal of Health and Social Behavior, 41, 106–119.

    Benzeval, M., Green, M. J., & Leyland, A. H. (2011). Do social inequalities inhealth  widen or converge with age? Longitudinal evidence from threecohorts  in the West of Scotland. BMC Public Health, 11, 947.

    Case,  A.,& Deaton, A. (2005). Brokendownbywork andsex:Howour healthdeclines.  In D. A.Wise (Ed.), Analyses in the economics of aging (pp. 185–205).  Chicago: Chicago University Press.

    Corna, L. M. (2013). A life course perspective on socioeconomic inequalitiesin  health: A critical review of conceptual frameworks. Advances in LifeCourse  Research, 18, 150–159.

    Cutler, D.M.,& Lleras-Muney, A. (2010). Understandingdifferences in healthbehaviors  by education.  Journal of Health Economics, 29, 1–28.

    Cutler, D. M., Lleras-Muney, A., & Vogl, T. (2011). Socioeconomic status andhealth:  Dimensions andmechanisms. In S. Glies & P. C. Smith (Eds.), TheOxford  handbook of health economics (pp. 124–163). Oxford: OxfordUniversity Press.

    Deaton, A. (1997). The analysis of household surveys: A microeconometric approach to development policy (World Bank). Baltimore: The JohnsHopkins  University Press.

    Ferraro, K. F., & Farmer, M. M. (1996). Double jeopardy, aging as leveller, orpersistent health inequality? A longitudinal analysis of white andblackAmericans.  Journal of Gerontology, 51B,  S319–S328.

    Gandini, S.,Botteri,E., Iodice, S.,Boniol,M.,Lowenfels,A. B., Maisonneuve,P.,et  al. (2008). Tobacco smokingandcancer:Ameta-analysis. International Journal of Cancer, 122,  155–164.

    Guryan, J., Hurst, E., & Kearney, M. (2008). Parental education and parentaltime  with children. The Journal of Economic Perspectives, 22, 23–46.

    He,  F. J ., Nowson, C. A. , Lucas, M., & MacGregor, G. A. (2007). Increasedconsumption of fruit and vegetables is related to a reduced risk of  coronary  heart disease: Meta-analysis of cohort studies.  Journal of Human  Hypertension, 21, 717–728.

    Herd, P. (2006). Do functional health inequalities decrease in old age?Educational status and functional decline among the 1931–1941 birthcohort. Research on Aging, 28, 375–392.

    Huijts, T.,Eikemo, T.A.,& Skalická, V. (2010). Income-related health inequal-ities  in the Nordic countries: Examining the role of education, occupa-tional  class and age. Social Science & Medicine, 71, 1964–1972.

    Idler,  E. L.,& Benyamini, Y. (1997). Self-rated health andmortality: A review

    of   twenty-seven community studies. Journal of Health and Social Behav-ior,   38, 21–37.

     Jeon, C. Y., Lokken,R. P., Hu, F. B., & VanDam, R.M. (2007). Physicalactivityof moderate   intensity and risk of type 2 diabetes: A systematic review.Diabetes Care, 30, 744–752.

    Kim, J., & Durden, K. (2007). Socioeconomic status and age trajectories of health.  Social Science & Medicine, 65, 2489–2502.

    D.  Kuh & Shlomo, Y. B. (Eds.) ,  A life course approach to chronic diseaseepidemiology (Vol. 2). Oxford: Oxford University Press.

    Lundberg,O., Yngwe,M. Å . , Stjärne,M.K.,Elstad,J. I.,Ferrarini,T., Kangas, O.,et  al. (2008). The role ofwelfare state principles andgenerosity in social

    policy programmes for public health: An international comparativestudy.  The Lancet, 372,  1633–1640.

    Lynch, S. M. (2003). Cohort and life course patterns in the relationshipbetween education and health: A hierarchical approach. Demography,40,  309–331.

    Mackenbach, J. P., Stirbu, I., Roskam, A. J. R., Schaap, M. M., Menvielle, G.,Leinsalu, M., et al. (2008). Socioeconomic inequalities in health in 22European countries. New England Journal of Medicine, 358,  2468–2481.

    Marmot, M.,Friel, S.,Bell, R.,Houweling, T. A.,& Taylor, S. (2008). Closing thegap  in a generation: Health equity through action on the social deter-

    minants  of health. The Lancet, 372,  1661–1669.O’Brien, R.M.,Hudson,K., & Stockard, J. (2008). A mixedmodel estimation of age, period,and cohorteffects.  SociologicalMethodsResearch,36 , 402–442.

    OECD. (2008). Growing unequal? Income distribution and poverty in OECDcountries Paris: OECD Publishing.

    OECD. (2011). Society at a glance 2011 – OECD social indicators. Paris: OECDPublishing.

    Pampel,  F. C.,Krueger, P.M.,& Denney, J.T. (2010). Socioeconomicdisparitiesin  health behaviors.  Annual Review of Sociology, 36 , 349.

    Reither, E. N.,Hauser, R.M.,& Yang, Y. (2009). Do birth cohorts matter? Age–period–cohort analyses of the obesity epidemic in the United States.Social  Science & Medicine, 69, 1439–1448.

    Ross, C.E.,& Wu, C.L. (1996). Education, age, and the cumulative advantagein  health.  Journal of Health and Social Behavior, 37 , 104–120.

    Sanderson,   S. C.,Waller,  J., Jarvis, M. J., Humphries,   S.E., &Wardle,J. (2009).Awareness of lifestylerisk factors for cancer andheart disease  amongadults  in the  UK. Patient Education and  Counseling, 74,  221–227.

    Sarma, S., Thind, A., & Chu, M. (2011). Do new cohorts of family physicianswork   less compared to their older predecessors? The evidence fromCanada. Social Science & Medicine, 72, 2049–2058.

    Shkolnikov, V. M., Andreev, E. M., Jdanov, D. A., Jasilionis, D., Kravdal, Ø. ,Vågerö,  D., et al. (2012). Increasing absolute mortality disparities byeducation  in Finland, Norway and Sweden, 1971–2000.  Journal of Epi-demiology and Community Health, 66 , 372–378.

    Sofi, F., Capalbo, A., Cesari, F., Abbate, R., & Gensini, G. F. (2008). Physicalactivity during leisure time and primary prevention of coronary heartdisease:  Anupdatedmeta-analysisof cohort studies. European Journal of Cardiovascular Prevention & Rehabilitation, 15, 247–257.

    Smith, J. P. (2004). Unraveling the SES: Health connection. Population andDevelopment Review, 30, 108–132.

    Sørensen,M., &Gill,D.L. (2008). Perceivedbarriers tophysicalactivityacrossNorwegian adult age groups, gender and stagesof change. Scandinavian Journal of Medicine & Science in Sports, 18, 651–663.

    van  Kippersluis, H., O’Donnell, O., van Doorslaer, E., & van Ourti, T. (2010).

    Socioeconomic differences in health over the life cycle in an egalitariancountry. Social Science & Medicine, 70, 428–438.

    Welch, N.,McNaughton, S. A.,Hunter, W., Hume, C.,& Crawford,D. (2009). Isthe  perception of time pressure a barrier to healthy eating andphysicalactivity  among women? Public Health Nutrition, 12, 888–895.

    Wilson,  A., Shuey, K., & Elder, G. (2007). Cumulative advantage processes asmechanisms of inequality in life course health.  American Journal of Sociology, 112,  1886–1924.

    World Health Organization. (2003). Diet, nutrition and the prevention of chronic   diseases. WHO Technical Report Series No. 916  .  Geneva,Switzerland.

     A.   Øvrum  et   al.   /   Advances  in   Life   Course  Research  19   (2014)   1–13   13

    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