Advanced allograft technology that delivers regenerative capacity in a versatile 100% pure human bone graft.

ADVANCEDALLOGRAFTTECHNOLOGY

Influx® is a line of allograft processed from pure human bone that improves the availability of inductive properties by maximizing the exposure of growth factors and proteins in a versatile scaffold.

Osteoinductive Potential Proven regenerative capacity by exhibiting all five elements of new bone formation in a validated animal model.3

Osteoconductive Maximized surface area provides an optimal environment for cellular attachment and proliferation.

Terminally SterilizedProvides device level assurance of safety (10-6).4

Room Temp StorageAmbient storage for convenient distribution and consignment.

100% Human BoneMade of 100% human bone, no extraneous carriers, fillers, or binding agents.

Advanced ProcessingEnhanced regenerative capacity and handling compared to particulate DBM.2

100% PURE HUMAN BONE

Figure 1. Histological Evidence of Bone Formation1

Chondrocytes

Bone Marrow

Cartilage

Osteoblasts

Regenerative Bone

DBM STRIPS AVAILABLE SIZES

Size Product Code

50 x 10 x 5 mm IFLX-LS-051

50 x 20 x 5 mm IFLX-LS-052

100 x 10 x 5 mm IFLX-LS-110

100 x 20 x 5 mm IFLX-LS-120

DBM FIBERS AVAILABLE SIZES

Size Product Code

1 cc IFLX-CF-01

2.5 cc IFLX-CF-02

5 cc IFLX-CF-05

10 cc IFLX-CF-10

Influx® Demineralized Cortical Bone Fibers An advanced allograft that combines the regenerative capacity of interconnected fibers with the availability of growth factors endogenous to cortical bone. Fibers are available in multiple sizes and in strip format. Proprietary Processing

+ Proven regenerative capacity in a validated animal model (Figure 1).5

+ Increased patient safety through terminal sterilization

Novel Small Diameter Fibers+ An ideal scaffold for autologous cells to augment conductive and inductive properties.6

+ Cohesive handling characteristics to provide precise graft placement that is resistant to irrigation.7 Handles best when hydrated with blood, BMA, or PRP.

Influx® Demineralized Bone Matrix Putty Fully moldable, 100% demineralized bone graft putty offers optimal regenerative capacity through a proprietary processing of demineralized cortical fibers and demineralized cortical particulate. Putty is available in multiple sizes.

Optimal Regenerative Capacity + Validated to produce a positive osteoinductive response8

+ Processed for enhanced regenerative capacity compared to particulate DBM2

Ease-of-Use+ Maintains moldable, cohesive handling characteristics to fill irregular defects and provide lavage resistance.+ Ready-to-use directly out of packaging with no need for graft preparation or hydration.

MULTIPLE SIZES AND CONFIGURATIONS FOR EASE-OF-USE

IN A VARIETY OF APPLICATIONS

DBM PUTTY AVAILABLE SIZES

Size Product Code

1 cc IFLX-PT-01

2.5 cc IFLX-PT-02

5 cc IFLX-PT-05

10 cc IFLX-PT-10

DBM PUTTYAvailable in four sizes: 1cc, 2.5cc, 5cc and 10cc sizes.

CORTICAL FIBERSAvailable in four sizes: 1cc, 2.5cc, 5cc and 10cc sizes.

CORTICAL FIBER STRIPS Available in four sizes and in a dual-strip configuration.

istobiologics.com45 South Street • Hopkinton, MA 01748©2019 Isto Biologics. All rights reserved. Influx is a registered trademark of Isto Technologies II LLC and processed by DCI Donor Services - Tissue Bank. Isto Technologies II LLC and Arteriocyte Medical Systems, Inc. are jointly DBA Isto Biologics.

Schedule a case with your Isto sales representative or call customer service at 888.705.ISTO.

OFFERED IN MULTIPLE SIZES AND CONFIGURATIONS

ADVANCED ALLOGRAFT TECHNOLOGY.

AMS98110LBL Rev 3

Processed and distributed by DCI Donor Services - Tissue Bank.

Reference:1. Kanczler, JM and Oreffo, RO. Eur Cell Mater. 2008, 15, 100-114; 2. Martin GJ, et. Al. Spine, 1999, 24, 637-645; 3. Data on file, DCI Donor Services Tissue Bank; 4. Data on file, DCI Donor Services Tissue Bank; 5. Data on file, DCI Donor Services Tissue Bank; 6. Muschler GF. J Bone Joint Surg Am. 1997, 79, 1699-1709; 7. Data on file, DCI Donor Services Tissue Bank; 8. Data on file, DCI Donor Services Tissue Bank.

Osteoinductive Potential Proven regenerative capacity by exhibiting all five elements of new bone formation in a validated animal model.3

Osteoconductive Maximized surface area provides an optimal environment for cellular attachment and proliferation.

Terminally SterilizedProvides device level assurance of safety (10-6).4

Room Temp StorageAmbient storage for convenient distribution and consignment.

100% Human BoneMade of 100% human bone, no extraneous carriers, fillers, or binding agents.

Advanced ProcessingEnhanced regenerative capacity and handling compared to particulate DBM.2