Adrenergic ReceptorBeta Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines especially norepinephrineand epinephrine Many cells possess these receptors and the binding of a catecholamine to the receptor will generally stimulatethe sympathetic nervous system The sympathetic nervous system is responsible for the fight-or-flight response which includeswidening the pupils of the eye mobilizing energy and diverting blood flow from non-essential organs to skeletal muscle There aretwo main groups of adrenergic receptors α and β with several subtypes α receptors have the subtypes α1 and α2 β receptorshave the subtypes β1 β2 and β3 All three are linked to Gs proteins which in turn are linked to adenylate cyclase Agonist bindingthus causes a rise in the intracellular concentration of the second messenger cAMP Downstream effectors of cAMP includecAMP-dependent protein kinase (PKA) which mediates some of the intracellular events following hormone binding

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Adrenergic Receptor Agonists Antagonists Inhibitors Activators amp Modulators

(+)-Penbutolol ((R)-Penbutolol (+)-Isopenbutolol) Cat No HY-116790A

(+)-Penbutolol is a β-adrenoceptor antagonistwith an IC of 074 μM (+)-Penbutolol is an50

optical isomer of l-penbutolol with Na+

channel-blocking action

Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

(4E)-SUN9221Cat No HY-U00367

(4E)-SUN9221 is a potent antagonist of and withα1-adrenergic receptor 5-HT2 receptor

antihypertensive and anti-platelet aggregationactivities

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

(R)-(+)-AtenololCat No HY-B2111

(R)-(+)-Atenolol is the less active enantiomer ofthe (RS)-atenolol (RS)-atenolol is aβ-adrenergic receptor antagonist

Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg

(R)-Carvedilol ((R)-BM 14190) Cat No HY-B0006C

(R)-Carvedilol ((R)-BM 14190) the R-enantiomer ofCarvedilol is a non-selective blockerβα-1(R)-Carvedilol exerts protection against thevascular or cardiac toxicity of Doxorubicin (DOX)

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

(R)-TerazosinCat No HY-B0371B

(R)-Terazosin is an active R-enantiomer ofTerazosin (R)-Terazosin is a potent

antagonist with values of 651α1-adrenoceptor Ki

nM 101 nM and 197 nM for andα1a α1b respectivelyα1d-adrenoceptor

Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

(Rac)-Rotigotine hydrochlorideCat No HY-15394

(Rac)-Rotigotine hydrochloride is a racemate ofRotigotine

Purity 9776Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

(RS)-ButyryltimololCat No HY-102032A

(RS)-Butyryltimolol is the racemate ofButyryltimolol Butyryltimolol an effectiveprodrug of Timolol improves the cornealpenetration of Timolol Butyryltimolol is aβ-adrenergic blocker

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

(S)-Carvedilol ((S)-BM 14190) Cat No HY-B0006B

(S)-Carvedilol the S-enantiomer of Carvedilol isa non-selective blocker (S)-Carvedilolβα-1exerts protection against the vascular or cardiactoxicity of Doxorubicin (DOX)

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

(S)-TerazosinCat No HY-B0371D

(S)-Terazosin is an active S-enantiomer ofTerazosin (S)-Terazosin is a potent andhigh-affinity antagonist with α-adrenoceptor Ki

values of 391 nM 079 nM and 116 nM for α1a and respectivelyα1b α1d-adrenoceptor

Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

(S)-Timolol Maleate (L-714465 Maleate MK 950) Cat No HY-17380

(S)-Timolol Maleate (L-714465 Maleate) is anon-cardioselective hydrophilic β-adrenoceptorblocker (S)-Timolol Maleate is widely used asstandard medication for intraocular pressure(glaucoma) by preventing the production of aqueoushumor

Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg

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(plusmn)-BefunololCat No HY-101752

(plusmn)-Befunolol is a blocking agentβ-adrenoceptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

(plusmn)-Bisoprolol hemifumarate (Bisoprolol hemifumarate salt) Cat No HY-B0076

(plusmn)-Bisoprolol (hemifumarate) is a selective typeβ1 adrenergic receptor blocker Target AdrenergicReceptor Approved July 31 1992 Bisoprolol onbeta 1-adrenoceptor peptide induced autoimmunemyocardial damage

Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg

25-DideoxyadenosineCat No HY-135878

25-Dideoxyadenosine is a potent andnon-competitive inhibitor viaadenylyl cyclasebinding the P-site with an of 3 microM IC50

25-Dideoxyadenosine is a nucleoside analog andexerts a potent action in heartantiadrenergic

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg 250 mg

4-Hydroxypropranolol D7 hydrochloride ((plusmn)-4-hydroxy Propranolol D7 hydrochloride) Cat No HY-100634S

4-Hydroxypropranolol D7 hydrochloride((plusmn)-4-hydroxy Propranolol D7 hydrochloride) is adeuterium labeled 4-Hydroxypropranololhydrochloride

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

4-Hydroxypropranolol hydrochloride ((plusmn)-4-hydroxy Propranolol hydrochloride) Cat No HY-100634

4-Hydroxypropranolol hydrochlorid is an activemetabolite of Propranolol 4-Hydroxypropranololhydrochlorid is of comparable potency toPropranolol

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

5-HT2 antagonist 1Cat No HY-U00365

5-HT2 antagonist 1 is a potent antagonist of with weak 5-HT2 receptor α1 adrenoceptor

blocking activity

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

AaptamineCat No HY-N4225

Aaptamine a spongean alkaloid isolated from a seasponge Aaptos aaptos is a competitive antagonistof and activates the p21 promoterα-adrenoceptorin a p53-independent manner

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Acebutolol D7Cat No HY-17497S

Acebutolol D7 is a deuterium labeled AcebutololAcebutolol is a selective β1 adrenergic receptorantagonist used in the treatment of hypertensionangina pectoris and cardiac arrhythmias

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Acebutolol hydrochlorideCat No HY-17497A

Acebutolol hydrochloride is a β1 adrenergic antagonist Acebutololreceptor (β1AR)

hydrochloride is used in the treatment ofhypertension angina pectoris and cardiacarrhythmias

Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 5 g 10 g

ACTH (1-14) (Adrenocorticotropic Hormone Fragment 1-14) Cat No HY-P1582

ACTH (1-14) is a fragment of adrenocorticotrophinwhich regulates cortisol and androgen production

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

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ACTH (1-14) (TFA) (Adrenocorticotropic Hormone Fragment 1-14 TFA) Cat No HY-P1582A

ACTH (1-14) (TFA) is a fragment ofadrenocorticotrophin which regulates cortisol andandrogen production

Purity 9855Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

ADRA1D receptor agonist 1Cat No HY-135270

ADRA1D receptor agonist 1 (compound (R)-9S) is apotent selective and orally active α1D

antagonist with a of 16 nMadrenoceptor Ki

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

AGN 192836Cat No HY-100300

AGN 192836 is a potent and selective α2 adrenergicagonist with s of 87 41 and 66 nM forEC50

α2A α2B and α2C receptor respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Ajmalicine (Raubasine) Cat No HY-N1919

Ajmalicine (Raubasine) is found in herbs ofCatharanthus roseus is an antihypertensive drugused in the treatment of high blood pressuredecreases peripheral resistance and bloodpressure

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Alfuzosin (SL 77499) Cat No HY-B0192

Alfuzosin is an α1 adrenergic receptor antagonistused to treat benign prostatic hyperplasia (BPH)

Purity 9981Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

Alfuzosin hydrochloride (SL 77499-10) Cat No HY-B0192A

Alfuzosin hydrochloride is an α1 adrenergicreceptor antagonist used to treat benign prostatichyperplasia (BPH)

Purity 9873Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

Amezinium methylsulfate (Amezinium metilsulfate Lu-1631) Cat No HY-A0275

Amezinium metilsulfate has multiple mechanismsincluding stimulation of alpha and beta-1receptors and inhibition ofnoradrenaline andtyramine uptake

Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 1 g

Amibegron hydrochloride (SR 58611A) Cat No HY-103207

Amibegron hydrochloride is a selective agonist with an of 35 nMβ3-adrenoceptor EC50

for in rat colon Amibegronβ-adrenoceptorhydrochloride has anxiolytic and antidepressantactivity

Purity gt990Clinical Data No Development ReportedSize 5 mg

Amitraz (BTS-27419) Cat No HY-B1111

Amitraz is a non-systemic acaricide andinsecticide with alpha-adrenergic agonistactivity interaction with octopamine receptors ofthe central nervous system and inhibition ofmonoamine oxidases and prostaglandin synthesis

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg

AncarololCat No HY-100141

Ancarolol is a blocking agentbeta-adrenergic

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

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AR-08Cat No HY-U00371

AR-08 is an agonist of α2-adrenergic receptorused for the treatment of attention deficithyperactivety disorder (ADHD)

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

ArbutamineCat No HY-16056

Arbutamine is a short-acting synthetic potentnonselective agonist thatβ-adrenoceptorincreases heart rate cardiac contractility andsystolic blood pressure Arbutamine is acatecholamine for a pharmacological cardiac stressagen

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

ArotinololCat No HY-122537A

Arotinolol is a nonselective αβ-adrenergic blocker and a vasodilating β-blockerreceptor

Arotinolol also shows potency for inhibiting thebinding of the radioligand I-ICYP to125

-serotonergic receptor sites5HT1B

Purity 9818Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg

Asenapine (Org 5222) Cat No HY-10121

Asenapine(Org 5222) inhibits adrenergic receptor(α1 α2A α2B α2C) with Ki of 025-12 nM andalso inhibits 5-HT receptor (1A 1B 2A 2B 2C5A 6 7) with Ki of 003-40 nM

Purity 9881Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Atenolol ((RS)-Atenolol) Cat No HY-17498

Atenolol is a selective β1 receptor antagonistTarget Adrenergic Receptor Atenolol is acardioselective beta-adrenergic blocker possessingproperties and potency similar to propranolol butwithout a negative inotropic effect [1 2]

Purity 9961Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g

Atipamezole (MPV 1248) Cat No HY-12380A

Atipamezole is a synthetic α -adrenoceptor2

with a of 16 nMantagonist Ki

Purity 9948Clinical Data Phase 1Size 10 mM times 1 mL 10 mg 50 mg

Atipamezole hydrochloride (MPV-1248 hydrochloride) Cat No HY-12380

Atipamezole hydrochloride is a synthetic with a of 16 nMα -adrenoceptor antagonist2 Ki

Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg

Bambuterol ((plusmn)-Bambuterol KWD-2183) Cat No HY-17501

Bambuterol ((plusmn)-Bambuterol KWD-2183) is a longacting beta-adrenoceptor agonist (LABA) used inthe treatment of asthma it also is a prodrug ofterbutaline

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Bambuterol hydrochloride ((plusmn)-Bambuterol hydrochloride KWD-2183 hydrochloride) Cat No HY-17501A

Bambuterol hydrochloride ((plusmn)-Bambuterolhydrochloride KWD-2183 hydrochloride) is a longacting beta-adrenoceptor agonist (LABA) used inthe treatment of asthma it also is a prodrug ofterbutaline

Purity 9957Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Batefenterol (GSK961081 TD-5959) Cat No HY-12980

Batefenterol (GSK961081TD-5959) is a novel receptor antagonist andmuscarinic

agonist displays high affinityβ -adrenoceptor2

for hM2 hM3 muscarinic and hβ -adrenoceptor with2

values of 14 13 and 37 nM respectivelyKi

Purity 9817Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

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Benzquinamide (P2647 BZQ Benzoquinamide) Cat No HY-U00244

Benzquinamide (P2647) is an antiemetic which canbind to the and α2A α2B α2C adrenergic

(α2-AR) with K values of 1365 691receptors i

and 545 nM respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

BetaxololCat No HY-B0381

Betaxolol is a selective beta1 adrenergic receptorblocker used in the treatment of hypertension andglaucoma Target Beta1 Adrenergic ReceptorBetaxolol is a cardioselective beta-adrenergicreceptor blocking agent Betaxolol (5 mgkg viaip

Purity 9695Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Betaxolol hydrochloride (SL75212) Cat No HY-B0381A

Betaxolol Hydrochloride is a selective beta1adrenergic receptor blocker used in the treatmentof hypertension and glaucoma Target Beta1Adrenergic Receptor Betaxolol hydrochloride is acardioselective beta-adrenergic receptor blockingagent

Purity 9894Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Bevantolol hydrochlorideCat No HY-121186

Bevantolol hydrochloride is a selective andβ1α1-adrenergic receptor antagonist with valuespKi

of 783 69 in rat cerebral cortex respectivelyBevantolol hydrochloride is a potent Ca2+

antagonist

Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 25 mg 50 mg 100 mg

BI-167107Cat No HY-121251

BI-167107 is a high affinity full agonist thatbinds to the β2 adrenergic receptor ( ) with aβ2ARdissociation constant of 84 pMKd

Purity 9981Clinical DataSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Bometolol HydrochlorideCat No HY-U00386

Bometolol Hydrochloride is a beta-adrenergicblocking agent used for the research ofcardiovascular disease

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Brimonidine (UK 14304 AGN190342) Cat No HY-B0659

Brimonidine (UK 14304) is a full α2-adrenergicreceptor (α2-AR) agonist

Purity 9965Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Brimonidine tartrate (UK 14304 tartrate AGN190342 tartrate) Cat No HY-B0659A

Brimonidine tartrate (UK 14304 tartrate) is a fullα2-adrenergic receptor (α2-AR) agonist

Purity 9990Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

BRL 37344 sodium (BRL 37344A) Cat No HY-101325

BRL 37344 sodium (BRL 37344A) is a specific agonist BRL 37344 sodiumβ3-adrenergic receptor

treatment significantly lowers the body weight ofobese mice

Purity gt990Clinical Data No Development ReportedSize 1 mg

Brombuterol D9 (Bromobuterol D9) Cat No HY-131104S

Brombuterol D9 (Bromobuterol D9) is a deuteriumlabeled Brombuterol Brombuterol is a β-adrenergic

agonistreceptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

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Brombuterol D9 hydrochloride (Bromobuterol D9 hydrochloride) Cat No HY-131104AS

Brombuterol D9 hydrochloride (Bromobuterol D9hydrochloride) is a deuterium labeled Brombuterolhydrochloride Brombuterol hydrochloride is a

agonistβ-adrenergic receptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Brombuterol hydrochloride (Bromobuterol hydrochloride) Cat No HY-131145

Brombuterol hydrochloride (Bromobuterolhydrochloride) is a agonistβ-adrenergic receptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

BucindololCat No HY-103214

Bucindolol is a blockerβ1-adrenergic receptorwith intrinsic sympathomimetic activity used inthe research of heart failure

Purity gt990Clinical Data No Development ReportedSize 1 mg 5 mg

Carbazochrome sodium sulfonate (AC-17) Cat No HY-B0491A

Carbazochrome (sodium sulfonate) (AC-17) is anantihemorrhagic agent

Purity 9951Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg

Carteolol hydrochloride (OPC-1085 hydrochloride) Cat No HY-17495A

Carteolol hydrochloride (OPC-1085 hydrochloride)is a non-selective beta blocker used to treatglaucoma

Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg

Carvedilol (BM 14190) Cat No HY-B0006

Carvedilol (BM 14190) is a non-selective βα-1blocker Carvedilol inhibits lipid peroxidation ina dose-dependent manner with an IC of 5 μM50

Carvedilol is a multiple action antihypertensiveagent with potential use in angina and congestiveheart failure

Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) Cat No HY-B0006A

Carvedilol phosphate hemihydrate (BM 14190phosphate hemihydrate) is a non-selective βα-1blocker Carvedilol phosphate hemihydrate inhibits

with an IC of 5 μMlipid peroxidation 50

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Centanafadine (EB-1020) Cat No HY-16736

Centanafadine is dual norepinephrine (NE)dopamine transporter inhibitor also inhibits(DA)

serotonin transporter with of 6 nM 38 nMIC s50

and 83 nM for human NE DA and serotonintransporter respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Centanafadine hydrochloride (EB-1020 hydrochloride) Cat No HY-16736A

Centanafadine (hydrochloride) is dual transporternorepinephrine (NE)dopamine (DA)

inhibitor also inhibits serotonin transporterwith of 6 nM 38 nM and 83 nM for human NEIC s50

DA and serotonin transporter respectively

Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

CGP 20712 A (CGP 20712 mesylate) Cat No HY-101355B

CGP 20712 A (CGP 20712 mesylate) is a highlyselective ltBgtβ1-adrenoceptorltBgtantagonist with an of 07 nM CGP 20712 AIC50

exhibits ~10000-fold selectivity overβ2-adrenoceptors

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg

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Cicloprolol hydrochlorideCat No HY-U00066

Cicloprolol is a partial β 1-adrenoceptoragonist

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Cimaterol-D7Cat No HY-100935S

Cimaterol-D7 is the deuterium labeled CimaterolCimaterol is a potent agonist of β-adrenergicreceptors (pEC s=813 878 and 662 for human50

β1 β2 and β3 respectively) Cimaterol has beenused in farmed animals to increase carcass massand to alter muscle and fat deposition

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Cimbuterol-D9Cat No HY-131105S

Cimbuterol-D9 is the deuterium labeled CimbuterolCimbuterol is aβ-adrenergic agonist

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

CL 316243Cat No HY-116771A

CL316243 is a highly potent selective agonist with a of 3 nMβ3-adrenoceptor EC50

but is an extremely poor toβ12- receptors

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg

ClenproperolCat No HY-100699

Clenproperol is a agonistβ2-adrenergic

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Clenproperol-D7Cat No HY-100699S

Clenproperol-D7 is the deuterium labeledClenproperol Clenproperol is a β2-adrenergicagonist

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

ClonidineCat No HY-12721

Clonidine is an agonist which isalpha 2-adrenergicused extensively in anesthesia research

Purity 9879Clinical Data LaunchedSize 1 mg 5 mg

Clonidine hydrochlorideCat No HY-B0409A

Clonidine hydrochloride is an agonist of and potent antihypertensiveα2-adrenoceptor

agent

Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Clorprenaline D7Cat No HY-131106S

Clorprenaline D7 is a deuterium labeledClorprenaline Clorprenaline is a β2-adrenergic

agonist that is implicated in bronchialreceptorexpansion Clorprenaline has the potential forasthma research

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Clorprenaline hydrochlorideCat No HY-B1347

Clorprenaline hydrochloride is a β -adrenergic2

agonist that is implicated in bronchialreceptorexpansion Clorprenaline has the potential forasthma research

Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg

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D2343Cat No HY-U00206

D2343 is a agonist and also is anβ2-adrenoceptor inhibitorα1- adrenoceptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Dabuzalgron (Ro 115-1240) Cat No HY-117071

Dabuzalgron (Ro 115-1240) is an orally active andselective agonist forα-1A adrenergic receptorthe treatment of urinary incontinence Dabuzalgronprotects against Doxorubicin-inducedcardiotoxicity by preserving mitochondrialfunction

Purity 9872Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg

Dapiprazole hydrochlorideCat No HY-A0142A

Dapiprazole hydrochloride is a potent α-adrenergicblocking drug which is used to reverse mydriasisafter eye examination

Purity 9997Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

Deriglidole (SL 86-0715) Cat No HY-101683

Deriglidole is a peripheral adrenoceptorantagonist with a high affinity forα -adrenoceptors2

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

DetomidineCat No HY-B0163

Detomidine produce dose-dependent sedative andanalgesic effects is a nonnarcotic syntheticα2-adrenergic agonist Target α2-adrenergicagonist Detomidine is an imidazole derivative andα2-adrenergic agonist used as a large animalsedative primarily used in horses

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Detomidine carboxylic acidCat No HY-135895

Detomidine carboxylic acid is the major urinarymetabolite of Detomidine Detomidine is asynthetic agonist and an animalα2-adrenergicanalgesic sedative Detomidine also has cardiacand respiratory effects and an antidiureticaction

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Detomidine hydrochlorideCat No HY-B0163A

Detomidine hydrochloride produce dose-dependentsedative and analgesic effects is a nonnarcoticsynthetic α2-adrenergic agonist Targetα2-adrenergic agonist Detomidine is an imidazolederivative and α2-adrenergic agonist used as alarge animal sedative primarily used inhellip

Purity 9982Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Dexmedetomidine hydrochloride ((+)-Medetomidine

hydrochloride (S)-Medetomidine hydrochloride) Cat No HY-17034A

Dexmedetomidine Hydrochloride is an agonist ofadrenergic alpha-2 receptor which is used inveterinary medicine for its analgesic and sedativeproperties

Purity 9854Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg

Diacetolol D7Cat No HY-100635S

Diacetolol D7 is a deuterium labeled DiacetololDiacetolol is the major metabolite of AcebutololDiacetolol is a blocking andβ-adrenoceptoranti-arrhythmic agent

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

DicentrineCat No HY-N6969

Dicentrine is a natural product isolated from theplant with antihypertensiveLindera megaphyllaeffect Dicentrine is an α -adrenoceptor1

antagonist which has effective against humanhyperplastic prostates

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

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DL-Epinephrine ((plusmn)-Epinephrine DL-Adrenaline (plusmn)-Adrenaline) Cat No HY-B0447

DL-Epinephrine is the racemate of epinephrineL-Epinephrine is a hormone secreted by the medullaof the adrenal glands L-Epinephrine is an

and receptor agonistα-adrenergic β-adrenergic

Purity gt990Clinical Data No Development ReportedSize 500 mg 1 g 5 g

DL-Norepinephrine hydrochlorideCat No HY-N7142

DL-Norepinephrine hydrochloride is a syntheticphenylethylamine that mimics the sympathomimeticactions of the endogenousnorepinephrineDL-Norepinephrine hydrochloride isa neurotransmitter targets α1 and β1

has an increasing effecthellipadrenoceptors

Purity 9953Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg

Dobutamine hydrochlorideCat No HY-15746

Dobutamine hydrochloride is a syntheticcatecholamine that acts on α1-AR β1-AR β2-AR

Dobutamine(α-1 β-1 andβ-2 adrenoceptors)hydrochloride is a selective β1-AR agonistrelatively weak activity at α1-AR and β2-AR

Purity 9947Clinical Data LaunchedSize 10 mM times 1 mL 100 mg

Dopexamine hydrochloride (FPL60278AR) Cat No HY-U00205

Dopexamine hydrochloride is a β2 adrenergic agonistreceptor

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Doxazosin (UK 33274) Cat No HY-B0098

Doxazosin (UK 33274) is a quinazoline-derivativethat selectively antagonizes postsynaptic

α1-adrenergic receptors

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Doxazosin D8 (UK 33274 D8) Cat No HY-B0098S

Doxazosin D8 (UK 33274 D8) is a deuterium labeledDoxazosin (UK 33274) Doxazosin is aquinazoline-derivative that selectivelyantagonizes postsynaptic α1 adrenergic receptors

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Doxazosin mesylate (UK 33274 mesylate) Cat No HY-B0098A

Doxazosin mesylate (UK 33274) is aquinazoline-derivative that selectivelyantagonizes postsynaptic α1-adrenergic receptors

Purity 9860Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g

EcastololCat No HY-101691

Ecastolol is a beta adrenergic receptorantagonist with antianginal activities

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Epanolol (Visacor ICI141292) Cat No HY-U00183

Epanolol (Visacor ICI141292) is a potent partial agonist with a greaterβ-adrenoceptor

affinity for - than β2-adrenoceptorsβ1

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Esmolol hydrochlorideCat No HY-B1392

Esmolol hydrochloride is a beta adrenergicreceptor blocker

Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Falintolol (Z)-Cat No HY-U00283

Falintolol (Z)- a new antagonist isβ-adrenergiccharacterized by the presence of an oximefunction

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Fenmetozole TosylateCat No HY-U00402

Fenmetozole Tosylate is an antagonist of theactions of ethanol also antagonizes α2-adrenergic

and acts as an antidepressant drugreceptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Fenoterol (Th-1165 Phenoterol) Cat No HY-B0976

Fenoterol is a β 2 adrenergic agonist designed toopen up the airways to the lungs is classed assympathomimetic β2 agonist and asthma medication

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Fenoterol hydrobromide (Fenoterol bromide Th-1165a Phenoterol hydrobromide) Cat No HY-B0976A

Fenoterol hydrobromide is a β 2 adrenergic agonistdesigned to open up the airways to the lungs isclassed as sympathomimetic β2 agonist and asthmamedication

Purity 9971Clinical Data LaunchedSize 100 mg

Fenspiride HydrochlorideCat No HY-A0027

Fenspiride Hcl is an α adrenergic and H1 histaminereceptor antagonist IC50 value TargetAdrenergic receptor H1 receptor Fenspiridehydrochloride is a bronchodilator withanti-inflammatory properties

Purity 9903Clinical Data LaunchedSize 10 mM times 1 mL 100 mg

FiduxosinCat No HY-U00399

Fiduxosin is a potent antagonistα1-adrenoceptorwith of 0160 nM 249 nM and 0920 nM forKi

α1a- α1b- and α1d-adrenoceptors respectively

Purity gt98Clinical Data No Development ReportedSize 5 mg

Formoterol Fumarate (Formoterol) Cat No HY-B0010

Formoterol fumarate(Foradil) is a potentselective and long-acting β2-adrenoceptor agonist

Purity 9894Clinical Data LaunchedSize 10 mg 50 mg

G-Protein antagonist peptideCat No HY-P1376

G-Protein antagonist peptide is the substanceP-related peptide that inhibits binding of Gproteins to their receptors G-Protein antagonistpeptide competitively and reversibly inhibits

activation of Gi or GoM2 muscarinic receptorand inhibits Gs activation by β-adrenoceptors

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

G-Protein antagonist peptide TFACat No HY-P1376A

G-Protein antagonist peptide TFA is the substanceP-related peptide that inhibits binding of Gproteins to their receptors G-Protein antagonistpeptide TFA competitively and reversibly inhibits

activation of Gi or GoM2 muscarinic receptorand inhibits Gs activation by β-adrenoceptors

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Glaucine (OO-Dimethylisoboldine S-(+)-Glaucine NSC 34396) Cat No HY-N3945

Glaucine (OO-Dimethylisoboldine) is an alkaloidisolated from Crantz withGlaucium flavumantitussive bronchodilation and anti-inflammatoryproperties

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

wwwMedChemExpresscom 11

Gramine (Donaxine) Cat No HY-N0166

Gramine (Donaxine) is a natural alkaloid isolatedfrom giant reed acts as an active adiponectin

agonist with s of 32 andreceptor (AdipoR) IC50

42 microM for AdipoR2 and AdipoR1 respectivelyGramine is also a human and mouse β2-Adrenergic

agonistreceptor (β2-AR)

Purity 9945Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg

Guanabenz Acetate (BR-750 Wy8678 acetate) Cat No HY-B0566

Guanabenz (Acetate) (BR-750) is an alpha-2selective adrenergic agonist used as anantihypertensive agent

Purity 9888Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg

GuanfacineCat No HY-17416A

Guanfacine is a selective α2A receptor agonistTarget α2A Receptor Guanfacine is asympatholytic It is a selective α2A receptoragonist

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Guanfacine hydrochlorideCat No HY-17416

Guanfacine hydrochloride an anti-hypertensiveagent is a selective α2A-adrenoceptor agonistwith Kd of 31 nM and displays 60-fold selectivityover α2B-adrenoceptors IC50 Value 31 nM(Kd)Target Adrenergic Receptor Guanfacine is asympatholytic

Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Guanoxabenz (Hydroxyguanabenz) Cat No HY-U00123

Guanoxabenz is an α2 adrenergic receptoragonist

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Higenamine (Norcoclaurine) Cat No HY-N2037

Higenamine (Norcoclaurine) a β2-AR agonist is akey component of the Chinese herb aconite rootthat prescribes for treating symptoms of heartfailure in the oriental Asian countriesHigenamine (Norcoclaurine) has anti-apoptoticeffects

Purity gt98Clinical Data Phase 1Size 5 mg 10 mg 20 mg

Higenamine hydrochloride (Norcoclaurine hydrochloride) Cat No HY-N2037A

Higenamine hydrochloride (Norcoclaurinehydrochloride) a agonist is a keyβ2-ARcomponent of the Chinese herb aconite root thatprescribes for treating symptoms of heart failurein the oriental Asian countries

Purity 9904Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg

HOKU-81 (4-Hydroxytulobuterol) Cat No HY-50291

HOKU-81 a new bronchodilator is one of themetabolites of tulobuterol IC50 Value TargetAdrenergic Receptor Effects of HOKU-81 on isolatedtrachea and atria of guinea pigs were comparedwith those of various bronchodilators

Purity gt950Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 25 mg

Hydrocortisone 17-butyrate (Cortisol 17-butyrate Hydrocortisone butyrate) Cat No HY-B0983

Hydrocortisone 17-butyrate is an adrenocorticohormone

Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 200 mg

HydroxybupropionCat No HY-100637

Hydroxybupropion is the major active metabolite ofBupropion Hydroxybupropion is metabolized byCYP2B6Bupropion is an atypical antidepressant andsmoking-cessation agent Hydroxybupropion inhibits

with an value of 17norepinephrine uptake IC50

μM

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

ICI 118551 hydrochloride (ICI 118551 hydrochloride) Cat No HY-13951

ICI 118551 (hydrochloride) is a highly selective antagonist with s ofβ2 adrenergic receptor Ki

07 495 and 611 nM for β2 β1 and β3 receptorsrespectively

Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Idazoxan hydrochloride (RX 781094 hydrochloride) Cat No HY-14561A

Idazoxan hydrochloride (RX 781094 hydrochloride)is an antagonist and is also aα -adrenoceptor2

antagonistimidazoline receptors (IRs)competitively antagonized the centrally inducedhypotensive effect of imidazoline-like drugs(IMs)

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Imoxiterol (RP 58802B) Cat No HY-101585

Imoxiterol (RP 58802B) is a agonistβ-adrenergic

Purity gt980Clinical Data No Development ReportedSize 1 mg

IndacaterolCat No HY-14299

Indacaterol(Onbrez Arcapta) is anultra-long-acting β-adrenoceptor agonist IC50value Target β-adrenoceptor Indacaterol inhibitscAMP production in Chinese hamster ovary cellsstably transfected with human β2 adrenoceptorswith pEC50 of 806

Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Indacaterol maleate (QAB149) Cat No HY-14299A

Indacaterol (QAB149) maleate is anultra-long-acting β-adrenoceptor agonist

Purity 9992Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

IndanidineCat No HY-101717

Indanidine is an agonistalpha-adrenergic

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Indoramin D5 (Indoramine D5 Wy-21901 D5) Cat No HY-12760S

Indoramin D5 is deuterium labeled Indoramin whichis a piperidine antiadrenergic agent

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) Cat No HY-N0761

Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid)is a cinnamic acid derivative that hasantidiabetic activity Isoferulic acid binds toand activates α1-adrenergic receptors (IC =14 microM)50

to enhance secretion of β-endorphin (EC =52250

nM) and increase glucose use

Purity 9982Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg

Isoprenaline hydrochloride (Isoproterenol hydrochloride) Cat No HY-B0468

Isoprenaline hydrochloride is a non-selective agonist with potentbeta-adrenergic receptor

peripheral vasodilator bronchodilator andcardiac stimulating activities

Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 200 mg 1 g

Isoxsuprine hydrochlorideCat No HY-B1270

Isoxsuprine hydrochloride is a beta-adrenergic agonist with s of 1365 μΜ and 348 μΜreceptor Ki

for myometrial and placcntal beta-adrenergicreceptor respectively Isoxsuprine hydrochlorideis also a antagonistNMDA receptor

Purity 9887Clinical Data No Development ReportedSize 200 mg

wwwMedChemExpresscom 13

Ivabradine D3 HydrochlorideCat No HY-B0162AS1

Ivabradine D3 Hydrochloride is the deuteriumlabeled Ivabradine hydrochloride Ivabradinehydrochloride is a new I inhibitor with IC of 29f 50

μM and used as a pure heart rate lowering agent

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Ivabradine D6 hydrochlorideCat No HY-B0162AS

Ivabradine D6 hydrochloride is the deuteriumlabeled Ivabradine hydrochloride Ivabradinehydrochloride is a new I inhibitor with IC of 29f 50

μM and used as a pure heart rate lowering agent

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Ivabradine hydrochlorideCat No HY-B0162A

Ivabradine hydrochloride is an orallybioavailable hyperpolarization-activated cyclicnucleotide-gated ( ) channel blockerHCN

Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg

JP1302 dihydrochlorideCat No HY-103213

JP1302 dihydrochloride is a selective highaffinity antagonist of the alpha2C-adrenoceptor

with a value(α -adrenoceptor)2C Kb

(antagonist activity) of 16 nM and a K (bindingi

affinity) value of 28 nM

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Ko-3290Cat No HY-101721

Ko-3290 is an antagonist of withβ-adrenoceptorcardioselectivity and antilipolytic effects inanimals

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

KUL-7211 racemateCat No HY-19673A

KUL-7211 racemate is the racemate of KUL-7211KUL-7211 is a selective agonistβ-adrenoceptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

L-(-)-α-Methyldopa (MK-351 Methyldopa) Cat No HY-B0225

Methyldopa is an alpha-adrenergic agonist(selective for α2-adrenergic receptors)psychoactive drug used as a sympatholytic orantihypertensive

Purity gt98Clinical Data LaunchedSize 500 mg

L-(-)-α-Methyldopa (hydrate) (MK-351 hydrate Methyldopa hydrate) Cat No HY-B0225B

L-(-)-α-Methyldopa hydrate is an alpha-adrenergicagonist (selective for α2-adrenergic receptors)psychoactive drug used as a sympatholytic orantihypertensive

Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g

L-(-)-α-Methyldopa hydrochloride (MK-351 hydrochloride Methyldopa hydrochloride) Cat No HY-B0225A

L-(-)-α-Methyldopa hydrochloride is analpha-adrenergic agonist (selective forα2-adrenergic receptors) psychoactive drug used asa sympatholytic or antihypertensive

Purity gt98Clinical Data LaunchedSize 500 mg

L-765314Cat No HY-101385

L-765314 is a potent and selective α1b adrenergic antagonist with s of 54 nM and 20 nMreceptor Ki

for rat and human α1b adrenergic receptorrespectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

L-771688Cat No HY-U00237

L-771688 is a highly selective α1A-Adrenoceptorantagonist with a of 043plusmn002 nMKi

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

L-Epinephrine Bitartrate ((-)-Epinephrine (+)-bitartrate

salt L-Adrenaline (+)-bitartrate salt) Cat No HY-B0447A

L-Epinephrine bitartrate is an andα-adrenergic receptor agonist L-Epinephrine is aβ-adrenergic

hormone secreted by the medulla of the adrenalglands

Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g

L755507Cat No HY-19334

L755507 is a potent selective agonist of β -AR3

with an of 35 nMIC50

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg

Labetalol hydrochloride (AH-5158 hydrochloride Sch-15719W) Cat No HY-B1108

Labetalol hydrochloride is a mixed alphabetaadrenergic antagonist that is used to treat highblood pressure

Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 100 mg

Landiolol hydrochloride (ONO1101 hydrochloride) Cat No HY-100607A

Landiolol hydrochloride (ONO1101 hydrochloride) isa highly beta1 selective ultra-short acting

-blocker (β1β2 selectivity=2551 abetahalf-life of 4min) acts as an adrenoceptorantagonist

Purity 9996Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg

Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat No HY-14537

Latrepirdine dihydrochloride is a neuroactivecompound with antagonist activity athistaminergic α-adrenergic and serotonergicreceptors Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and

( ) secretionamyloid-β Aβ

Purity 9975Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg 200 mg

Levalbuterol ((R)-Albuterol (R)-Salbutamol Levosalbutamol) Cat No HY-B1675

Levalbuterol ((R)-Albuterol (R)-Salbutamol) is ashort-acting agonistβ2-adrenergic receptorand the active (R)-enantiomer of SalbutamolLevalbuterol is a more potent bronchodilator thanSalbutamol and has the potential for the treatmentof COPDltbrgt

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Levalbuterol tartrate (Levosalbutamol tartrate) Cat No HY-17457

Levosalbutamol tartrate(levalbuterol) is theR-enantiomer of the short-acting β2-adrenergicreceptor agonist salbutamol IC50 Value Targetβ2-adrenergic receptor Levosalbutamol andsalbutamol produced significantly betterbronchodilator responses than placebo

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Levobetaxolol hydrochloride ((S)-Betaxolol hydrochloride AL-1577A) Cat No HY-B0381B

Levobetaxolol hydrochloride is a beta-adrenergicreceptor inhibitor (beta blocker) used to lowerthe pressure in the eye in treating conditionssuch as glaucoma

Purity 9811Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Lidanserin (ZK-33839) Cat No HY-101815

Lidanserin (ZK-33839) acts as a and5-HT2A

antagonistα -adrenergic receptor1

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg

wwwMedChemExpresscom 15

LofexidineCat No HY-B1052A

Lofexidine is a selective agonistα2-receptorcommonly used to alleviate the physical symptomsof heroin and other types of opioid withdrawal

Purity 9908Clinical Data LaunchedSize 10 mM times 1 mL 50 mg

Lofexidine hydrochloride (Baq-168 MDL-14042) Cat No HY-B1052

Lofexidine (hydrochloride) is a selective agonist commonly used to alleviateα2-receptor

the physical symptoms of heroin and other types ofopioid withdrawal

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Lusaperidone (R107474) Cat No HY-U00117

Lusaperidone (R107474) is an α2 adrenergic antagonist with s of 013 and 015 nMreceptor Ki

for α2A and α2C respectively

Purity 9774Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg

LY377604Cat No HY-13713

LY377604 is a human β -adrenergic receptor3

agonist with an of 24 nM and also a -EC50 β1

and - antagonistβ2 adrenergic receptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Mebeverine D6 HydrochlorideCat No HY-A0078S

Mebeverine D6 Hydrochloride is the deuteriumlabeled Mebeverine which is an antimuscarinic

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Mebeverine metabolite O-desmethyl Mebeverine alcohol (O-desmethyl Mebeverine alcohol) Cat No HY-G0008

Mebeverine metabolite O-desmethyl Mebeverinealcohol is a metabolite of Mebeverine which is apotent inhibitor causing relaxationα1 repectorof the gastrointestinal tract

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

MedetomidineCat No HY-17034

Medetomidine(Domtor) is a potent highly selectiveα2-adrenoceptor agonist (Ki values are 108 and1750 nM for α2- and α1-adrenoceptorsrespectively)

Purity 9997Clinical Data LaunchedSize 5 mg 10 mg 50 mg

Medetomidine hydrochloride (MPV785) Cat No HY-17034B

Medetomidine hydrochloride is an agonist ofadrenergic alpha-2 receptor which is used inveterinary medicine for its analgesic and sedativeproperties

Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

Metaproterenol (Orciprenaline) Cat No HY-B1276A

Metaproterenol (Orciprenaline) is a direct-actingsympathomimetic and a β2-adrenergic receptor (β2AR)agonist with an of 68 nM MetaproterenolIC50

also has anti-inflammatory activity

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Metaproterenol hemisulfate (Orciprenaline hemisulfate) Cat No HY-B1276

Metaproterenol hemisulfate (Orciprenalinehemisulfate) is a direct-acting sympathomimeticand a agonist withβ2-adrenergic receptor (β2AR) an of 68 nM Metaproterenol hemisulfate alsoIC50

has anti-inflammatory activity

Purity 9986Clinical Data No Development ReportedSize 10 mM times 1 mL 50 mg 100 mg

16 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Metipranolol hydrochlorideCat No HY-16316

Metipranolol hydrochloride is a non-selective β blocking agentadrenergic receptor

Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

MetoprololCat No HY-17503

Metoprolol (Toprol) is a selective β1 receptorblocker used in treatment of several diseases ofthe cardiovascular system especiallyhypertension IC50 value Target β1 receptor

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Metoprolol SuccinateCat No HY-17503A

Metoprolol Succinate (Toprol XL) is a selective β1receptor blocker used in treatment of severaldiseases of the cardiovascular system especiallyhypertension IC50 value Target β1 receptor

Purity 9954Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg

Metoprolol TartrateCat No HY-17503B

Metoprolol is a cardioselective β1-adrenergicblocking agent Target β1- adrenergic ReceptorPatients took 50 mg metoprolol twice daily withweekly titration to response or 200 mg twicedaily

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

MG 1Cat No HY-U00110

MG 1 is an α1 antagonistadrenergic receptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Midaglizole hydrochloride ((plusmn)-DG5128 DG5128) Cat No HY-U00165

Midaglizole hydrochloride (DG5128) is apreferential antagonistα2-adrenoceptorMidaglizole hydrochloride (DG5128) exhibits 74times higher affinity ( =628) towardpKi

α2-adrenoceptor than α1-adrenoceptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Mirabegron (YM178) Cat No HY-14773

Mirabegron is a selective β -adrenoceptor3

agonist with of 224 nMEC50

Purity 9908Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Moxisylyte hydrochloride (Thymoxamine hydrochloride) Cat No HY-B1435

Moxisylyte (hydrochloride) is (alpha 1-blocker)antagonist it can vasodilates cerebral vesselswithout reducing blood pressure It is also usedlocally in the eye to reverse the mydriasis causedby phenylephrine and other sympathomimetic agents

Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 1 g

Nadolol (SQ-11725) Cat No HY-B0804

Nadolol (SQ-11725) is a non-selective and orallyactive blocker and is aβ-adrenergic receptorssubstrate of organic anion transportingpolypeptide 1A2 (OATP1A2) Nadolol has the thepotential for high blood pressure angina pectorisand vascular headaches research

Purity gt98Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 250 mg 500 mg

Nadolol D9 (SQ-11725 D9) Cat No HY-B0804S

Nadolol D9 (SQ-11725 D9) is the deuterium labeledNadolol Nadolol is a non-selective and orallyactive blockerβ-adrenergic receptors

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

wwwMedChemExpresscom 17

Naftopidil (KT-611 BM-15275) Cat No HY-B0391

Naftopidil (Flivas) a selective α1-adrenergicreceptor antagonist or alpha blocker is anantihypertensive drug

Purity 9883Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g

NaminterolCat No HY-101822

Naminterol is a phenethanolamine derivative is a agonist with bronchodilatoryβ adrenoceptor2

properties Naminterol is used for treatment ofasthma

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Naphazoline hydrochlorideCat No HY-B0446

Naphazoline hydrochloride is an ocularvasoconstrictor and imidazoline derivativesympathomimetic amine Target Adrenergic ReceptorNaphazoline hydrochloride is the common name for2-(1-naphthylmethyl)-2-imidazoline hydrochloride

Purity 9856Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g

Nebivolol (R 065824) Cat No HY-B0203

Nebivolol selectively inhibits β1- adrenergicreceptor with IC50 of 08 nM Target β1-adrenergic receptor Nebivolol reduces cellproliferation of human coronary smooth musclecells (haCSMCs) and endothelial cells (haECs) in aconcentration- and time-dependent maner

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Nebivolol hydrochloride (R 065824 hydrochloride) Cat No HY-B0203A

Nebivolol hydrochloride selectively inhibits β1-adrenergic receptor with IC50 of 08 nM Targetβ1- adrenergic receptor Nebivolol reduces cellproliferation of human coronary smooth musclecells (haCSMCs) and endothelial cells (haECs) in aconcentration- and time-dependent maner

Purity 9873Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 500 mg

Nefazodone hydrochloride (BMY-13754 MJ-13754-1) Cat No HY-B1396

Nefazodone hydrochloride is an antidepressantdrug

Purity 9971Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

NicergolineCat No HY-B0702

Nicergoline is an ergot derivative used to treatsenile dementia and other disorders with vascularorigins Target Alpha-1A adrenergic receptorNicergoline acts by inhibiting the postsynapticalpha(1)-adrenoceptors on vascular smooth muscle

Purity 9906Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

Norepinephrine (Levarterenol L-Noradrenaline) Cat No HY-13715

Norepinephrine (Levarterenol L-Noradrenaline) isa -selective agonist withβ1 adrenergic receptor

of 537 μMEC50

Purity 9808Clinical Data LaunchedSize 10 mM times 1 mL 500 mg

Norepinephrine bitartrate monohydrate (Levarterenol

bitartrate monohydrate hellip) Cat No HY-13715B

Norepinephrine bitartrate monohydrate(Levarterenol bitartrate monohydrateL-Noradrenaline bitartrate monohydrate) is a

-selective agonist withβ1 adrenergic receptor of 537 μMEC50

Purity 9975Clinical Data LaunchedSize 500 mg 1 g 5 g

Norepinephrine hydrochloride (Levarterenol hydrochloride

L-Noradrenaline hydrochloride) Cat No HY-13715A

Norepinephrine hydrochloride (Levarterenolhydrochloride) is a -selective β1 adrenergic

agonist with of 537 μMreceptor EC50

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

18 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

NRA-0160Cat No HY-101641

NRA-0160 is a selective dopamine D4 receptorantagonist with a value of 048 nM and withKi

negligible affinity for dopamine D2 receptor( gt10000 nM) ( 39 nM) ratKi D3 receptor Ki

( 180 nM) and rat 5-HT2A receptor Ki α1 ( 237 nM)adrenoceptor Ki

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Octopamine hydrochloride ((plusmn)-p-Octopamine hydrochlorid) Cat No HY-B0528A

Octopamine hydrochloride ((plusmn)-p-Octopaminehydrochlorid) is an endogenous biogenic amine thatis closely related to norepinephrine and haseffects on the adrenergic and dopaminergicsystems

Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 500 mg 1 g 5 g

Olanzapine (LY170053) Cat No HY-14541

Olanzapine (LY170053) is a selective monoaminergicantagonist with high affinity binding to serotonin

( =7 4 11 57 and 5H1 5HT2A2C 5HT3 5HT6 Ki

nM respectively) ( =11 to 31dopamine D1-4 Ki

nM) ( =19-25 nM) andmuscarinic M1-5 Ki

( =19 nM)adrenergic α1 receptor Ki

Purity 9994Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg

Olanzapine D3 (LY170053 D3) Cat No HY-14541S

Olanzapine D3 (LY170053 D3) is the deuteriumlabeled Olanzapine

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

OPC-28326Cat No HY-101610

OPC-28326 is a selective peripheral vasodilatorand an angatonist of withα2-adrenergic receptor

of 2040 285 and 55nM for α2A- α2B- andKi

α2C-adrenoceptors respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Oxprenolol hydrochloride (Ba 39089) Cat No HY-B1486

Oxprenolol hydrochloride (Ba 39089) is an orallybioavailable receptor ( )β-adrenergic β-ARantagonist with a of 710 nM in a radioligandKi

binding assay using rat heart muscle

Purity 9986Clinical Data LaunchedSize 10 mM times 1 mL 100 mg

Paliperidone (9-Hydroxyrisperidone) Cat No HY-A0019

Paliperidone (9-Hydroxyrisperidone) the majoractive metabolite of Risperidone is a dopamine

antagonist and antagonistD2 5-HT2APaliperidone is also active as an antagonist at

and receptors andα1 α2 adrenergic receptorsH1-histaminergic

Purity 9987Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg

PamatololCat No HY-U00019

Pamatolol is a cardioselective beta-adrenoceptorantagonist without sympathomimetic activity

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox (SLV-308) is a partial dopamine D2and partial agonist and a D3 receptor serotonin

agonist with s of 8 925-HT1A receptor pEC50

and 63 respectively

Purity gt98Clinical Data Phase 3Size 1 mg 5 mg

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

Pardoprunox (SLV-308) hydrochloride is a partial and partial agonistdopamine D2 D3 receptor

and a agonist withserotonin 5-HT1A receptors of 8 92 and 63 respectivelypEC50

Purity 9824Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

wwwMedChemExpresscom 19

Pargolol hydrochloride (Ko 1400 hydrochloride) Cat No HY-101658

Pargolol hydrochloride is a β adrenergic antagonistreceptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Penbutolol sulfate ((-)-Terbuclomine) Cat No HY-B1154

Penbutolol sulfate is able to bind to both beta-1adrenergic receptors and beta-2 adrenergicreceptors (the two subtypes) thus making it anon-selective β blocker Penbutolol is asympathomimetic drugused in the treatment of highblood pressure

Purity 9962Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

PerphenazineCat No HY-A0077

Perphenazine is a typical antipsychotic druginhibits 5-HT receptor Alpha-1A adrenergic2A

receptor Dopamine receptor D2D3 D2L receptorand with values ofHistamine H1 receptor Ki

56 10 0765013 34 and 8 nM respectively

Purity 9990Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g

Perphenazine D8 DihydrochlorideCat No HY-A0077AS

Perphenazine D8 Dihydrochloride is the deuteriumlabeled Perphenazine which is a typicalantipsychotic drug(5-HT Dopamine receptorligand)

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

PF-610355Cat No HY-14296

PF-610355 is a long-acting inhaled agonist with an ofβ -adrenoreceptor2 EC50

026 nM PF-610355 has the potential for the studyof asthma and COPD

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Phenoxybenzamine hydrochlorideCat No HY-B0431A

Phenoxybenzamine hydrochloride is a selectiveantagonist of both andα-adrenoceptor

that is commonly used for thecalmodulintreatment of hypertension specifically caused bypheochromocytoma

Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 200 mg 500 mg 1 g

Phentolamine mesylate (Phentolamine methanesulfonate) Cat No HY-B0362A

Phentolamine mesylate is a competitive reversible antagonist with an between 5α-adrenoceptor IC50

and 30 nM

Purity 9983Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Phenylephrine ((R)-(-)-Phenylephrine L-Phenylephrine) Cat No HY-B0769

(R)-(-)-Phenylephrine is a selective agonist primarily used as aα -adrenoceptor1

decongestant

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Phenylephrine hydrochloride ((R)-(-)-Phenylephrine

hydrochloride L-Phenylephrine hydrochloride) Cat No HY-B0471

(R)-(-)-Phenylephrine hydrochloride is a selective agonist with of 586 487α -adrenoceptor1 pK si

and 470 for α α and α receptors1D 1B 1A

respectively

Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Phenylethanolamine ACat No HY-131103

Phenylethanolamine A acts as a β-adrenergicagonist Phenylethanolamine A is a byproductduring the Ractopamine synthesis process

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

20 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Phenylethanolamine A-D3Cat No HY-131103S

Phenylethanolamine A-D3 is a deuterium labeledPhenylethanolamine A Phenylethanolamine A acts asa β-adrenergic agonist Phenylethanolamine A is abyproduct during the Ractopamine synthesisprocess

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Pimozide (R6238) Cat No HY-12987

Pimozide is a antagonistdopamine receptorwith s of 14 nM 25 nM and 588 nM for dopamineKi

D2 D3 and D1 receptors respectively and alsohas affinity at with a of 39α1-adrenoceptor Ki

nM Pimozide also inhibits and STAT3 STAT5

Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 50 mg

Pimozide D4 (R6238 D4) Cat No HY-12987S

Pimozide D4 (R6238 D4) is a deuterium labeledPimozide

Purity gt98Clinical Data Phase 4Size 1 mg 5 mg

Pindolol (LB-46) Cat No HY-B0982

Pindolol (LB-46) is a nonselective β-blocker withpartial beta-adrenergic receptor agonist activityalso functions as a 5-HT1A receptor weak partialantagonist (Ki=33nM)

Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg

Piperoxan hydrochloride (Benodaine hydrochloride) Cat No HY-100850

Piperoxan hydrochloride is an α adrenoceptor2

antagonist

Purity 9939Clinical Data No Development ReportedSize 10 mM times 1 mL 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

PiribedilCat No HY-12707

Piribedil is a ( )dopamine D receptor2 D R2

agonist which also displays antagonist property at ( )hα -adrenoceptor1A hα -AR1A

Purity 9990Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg 500 mg

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Piribedil D8 is the deuterium labeled Piribedilwhich is an antiparkinsonian agent

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

PrazosinCat No HY-B0193

Prazosin is an alpha-adrenergic blocker and is asympatholytic drug used to treat high bloodpressure and anxiety PTSD and panic disorderTarget Adrenergic Receptor Prazosin is asympatholytic drug used to treat high bloodpressure and anxiety PTSD andpanic disorder

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Prazosin hydrochlorideCat No HY-B0193A

Prazosin hydrochloride is an alpha-adrenergicblocker and is a sympatholytic drug used to treathigh blood pressure and anxiety PTSD and panicdisorder

Purity 9973Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 200 mg 500 mg

Pronethalol ((plusmn)-Pronethalo) Cat No HY-B1238

Pronethalol is a non-selective beta-adrenergicblocking agent protect against and to reverseDigitalis-induced ventricular arrhythmias Targetbeta-adrenergic receptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

wwwMedChemExpresscom 21

PropranololCat No HY-B0573B

Propranolol is a nonselective β-adrenergic receptor antagonist has high affinity for the β1AR(βAR)

and β2AR with values of 18 nM and 08 nMKi

respectively Propranolol inhibits [ H]-DHA3

binding to rat brain membrane preparation with an of 12 nMIC50

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Propranolol D7 hydrochlorideCat No HY-B0573S

Propranolol D7 hydrochloride is a deuteriumlabeled Propranolol hydrochloride Propranololhydrochloride is a nonselective β-adrenergic

antagonist has high affinity forreceptor (βAR)the β1AR and β2AR with values of 18 nM and 08Ki

nM respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Propranolol hydrochlorideCat No HY-B0573

Propranolol hydrochloride is a nonselective antagonist has highβ-adrenergic receptor (βAR)

affinity for the β1AR and β2AR with values ofKi

18 nM and 08 nM respectively

Purity 9979Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 1 g

QF0301BCat No HY-101690

QF0301B is an antagonistα1 adrenergic receptorand a low α2 adrenoceptor 5-HT2A and histamineH1 receptor blocker

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Rauwolscine hydrochloride (α-Yohimbine hydrochloride

Corynanthidine hydrochloride Isoyohimbine hydrochloride) Cat No HY-12710A

Rauwolscine hydrochloride is a potent and specific receptor antagonist with a of 12α2 adrenergic Ki

nM

Purity 9995Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg

Ritanserin (R 55667) Cat No HY-10791

Ritanserin (R 55667) is a highly potentrelatively selective orally active long actingantagonist of with an of5-HT receptor2 IC50

09 nM less active on Histamine H Dopamine1

D Adrenergic α Adrenergic α receptors2 1 2

Purity gt990Clinical Data Phase 2Size 10 mM times 1 mL 5 mg

Ritodrine hydrochloride (DU21220 hydrochloride) Cat No HY-B0452

Ritodrine hydrochloride (DU21220 hydrochloride) isa β-2 adrenergic receptor agonist Target β-2Adrenergic Receptor Ritodrine is a tocolytic drugused to stop premature labor

Purity 9901Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Ro 363Cat No HY-123268

Ro 363 is a potent and highly selective agonist RO 363 is an effectiveβ1-adrenoceptor

inotropic stimulant and is a cardiovascularmodulator that reduces diastolic blood pressureand pronounces increases in myocardialcontractility

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine (N-0437 N-0923) is a full agonist of a partial agonist of thedopamine receptor

and an antagonist of the5-HT1A receptor with s of 071nMα2B-adrenergic receptor Ki

4-15nM and 83nM for the dopamine D3 receptorand D2 D5 D4 receptors and dopaminehellip

Purity 9998Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Rotigotine Hydrochloride (N-0923 Hydrochloride) Cat No HY-A0007

Rotigotine Hydrochloride (N-0923 Hydrochloride) isa full agonist of a partialdopamine receptoragonist of the and an5-HT1A receptorantagonist of the with α2B-adrenergic receptor Ki

of 071nM 4-15nM and 83nM for the dopamine D3receptor and D2 D5 D4 receptors and dopaminehellip

Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg

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RS 17053 hydrochloride (RS-17053) Cat No HY-101336

RS 17053 hydrochloride is a potent and selective antagonist with a valueα1 adrenoceptorA pKi

of 91 in native cell membrane and a valuepA2

of 98 in functional assays

Purity 9925Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Salbutamol (Albuterol AH-3365) Cat No HY-B1037

Salbutamol is a short-acting β2-adrenergicreceptor agonist used for the relief ofbronchospasm in conditions such as asthma andchronic obstructive pulmonary disease (COPD)

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Salbutamol hemisulfate (Albuterol hemisulfate AH-3365 hemisulfate) Cat No HY-B0436

Salbutamol Hemisulfate (Albuterol hemisulfate) isa short-acting β2 adrenergic receptor agonistTarget β2 Adrenergic Receptor SalbutamolHemisulfate (Albuterol hemisulfate) is ashort-acting selective beta2-adrenergic receptoragonist used in the treatment of asthma andhellip

Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Salmeterol (GR33343X) Cat No HY-14302

Salmeterol is a long-acting beta2-adrenergicreceptor (beta 2AR) agonist used clinically totreat asthma

Purity 9968Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Salmeterol xinafoate (GR 33343X xinafoate) Cat No HY-17453

Salmeterol xinafoate is a long-acting beta-2adrenergic receptor ( ) agonist with ofβ AR2 Ki

15 nM for WT β AR and used for asthma2

treatment

Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 200 mg

Salmeterol-D3Cat No HY-135119

Salmeterol-D3 is the deuterium labeled Salmeterol(HY-14302) Salmeterol is a long-acting

agonist that is used forbeta2-adrenergic receptorthe study of asthma and chronic obstructivepulmonary disease (COPD)

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Scopine (67-Epoxytropine) Cat No HY-B0459

Scopine is the metabolite of anisodine which is aα1-adrenergic receptor agonist and used in thetreatment of acute circulatory shock

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Scopine hydrochloride (67-Epoxytropine hydrochloride) Cat No HY-B0459A

Scopine hydrochloride (67-Epoxytropinehydrochloride) is the metabolite of anisodinewhich is a α1-adrenergic receptor agonist and usedin the treatment of acute circulatory shock

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Sertindole (Lu 23-174) Cat No HY-14543

Sertindole a neuroleptic is one of the newerantipsychotic medications available TargetMulti-target In vitro studies showed thatsertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergicreceptors

Purity 9976Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

Setiptiline (Org-8282) Cat No HY-32329

Setiptiline (Org-8282) is a serotonin receptorantagonist Setiptiline is a tetracyclicantidepressant (TeCA) which acts as anoradrenergic and specific serotonergicantidepressant (NaSSA)

Purity 9654Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg 200 mg

wwwMedChemExpresscom 23

Silodosin (KAD 3213 KMD 3213) Cat No HY-10122

Silodosin (KAD 3213 KMD 3213) is a potentselective and orally active α1A-adrenergic receptor

blocker(α1A-AR)

Purity 9996Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Solabegron (GW 427353) Cat No HY-19436

Solabegron (GW 427353) is a selective agonist stimulating cAMPβ -adrenergic receptor3

accumulation in Chinese hamster ovary cellsexpressing the human β -AR with an value3 EC50

of 22 nM

Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg

Sotalol D6 hydrochlorideCat No HY-B0437AS

Sotalol D6 hydrochloride is a deuterium labeledSotalol hydrochloride Sotalol hydrochloride is anon-selective competitive β-adrenergic receptorantagonist that also exhibits Class IIIantiarrhythmic properties by its inhibition of

potassium channels

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Sotalol hydrochloride (MJ 1999) Cat No HY-B0437

Sotalol hydrochloride (MJ 1999) is a non-selectivecompetitive antagonist thatβ-adrenergic receptoralso exhibits Class III antiarrhythmic propertiesby its inhibition of potassium channels

Purity 9977Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 200 mg 500 mg 1 g

Spirendolol (Li 32-468 S 32-468 Substance 32468) Cat No HY-101817

Spirendolol is a β adrenergic receptorantagonist

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

SR59230ACat No HY-100672

SR59230A is a potent selective and blood-brainbarrier penetrating β3-adrenergic receptorantagonist with s of 40 408 and 648 nM forIC50

β3 β1 and β2 receptors respectively

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

SR59230A hydrochlorideCat No HY-103200

SR59230A hydrochloride is a potent selective andblood-brain barrier penetrating β3-adrenergic

antagonist with s of 40 408 andreceptor IC50

648 nM for β3 β1 and β2 receptors respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Synephrine (Oxedrine) Cat No HY-N0132

Synephrine (Oxedrine) is an andα-adrenergic agonist derived from the β-adrenergic Citrus

it has sympathomimetic andaurantiumstructural similarities to ephedra and ephedrinealkaloids

Purity gt98Clinical Data No Development ReportedSize 5 mg

Synephrine hydrochloride (Oxedrine hydrochloride) Cat No HY-N0132A

Synephrine hydrochloride (Oxedrine hydrochloride)is an and agonist derivedα-adrenergic β-adrenergicfrom the it hasCitrus aurantiumsympathomimetic and structural similarities toephedra and ephedrine alkaloids

Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg 500 mg

Talipexole dihydrochloride (B-HT 920 dihydrochloride) Cat No HY-A0008

Talipexole dihydrochloride (B-HT 920dihydrochloride) is a dopamine D2 receptoragonist α2-adrenoceptor agonist and 5-HT3receptor antagonist which displaysantiParkinsonian activity

Purity 9999Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

24 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

TamsulosinCat No HY-B0661

Tamsulosin is a selective α1 receptor antagonistTarget α1 receptor Tamsulosin is a selective α1receptor antagonist that has preferentialselectivity for the α1A receptor in the prostateversus the α1B receptor in the blood vessels

Purity 9962Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Tamsulosin hydrochloride ((R)-(-)-YM12617 LY253351) Cat No HY-B0661A

Tamsulosin hydrochloride((R)-(-)-YM12617LY253351)is a selective α1 receptor antagonist Target α1receptor Tamsulosin is a selective α1 receptorantagonist that has preferential selectivity forthe α1A receptor in the prostate versus the α1Breceptor in the blood vessels

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

TD-5471 hydrochlorideCat No HY-19942A

TD-5471 hydrochloride is a potent and selectivefull agonist of the human β -adrenoceptor2

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) Cat No HY-101755

Tedatioxetine hydrobromide acts as a triplereuptake inhibitor and 5-HT2A 5-HT2C 5-HT3

and antagonistα -adrenergic receptor1A

Purity 9844Clinical Data Phase 2Size 1 mg 5 mg

TeoprololCat No HY-U00016

Teoprolol is a blockerβ-adrenergic receptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

TerazosinCat No HY-B0371

Terazosin is a quinazoline derivative and acompetitive and orally active α1-adrenoceptorantagonist Terazosin works by relaxing bloodvessels and the opening of the bladder Terazosinhas the potential for benign prostatic hyperplasia(BPH) and high blood pressure treatment

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Terazosin hydrochlorideCat No HY-B0371F

Terazosin hydrochloride is a quinazolinederivative and a competitive and orally active

antagonist Terazosinα1-adrenoceptorhydrochloride works by relaxing blood vessels andthe opening of the bladder

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Terazosin hydrochloride dihydrateCat No HY-B0371A

Terazosin hydrochloride dihydrate is a quinazolinederivative and a competitive and orally active

antagonist Terazosinα1-adrenoceptorhydrochloride dihydrate works by relaxing bloodvessels and the opening of the bladder

Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 100 mg

Terbutaline sulfate (Terbutaline hemisulfate) Cat No HY-B0802

Terbutaline sulfate is a β2-adrenergic receptoragonist a fast-acting bronchodilator and atocolytic to delay premature labor

Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g

Tertatolol ((plusmn)-Tertatolol Racemic Tertatolol dl-Tertatolol) Cat No HY-U00356

Tertatolol is a potent antagonist of and withbeta-adrenoceptor 5-HT receptor

unique renal vasodilatatory effects

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

wwwMedChemExpresscom 25

TetrahydroalstonineCat No HY-N1163

Tetrahydroalstonine a indole alkaloid isolatedfrom the fruits of is a selectiveRhazya stricta

antagonistalpha 2-adrenoceptor

Purity 9995Clinical Data No Development ReportedSize 1 mg 5 mg

Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride) Cat No HY-B0556A

Tetrahydrozoline (hydrochloride) is aα-adrenoceptor agonist Target α-adrenoceptorahydrozoline is an imidazoline derivative withalpha receptor agonist activity widely availablein over-the-counter topical ocular and nasalformulations

Purity 9990Clinical Data LaunchedSize 10 mM times 1 mL 500 mg

Tiodazosin (BL-5111) Cat No HY-100255

Tiodazosin is a potent competitive postsynaptic antagonistalpha adrenergic receptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

TizanidineCat No HY-B0194

Tizanidine is an α2-adrenergic receptor agonistand inhibits neurotransmitter release from CNSnoradrenergic neurons Target α2-adrenergicreceptor Tizanidine is a drug that is used as amuscle relaxant It is a centrally acting α2adrenergic agonist

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Tizanidine hydrochlorideCat No HY-B0194A

Tizanidine hydrochloride is an α2-adrenergicreceptor agonist and inhibits neurotransmitterrelease from CNS noradrenergic neurons Targetα2-adrenergic receptor Tizanidine is a drug thatis used as a muscle relaxant It is a centrallyacting α2 adrenergic agonist

Purity 9948Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Todralazine (Ecarazine) Cat No HY-B1001

Todralazine (Ecarazine) is an anti-hypertensiveagent acts as a blocker with antioxidantβ AR2

and free radical scavenging activity

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Todralazine hydrochloride (Ecarazine hydrochloride) Cat No HY-B1001A

Todralazine hydrochloride (Ecarazinehydrochloride) is an anti-hypertensive agent actsas a blocker with antioxidant and freeβ AR2

radical scavenging activity

Purity 9817Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Tolazoline (Imidaline NSC35110) Cat No HY-A0066

Tolazoline(Imidaline) is a non-selectivecompetitive α-adrenergic receptor antagonist

Purity gt98Clinical Data No Development ReportedSize 500 mg

Tolazoline hydrochloride (Imidaline hydrochloride NSC35110 hydrochloride) Cat No HY-A0066A

Tolazoline (hydrochloride)(Imidaline(hydrochloride)) Hcl is a non-selectivecompetitive α-adrenergic receptor antagonist

Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g

Trifluoperazine D8Cat No HY-B0532S

Trifluoperazine D8 is a deuterium labeledTrifluoperazine Trifluoperazine is anantipsychotic phenothiazine agent and a selective

antagonist Trifluoperazineα1-adrenergic receptoris also a potent dopamine D2 receptorinhibitor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

26 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Trifluoperazine dihydrochloride (TFP) is anantipsychotic phenothiazine agent and a selective

antagonist Trifluoperazineα1-adrenergic receptordihydrochloride is also a potent dopamine D2

inhibitorreceptor

Purity gt990Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Tropodifene (Tropaphen) Cat No HY-U00313

Tropodifene (Tropaphen) is an α-Adrenergic receptorinhibitor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Tulobuterol (C-78 free base) Cat No HY-B1810

Tulobuterol (C-78 free base) is a long-acting agonist which reduces theβ -adrenoceptor2

frequency of exacerbations of chronic obstructivepulmonary disease and bronchial asthma

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Tulobuterol hydrochloride (C-78) Cat No HY-W011733

Tulobuterol hydrochloride (C-78) is a long-actingβ -adrenoceptor2 agonist which reduces thefrequency of exacerbations of chronic obstructive

pulmonary disease and bronchial asthma

Purity 9982Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 100 mg 500 mg

Ulimorelin (TZP-101) Cat No HY-14903

Ulimorelin (TZP-101) is a ghrelin receptor (GRLN)agonist with an of 29 nM and a of 16 nMEC50 Ki

Ulimorelin is a prokinetic agent and causesvasorelaxation through competitive antagonistaction at Ulimorelin stimulatesα1-adrenoceptorsintestinal motility and is used for malnutrition

Purity gt98Clinical Data Phase 3Size 1 mg 5 mg

UrapidilCat No HY-B0716

Urapidil is an antagonist andα1 adrenoreceptora agonist5-HT receptor1A

Purity 9989Clinical Data LaunchedSize 10 mM times 1 mL 50 mg

Urapidil D6Cat No HY-B0716S

Urapidil D6 is a deuterium labeled UrapidilUrapidil is an antagonist and aα1-adrenoreceptor

agonist5-HT receptor1A

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Urapidil hydrochlorideCat No HY-B0354A

Urapidil HCl is an α1-adrenoceptor antagonist and5-HT1A receptor agonist

Purity gt990Clinical Data LaunchedSize 5 mg 10 mg 25 mg

Vanilpyruvic acid (Vanylpyruvic acid) Cat No HY-101416

Vanilpyruvic acid is a catecholamine metaboliteand precursor to vanillactic acid

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg

Vatinoxan hydrochloride (MK-467 hydrochloride L-659066 hydrochloride) Cat No HY-19057A

Vatinoxan hydrochloride (MK-467hydrochlorideL-659066 hydrochloride) is aperipheral antagonistα2 adrenergic receptor

Purity 9928Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg

wwwMedChemExpresscom 27

Vilanterol (GW642444) Cat No HY-14300

Vilanterol (GW642444) is a long-acting (β -AR) agonist with 24 hβ -adrenoceptor2 2

activity The s for β -ARβ -AR andpEC50 2 1

β -AR is 1037plusmn005 698plusmn003 and 736plusmn0033

respectively

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

Vilanterol trifenatate (GW642444 trifenatate) Cat No HY-14300A

Vilanterol trifenatate (GW642444 trifenatate) is along-acting (β -AR) agonistβ -adrenoceptor2 2

with inherent 24-hour activity The s forpEC50

β -AR β -AR and β -AR are 1037 698 and2 1 3

736 respectively

Purity 9902Clinical Data LaunchedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Xylazine (BAY 1470) Cat No HY-B0443

Xylazine (BAY 1470) is a strong α2-adrenergicagonist whose effects are mediated via stimulationof central α2-receptors Xylazine hydrochloride isused as a sedative analgesic and muscle relaxantin veterinary medicine

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Xylazine hydrochloride (BAY 1470 hydrochloride) Cat No HY-B0443A

Xylazine hydrochloride (BAY 1470 hydrochloride) isa strong agonist whose effects areα2-adrenergicmediated via stimulation of central α2-receptorsXylazine hydrochloride is used as a sedativeanalgesic and muscle relaxant in veterinarymedicine

Purity 9990Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg 500 mg

Xylometazoline hydrochlorideCat No HY-B0475

Xylometazoline hydrochloride is an α-adrenoceptoragonist commonly used as nasal decongestant

Purity 9988Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g

YohimbineCat No HY-12715

Yohimbine is a potent and relatively nonselectivealpha 2-adrenergic receptor (AR) antagonist withIC50 of 06 μM

Purity gt98Clinical Data Phase 4Size 500 mg

Yohimbine HydrochlorideCat No HY-N0127

Yohimbine Hydrochloride is an alpha2-adrenoreceptor antagonist blocking the pre- andpostsynaptic alpha-2 adrenoreceptors and causingan increased release of noradrenaline anddopamine

Purity 9985Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g

YS-49Cat No HY-15477

YS-49 is a (a downstream target of RhoA)PI3KAktactivator to reduce RhoAPTEN activation in the3-methylcholanthrene-treated cells YS-49 inhibits

-stimulated proliferationangiotensin II (Ang II)of VSMCs via induction of heme oxygenase (HO)-1

Purity 9538Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg

YS-49 monohydrateCat No HY-15477A

YS-49 (monohydrate) is a (a downstreamPI3KAkttarget of RhoA) activator to reduce RhoAPTENactivation in the 3-methylcholanthrene-treatedcells YS-49 inhibits angiotensin II (Ang

-stimulated proliferation of VSMCs viaII)induction of heme oxygenase (HO)-1

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg

Zilpaterol-d7Cat No HY-A0072S

Zilpaterol-d7 is a deuterium labeled Zilpaterol

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

28 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Zinterol (MJ 9184) Cat No HY-14304

Zinterol (MJ 9184) is a potent and selective agonist Zinterol increases I inβ2-adrenoceptor Ca

a concentration-dependent manner with an EC of50

22 nM

Purity gt98Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg 10 mg

ZK-90055 hydrochlorideCat No HY-U00293

ZK-90055 hydrochloride is a β2 adrenergic agonistreceptor

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

α1 adrenoceptor-MO-1Cat No HY-U00333

α1 adrenoceptor-MO-1 an S enantiomer hasaffinity at showsalpha 1 adrenergic receptoralphalytic activity and possesses analgesicaction more active than R enantiomer

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

β3-AR agonist 1Cat No HY-101514

β3-AR agonist 1 (compound 15) is a highly potentselective and orally available β3-adrenergic

agonist ( =18 nM) beingreceptor (β3-AR) EC50

inactive to β1- β2- and α1A-AR (β1β3 β2β3and α1Aβ3gt556-fold)

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

β3-AR agonist 2Cat No HY-U00391

β -AR agonist 2 is a potent and selective3

( ) agonist with anβ -adrenergic receptor3 β -AR3

of 8 nMEC50

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

wwwMedChemExpresscom 29